Drug Delivery
Tumor Microenvironment
Solid Tumors
Experimental Therapeutics
Identify pathways for drug delivery to solid tumors (and beyond the liver)
Engineering strategies to temporal and special delivery of drug combinations targeting different components of the tumor microenvironment
Delivery of macromolecules to solid tumors
Novel anticancer targeted strategies to boost intratumoral immune system
Scientific activity has been focused on the design of targeted entities, namely lipid-based nanosystems for drug and nucleic acid delivery, addressing the impact on the tumor microenvironment and cancer cells, both at the cellular and molecular level. Scientific competences include formulation and characterization of lipid nanovesicles, in vitro and in vivo mechanistic studies, in vitro cytotoxicity, biodistribution, and therapeutic testing in animal models of cancer.
The goals of the group also point towards the identification and validation of target proteins overexpressed in tumors associated with clear unmet medical needs. This aims at identifying novel pathways for drug delivery to solid tumors (and beyond the liver), combined with the demonstration of their importance for the tumorigenic process. We believe that this strategy will enable to establish the mechanism of action of the targeted strategies the members of the group have been working on, either with single or drug combinations. It will ultimately overcome the challenges posed by drug resistance and metastasis, thus leading to decrease of overall tumor burden and relapse as well, clearly benefiting cancer patients.
To further support the achievement of the referred scientific goals, and increase the translational potential of the generated knowledge, the involvement of researchers from hospitals and clinicians will be fostered at the early stages of the projects. This will be crucial to support the identified target proteins as markers for drug targeting, namely in patients-derived samples and validate the proposed targeting strategies.
Information about journal articles, updated at 01-12-2024, from platform CIÊNCIAVITAE.
Exosomes modified with anti-MEK1 siRNA lead to an effective silencing of triple negative breast cancer cells
Ferreira, Débora; Santos-Pereira, Cátia; Costa, Marta; Afonso, Julieta; Yang, Sujuan; Hensel, Janine; McAndrews, Kathleen M.; et al, 2023. Biomaterials Advances. 154. 2023. http://dx.doi.org/10.1016/j.bioadv.2023.213643 . 10.1016/j.bioadv.2023.213643 . Biomaterials Advances
Design of experiment (DoE) as a quality by design (QbD) tool to optimize formulations of lipid nanoparticles for nose-to-brain drug delivery
A.C. Correia; J.N. Moreira; J.M. Sousa Lobo; A.C. Silva, 2023. Expert Opinion on Drug Delivery. 2023. https://doi.org/10.1080/17425247.2023.2274902 . 10.1080/17425247.2023.2274902 . Expert Opinion on Drug Delivery
Preclinical validation of a new hybrid molecule loaded in liposomes for melanoma management
Pinho, Jacinta O.; Matias, Mariana; Marques, Vanda; Eleutério, Carla; Fernandes, Célia; Gano, Lurdes; Amaral, Joana D.; et al, 2023. Biomedicine & Pharmacotherapy. 157. 2023. http://dx.doi.org/10.1016/j.biopha.2022.114021 . 10.1016/j.biopha.2022.114021 . published Biomedicine & Pharmacotherapy
Current Insights on Lipid-Based Nanosystems 2023
Ana Catarina Silva; João Nuno Moreira; José Manuel Sousa Lobo, 2023. Pharmaceuticals. 2023. https://doi.org/10.3390/ph16121700 . 10.3390/ph16121700 . Pharmaceuticals
In situ hydrogel containing diazepam-loaded nanostructured lipid carriers (DZP-NLC) for nose-to-brain delivery: development, characterization and deposition studies in a 3D-printed human nasal cavity model
Pina Costa, Cláudia; Nižic Nodilo, Laura; Silva, Renata; Martins, Eva; Zadravec, Dijana; Kalogjera, Livije; Nuno Moreira, João; et al, 2023. International Journal of Pharmaceutics. 644. 2023. http://dx.doi.org/10.1016/j.ijpharm.2023.123345 . 10.1016/j.ijpharm.2023.123345 . published International Journal of Pharmaceutics
New advances in exosome-based targeted drug delivery systems
Ferreira, Débora; Moreira, João Nuno; Rodrigues, Lígia R., 2022. Critical Reviews in Oncology/Hematology. 172. 2022. http://dx.doi.org/10.1016/j.critrevonc.2022.103628 . 10.1016/j.critrevonc.2022.103628 . Critical Reviews in Oncology/Hematology
Editorial—Current Insights on Lipid-Based Nanosystems
Ana Catarina Silva; João Nuno Moreira; José Manuel Sousa Lobo, 2022. Pharmaceuticals. 2022. https://doi.org/10.3390/ph15101267 . 10.3390/ph15101267 . Pharmaceuticals
Nucleolin expression has prognostic value in neuroblastoma patients
Cangelosi, Davide; Brignole, Chiara; Bensa, Veronica; Tamma, Roberto; Malaguti, Fabiana; Carlini, Barbara; Giusto, Elena; et al, 2022. eBioMedicine. 85. 2022. http://dx.doi.org/10.1016/j.ebiom.2022.104300 . 10.1016/j.ebiom.2022.104300 . eBioMedicine
