Advanced Therapies Group

Near-Infrared Light Activated Formulation for the Spatially Controlled Release of CRISPR-Cas9 Ribonucleoprotein for Brain Gene Editing

Simões, Susana; Lino, Miguel; Barrera, Angela; Rebelo, Catarina; Tomatis, Francesca; Vilaça, Andreia; Breunig, Christopher; et al, 2024. Angewandte Chemie International Edition. 2024. http://dx.doi.org/10.1002/anie.202401004 . 10.1002/anie.202401004 . Angewandte Chemie International Edition

Cellular reprogramming as a tool to model human aging in a dish

Patricia R. Pitrez; Luis M. Monteiro; Oliver Borgogno; Xavier Nissan; Jerome Mertens; Lino Ferreira, 2024. Nature Communications. 2024. https://doi.org/10.1038/s41467-024-46004-5 . 10.1038/s41467-024-46004-5 . Nature Communications

Reconstruction of cell-specific models capturing the influence of metabolism on DNA methylation in cancer

Tânia Barata; Vítor Pereira; Ricardo Pires das Neves; Miguel Rocha, 2024. Computers in Biology and Medicine. 2024. https://doi.org/10.1016/j.compbiomed.2024.108052 . 10.1016/j.compbiomed.2024.108052 . Computers in Biology and Medicine

POSEIDON: Peptidic Objects SEquence-based Interaction with cellular DOmaiNs: a new database and predictor

Preto, António J.; Caniceiro, Ana B.; Duarte, Francisco; Fernandes, Hugo; Ferreira, Lino; Mourão, Joana; Moreira, Irina S., 2024. Journal of Cheminformatics. 1. 16. 2024. http://dx.doi.org/10.1186/s13321-024-00810-7 . 10.1186/s13321-024-00810-7 . Journal of Cheminformatics

Imaging platforms to dissect the in vivo communication, biodistribution and controlled release of extracellular vesicles

Banerjee, Arnab; Lino, Miguel; Jesus, Carlos; Ribeiro, Quélia; Abrunhosa, Antero; Ferreira, Lino, 2023. Journal of Controlled Release. 549 - 563. 360. 2023. http://dx.doi.org/10.1016/j.jconrel.2023.06.039 . 10.1016/j.jconrel.2023.06.039 . Journal of Controlled Release

Small extracellular vesicles administered directly in the brain promote neuroprotection and decreased microglia reactivity in a stroke mouse model

Lino, Miguel M.; Rondão, Tiago; Banerjee, Arnab; Aires, Inês; Rodrigues, Magda; Reis, Tiago; Santinha, António; et al, 2023. Nanoscale. 18212 - 18217. 45. 15. 2023. http://dx.doi.org/10.1039/d3nr03861k . 10.1039/d3nr03861k . Nanoscale

Retinoic Acid-Loaded Nanoparticles Promote Neurovascular Protection in Stroke.

Marta Pereira; Alba Grayston; Miguel García-Gabilondo; Vitor Francisco; Ana Clara Cristovao; João Pedro Marto; Helena L. A. Vieira; et al, 2023. Stroke. 2023. https://doi.org/10.1161/STROKEAHA.122.041839 . 10.1161/strokeaha.122.041839 . Stroke

Reconsidering the role of blood-brain barrier in Alzheimer's disease: From delivery to target.

Sousa JA; Bernardes C; Bernardo-Castro S; Lino M; Albino I; Ferreira L; Brás J; et al, 2023. Frontiers in aging neuroscience. 2023. https://europepmc.org/articles/PMC9978015 . 10.3389/fnagi.2023.1102809 . Frontiers in aging neuroscience

Engineering optical tools for remotely controlled brain stimulation and regeneration

Artur Filipe Rodrigues; Catarina Rebelo; Tiago Reis; Susana Simões; Liliana Bernardino; João Peça; Lino Ferreira, 2023. Biomaterials Science. 2023. https://doi.org/10.1039/D2BM02059A . 10.1039/D2BM02059A . Biomaterials Science

Author Correction: Efficient spatially targeted gene editing using a near-infrared activatable protein-conjugated nanoparticle for brain applications

Catarina Rebelo; Tiago Reis; Joana Guedes; Cláudia Saraiva; Artur Filipe Rodrigues; Susana Simões; Liliana Bernardino; et al, 2023. Nature Communications. 2023. https://doi.org/10.1038/s41467-023-39976-3 . 10.1038/s41467-023-39976-3 . Nature Communications

Acidic sophorolipid and antimicrobial peptide based formulation as antimicrobial and antibiofilm agents.

Seena S; Ferrão R; Pala M; Roelants SLKW; Soetaert W; Stevens CV; Ferreira L; Rai A, 2023. Biomaterials advances. 2023. https://doi.org/10.1016/j.bioadv.2023.213299 . 10.1016/j.bioadv.2023.213299 . Biomaterials advances

Designing Cell Delivery Peptides and SARS-CoV-2-Targeting Small Interfering RNAs: A Comprehensive Bioinformatics Study with Generative Adversarial Network-Based Peptide Design and <i>In Vitro</i> Assays

González, Ricardo D.; Simões, Susana; Ferreira, Lino; Carvalho, Alexandra T. P., 2023. Molecular Pharmaceutics. 6079 - 6089. 12. 20. 2023. http://dx.doi.org/10.1021/acs.molpharmaceut.3c00444 . 10.1021/acs.molpharmaceut.3c00444 . Molecular Pharmaceutics

The evolution of blood brain barrier permeability changes after stroke, and its implications on clinical outcome: a systematic review and meta-analysis.

Sara Bernardo-Castro; João André Sousa; Martins E; Helena Donato; Nunes CA; d'Almeida OC; Miguel Castelo-Branco; et al, 2023. International journal of stroke : official journal of the International Stroke Society. 2023. https://doi.org/10.1177/17474930231166306 . 10.1177/17474930231166306 . International journal of stroke : official journal of the International Stroke Society

Protein-Nanoparticle Interactions Govern the Interfacial Behavior of Polymeric Nanogels: Study of Protein Corona Formation at the Air/Water Interface.

Federico Traldi; Liu P; Inês Maria Cunha Albino; Ferreira L; Ali Zarbakhsh; Marina Resmini, 2023. International journal of molecular sciences. 2023. https://europepmc.org/articles/PMC9917661 . 10.3390/ijms24032810 . International journal of molecular sciences

Each Cellular Compartment Has a Characteristic Protein Reactive Cysteine Ratio Determining Its Sensitivity to Oxidation

Ricardo Pires das Neves; Mónica Chagoyen; Antonio Martinez-Lorente; Carlos Iñiguez; Ana Calatrava; Juana Calabuig; Francisco J. Iborra, 2023. Antioxidants. 2023. https://doi.org/10.3390/antiox12061274 . 10.3390/antiox12061274 . Antioxidants

Engineering graphene-based electrodes for optical neural stimulation

Artur Filipe Rodrigues; Ana P. M. Tavares; Susana Simões; Rui P. F. F. Silva; Tomás Sobrino; Bruno R. Figueiredo; Goreti Sales; Lino Ferreira, 2023. Nanoscale. 2023. https://doi.org/10.1039/D2NR05256C . 10.1039/D2NR05256C . Nanoscale

(Epi)transcriptomics in cardiovascular and neurological complications of COVID-19.

Jusic A; Stellos K; Ferreira L; Baker AH; Devaux Y, 2022. Journal of molecular and cellular cardiology plus. 2022. https://europepmc.org/articles/PMC9330360 . 10.1016/j.jmccpl.2022.100013 . Journal of molecular and cellular cardiology plus

MicroRNA-124-3p-enriched small extracellular vesicles as a therapeutic approach for Parkinson’s disease

2022. Molecular Therapy. 2022. http://dx.doi.org/10.1016/j.ymthe.2022.06.003 . 10.1016/j.ymthe.2022.06.003 . Molecular Therapy

Antimicrobial peptide-based materials: opportunities and challenges

Akhilesh Rai; Rafaela Ferrão; Paulo Palma; Tatiana Patricio; Paula Parreira; Elsa Anes; Chiara Tonda-Turo; et al, 2022. Journal of Materials Chemistry B. 2022. https://doi.org/10.1039/D1TB02617H . 10.1039/D1TB02617H . Journal of Materials Chemistry B

Reconstruction of tissue-specific genome-scale metabolic models for human cancer stem cells

Barata, Tânia; Vieira, Vítor; Rodrigues, Rúben; Neves, Ricardo Pires das; Rocha, Miguel, 2022. Computers in Biology and Medicine. 142. 2022. http://dx.doi.org/10.1016/j.compbiomed.2021.105177 . 10.1016/j.compbiomed.2021.105177 . Computers in Biology and Medicine

Antimicrobial Peptide-Tether Dressing Able to Enhance Wound Healing by Tissue Contact

Akhilesh Rai; Rafaela Ferrão; Denise Marta; Andreia Vilaça; Miguel Lino; Tiago Rondão; Jian Ji; Artur Paiva; Lino Ferreira, 2022. ACS Applied Materials & Interfaces. 2022. https://doi.org/10.1021/acsami.2c06601 . 10.1021/acsami.2c06601 . ACS Applied Materials & Interfaces

Unraveling the potential of endothelial progenitor cells as a treatment following ischemic stroke.

Custodia A; Ouro A; Sargento-Freitas J; Aramburu-Núñez M; Pías-Peleteiro JM; Pablo Hervella; Rosell A; et al, 2022. Frontiers in neurology. 2022. https://europepmc.org/articles/PMC9492921 . 10.3389/fneur.2022.940682 . Frontiers in neurology

Strategies and challenges for non-viral delivery of non-coding RNAs to the heart.

Vilaça A; de Windt LJ; Hugo Fernandes; Ferreira L, 2022. Trends in molecular medicine. 2022. https://doi.org/10.1016/j.molmed.2022.10.002 . 10.1016/j.molmed.2022.10.002 . Trends in molecular medicine

Efficient spatially targeted gene editing using a near-infrared activatable protein-conjugated nanoparticle for brain applications

Catarina Rebelo; Tiago Reis; Joana Guedes; Cláudia Saraiva; Artur Filipe Rodrigues; Susana Simões; Liliana Bernardino; et al, 2022. Nature Communications. 2022. https://doi.org/10.1038/s41467-022-31791-6 . 10.1038/s41467-022-31791-6 . Nature Communications

A Polymeric Nanoparticle Formulation for Targeted mRNA Delivery to Fibroblasts

Artur Filipe Rodrigues; Catarina Rebelo; Susana Simões; Cristiana Paulo; Sónia Pinho; Vítor Francisco; Lino Ferreira, 2022. Advanced Science. 2022. https://doi.org/10.1002/advs.202205475 . 10.1002/advs.202205475 . Advanced Science

Intercellular transfer of miR-200c-3p impairs the angiogenic capacity of cardiac endothelial cells

2022. Molecular Therapy. 2257 - 2273. 6. 30. 2022. http://dx.doi.org/10.1016/j.ymthe.2022.03.002 . 10.1016/j.ymthe.2022.03.002 . Molecular Therapy

Extracellular vesicles enriched with an endothelial cell pro-survival microRNA affects skin tissue regeneration

2022. Molecular Therapy - Nucleic Acids. 307 - 327. 28. 2022. http://dx.doi.org/10.1016/j.omtn.2022.03.018 . 10.1016/j.omtn.2022.03.018 . Molecular Therapy - Nucleic Acids

Multi-parametric surface plasmon resonance-based intake quantification of label-free light-activated nanoparticles by therapeutic limbal stem cells for corneal blindness

2022. Nano Select. 2022. http://dx.doi.org/10.1002/nano.202200027 . 10.1002/nano.202200027 . Nano Select

A NIR-II emissive polymer AIEgen for imaging-guided photothermal elimination of bacterial infection

2022. Biomaterials. 121579 - 121579. 286. 2022. http://dx.doi.org/10.1016/j.biomaterials.2022.121579 . 10.1016/j.biomaterials.2022.121579 . Biomaterials

Interindividual heterogeneity affects the outcome of human cardiac tissue decellularization

Tenreiro, Miguel F.; Almeida, Henrique V.; Calmeiro, Tomás; Fortunato, Elvira; Ferreira, Lino; Alves, Paula M.; Serra, Margarida, 2021. Scientific Reports. 1. 11. 2021. http://dx.doi.org/10.1038/s41598-021-00226-5 . 10.1038/s41598-021-00226-5 . Scientific Reports

Engineered extracellular vesicles as brain therapeutics

Lino, Miguel M.; Simões, Susana; Tomatis, Francesca; Albino, Inês; Barrera, Angela; Vivien, Denis; Sobrino, Tomas; Ferreira, Lino, 2021. Journal of Controlled Release. 472 - 485. 338. 2021. http://dx.doi.org/10.1016/j.jconrel.2021.08.037 . 10.1016/j.jconrel.2021.08.037 . Journal of Controlled Release

Re-Use of Caco-2 Monolayers in Permeability Assays—Validation Regarding Cell Monolayer Integrity

Pires, Cristiana L.; Praça, Catarina; Martins, Patrícia A. T.; Batista de Carvalho, Ana L. M.; Ferreira, Lino; Marques, Maria Paula M.; Moreno, Maria João, 2021. Pharmaceutics. 10. 13. 2021. http://dx.doi.org/10.3390/pharmaceutics13101563 . 10.3390/pharmaceutics13101563 . Pharmaceutics

Human Extracellular-Matrix Functionalization of 3D hiPSC-Based Cardiac Tissues Improves Cardiomyocyte Maturation

Almeida, Henrique V.; Tenreiro, Miguel F.; Louro, Ana F.; Abecasis, Bernardo; Santinha, Deolinda; Calmeiro, Tomás; Fortunato, Elvira; et al, 2021. ACS Applied Bio Materials. 1888 - 1899. 2. 4. 2021. http://dx.doi.org/10.1021/acsabm.0c01490 . 10.1021/acsabm.0c01490 . ACS Applied Bio Materials

Toxicological Profile of Umbilical Cord Blood-Derived Small Extracellular Vesicles

Rodrigues, Silvia C.; Cardoso, Renato M. S.; Gomes, Claudia F.; Duarte, Filipe V.; Freire, Patricia C.; Neves, Ricardo; Simoes-Correia, Joana, 2021. Membranes. 9. 11. 2021. http://dx.doi.org/10.3390/membranes11090647 . 10.3390/membranes11090647 . Membranes

Therapeutic Nanoparticles for the Different Phases of Ischemic Stroke

Bernardo-Castro, Sara; Albino, Inês; Barrera-Sandoval, Ángela María; Tomatis, Francesca; Sousa, João André; Martins, Emanuel; Simões, Susana; et al, 2021. Life. 6. 11. 2021. http://dx.doi.org/10.3390/life11060482 . 10.3390/life11060482 . Life

Immunomodulatory Properties of Umbilical Cord Blood-Derived Small Extracellular Vesicles and Their Therapeutic Potential for Inflammatory Skin Disorders

Sílvia C. Rodrigues; Renato M. S. Cardoso; Patricia C. Freire; Cláudia F. Gomes; Filipe V. Duarte; Ricardo Pires das Neves; Joana Simões-Correia, 2021. International Journal of Molecular Sciences. 2021. https://doi.org/10.3390/ijms22189797 . 10.3390/ijms22189797 . International Journal of Molecular Sciences

Screening for Colorectal Cancer Leading into a New Decade: The “Roaring ‘20s” for Epigenetic Biomarkers?