Antagonist G-targeted liposomes for improved delivery of anticancer drugs in small cell lung carcinoma
Carvalheiro, Manuela; Ferreira-Silva, Margarida; Holovanchuk, Denys; Marinho, H. Susana; Moreira, João Nuno (EF1B-FA3D-0787); Soares, Helena; Corvo, M. Luisa; Cruz, Maria Eugénia M., 2022. International Journal of Pharmaceutics. 612. 2022. http://dx.doi.org/10.1016/j.ijpharm.2021.121380 . 10.1016/j.ijpharm.2021.121380 . International Journal of Pharmaceutics
Immunotherapy in triple-negative breast cancer: Insights into tumor immune landscape and therapeutic opportunities
Ribeiro, Rita; Carvalho, Maria João; Goncalves, João; Moreira, João Nuno, 2022. Frontiers in Molecular Biosciences. 9. 2022. http://dx.doi.org/10.3389/fmolb.2022.903065 . 10.3389/fmolb.2022.903065 . published Frontiers in Molecular Biosciences
Abstract 1276: Nucleolin has prognostic value in neuroblastoma patients
Cangelosi, Davide; Brignole, Chiara; Bensa, Veronica; Tamma, Roberto; Malaguti, Fabiana; Carlini, Barbara; Calarco, Enzo; et al, 2022. Cancer Research. 1276 - 1276. 12_Supplem. 82. 2022. http://dx.doi.org/10.1158/1538-7445.am2022-1276 . 10.1158/1538-7445.am2022-1276 . Cancer Research
Lipid nanoparticles strategies to modify pharmacokinetics of central nervous system targeting drugs: Crossing or circumventing the blood–brain barrier (BBB) to manage neurological disorders
Correia, A.C.; Monteiro, A.R.; Silva, R.; Moreira, João Nuno; Sousa Lobo, J.M.; Silva, A.C., 2022. Advanced Drug Delivery Reviews. 189. 2022. http://dx.doi.org/10.1016/j.addr.2022.114485 . 10.1016/j.addr.2022.114485 . Advanced Drug Delivery Reviews
Targeted liposomal doxorubicin/ceramides combinations: The importance to assess the nature of drug interaction beyond bulk tumor cells
Cruz, Ana Filipa; Fonseca, Nuno A.; Malheiro, Ana Rita; B. Melo, Joana; Gaspar, Maria Manuela; Fernandes, Rui; Moura, Vera; Simões, Sérgio; Moreira, João Nuno, 2022. European Journal of Pharmaceutics and Biopharmaceutics. 61 - 77. 172. 2022. http://dx.doi.org/10.1016/j.ejpb.2022.01.006 . 10.1016/j.ejpb.2022.01.006 . European Journal of Pharmaceutics and Biopharmaceutics
Nucleolin Overexpression Predicts Patient Prognosis While Providing a Framework for Targeted Therapeutic Intervention in Lung Cancer
Valério-Fernandes, Ângela; Fonseca, Nuno A.; Gonçalves, Nélio; Cruz, Ana F.; Pereira, Marta I.; Gregório, Ana C.; Moura, Vera; et al, 2022. Cancers. 9. 14. 2022. http://dx.doi.org/10.3390/cancers14092217 . 10.3390/cancers14092217 . Cancers
Cancer Stem Cells and Nucleolin as Drivers of Carcinogenesis
Carvalho, Laura Sofia; Gonçalves, Nélio; Fonseca, Nuno André; Moreira, João Nuno, 2021. Pharmaceuticals. 1. 14. 2021. http://dx.doi.org/10.3390/ph14010060 . 10.3390/ph14010060 . Pharmaceuticals
Intranasal delivery of nanostructured lipid carriers, solid lipid nanoparticles and nanoemulsions: A current overview of in vivo studies
Cláudia Pina Costa; João Nuno Moreira; José Manuel Sousa Lobo; Ana Catarina Silva, 2021. Acta Pharmaceutica Sinica B. 2021. https://doi.org/10.1016/j.apsb.2021.02.012 . 10.1016/j.apsb.2021.02.012 . Acta Pharmaceutica Sinica B
GMP-grade nanoparticle targeted to nucleolin downregulates tumor molecular signature, blocking growth and invasion, at low systemic exposure
Fonseca, Nuno A.; Gregório, Ana C.; Mendes, Vera M.; Lopes, Rui; Abreu, Teresa; Simões, Sérgio; Moreira, João Nuno, 2021. Nano Today. 37. 2021. http://dx.doi.org/10.1016/j.nantod.2021.101095 . 10.1016/j.nantod.2021.101095 . Nano Today
Quality by design (QbD) optimization of diazepam-loaded nanostructured lipid carriers (NLC) for nose-to-brain delivery: toxicological effect of surface charge on human neuronal cells
Costa, C.P.; Cunha, S.; Moreira, J. N.; Silva, R.; Gil-Martins, E.; Silva, V.; Azevedo, L.; et al, 2021. International Journal of Pharmaceutics. 2021. http://dx.doi.org/10.1016/j.ijpharm.2021.120933 . 10.1016/j.ijpharm.2021.120933 . International Journal of Pharmaceutics
Cell surface Nucleolin represents a novel cellular target for neuroblastoma therapy
Brignole, Chiara; Bensa, Veronica; Fonseca, Nuno A.; Del Zotto, Genny; Bruno, Silvia; Cruz, Ana F.; Malaguti, Fabiana; et al, 2021. Journal of Experimental & Clinical Cancer Research. 1. 40. 2021. http://dx.doi.org/10.1186/s13046-021-01993-9 . 10.1186/s13046-021-01993-9 . Journal of Experimental & Clinical Cancer Research
Modelling the impact of nucleolin expression level on the activity of F3 peptide-targeted pH-sensitive pegylated liposomes containing doxorubicin
Rui Lopes; Kevin Shi; Nuno A. Fonseca; Adelina Gama; José S. Ramalho; Luís Almeida; Vera Moura; et al, 2021. Drug Delivery and Translational Research. 2021. https://doi.org/10.1007/s13346-021-00972-z . 10.1007/s13346-021-00972-z . Drug Delivery and Translational Research
The Enhanced Efficacy of Intracellular Delivery of Doxorubicin/C6-Ceramide Combination Mediated by the F3 Peptide/Nucleolin System Is Supported by the Downregulation of the PI3K/Akt Pathway
Ana Filipa Fernandes da Cruz; Mariana Biscaia Caleiras; Nuno A. Fonseca; Nélio Gonçalves; Vera M. Mendes; Susana F. Sampaio; Vera Moura; et al, 2021. Cancers. 2021. https://www.mdpi.com/2072-6694/13/12/3052 . 10.3390/cancers13123052 . Cancers
In Vitro Studies on Nasal Formulations of Nanostructured Lipid Carriers (NLC) and Solid Lipid Nanoparticles (SLN)
Cláudia Pina Costa; Sandra Barreiro; João Nuno Moreira; Renata Silva; Hugo Almeida; José Manuel Sousa Lobo; Ana Catarina Silva, 2021. Pharmaceuticals. 711 - 711. 8. 14. 2021. https://doi.org/10.3390/ph14080711 . 10.3390/ph14080711 . Pharmaceuticals
Using the quality by design (QbD) approach to optimize formulations of lipid nanoparticles and nanoemulsions: A review
Cunha, S.; Costa, C.P.; Moreira, João Nuno; Sousa Lobo, J.M.; Silva, A. C., 2020. Nanomedicine: Nanotechnology, Biology and Medicine. 2020. http://dx.doi.org/10.1016/j.nano.2020.102206 . 10.1016/j.nano.2020.102206 . in press Nanomedicine: Nanotechnology, Biology and Medicine
Application of the Quality-by-Design (QbD) Approach to Improve the Nose-to-Brain Delivery of Diazepam-Loaded Nanostructured Lipid Carriers (NLCs)
Costa, Cláudia Pina; Cunha, Sara; Peixoto, Andreia F.; Moreira, João Nuno; Lobo, José Manuel Sousa; Silva, Ana Catarina, 2020. Proceedings. 1. 78. 2020. http://dx.doi.org/10.3390/iecp2020-08658 . 10.3390/iecp2020-08658 . Proceedings
Current challenges and emerging opportunities of CAR-T cell therapies
Abreu, Teresa R.; Fonseca, Nuno A.; Gonçalves, Nélio; Moreira, João Nuno (EF1B-FA3D-0787), 2020. Journal of Controlled Release. 246 - 261. 319. 2020. http://dx.doi.org/10.1016/j.jconrel.2019.12.047 . 10.1016/j.jconrel.2019.12.047 . Journal of Controlled Release
Nose-to-brain delivery of lipid-based nanosystems for epileptic seizures and anxiety crisis
Costa, C.; Moreira, J.N.; Amaral, M.H.; Sousa Lobo, J.M.; Silva, A.C., 2019. Journal of Controlled Release. 187 - 200. 295. 2019. http://dx.doi.org/10.1016/j.jconrel.2018.12.049 . 10.1016/j.jconrel.2018.12.049 . published Journal of Controlled Release
Nucleolin-based targeting strategies for cancer therapy: from targeted drug delivery to cytotoxic ligands
Romano, Sofia; Fonseca, Nuno; Simões, Sérgio; Gonçalves, João; Moreira, João Nuno, 2019. Drug Discovery Today. 1985 - 2001. 10. 24. 2019. http://dx.doi.org/10.1016/j.drudis.2019.06.018 . 10.1016/j.drudis.2019.06.018 . published Drug Discovery Today
Targeting Cancer Stem Cells and Non-Stem Cancer Cells: The Potential of Lipid- Based Nanoparticles
Cruz, Ana Filipa; Fonseca, Nuno Andre; Moura, Vera; Simoes, Sergio; Moreira, Joao Nuno, 2018. Current Pharmaceutical Design. 6563 - 6572. 43. 23. 2018. http://dx.doi.org/10.2174/1381612823666171115105252 . 10.2174/1381612823666171115105252 . Current Pharmaceutical Design
Nucleolin is expressed in patient-derived samples and glioblastoma cells, enabling improved intracellular drug delivery and cytotoxicity
Balça-Silva, Joana; do Carmo, Anália; Tão, Hermínio; Rebelo, Olinda; Barbosa, Marcos; Moura-Neto, Vivaldo; Sarmento-Ribeiro, Ana Bela; Lopes, Maria Celeste; Moreira, João Nuno, 2018. Experimental Cell Research. 68 - 77. 1. 370. 2018. http://dx.doi.org/10.1016/j.yexcr.2018.06.005 . 10.1016/j.yexcr.2018.06.005 . published Experimental Cell Research
Anticancer activity and antibody-dependent cell-mediated cytotoxicity of novel anti-nucleolin antibodies
Romano, Sofia; Moura, Vera; Simões, Sérgio; Moreira, João Nuno; Gonçalves, João, 2018. Scientific Reports. 1. 8. 2018. http://dx.doi.org/10.1038/s41598-018-25816-8 . 10.1038/s41598-018-25816-8 . Scientific Reports
Meeting the needs of breast cancer: A nucleolin's perspective
Gregório, Ana C.; Lacerda, Manuela; Figueiredo, Paulo; Simões, Sérgio; Dias, Sérgio; Moreira, João Nuno, 2018. Critical Reviews in Oncology/Hematology. 89 - 101. 125. 2018. http://dx.doi.org/10.1016/j.critrevonc.2018.03.008 . 10.1016/j.critrevonc.2018.03.008 . Critical Reviews in Oncology/Hematology
Nanoparticulate vaccine inhibits tumor growth via improved T cell recruitment into melanoma and huHER2 breast cancer
Zupancic, Eva; Curato, Caterina; Kim, Jung-Seok; Yeini, Eilam; Porat, Ziv; Viana, Ana S.; Globerson-Levin, Anat; et al, 2018. Nanomedicine: Nanotechnology, Biology and Medicine. 835 - 847. 3. 14. 2018. http://dx.doi.org/10.1016/j.nano.2017.12.011 . 10.1016/j.nano.2017.12.011 . Nanomedicine: Nanotechnology, Biology and Medicine
Therapeutic Implications of the Molecular and Immune Landscape of Triple-Negative Breast Cancer
Gregório, Ana C.; Lacerda, Manuela; Figueiredo, Paulo; Simões, Sérgio; Dias, Sérgio; Moreira, João Nuno; Ana C. Gregório; et al, 2017. Pathology & Oncology Research. 701 - 716. 4. 24. 2017. http://dx.doi.org/10.1007/s12253-017-0307-2 . 10.1007/s12253-017-0307-2 . Pathology & Oncology Research