Almeida-Lousada, Hélder; Mestre, André; Ramalhete, Sara; Price, Aryeh J.; de Mello, Ramon Andrade; Marreiros, Ana D.; Neves, Ricardo Pires das; Castelo-Branco, Pedro, 2021. Current Oncology. 4874 - 4893. 6. 28. 2021. http://dx.doi.org/10.3390/curroncol28060411 . 10.3390/curroncol28060411 . Current Oncology

Identification of colorectal cancer associated biomarkers: an integrated analysis of miRNA expression

Fonseca, André; Ramalhete, Sara Ventura; Mestre, André; Pires das Neves, Ricardo; Marreiros, Ana; Castelo-Branco, Pedro; Roberto, Vânia Palma, 2021. Aging. 21991 - 22029. 18. 13. 2021. http://dx.doi.org/10.18632/aging.203556 . 10.18632/aging.203556 . Aging

Development of an optimized and scalable method for isolation of umbilical cord blood-derived small extracellular vesicles for future clinical use

Renato M. S. Cardoso; Silvia C. Rodrigues; Claudia F. Gomes; Filipe V. Duarte; Maryse Romao; Ermelindo C. Leal; Patricia C. Freire; Ricardo Neves; Joana Simões-Correia, 2021. STEM CELLS Translational Medicine. 2021. https://doi.org/10.1002/sctm.20-0376 . 10.1002/sctm.20-0376 . STEM CELLS Translational Medicine

Revisiting gene delivery to the brain: silencing and editing

João Conniot; Sepehr Talebian; Susana Simões; Lino Ferreira; João Conde, 2021. Biomaterials Science. 1065 - 1087. 4. 9. 2021. https://doi.org/10.1039/D0BM01278E . 10.1039/D0BM01278E . Biomaterials Science

Biomedical applications of the peptide decorated gold nanoparticles

Rai, Akhilesh; Ferreira, Lino, 2021. Critical Reviews in Biotechnology. 186 - 215. 2. 41. 2021. http://dx.doi.org/10.1080/07388551.2020.1853031 . 10.1080/07388551.2020.1853031 . Critical Reviews in Biotechnology

Induced pluripotent stem cell-derived vascular networks to screen nano–bio interactions

Estronca, Luís; Francisco, Vitor; Pitrez, Patrícia; Honório, Inês; Carvalho, Lara; Vazão, Helena; Blersch, Josephine; et al, 2021. Nanoscale Horizons. 2021. http://dx.doi.org/10.1039/d0nh00550a . 10.1039/d0nh00550a . published Nanoscale Horizons

Exogenous loading of miRNAs into small extracellular vesicles

Abreu, Ricardo C.; Ramos, Cristiana V.; Becher, Clarissa; Lino, Miguel; Jesus, Carlos; Costa Martins, Paula A.; Martins, Patrícia A. T.; et al, 2021. Journal of Extracellular Vesicles. 10. 10. 2021. http://dx.doi.org/10.1002/jev2.12111 . 10.1002/jev2.12111 . Journal of Extracellular Vesicles

High-throughput screening of nanoparticles in drug delivery

Inês Tomé; Vitor Francisco; Hugo Fernandes; Lino Ferreira, 2021. APL Bioengineering. 2021. https://doi.org/10.1063/5.0057204 . 10.1063/5.0057204 . APL Bioengineering

Antimicrobial and pro-angiogenic properties of soluble and nanoparticle-immobilized LL37 peptides

Michela Comune; Akhilesh Rai; Paulo Palma; Chiara TondaTuro; Lino Ferreira, 2021. Biomaterials Science. 2021. https://doi.org/10.1039/D1BM01034D . 10.1039/D1BM01034D . Biomaterials Science

Refinement of a differentiation protocol using neuroblastoma SH-SY5Y cells for use in neurotoxicology research

Rui F. Simões; Rafaela Ferrão; Margarida R. Silva; Sonia L.C. Pinho; Lino Ferreira; Paulo J. Oliveira; Teresa Cunha-Oliveira, 2021. Food and Chemical Toxicology. 111967 - 111967. 149. 2021. https://doi.org/10.1016/j.fct.2021.111967 . 10.1016/j.fct.2021.111967 . Food and Chemical Toxicology

Spatially resolved analysis of FFPE tissue proteomes by quantitative mass spectrometry.

Buczak K; Kirkpatrick JM; Truckenmueller F; Santinha D; Ferreira L; Roessler S; Singer S; Beck M; Ori A, 2020. Nature protocols. 2020. http://europepmc.org/abstract/med/32737464 . 10.1038/s41596-020-0356-y . Nature protocols

A Light-Triggerable Nanoparticle Library for the Controlled Release of Non-Coding RNAs

Blersch, Josephine; Francisco, Vitor; Rebelo, Catarina; Jiménez-Balsa, Adrian; Antunes, Helena; Gonzato, Carlo; Pinto, Sandra; et al, 2020. Angewandte Chemie International Edition. 1985 - 1991. 5. 59. 2020. http://dx.doi.org/10.1002/anie.201911398 . 10.1002/anie.201911398 . Angewandte Chemie International Edition

Native and bioengineered extracellular vesicles for cardiovascular therapeutics.

de Abreu RC; Fernandes H; da Costa Martins PA; Sahoo S; Emanueli C; Ferreira L, 2020. Nature reviews. Cardiology. 2020. http://europepmc.org/abstract/med/32483304 . 10.1038/s41569-020-0389-5 . Nature reviews. Cardiology

Advances and challenges in retinoid delivery systems in regenerative and therapeutic medicine

Raquel Ferreira; Joseph Napoli; Tariq Enver; Liliana Bernardino; Lino Ferreira, 2020. Nature Communications. 2020. https://doi.org/10.1038/s41467-020-18042-2 . 10.1038/s41467-020-18042-2 . Nature Communications

Pathophysiology of Blood–Brain Barrier Permeability Throughout the Different Stages of Ischemic Stroke and Its Implication on Hemorrhagic Transformation and Recovery

Bernardo-Castro, Sara; Sousa, João André; Brás, Ana; Cecília, Carla; Rodrigues, Bruno; Almendra, Luciano; Machado, Cristina; et al, 2020. Frontiers in Neurology. 11. 2020. http://dx.doi.org/10.3389/fneur.2020.594672 . 10.3389/fneur.2020.594672 . Frontiers in Neurology

A high-throughput screening platform to identify nanocarriers for efficient delivery of RNA-based therapies

Francisco, Vitor; Rebelo, Catarina; Rodrigues, Artur Filipe; Blersch, Josephine; Fernandes, Hugo; Ferreira, Lino, 2020. Methods. 2020. http://dx.doi.org/10.1016/j.ymeth.2020.12.002 . 10.1016/j.ymeth.2020.12.002 . Methods

Vulnerability of progeroid smooth muscle cells to biomechanical forces is mediated by MMP13.

Pitrez PR; Estronca L; Monteiro LM; Colell G; Vazão H; Santinha D; Harhouri K; et al, 2020. Nature communications. 2020. http://europepmc.org/abstract/med/32807790 . 10.1038/s41467-020-17901-2 . Nature communications

A light-triggerable formulation to control the stability of pro-angiogenic transcription factor hypoxia inducible factor-1a (HIF-1a)

Josephine Blersch; Vitor Francisco; Catarina Rebelo; Adrian Jiménez-Balsa; Helena Antunes; Sandra Pinto; Susana Simões; Akhilesh Rai; Lino Ferreira, 2020. Nanoscale. 2020. https://doi.org/10.1039/C9NR10503D . 10.1039/C9NR10503D . Nanoscale

Correction to: In vitro mechanistic studies on a-amanitin and its putative antidotes

Daniela Ferreira Rodrigues; Ricardo Pires das Neves; Alexandra T. P. Carvalho; Maria Lourdes Bastos; Vera M. Costa; Félix Carvalho, 2020. Archives of Toxicology. 2020. https://doi.org/10.1007/s00204-020-02735-0 . 10.1007/s00204-020-02735-0 . Archives of Toxicology

In vitro mechanistic studies on a-amanitin and its putative antidotes

Daniela Ferreira Rodrigues; Ricardo Pires das Neves; Alexandra T. P. Carvalho; Maria Lourdes Bastos; Vera M. Costa; Félix Carvalho, 2020. Archives of Toxicology. 2020. https://doi.org/10.1007/s00204-020-02718-1 . 10.1007/s00204-020-02718-1 . Archives of Toxicology

Unveiling the molecular crosstalk in a human induced pluripotent stem cell-derived cardiac model

Bernardo Abecasis; Patrícia Gomes-Alves; Susana Rosa; Pedro J. Gouveia; Lino Ferreira; Margarida Serra; Paula M. Alves, 2019. Biotechnology and Bioengineering. 1245 - 1252. 5. 116. 2019. https://doi.org/10.1002/bit.26929 . 10.1002/bit.26929 . Biotechnology and Bioengineering

A near infrared light-triggerable modular formulation for the delivery of small biomolecules

Ferreira, Lino, 2019. Journal of Nanobiotechnology. 2019. http://dx.doi.org/10.1186/s12951-019-0530-y . 10.1186/s12951-019-0530-y . Journal of Nanobiotechnology

Soft culture substrates favor stem-like cellular phenotype and facilitate reprogramming of human mesenchymal stem/stromal cells (hMSCs) through mechanotransduction

Neves, Ricardo, 2019. Scientific Reports. 2019. http://dx.doi.org/10.1038/s41598-019-45352-3 . 10.1038/s41598-019-45352-3 . Scientific Reports

Bioprocess decision support tool for scalable manufacture of extracellular vesicles

Ferreira, Lino, 2019. Biotechnology and Bioengineering. 2019. http://dx.doi.org/10.1002/bit.26809 . 10.1002/bit.26809 . Biotechnology and Bioengineering

A light-triggerable nanoparticle library for the controlled release of non-coding RNAs.