The cancer stem cell phenotype as a determinant factor of the heterotypic nature of breast tumors
Fonseca, Nuno A.; Cruz, Ana Filipa; Moura, Vera; Simões, Sérgio; Moreira, João Nuno, 2017. Critical Reviews in Oncology/Hematology. 111 - 121. 113. 2017. http://dx.doi.org/10.1016/j.critrevonc.2017.03.016 . 10.1016/j.critrevonc.2017.03.016 . Critical Reviews in Oncology/Hematology
Rational design of nanoparticles towards targeting antigen-presenting cells and improved T cell priming
Zupancic, Eva; Curato, Caterina; Paisana, Maria; Rodrigues, Catarina; Porat, Ziv; Viana, Ana S.; Moreira, João N.; et al, 2017. Journal of Controlled Release. 182 - 195. 258. 2017. http://dx.doi.org/10.1016/j.jconrel.2017.05.014 . 10.1016/j.jconrel.2017.05.014 . Journal of Controlled Release
Intravenous administration of brain-targeted stable nucleic acid lipid particles alleviates Machado-Joseph disease neurological phenotype
Conceição, Mariana; Mendonça, Liliana; Nóbrega, Clévio; Gomes, Célia; Costa, Pedro; Hirai, Hirokazu; Moreira, João Nuno; et al, 2016. Biomaterials. 124 - 137. 82. 2016. http://dx.doi.org/10.1016/j.biomaterials.2015.12.021 . 10.1016/j.biomaterials.2015.12.021 . published Biomaterials
Inoculated Cell Density as a Determinant Factor of the Growth Dynamics and Metastatic Efficiency of a Breast Cancer Murine Model
Gregório, Ana C.; Fonseca, Nuno A.; Moura, Vera; Lacerda, Manuela; Figueiredo, Paulo; Simões, Sérgio; Dias, Sérgio; Moreira, João Nuno, 2016. PLOS ONE. 11. 11. 2016. http://dx.doi.org/10.1371/journal.pone.0165817 . 10.1371/journal.pone.0165817 . PLOS ONE
Safety profile of the intravenous administration of brain-targeted stable nucleic acid lipid particles
Conceição, Mariana; Mendonça, Liliana; Nóbrega, Clévio; Gomes, Célia; Costa, Pedro; Hirai, Hirokazu; Moreira, João Nuno; et al, 2016. Data in Brief. 700 - 705. 6. 2016. http://dx.doi.org/10.1016/j.dib.2016.01.017 . 10.1016/j.dib.2016.01.017 . Data in Brief
Dual release of a hydrophilic and a hydrophobic osteogenic factor from a single liposome
Nelson Monteiro; Albino Martins; Ricardo A. Pires; Susana Faria; Nuno A. Fonseca; João N. Moreira; Rui L. Reis; et al, 2016. RSC Advances. 114599 - 114612. 115. 6. 2016. https://doi.org/10.1039/C6RA21623D . 10.1039/C6RA21623D . RSC Advances
Development of e-learning platform about biologic drugs with focus on monoclonal antibodies
J. Goncalves; L. Graça; Moreira, João Nuno; I. V. Figueiredo; F. Scappaticci; J. Eurico Fonseca; F. Magro; et al, 2016. International Journal of Clinical Pharmacy. 519 - 520. 2. 38. 2016. published International Journal of Clinical Pharmacy
Antibacterial activity of chitosan nanofiber meshes with liposomes immobilized releasing gentamicin
Monteiro, Nelson; Martins, Margarida; Martins, Albino; Fonseca, Nuno A.; Moreira, João N.; Reis, Rui L.; Neves, Nuno M., 2015. Acta Biomaterialia. 196 - 205. 18. 2015. http://dx.doi.org/10.1016/j.actbio.2015.02.018 . 10.1016/j.actbio.2015.02.018 . Acta Biomaterialia
Nucleolin overexpression in breast cancer cell sub-populations with different stem-like phenotype enables targeted intracellular delivery of synergistic drug combination
Fonseca, Nuno A.; Rodrigues, Ana S.; Rodrigues-Santos, Paulo; Alves, Vera; Gregório, Ana C.; Simões, Sérgio; Moreira, João Nuno, 2015. Biomaterials. 76 - 88. 69. 2015. http://dx.doi.org/10.1016/j.biomaterials.2015.08.007 . 10.1016/j.biomaterials.2015.08.007 . published Biomaterials
Translational Peptide-associated Nanosystems: Promising Role as Cancer Vaccines
Zupancic, Eva; Peres, Carina; I Matos, Ana; Lopes, Joao; N Moreira, Joao; S Gaspar, Rogerio; F Florindo, Helena, 2015. Current Topics in Medicinal Chemistry. 291 - 313. 3. 16. 2015. http://dx.doi.org/10.2174/1568026615666150701115508 . 10.2174/1568026615666150701115508 . Current Topics in Medicinal Chemistry
Bridging cancer biology and the patients' needs with nanotechnology-based approaches
Fonseca, Nuno A.; Gregório, Ana C.; Valério-Fernandes, Ângela; Simões, Sérgio; Moreira, João N., 2014. Cancer Treatment Reviews. 626 - 635. 5. 40. 2014. http://dx.doi.org/10.1016/j.ctrv.2014.02.002 . 10.1016/j.ctrv.2014.02.002 . published Cancer Treatment Reviews
Development of a Novel Nanoparticle-based Therapeutic Vaccine for Breast Cancer Immunotherapy
Zupancic, Eva; Silva, JoanaM; Videira, Mafalda A.; Moreira, João N.; Florindo, Helena F., 2014. Procedia in Vaccinology. 62 - 67. 8. 2014. http://dx.doi.org/10.1016/j.provac.2014.07.011 . 10.1016/j.provac.2014.07.011 . published Procedia in Vaccinology
Immobilization of bioactive factor-loaded liposomes on the surface of electrospun nanofibers targeting tissue engineering
Monteiro, Nelson; Martins, Albino; Pires, Ricardo; Faria, Susana; Fonseca, Nuno A.; Moreira, João N.; Reis, Rui L.; Neves, Nuno M., 2014. Biomater. Sci.. 1195 - 1209. 9. 2. 2014. http://dx.doi.org/10.1039/c4bm00069b . 10.1039/c4bm00069b . published Biomater. Sci.
Simultaneous active intracellular delivery of doxorubicin and C6-ceramide shifts the additive/antagonistic drug interaction of non-encapsulated combination
Fonseca, Nuno A.; Gomes-da-Silva, Lígia C.; Moura, Vera; Simões, Sérgio; Moreira, João Nuno, 2014. Journal of Controlled Release. 122 - 131. 196. 2014. http://dx.doi.org/10.1016/j.jconrel.2014.09.024 . 10.1016/j.jconrel.2014.09.024 . Journal of Controlled Release
Instructive Nanofibrous Scaffold Comprising Runt-Related Transcription Factor 2 Gene Delivery for Bone Tissue Engineering
Monteiro, Nelson; Ribeiro, Diana; Martins, Albino; Faria, Susana; Fonseca, Nuno A.; Moreira, João N.; Reis, Rui L.; Neves, Nuno M., 2014. ACS Nano. 8082 - 8094. 8. 8. 2014. http://dx.doi.org/10.1021/nn5021049 . 10.1021/nn5021049 . published ACS Nano
Impact of anti-PLK1 siRNA-containing F3-targeted liposomes on the viability of both cancer and endothelial cells
Gomes-da-Silva, Lígia C.; Ramalho, José S.; Pedroso de Lima, Maria C.; Simões, Sérgio; Moreira, João N., 2013. European Journal of Pharmaceutics and Biopharmaceutics. 356 - 364. 3. 85. 2013. http://dx.doi.org/10.1016/j.ejpb.2013.04.007 . 10.1016/j.ejpb.2013.04.007 . published European Journal of Pharmaceutics and Biopharmaceutics
Impact of PLK-1 silencing on endothelial cells and cancer cells of diverse histological origin
Gomes, C.P.; Gomes-da-Silva, L.C.; Ramalho, J.S.; de Lima, M.C.P.; Simões, S.; Moreira, J.N., 2013. Current Gene Therapy. 189 - 201. 3. 13. 2013. http://www.scopus.com/inward/record.url?eid=2-s2.0-84878633310&partnerID=MN8TOARS . 10.2174/1566523211313030004 . Current Gene Therapy
Efficient intracellular delivery of siRNA with a safe multitargeted lipid-based nanoplatform
Gomes-da-Silva, Lígia C; Fernández, Yolanda; Abasolo, Ibane; Schwartz, Simo; Ramalho, José S; Pedroso de Lima, Maria C; Simões, Sérgio; Moreira, João N, 2013. Nanomedicine. 1397 - 1413. 9. 8. 2013. http://dx.doi.org/10.2217/nnm.12.174 . 10.2217/nnm.12.174 . published Nanomedicine
MRI Tracking of Macrophages Labeled with Glucan Particles Entrapping a Water Insoluble Paramagnetic Gd-Based Agent
Figueiredo, S.; Cutrin, J.C.; Rizzitelli, S.; De Luca, E.; Moreira, J.N.; Geraldes, C.F.G.C.; Aime, S.; Terreno, E., 2013. Molecular Imaging and Biology. 307 - 315. 3. 15. 2013. http://www.scopus.com/inward/record.url?eid=2-s2.0-84877727777&partnerID=MN8TOARS . 10.1007/s11307-012-0603-x . Molecular Imaging and Biology
On the use of dexamethasone-loaded liposomes to induce the osteogenic differentiation of human mesenchymal stem cells
Monteiro, Nelson; Martins, Albino; Ribeiro, Diana; Faria, Susana; Fonseca, Nuno A.; Moreira, João N.; Reis, Rui L.; Neves, Nuno M.; Moreira, João Nuno, 2013. Journal of Tissue Engineering and Regenerative Medicine. 1056 - 1066. 9. 9. 2013. http://dx.doi.org/10.1002/term.1817 . 10.1002/term.1817 . published Journal of Tissue Engineering and Regenerative Medicine
Tumor-targeted chlorotoxin-coupled nanoparticles for nucleic acid delivery to glioblastoma cells: a promising system for glioblastoma treatment
Costa, Pedro M; Cardoso, Ana L; Mendonça, Liliana S; Serani, Angelo; Custódia, Carlos; Conceição, Mariana; Moreira, João N; Pereira de Almeida, Luís; Pedroso de Lima, Maria C, 2013. Molecular Therapy - Nucleic Acids. 2. 2013. http://dx.doi.org/10.1038/mtna.2013.30 . 10.1038/mtna.2013.30 . published Molecular Therapy - Nucleic Acids
Challenging the future of siRNA therapeutics against cancer: the crucial role of nanotechnology
Gomes-da-Silva, Lígia Catarina; Simões, Sérgio; Moreira, João Nuno; Gomes-da-Silva, L.C.; Simões, S.; Moreira, J.N., 2013. Cellular and Molecular Life Sciences. 1417 - 1438. 8. 71. 2013. http://dx.doi.org/10.1007/s00018-013-1502-2 . 10.1007/s00018-013-1502-2 . published Cellular and Molecular Life Sciences
Development, Characterization and In Vitro Evaluation of Single or Co-Loaded Imatinib Mesylate Liposomal Formulations
Pinto, Ana Catarina; Ângelo, Susana; Moreira, João Nuno; Simões, Sérgio, 2012. Journal of Nanoscience and Nanotechnology. 2891 - 2900. 3. 12. 2012. http://dx.doi.org/10.1166/jnn.2012.5703 . 10.1166/jnn.2012.5703 . Journal of Nanoscience and Nanotechnology