Ferreira, Lino, 2019. Angewandte Chemie (International ed. in English). 2019. https://doi.org/10.1002/anie.201911398 . 10.1002/anie.201911398 . Angewandte Chemie (International ed. in English)

A High-Throughput Screening Method to Identify Compounds Displaying Human Vascular Embryonic Toxicity

Ferreira, Lino, 2019. Current Protocols in Stem Cell Biology. 2019. http://dx.doi.org/10.1002/cpsc.93 . 10.1002/cpsc.93 . Current Protocols in Stem Cell Biology

Derivation of Brain Capillary-like Endothelial Cells from Human Pluripotent Stem Cell-Derived Endothelial Progenitor Cells.

Ferreira, Lino, 2019. Stem cell reports. 2019. https://europepmc.org/articles/PMC6829749 . 10.1016/j.stemcr.2019.08.002 . Stem cell reports

What human blood-brain barrier models can tell us about BBB function and drug discovery?

Ferreira, Lino, 2019. Expert opinion on drug discovery. 2019. https://doi.org/10.1080/17460441.2019.1646722 . 10.1080/17460441.2019.1646722 . Expert opinion on drug discovery

The Kinetics of Small Extracellular Vesicle Delivery Impacts Skin Tissue Regeneration

Ferreira, Lino, 2019. ACS Nano. 2019. http://dx.doi.org/10.1021/acsnano.9b00376 . 10.1021/acsnano.9b00376 . ACS Nano

A positron-emission tomography (PET)/magnetic resonance imaging (MRI) platform to track in vivo small extracellular vesicles

Arnab Banerjee; Vitor Alves; Tiago Rondão; José Sereno; Ângela Neves; Miguel Lino; Andreia Ribeiro; Antero J. Abrunhosa; Lino S. Ferreira, 2019. Nanoscale. 13243 - 13248. 28. 11. 2019. https://doi.org/10.1039/C9NR02512J . 10.1039/C9NR02512J . Nanoscale

Spatially Confining Surface Roughness on Exponentially Growing Polyelectrolyte Multilayer Films

Ferreira, Lino, 2019. Advanced Materials Interfaces. 2019. http://dx.doi.org/10.1002/admi.201900702 . 10.1002/admi.201900702 . Advanced Materials Interfaces

A photodynamic antibacterial spray-coating based on the host–guest immobilization of the photosensitizer methylene blue

Tian-tian Yao; Jing Wang; Yun-fan Xue; Wei-jiang Yu; Qiang Gao; Lino Ferreira; Ke-Feng Ren; Jian Ji, 2019. Journal of Materials Chemistry B. 2019. https://doi.org/10.1039/C9TB01069F . 10.1039/C9TB01069F . Journal of Materials Chemistry B

Functional characterization of iPSC-derived arterial- and venous-like endothelial cells

Ferreira, Lino, 2019. Scientific Reports. 2019. http://dx.doi.org/10.1038/s41598-019-40417-9 . 10.1038/s41598-019-40417-9 . Scientific Reports

Osmotic modulation of chromatin impacts on efficiency and kinetics of cell fate modulation

Ferreira, Lino, 2018. Scientific Reports. 2018. http://dx.doi.org/10.1038/s41598-018-25517-2 . 10.1038/s41598-018-25517-2 . Scientific Reports

Cooperative Transcription Factor Induction Mediates Hemogenic Reprogramming

Ferreira, Lino, 2018. Cell Reports. 2018. http://dx.doi.org/10.1016/j.celrep.2018.11.032 . 10.1016/j.celrep.2018.11.032 . Cell Reports

A nanoformulation for the preferential accumulation in adult neurogenic niches

Ferreira, Lino, 2018. Journal of Controlled Release. 2018. http://dx.doi.org/10.1016/j.jconrel.2018.06.013 . 10.1016/j.jconrel.2018.06.013 . Journal of Controlled Release

STROKE34 Study Protocol: A Randomized Controlled Phase IIa Trial of Intra-Arterial CD34+ Cells in Acute Ischemic Stroke

Ferreira, Lino, 2018. Frontiers in Neurology. 2018. http://dx.doi.org/10.3389/fneur.2018.00302 . 10.3389/fneur.2018.00302 . Frontiers in Neurology

Intravenous administration of retinoic acid-loaded polymeric nanoparticles prevents ischemic injury in the immature brain

Ferreira, Lino, 2018. Neuroscience Letters. 2018. http://dx.doi.org/10.1016/j.neulet.2018.02.066 . 10.1016/j.neulet.2018.02.066 . Neuroscience Letters

MicroRNA-124-loaded nanoparticles increase survival and neuronal differentiation of neural stem cells in vitro but do not contribute to stroke outcome in vivo

Ferreira, Lino, 2018. PLOS ONE. 2018. http://dx.doi.org/10.1371/journal.pone.0193609 . 10.1371/journal.pone.0193609 . PLOS ONE

Endothelial Progenitor Cells influence acute and subacute stroke hemodynamics

Ferreira, Lino, 2018. Journal of the Neurological Sciences. 2018. http://dx.doi.org/10.1016/j.jns.2017.12.028 . 10.1016/j.jns.2017.12.028 . Journal of the Neurological Sciences

Cecropin-Melittin Functionalized Polyurethane Surfaces Prevent Staphylococcus epidermidis Adhesion without Inducing Platelet Adhesion and Activation

Ferreira, Lino, 2018. Advanced Materials Interfaces. 2018. http://dx.doi.org/10.1002/admi.201801390 . 10.1002/admi.201801390 . Advanced Materials Interfaces

Atomistic-Level Investigation of a LL37-Conjugated Gold Nanoparticle By Well-Tempered Metadynamics

André F. Ferreira; Michela Comune; Akhilesh Rai; Lino Ferreira; Pedro N. Simões, 2018. The Journal of Physical Chemistry B. 2018. https://doi.org/10.1021/acs.jpcb.8b05717 . 10.1021/acs.jpcb.8b05717 . The Journal of Physical Chemistry B

Modulation of Angiogenic Activity by Light-Activatable miRNA-Loaded Nanocarriers

Miguel M. Lino; Susana Simões; Andreia Vilaça; Helena Antunes; Alessandra Zonari; Lino Ferreira, 2018. ACS Nano. 2018. https://doi.org/10.1021/acsnano.7b07538 . 10.1021/acsnano.7b07538 . ACS Nano

Mitochondrial levels determine variability in cell death by modulating apoptotic gene expression

Márquez-Jurado, S.; Díaz-Colunga, J.; Das Neves, R.P.; Martinez-Lorente, A.; Almazán, F.; Guantes, R.; Iborra, F.J., 2018. Nature Communications. 1. 9. 2018. http://www.scopus.com/inward/record.url?eid=2-s2.0-85041107950&partnerID=MN8TOARS . 10.1038/s41467-017-02787-4 . Nature Communications

Stem cells as vehicles and targets of nanoparticles.

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Validating the RedMIT/GFP-LC3 Mouse Model by Studying Mitophagy in Autosomal Dominant Optic Atrophy Due to the OPA1Q285STOP Mutation

Neves, Ricardo, 2018. Frontiers in Cell and Developmental Biology. 2018. http://dx.doi.org/10.3389/fcell.2018.00103 . 10.3389/fcell.2018.00103 . Frontiers in Cell and Developmental Biology

Nanoparticles Conjugated with Photocleavable Linkers for the Intracellular Delivery of Biomolecules

Adrián Jiménez-Balsa; Sandra Pinto; Emanuel Quartin; Miguel M. Lino; Vitor Francisco; Lino Ferreira, 2018. Bioconjugate Chemistry. 2018. https://doi.org/10.1021/acs.bioconjchem.7b00820 . 10.1021/acs.bioconjchem.7b00820 . Bioconjugate Chemistry

Osmotic modulation of chromatin impacts on efficiency and kinetics of cell fate modulation

Neves, Ricardo, 2018. Scientific Reports. 2018. http://dx.doi.org/10.1038/s41598-018-25517-2 . 10.1038/s41598-018-25517-2 . Scientific Reports

Endothelial progenitor cells enhance blood-brain barrier permeability in subacute stroke.