Lipid-Based Nanoparticles for siRNA Delivery in Cancer Therapy: Paradigms and Challenges
Gomes-da-Silva, Lígia C.; Fonseca, Nuno A.; Moura, Vera; Pedroso de Lima, Maria C.; Simões, Sérgio; Moreira, João N., 2012. Accounts of Chemical Research. 1163 - 1171. 7. 45. 2012. http://dx.doi.org/10.1021/ar300048p . 10.1021/ar300048p . published Accounts of Chemical Research
Toward a siRNA-containing nanoparticle targeted to breast cancer cells and the tumor microenvironment
Gomes-da-Silva, Lígia C.; Santos, Adriana O.; Bimbo, Luís M.; Moura, Vera; Ramalho, José S.; Pedroso de Lima, Maria C.; Simões, Sérgio; Moreira, João N., 2012. International Journal of Pharmaceutics. 9 - 19. 1-2. 434. 2012. http://dx.doi.org/10.1016/j.ijpharm.2012.05.018 . 10.1016/j.ijpharm.2012.05.018 . published International Journal of Pharmaceutics
[Visualization of deep lung lymphatic network using radioliposomes]. [Article in Portuguese]
Botelho, M.F.; De Lima, J.J.P.; Dormehl, I.C.; Fontes Baganha, M.; Gomes, C.M.; Santos, A.C.; Moreira, J.N.; Kilian, E., 2011. Revista Portuguesa de Pneumologia (English Edition). 5. 17. 2011. http://dx.doi.org/10.1016/j.rppnen.2011.09.002 . 10.1016/j.rppnen.2011.09.002 . Revista Portuguesa de Pneumologia (English Edition)
Selective Cytotoxicity of Oxysterols through Structural Modulation on Rings A and B. Synthesis, in Vitro Evaluation, and SAR
Carvalho, Joa~o F. S.; Silva, M. Manuel Cruz; Moreira, Joa~o N.; Simo~es, Se´rgio; Sa´ e Melo, M. Luisa, 2011. Journal of Medicinal Chemistry. 6375 - 6393. 18. 54. 2011. http://dx.doi.org/10.1021/jm200803d . 10.1021/jm200803d . Journal of Medicinal Chemistry
Yeast cell wall particles: a promising class of nature-inspired microcarriers for multimodal imaging
Figueiredo, Sara; Moreira, João Nuno; Geraldes, Carlos F. G. C.; Rizzitelli, Silvia; Aime, Silvio; Terreno, Enzo, 2011. Chemical Communications. 38. 47. 2011. http://dx.doi.org/10.1039/c1cc14019a . 10.1039/c1cc14019a . published Chemical Communications
Supramolecular protamine/Gd-loaded liposomes adducts as relaxometric protease responsive probes
Figueiredo, S.; Moreira, J.N.; Geraldes, C.F.G.C.; Aime, S.; Terreno, E., 2011. Bioorganic and Medicinal Chemistry. 1131 - 1135. 3. 19. 2011. http://www.scopus.com/inward/record.url?eid=2-s2.0-79551487375&partnerID=MN8TOARS . 10.1016/j.bmc.2010.07.057 . Bioorganic and Medicinal Chemistry
Targeted and intracellular triggered delivery of therapeutics to cancer cells and the tumor microenvironment: impact on the treatment of breast cancer
Moura, Vera; Lacerda, Manuela; Figueiredo, Paulo; Corvo, Maria L.; Cruz, Maria E. M.; Soares, Raquel; de Lima, Maria C. Pedroso; Simões, Sérgio; Moreira, João N., 2011. Breast Cancer Research and Treatment. 61 - 73. 1. 133. 2011. http://dx.doi.org/10.1007/s10549-011-1688-7 . 10.1007/s10549-011-1688-7 . published Breast Cancer Research and Treatment
In vitro modulation of Bcl-2 levels in small cell lung cancer cells: effects on cell viability
Santos, A.O.; Pereira, J.P.; Pedroso de Lima, M.C.; Simões, S.; Moreira, J.N., 2010. Brazilian Journal of Medical and Biological Research. 1001 - 1009. 10. 43. 2010. http://dx.doi.org/10.1590/s0100-879x2010007500099 . 10.1590/s0100-879x2010007500099 . published Brazilian Journal of Medical and Biological Research
Sterols as Anticancer Agents: Synthesis of Ring-B Oxygenated Steroids, Cytotoxic Profile, and Comprehensive SAR Analysis
Carvalho, Joa~o F. S.; Silva, M. Manuel Cruz; Moreira, Joa~o N.; Simo~es, Se´rgio; Sa´ e Melo, M. Luisa, 2010. Journal of Medicinal Chemistry. 7632 - 7638. 21. 53. 2010. http://dx.doi.org/10.1021/jm1007769 . 10.1021/jm1007769 . published Journal of Medicinal Chemistry
Co-encapsulation of anti-BCR-ABL siRNA and imatinib mesylate in transferrin receptor-targeted sterically stabilized liposomes for chronic myeloid leukemia treatment
Mendonça, Liliana S.; Moreira, João N.; de Lima, Maria C. Pedroso; Simões, Sérgio, 2010. Biotechnology and Bioengineering. 884 - 893. 5. 107. 2010. http://dx.doi.org/10.1002/bit.22858 . 10.1002/bit.22858 . published Biotechnology and Bioengineering
Transferrin Receptor-Targeted Liposomes Encapsulating anti-BCR-ABLsiRNA or asODN for Chronic Myeloid Leukemia Treatment
Mendonc¸a, Liliana S.; Firmino, Filipe; Moreira, João N.; Pedroso de Lima, Maria C.; Simões, Se´rgio, 2010. Bioconjugate Chemistry. 157 - 168. 1. 21. 2010. http://dx.doi.org/10.1021/bc9004365 . 10.1021/bc9004365 . published Bioconjugate Chemistry
Liposomal imatinib-mitoxantrone combination: Formulation development and therapeutic evaluation in an animal model of prostate cancer
Pinto, Ana Catarina; Moreira, João Nuno; Simões, Sérgio, 2010. The Prostate. 81 - 90. 1. 71. 2010. http://dx.doi.org/10.1002/pros.21224 . 10.1002/pros.21224 . The Prostate
Design of peptide-targeted liposomes containing nucleic acids
Santos, Adriana O.; da Silva, Lígia C. Gomes; Bimbo, Luís M.; de Lima, Maria C. Pedroso; Simões, Sérgio; Moreira, João N., 2010. Biochimica et Biophysica Acta (BBA) - Biomembranes. 433 - 441. 3. 1798. 2010. http://dx.doi.org/10.1016/j.bbamem.2009.12.001 . 10.1016/j.bbamem.2009.12.001 . published Biochimica et Biophysica Acta (BBA) - Biomembranes
Synthesis and structure-activity relationship study of novel cytotoxic carbamate and N-acylheterocyclic bearing derivatives of betulin and betulinic acid
Santos, R.C.; Salvador, J.A.R.; Marín, S.; Cascante, M.; Moreira, J.N.; Dinis, T.C.P., 2010. Bioorganic and Medicinal Chemistry. 4385 - 4396. 12. 18. 2010. http://www.scopus.com/inward/record.url?eid=2-s2.0-77953321890&partnerID=MN8TOARS . 10.1016/j.bmc.2010.04.085 . Bioorganic and Medicinal Chemistry
Schedule treatment design and quantitative in vitro evaluation of chemotherapeutic combinations for metastatic prostate cancer therapy
Pinto, Ana Catarina; Ângelo, Susana; Moreira, João Nuno; Simões, Sérgio, 2010. Cancer Chemotherapy and Pharmacology. 275 - 284. 2. 67. 2010. http://dx.doi.org/10.1007/s00280-010-1315-z . 10.1007/s00280-010-1315-z . published Cancer Chemotherapy and Pharmacology
Targeted Lipoplexes for siRNA Delivery
Cardoso, Ana; Trabulo, Sara; Moreira, João Nuno; Düzgünes, Nejat; de Lima, Maria C. Pedroso, 2009. Methods in Enzymology. 267 - 287. 2009. http://dx.doi.org/10.1016/s0076-6879(09)65014-x . 10.1016/s0076-6879(09)65014-x . Methods in Enzymology
Efficient Chemoenzymatic Synthesis, Cytotoxic Evaluation, and SAR of Epoxysterols
Carvalho, Joa~o F. S.; Cruz Silva, M. Manuel; Moreira, Joa~o N.; Simo~es, Se´rgio; Sa´ e Melo, M. Luisa, 2009. Journal of Medicinal Chemistry. 4007 - 4019. 13. 52. 2009. http://dx.doi.org/10.1021/jm9003973 . 10.1021/jm9003973 . published Journal of Medicinal Chemistry
Non-viral lipid-based nanoparticles for cancer systemic gene silencing
João Nuno Moreira; A. Santos; Vera Moura; Maria C. Pedroso de Lima; Sérgio Simões; Moreira, J.N.; Santos, A.; et al, 2008. Journal of Nanoscience and Nanotechnology. 2187 - 2204 . 5. 8. 2008. http://www.scopus.com/inward/record.url?eid=2-s2.0-47149083118&partnerID=MN8TOARS . 10.1166/jnn.2008.319 . published Journal of Nanoscience and Nanotechnology
Ciprofloxacin sensitizes hormone-refractory prostate cancer cell lines to doxorubicin and docetaxel treatment on a schedule-dependent manner
Pinto, Ana Catarina; Moreira, João Nuno; Simões, Sérgio, 2008. Cancer Chemotherapy and Pharmacology. 445 - 454. 3. 64. 2008. http://dx.doi.org/10.1007/s00280-008-0892-6 . 10.1007/s00280-008-0892-6 . published Cancer Chemotherapy and Pharmacology
Simultaneous evaluation of viability and Bcl-2 in small-cell lung cancer
Santos, A.; Sarmento-Ribeiro, A. B.; de Lima, M. C. Pedroso; Simões, S.; Moreira, J. N., 2008. Cytometry Part A. 1165 - 1172. 12. 73A. 2008. http://dx.doi.org/10.1002/cyto.a.20634 . 10.1002/cyto.a.20634 . published Cytometry Part A
Bcl-2-Targeted Antisense Therapy (Oblimersen Sodium): Towards Clinical Reality
Moreira, João Nuno; Santos, Adriana; Simões, Sérgio, 2006. Reviews on Recent Clinical Trials. 217 - 235. 3. 1. 2006. http://dx.doi.org/10.2174/157488706778250050 . 10.2174/157488706778250050 . published Reviews on Recent Clinical Trials
Targeting of sterically stabilised pH-sensitive liposomes to human T-leukaemia cells