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Substrate Topography Modulates Cell Aging on a Progeria Cell Model

Patricia R. Pitrez; Luís Estronca; Helena Vazão; Anne-Laure Egesipe; Amélie Le Corf; Claire Navarro; Nicolas Lévy; et al, 2018. ACS Biomaterials Science & Engineering. 2018. https://doi.org/10.1021/acsbiomaterials.8b00224 . 10.1021/acsbiomaterials.8b00224 . ACS Biomaterials Science & Engineering

Light-triggerable formulations for the intracellular controlled release of biomolecules.

Lino MM; Ferreira L, 2018. Drug discovery today. 2018. http://europepmc.org/abstract/med/29326080 . 10.1016/j.drudis.2018.01.019 . Drug discovery today

Intracellular delivery of more than one protein with spatio-temporal control

Miguel M. Lino; Susana Simões; Sónia Pinho; Lino Ferreira; Lino MM; Simões S; Pinho S; Ferreira L, 2017. Nanoscale. 18668 - 18680. 47. 9. 2017. https://doi.org/10.1039/C7NR02414B . 10.1039/C7NR02414B . Nanoscale

Prolonged intracellular accumulation of light-inducible nanoparticles in leukemia cells allows their remote activation

Boto, Carlos; Quartin, Emanuel; Cai, Yijun; Martín-Lorenzo, Alberto; Cenador, María Begoña García; Pinto, Sandra; Gupta, Rajeev; et al, 2017. Nature Communications. 1. 8. 2017. http://dx.doi.org/10.1038/ncomms15204 . 10.1038/ncomms15204 . Nature Communications

Antimicrobial peptide-gold nanoscale therapeutic formulation with high skin regenerative potential.

Comune M; Rai A; Chereddy KK; Pinto S; Aday S; Ferreira AF; Zonari A; et al, 2017. Journal of controlled release : official journal of the Controlled Release Society. 2017. http://europepmc.org/abstract/med/28694030 . 10.1016/j.jconrel.2017.07.007 . Journal of controlled release : official journal of the Controlled Release Society

Findings on the interaction of the antimicrobial peptide cecropin-melittin with a gold surface from molecular dynamics studies

Ferreira, Lino, 2017. European Biophysics Journal. 2017. http://dx.doi.org/10.1007/s00249-016-1160-z . 10.1007/s00249-016-1160-z . European Biophysics Journal

Anti-Inflammatory Strategy for M2 Microglial Polarization Using Retinoic Acid-Loaded Nanoparticles

Ferreira, Lino, 2017. Mediators of Inflammation. 2017. http://dx.doi.org/10.1155/2017/6742427 . 10.1155/2017/6742427 . Mediators of Inflammation

Prolonged intracellular accumulation of light-inducible nanoparticles in leukemia cells allows their remote activation

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Exosomes secreted by cardiomyocytes subjected to ischaemia promote cardiac angiogenesis.

Ribeiro-Rodrigues TM; Laundos TL; Pereira-Carvalho R; Batista-Almeida D; Pereira R; Coelho-Santos V; Silva AP; et al, 2017. Cardiovascular research. 2017. http://europepmc.org/abstract/med/28859292 . 10.1093/cvr/cvx118 . Cardiovascular research

Erratum: Restoring heart function and electrical integrity: Closing the circuit.

Monteiro LM; Vasques-Nóvoa F; Ferreira L; Pinto-do-Ó P; Nascimento DS, 2017. NPJ Regenerative medicine. 2017. http://europepmc.org/abstract/med/29303158 . 10.1038/s41536-017-0020-5 . NPJ Regenerative medicine

Blue light potentiates neurogenesis induced by retinoic acid-loaded responsive nanoparticles.

Santos T; Ferreira R; Quartin E; Boto C; Saraiva C; Bragança J; Peça J; et al, 2017. Acta biomaterialia. 2017. http://europepmc.org/abstract/med/28673742 . 10.1016/j.actbio.2017.06.044 . Acta biomaterialia

Flexible nanofilms coated with aligned piezoelectric microfibers preserve the contractility of cardiomyocytes.

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Synthetic microparticles conjugated with VEGF165 improve the survival of endothelial progenitor cells via microRNA-17 inhibition.

Aday S; Zoldan J; Besnier M; Carreto L; Saif J; Fernandes R; Santos T; et al, 2017. Nature communications. 2017. http://europepmc.org/abstract/med/28963481 . 10.1038/s41467-017-00746-7 . Nature communications

High-throughput identification of small molecules that affect human embryonic vascular development.

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Biomechanical Strain Exacerbates Inflammation on a Progeria-on-a-Chip Model.

Ribas J; Zhang YS; Pitrez PR; Leijten J; Miscuglio M; Rouwkema J; Dokmeci MR; et al, 2017. Small (Weinheim an der Bergstrasse, Germany). 2017. http://europepmc.org/abstract/med/28211642 . 10.1002/smll.201603737 . Small (Weinheim an der Bergstrasse, Germany)

Challenging the great vascular wall: Can we envision a simple yet comprehensive therapy for stroke?

Machado-Pereira M; Santos T; Ferreira L; Bernardino L; Ferreira R, 2017. Journal of tissue engineering and regenerative medicine. 2017. http://europepmc.org/abstract/med/28182332 . 10.1002/term.2427 . Journal of tissue engineering and regenerative medicine

Restoring heart function and electrical integrity: closing the circuit.

Monteiro LM; Vasques-Nóvoa F; Ferreira L; Pinto-do-Ó P; Nascimento DS, 2017. NPJ Regenerative medicine. 2017. http://europepmc.org/abstract/med/29302345 . 10.1038/s41536-017-0015-2 . NPJ Regenerative medicine

Flexible nanofilms coated with aligned piezoelectric microfibers preserve the contractility of cardiomyocytes

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Traceable microRNA-124 loaded nanoparticles as a new promising therapeutic tool for Parkinson's disease.

Saraiva C; Ferreira L; Bernardino L, 2016. Neurogenesis (Austin, Tex.). 2016. http://europepmc.org/abstract/med/28405588 . 10.1080/23262133.2016.1256855 . Neurogenesis (Austin, Tex.)

Drug screening on Hutchinson Gilford progeria pluripotent stem cells reveals aminopyrimidines as new modulators of farnesylation.

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Cardiovascular Organ-on-a-Chip Platforms for Drug Discovery and Development

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Nanoparticle-mediated brain drug delivery: Overcoming blood-brain barrier to treat neurodegenerative diseases.

Saraiva C; Praça C; Ferreira R; Santos T; Ferreira L; Bernardino L, 2016. Journal of controlled release : official journal of the Controlled Release Society. 2016. http://europepmc.org/abstract/med/27208862 . 10.1016/j.jconrel.2016.05.044 . Journal of controlled release : official journal of the Controlled Release Society

High-density antimicrobial peptide coating with broad activity and low cytotoxicity against human cells.

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Nanomedicine Approaches to Modulate Neural Stem Cells in Brain Repair.

Santos T; Boto C; Saraiva CM; Bernardino L; Ferreira L, 2016. Trends in biotechnology. 2016. http://europepmc.org/abstract/med/26917252 . 10.1016/j.tibtech.2016.02.003 . Trends in biotechnology

Stem Cell-Based Human Blood-Brain Barrier Models for Drug Discovery and Delivery.

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Retinoic acid-loaded polymeric nanoparticles enhance vascular regulation of neural stem cell survival and differentiation after ischaemia.

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High Antimicrobial Activity and Low Human Cell Cytotoxicity of Core-Shell Magnetic Nanoparticles Functionalized with an Antimicrobial Peptide.

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MicroRNA-124 loaded nanoparticles enhance brain repair in Parkinson's disease.

Saraiva C; Paiva J; Santos T; Ferreira L; Bernardino L, 2016. Journal of controlled release : official journal of the Controlled Release Society. 2016. http://europepmc.org/abstract/med/27269730 . 10.1016/j.jconrel.2016.06.005 . Journal of controlled release : official journal of the Controlled Release Society

One-step synthesis of high-density peptide-conjugated gold nanoparticles with antimicrobial efficacy in a systemic infection model.

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Retinoic acid-loaded polymeric nanoparticles induce neuroprotection in a mouse model for Parkinson's disease.

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Lysophosphatidic acid enhances survival of human CD34(+) cells in ischemic conditions.

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Global variability in gene expression and alternative splicing is modulated by mitochondrial content

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Vascular disease modeling using induced pluripotent stem cells: focus in Hutching-Gilford progeria syndrome.

Pitrez P; Rosa SC; Almeida C; Ferreira L, 2015. 2015. http://europepmc.org/abstract/med/26474704 .

Development of a SMCs model from HGPS-iPS and proofs of principle.

Ferreira L, 2015. Orphanet journal of rare diseases. 2015. http://europepmc.org/abstract/PMC/PMC4652490 . 10.1186/1750-1172-10-s2-o3 . Orphanet journal of rare diseases

Inflammatory modulation of stem cells by Magnetic Resonance Imaging (MRI)-detectable nanoparticles

Ferreira, Lino, 2014. RSC Adv.. 2014. http://dx.doi.org/10.1039/c4ra04041d . 10.1039/c4ra04041d . RSC Adv.

Interaction of fullerene nanoparticles with biomembranes: From the partition in lipid membranes to effects on mitochondrial bioenergetics

Santos, S.M.; Dinis, A.M.; Peixoto, F.; Ferreira, L.; Jurado, A.S.; Videira, R.A., 2014. Toxicological Sciences. 117 - 129. 1. 138. 2014. http://www.scopus.com/inward/record.url?eid=2-s2.0-84894311599&partnerID=MN8TOARS . 10.1093/toxsci/kft327 . Toxicological Sciences

PLGA nanoparticles loaded with host defense peptide LL37 promote wound healing.

Chereddy KK; Her CH; Comune M; Moia C; Lopes A; Porporato PE; Vanacker J; et al, 2014. 2014. http://europepmc.org/abstract/med/25173841 . 10.1016/j.jconrel.2014.08.016 .

Boron nitride nanotube-mediated stimulation modulates F/G-actin ratio and mechanical properties of human dermal fibroblasts

Ricotti, L.; Das Neves, R.P.; Ciofani, G.; Canale, C.; Nitti, S.; Mattoli, V.; Mazzolai, B.; Ferreira, L.; Menciassi, A., 2014. Journal of Nanoparticle Research. 2. 16. 2014. http://www.scopus.com/inward/record.url?eid=2-s2.0-84894539117&partnerID=MN8TOARS . 10.1007/s11051-014-2247-z . Journal of Nanoparticle Research

A blood-resistant surgical glue for minimally invasive repair of vessels and heart defects

Lang, N.; Pereira, M.J.; Lee, Y.; Friehs, I.; Vasilyev, N.V.; Feins, E.N.; Ablasser, K.; et al, 2014. Science Translational Medicine. 218. 6. 2014. http://www.scopus.com/inward/record.url?eid=2-s2.0-84892553926&partnerID=MN8TOARS . 10.1126/scitranslmed.3006557 . Science Translational Medicine

Boron nitride nanotube-mediated stimulation modulates F/G-actin ratio and mechanical properties of human dermal fibroblasts

Ricotti, L.; Das Neves, R.P.; Ciofani, G.; Canale, C.; Nitti, S.; Mattoli, V.; Mazzolai, B.; Ferreira, L.; Menciassi, A., 2014. Journal of Nanoparticle Research. 2. 16. 2014. http://www.scopus.com/inward/record.url?eid=2-s2.0-84894539117&partnerID=MN8TOARS . 10.1007/s11051-014-2247-z . Journal of Nanoparticle Research

Combined Surface Micropatterning and Reactive Chemistry Maximizes Tissue Adhesion with Minimal Inflammation

Pereira, M.J.N.; Sundback, C.A.; Lang, N.; Cho, W.K.; Pomerantseva, I.; Ouyang, B.; Tao, S.L.; et al, 2014. Advanced Healthcare Materials. 565 - 571. 4. 3. 2014. http://www.scopus.com/inward/record.url?eid=2-s2.0-84898634094&partnerID=MN8TOARS . 10.1002/adhm.201300264 . Advanced Healthcare Materials

A stable and reproducible human blood-brain barrier model derived from hematopoietic stem cells

Cecchelli, R.; Aday, S.; Sevin, E.; Almeida, C.; Culot, M.; Dehouck, L.; Coisne, C.; et al, 2014. PLoS ONE. 6. 9. 2014. http://www.scopus.com/inward/record.url?eid=2-s2.0-84903316132&partnerID=MN8TOARS . 10.1371/journal.pone.0099733 . PLoS ONE

Antifungal activity of dental resins containing amphotericin B-conjugated nanoparticles

Lino, M.M.; Paulo, C.S.O.; Vale, A.C.; Vaz, M.F.; Ferreira, L.S., 2013. Dental Materials. 10. 29. 2013. http://www.scopus.com/inward/record.url?eid=2-s2.0-84884143064&partnerID=MN8TOARS . 10.1016/j.dental.2013.07.023 . Dental Materials

Efficient pro-survival/angiogenic miRNA delivery by an MRI-detectable nanomaterial

Gomes, R.S.M.; Neves, R.P.D.; Cochlin, L.; Lima, A.; Carvalho, R.; Korpisalo, P.; Dragneva, G.; et al, 2013. ACS Nano. 3362 - 3372. 4. 7. 2013. http://www.scopus.com/inward/record.url?eid=2-s2.0-84876588539&partnerID=MN8TOARS . 10.1021/nn400171w . ACS Nano

Differential internalization of amphotericin B - Conjugated nanoparticles in human cells and the expression of heat shock protein 70

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A highly tunable biocompatible and multifunctional biodegradable elastomer

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Efficient pro-survival/angiogenic miRNA delivery by an MRI-detectable nanomaterial

Gomes, R.S.M.; Neves, R.P.D.; Cochlin, L.; Lima, A.; Carvalho, R.; Korpisalo, P.; Dragneva, G.; et al, 2013. ACS Nano. 3362 - 3372. 4. 7. 2013. http://www.scopus.com/inward/record.url?eid=2-s2.0-84876588539&partnerID=MN8TOARS . 10.1021/nn400171w . ACS Nano

Boron Nitride Nanotube-Mediated Stimulation of Cell Co-Culture on Micro-Engineered Hydrogels

Ricotti, L.; Fujie, T.; Vazão, H.; Ciofani, G.; Marotta, R.; Brescia, R.; Filippeschi, C.; et al, 2013. PLoS ONE. 8. 8. 2013. http://www.scopus.com/inward/record.url?eid=2-s2.0-84881503335&partnerID=MN8TOARS . 10.1371/journal.pone.0071707 . PLoS ONE

Histamine modulates microglia function.

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Histamine stimulates neurogenesis in the rodent subventricular zone

Bernardino, L.; Eiriz, M.F.; Santos, T.; Xapelli, S.; Grade, S.; Rosa, A.I.; Cortes, L.; et al, 2012. Stem Cells. 773 - 784. 4. 30. 2012. http://www.scopus.com/inward/record.url?eid=2-s2.0-84859512101&partnerID=MN8TOARS . 10.1002/stem.1042 . Stem Cells

Polymeric nanoparticles to control the differentiation of neural stem cells in the subventricular zone of the brain

Santos, T.; Ferreira, R.; Maia, J.; Agasse, F.; Xapelli, S.; Cortes, L.; Bragancia, J.; et al, 2012. ACS Nano. 10463 - 10474. 12. 6. 2012. http://www.scopus.com/inward/record.url?eid=2-s2.0-84871596644&partnerID=MN8TOARS . 10.1021/nn304541h . ACS Nano

Proliferation and skeletal myotube formation capability of C2C12 and H9c2 cells on isotropic and anisotropic electrospun nanofibrous PHB scaffolds

Ricotti, L.; Polini, A.; Genchi, G.G.; Ciofani, G.; Iandolo, D.; Vazão, H.; Mattoli, V.; et al, 2012. Biomedical Materials. 3. 7. 2012. http://www.scopus.com/inward/record.url?eid=2-s2.0-84860717976&partnerID=MN8TOARS . 10.1088/1748-6041/7/3/035010 . Biomedical Materials