FONSECA, C; MOREIRA, J; CIUDAD, C; PEDROSODELIMA, M; SIMOES, S, 2005. European Journal of Pharmaceutics and Biopharmaceutics. 359 - 366. 2. 59. 2005. http://dx.doi.org/10.1016/j.ejpb.2004.08.012 . 10.1016/j.ejpb.2004.08.012 . published European Journal of Pharmaceutics and Biopharmaceutics
On the formulation of pH-sensitive liposomes with long circulation times
Simões, S; João Nuno Moreira; Nejat Düzgünes N; Maria C. Pedroso de Lima, 2004. Advanced Drug Delivery Reviews. 947 - 965. 7. 56. 2004. http://dx.doi.org/10.1016/j.addr.2003.10.038 . 10.1016/j.addr.2003.10.038 . Advanced Drug Delivery Reviews
Antagonist G-mediated targeting and cytotoxicity of liposomal doxorubicin in NCI-H82 variant small cell lung cancer
Moreira, J.N.; Gaspar, R., 2004. Brazilian Journal of Medical and Biological Research. 1185 - 1192. 8. 37. 2004. http://www.scopus.com/inward/record.url?eid=2-s2.0-4444282289&partnerID=MN8TOARS . 10.1590/s0100-879x2004000800008 . published Brazilian Journal of Medical and Biological Research
Technology evaluation: LErafAON, NeoPharm
Moreira, J.N.; Simões, S., 2003. Current Opinion in Molecular Therapeutics. 547 - 552. 5. 5. 2003. http://www.scopus.com/inward/record.url?eid=2-s2.0-0142154204&partnerID=MN8TOARS . published Current Opinion in Molecular Therapeutics
Adventures in targeting
Allen, T.M.; Sapra, P.; Moase, E.; Moreira, João Nuno; Iden, D., 2002. Journal of Liposome Research. 5 - 12. 1-2. 12. 2002. http://www.scopus.com/inward/record.url?eid=2-s2.0-0036331129&partnerID=MN8TOARS . 10.1081/LPR-120004771 . Journal of Liposome Research
Use of the post-insertion technique to insert peptide ligands into pre-formed stealth liposomes with retention of binding activity and cytotoxicity
Moreira, J.N.; Ishida, T.; Gaspar, R.; Allen, T.M.; Moreira, João N.; Ishida, Tatsuhiro; Gaspar, Rogério; Allen, Theresa M., 2002. Pharmaceutical Research. 265 - 269. 3. 19. 2002. http://www.scopus.com/inward/record.url?eid=2-s2.0-0036200912&partnerID=MN8TOARS . 10.1023/A:1014434732752 . published Pharmaceutical Research
Targeting Stealth liposomes in a murine model of human small cell lung cancer
Moreira, João N.; Gaspar, Rogério; Allen, Theresa M.; Moreira, J.N.; Gaspar, R.; Allen, T.M., 2001. Biochimica et Biophysica Acta (BBA) - Biomembranes. 167 - 176. 2. 1515. 2001. http://dx.doi.org/10.1016/s0005-2736(01)00411-4 . 10.1016/s0005-2736(01)00411-4 . published Biochimica et Biophysica Acta (BBA) - Biomembranes
A growth factor antagonist as a targeting agent for sterically stabilized liposomes in human small cell lung cancer
Moreira, J.N.; Hansen, C.B.; Gaspar, R.; Allen, T.M.; Moreira, João N.; Hansen, Christian B.; Gaspar, Rogério; Allen, Theresa M., 2001. Biochimica et Biophysica Acta - Biomembranes. 303 - 317. 2. 1514. 2001. http://www.scopus.com/inward/record.url?eid=2-s2.0-0035479680&partnerID=MN8TOARS . 10.1016/S0005-2736(01)00386-8 . published Biochimica et Biophysica Acta - Biomembranes
Carboplatin liposomes coated with O-palmitoylpullulan: In vitro characterization
Moreira, J.N.; Almeida, L.M.; Geraldes, C.F.; Madeira, V.M.C.; Costa, M.L., 1997. International Journal of Pharmaceutics. 153 - 164. 2. 147. 1997. http://dx.doi.org/10.1016/s0378-5173(96)04808-9 . 10.1016/s0378-5173(96)04808-9 . published International Journal of Pharmaceutics
Evaluation of in vitro stability of large unilamellar liposomes coated with a modified polysaccharide (O-palmitoylpullulan)
Moreira, J.N.; Almeida, L.M.; Geraldes, C.F.; Costa, M.L.; Moreira, J. N.; Almeida, L. M.; Geraldes, C. F.; Costa, M. L., 1996. Journal of Materials Science: Materials in Medicine. 301 - 303. 5. 7. 1996. http://www.scopus.com/inward/record.url?eid=2-s2.0-0030151980&partnerID=MN8TOARS . 10.1007/bf00058571 . published Journal of Materials Science: Materials in Medicine
Characterization of the in vitro dissolution of some commercial sustained release theophylline dosage forms
Veiga, F.; Simoes, S.; Moreira, J.N.; Sousa, A., 1994. Drug Development and Industrial Pharmacy. 1471 - 1483. 8. 20. 1994. http://www.scopus.com/inward/record.url?eid=2-s2.0-0028335187&partnerID=MN8TOARS . Drug Development and Industrial Pharmacy
5 88 out of 88 Publications
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