Mitochondrial variability as a source of extrinsic cellular noise

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Nanoparticles and surfaces presenting antifungal, antibacterial and antiviral properties

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VEGF-functionalized dextran has longer intracellular bioactivity than VEGF in endothelial cells

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Nanomedicine boosts neurogenesis: New strategies for brain repair

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Epigenetic engineering to reverse the Parkinson's expression state

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Towards the maturation and characterization of smooth muscle cells derived from human embryonic stem cells

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a-MSH regulates intergenic splicing of MC1R and TUBB3 in human melanocytes

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Towards the maturation and characterization of smooth muscle cells derived from human embryonic stem cells

Vazão, H.; das Neves, R.P.; Grãos, M.; Ferreira, L., 2011. PLoS ONE. 3. 6. 2011. http://www.scopus.com/inward/record.url?eid=2-s2.0-79952523704&partnerID=MN8TOARS . 10.1371/journal.pone.0017771 . PLoS ONE

Sensing the cardiac environment: Exploiting cues for regeneration

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Three-dimensional biomaterials for the study of human pluripotent stem cells

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Nanoparticles for intracellular-targeted drug delivery

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Controlling the neuronal differentiation of stem cells by the intracellular delivery of retinoic acid-loaded nanoparticles

Maia, J.; Santos, T.; Aday, S.; Agasse, F.; Cortes, L.; Malva, J.O.; Bernardino, L.; Ferreira, L., 2011. ACS Nano. 97 - 106. 1. 5. 2011. http://www.scopus.com/inward/record.url?eid=2-s2.0-79955113748&partnerID=MN8TOARS . 10.1021/nn101724r . ACS Nano

Nanoparticles for intracellular-targeted drug delivery

Paulo, C.S.O.; Pires Das Neves, R.; Ferreira, L.S., 2011. Nanotechnology. 49. 22. 2011. http://www.scopus.com/inward/record.url?eid=2-s2.0-81855212480&partnerID=MN8TOARS . 10.1088/0957-4484/22/49/494002 . Nanotechnology

Human embryonic stem cell-derived microvascular grafts for cardiac tissue preservation after myocardial infarction

Kraehenbuehl, T.P.; Ferreira, L.S.; Hayward, A.M.; Nahrendorf, M.; van der Vlies, A.J.; Vasile, E.; Weissleder, R.; Langer, R.; Hubbell, J.A., 2011. Biomaterials. 1102 - 1109. 4. 32. 2011. http://www.scopus.com/inward/record.url?eid=2-s2.0-78649446021&partnerID=MN8TOARS . 10.1016/j.biomaterials.2010.10.005 . Biomaterials

Improved survival, vascular differentiation and wound healing potential of stem cells co-cultured with endothelial cells

Pedroso, D.C.S.; Tellechea, A.; Moura, L.; Fidalgo-Carvalho, I.; Duarte, J.; Carvalho, E.; Ferreira, L., 2011. PLoS ONE. 1. 6. 2011. http://www.scopus.com/inward/record.url?eid=2-s2.0-79551528768&partnerID=MN8TOARS . 10.1371/journal.pone.0016114 . PLoS ONE

Connecting variability in global transcription rate to mitochondrial variability

das Neves, R.P.; Jones, N.S.; Andreu, L.; Gupta, R.; Enver, T.; Iborra, F.J., 2010. PLoS Biology. 12. 8. 2010. http://www.scopus.com/inward/record.url?eid=2-s2.0-78650442826&partnerID=MN8TOARS . 10.1371/journal.pbio.1000560 . PLoS Biology

Vascular differentiation of human embryonic stem cells in bioactive hydrogel-based scaffolds.

Gerecht, S.; Ferreira, L.S.; Langer, R.; Gerecht S; Ferreira LS; Langer R, 2010. Methods in molecular biology (Clifton, N.J.). 333 - 354. 584. 2010. http://www.scopus.com/inward/record.url?eid=2-s2.0-75649126900&partnerID=MN8TOARS . 10.1007/978-1-60761-369-5_18 . Methods in molecular biology (Clifton, N.J.)

Isolation, differentiation and characterization of vascular cells derived from human embryonic stem cells.

Levenberg, S.; Ferreira, L.S.; Chen-Konak, L.; Kraehenbuehl, T.P.; Langer, R., 2010. Nature protocols. 1115 - 1126. 6. 5. 2010. http://www.scopus.com/inward/record.url?eid=2-s2.0-77956696064&partnerID=MN8TOARS . 10.1038/nprot.2010.31 . Nature protocols

Antifungal nanoparticles and surfaces

Paulo, C.S.O.; Vidal, M.; Ferreira, L.S., 2010. Biomacromolecules. 2810 - 2817. 10. 11. 2010. http://www.scopus.com/inward/record.url?eid=2-s2.0-77957868674&partnerID=MN8TOARS . 10.1021/bm100893r . Biomacromolecules

MicroRNA-210 regulates mitochondrial free radical response to hypoxia and krebs cycle in cancer cells by targeting iron sulfur cluster protein ISCU

Favaro, E.; Ramachandran, A.; McCormick, R.; Gee, H.; Blancher, C.; Crosby, M.; Devlin, C.; et al, 2010. PLoS ONE. 4. 5. 2010. http://www.scopus.com/inward/record.url?eid=2-s2.0-77956402239&partnerID=MN8TOARS . 10.1371/journal.pone.0010345 . PLoS ONE

Stem cell-based therapies for heart regeneration: What did the bench teach us?

Ferreira, L.; Pedroso, D.C.S.; Vazão, H.; Gomes, R.S.M., 2010. Cardiovascular and Hematological Disorders - Drug Targets. 173 - 185. 3. 10. 2010. http://www.scopus.com/inward/record.url?eid=2-s2.0-78549255903&partnerID=MN8TOARS . Cardiovascular and Hematological Disorders - Drug Targets

Cell-responsive hydrogel for encapsulation of vascular cells

Kraehenbuehl, T.P.; Ferreira, L.S.; Zammaretti, P.; Hubbell, J.A.; Langer, R., 2009. Biomaterials. 4318 - 4324. 26. 30. 2009. http://www.scopus.com/inward/record.url?eid=2-s2.0-67650596617&partnerID=MN8TOARS . 10.1016/j.biomaterials.2009.04.057 . Biomaterials

Nanoparticles as tools to study and control stem cells

Ferreira, L., 2009. Journal of Cellular Biochemistry. 746 - 752. 4. 108. 2009. http://www.scopus.com/inward/record.url?eid=2-s2.0-70350435073&partnerID=MN8TOARS . 10.1002/jcb.22303 . Journal of Cellular Biochemistry

Non-leaching surfaces capable of killing microorganisms on contact

Ferreira, L.; Zumbuehl, A., 2009. Journal of Materials Chemistry. 7796 - 7806. 42. 19. 2009. http://www.scopus.com/inward/record.url?eid=2-s2.0-70350722395&partnerID=MN8TOARS . 10.1039/b905668h . Journal of Materials Chemistry

Association between active genes occurs at nuclear speckles and is modulated by chromatin environment

Brown, J.M.; Green, J.; Das Neves, R.P.; Neves, R.P.D.; Wallace, H.A.C.; Smith, A.J.H.; Hughes, J.; et al, 2008. Chemtracts. 411 - 413. 10. 21. 2008. http://www.scopus.com/inward/record.url?eid=2-s2.0-66849113444&partnerID=MN8TOARS . 10.1083/jcb.200803174 . Chemtracts

New Opportunities: The Use of Nanotechnologies to Manipulate and Track Stem Cells

Ferreira, L.; Karp, J.M.; Nobre, L.; Langer, R., 2008. Cell Stem Cell. 136 - 146. 2. 3. 2008. http://www.scopus.com/inward/record.url?eid=2-s2.0-48349135069&partnerID=MN8TOARS . 10.1016/j.stem.2008.07.020 . Cell Stem Cell

A biodegradable and biocompatible gecko-inspired tissue adhesive

Mahdavi, A.; Ferreira, L.; Sundback, C.; Nichol, J.W.; Chan, E.P.; Carter, D.J.D.; Bettinger, C.J.; et al, 2008. Proceedings of the National Academy of Sciences of the United States of America. 2307 - 2312. 7. 105. 2008. http://www.scopus.com/inward/record.url?eid=2-s2.0-40649128784&partnerID=MN8TOARS . 10.1073/pnas.0712117105 . Proceedings of the National Academy of Sciences of the United States of America

Intracellular delivery of core-shell fluorescent silica nanoparticles

Fuller, J.E.; Zugates, G.T.; Ferreira, L.S.; Ow, H.S.; Nguyen, N.N.; Wiesner, U.B.; Langer, R.S., 2008. Biomaterials. 1526 - 1532. 10. 29. 2008. http://www.scopus.com/inward/record.url?eid=2-s2.0-38549088954&partnerID=MN8TOARS . 10.1016/j.biomaterials.2007.11.025 . Biomaterials

Human embryoid bodies containing nano- And microparticulate delivery vehicles

Ferreira, L.; Squier, T.; Park, H.; Choe, H.; Kohane, D.S.; Langer, R., 2008. Advanced Materials. 2285 - 2291. 12. 20. 2008. http://www.scopus.com/inward/record.url?eid=2-s2.0-48349136691&partnerID=MN8TOARS . 10.1002/adma.200702404 . Advanced Materials

Repeated administration of d-amphetamine results in a time-dependent and dose-independent sustained increase in urinary excretion of p-hydroxyamphetamine in mice

Carvalho, F.; Soares, M.E.; Fernandes, E.; Remião, F.; Carvalho, M.; Duarte, J.A.; Pires-das-Neves, R.; Pereira, M.D.L.; Bastos, M.D.L., 2007. Journal of Health Science. 371 - 377. 4. 53. 2007. http://www.scopus.com/inward/record.url?eid=2-s2.0-34547566233&partnerID=MN8TOARS . 10.1248/jhs.53.371 . Journal of Health Science

Antifungal hydrogels

Zumbuehl, A.; Ferreira, L.; Kuhn, D.; Astashkina, A.; Long, L.; Yeo, Y.; Iaconis, T.; et al, 2007. Proceedings of the National Academy of Sciences of the United States of America. 12994 - 12998. 32. 104. 2007. http://www.scopus.com/inward/record.url?eid=2-s2.0-34548767010&partnerID=MN8TOARS . 10.1073/pnas.0705250104 . Proceedings of the National Academy of Sciences of the United States of America

Hyaluronic acid hydrogel for controlled self-renewal and differentiation of human embryonic stem cells

Gerecht, S.; Burdick, J.A.; Ferreira, L.S.; Townsend, S.A.; Langer, R.; Vunjak-Novakovic, G., 2007. Proceedings of the National Academy of Sciences of the United States of America. 11298 - 11303. 27. 104. 2007. http://www.scopus.com/inward/record.url?eid=2-s2.0-34547479732&partnerID=MN8TOARS . 10.1073/pnas.0703723104 . Proceedings of the National Academy of Sciences of the United States of America

Bioactive hydrogel scaffolds for controllable vascular differentiation of human embryonic stem cells

Ferreira, L.S.; Gerecht, S.; Fuller, J.; Shieh, H.F.; Vunjak-Novakovic, G.; Langer, R., 2007. Biomaterials. 2706 - 2717. 17. 28. 2007. http://www.scopus.com/inward/record.url?eid=2-s2.0-33947253443&partnerID=MN8TOARS . 10.1016/j.biomaterials.2007.01.021 . Biomaterials

Synthesis and characterization of photocurable elastomers from poly(glycerol-co-sebacate)

Nijst, C.L.E.; Bruggeman, J.P.; Karp, J.M.; Ferreira, L.; Zumbuehl, A.; Bettinger, C.J.; Langer, R., 2007. Biomacromolecules. 3067 - 3073. 10. 8. 2007. http://www.scopus.com/inward/record.url?eid=2-s2.0-35548988907&partnerID=MN8TOARS . 10.1021/bm070423u . Biomacromolecules

Vascular progenitor cells isolated from human embryonic stem cells give rise to endothelial and smooth muscle-like cells and form vascular networks in vivo

Ferreira, L.S.; Gerecht, S.; Shieh, H.F.; Watson, N.; Rupnick, M.A.; Dallabrida, S.M.; Vunjak-Novakovic, G.; Langer, R., 2007. Circulation Research. 286 - 294. 3. 101. 2007. http://www.scopus.com/inward/record.url?eid=2-s2.0-34548335261&partnerID=MN8TOARS . 10.1161/CIRCRESAHA.107.150201 . Circulation Research

Co-culture of human embryonic stem cells with murine embryonic fibroblasts on microwell-patterned substrates

Khademhosseini, A.; Ferreira, L.; Blumling III, J.; Yeh, J.; Karp, J.M.; Fukuda, J.; Langer, R., 2006. Biomaterials. 5968 - 5977. 36. 27. 2006. http://www.scopus.com/inward/record.url?eid=2-s2.0-33748769776&partnerID=MN8TOARS . 10.1016/j.biomaterials.2006.06.035 . Biomaterials

Structural analysis of dextran-based hydrogels obtained chemoenzymatically

Ferreira, L.; Figueirecio, M.M.; Gil, M.H.; Ramos, M.A., 2006. Journal of Biomedical Materials Research - Part B Applied Biomaterials. 55 - 64. 1. 77. 2006. http://www.scopus.com/inward/record.url?eid=2-s2.0-33645418697&partnerID=MN8TOARS . 10.1002/jbm.b.30394 . Journal of Biomedical Materials Research - Part B Applied Biomaterials

Cultivation of human embryonic stem cells without the embryoid body step enhances osteogenesis in vitro

Karp, J.M.; Ferreira, L.S.; Khademhosseini, A.; Kwon, A.H.; Yeh, J.; Langer, R.S., 2006. Stem Cells. 835 - 843. 4. 24. 2006. http://www.scopus.com/inward/record.url?eid=2-s2.0-33745504422&partnerID=MN8TOARS . 10.1634/stemcells.2005-0383 . Stem Cells

Effect of Cr(V) on reproductive organ morphology and sperm parameters: An experimental study in mice

Pereira, M.D.L.; Das Neves, R.P.; Oliveira, H.; Santos, T.M.; De Jesus, J.P., 2005. Environmental Health: A Global Access Science Source. 4. 2005. http://www.scopus.com/inward/record.url?eid=2-s2.0-23944463762&partnerID=MN8TOARS . 10.1186/1476-069X-4-9 . Environmental Health: A Global Access Science Source

Improving the adhesion of poly(ethylene terephthalate) fibers to poly(hydroxyethyl methacrylate) hydrogels by ozone treatment: Surface characterization and pull-out tests

Ferreira, L.; Evangelista, M.B.; Martins, M.C.L.; Granja, P.L.; Esteves, J.L.; Barbosa, M.A., 2005. Polymer. 9840 - 9850. 23. 46. 2005. http://www.scopus.com/inward/record.url?eid=2-s2.0-26844540116&partnerID=MN8TOARS . 10.1016/j.polymer.2005.08.033 . Polymer

Synthesis and characterization of new injectable and degradable dextran-based hydrogels

Maia, J.; Ferreira, L.; Carvalho, R.; Ramos, M.A.; Gil, M.H., 2005. Polymer. 9604 - 9614. 23. 46. 2005. http://www.scopus.com/inward/record.url?eid=2-s2.0-26844528911&partnerID=MN8TOARS . 10.1016/j.polymer.2005.07.089 . Polymer

Biocatalytic synthesis of highly ordered degradable dextran-based hydrogels

Ferreira, L.; Gil, M.H.; Cabrita, A.M.S.; Dordick, J.S., 2005. Biomaterials. 4707 - 4716. 23. 26. 2005. http://www.scopus.com/inward/record.url?eid=2-s2.0-14844303889&partnerID=MN8TOARS . 10.1016/j.biomaterials.2004.11.051 . Biomaterials

Hypericum androsaemum infusion increases tert-butyl hydroperoxide-induced mice hepatotoxicity in vivo

Valentão, P.; Carvalho, M.; Carvalho, F.; Fernandes, E.; Neves, R.P.D.; Pereira, M.L.; Andrade, P.B.; Seabra, R.M.; Bastos, M.L., 2004. Journal of Ethnopharmacology. 345 - 351. 2-3. 94. 2004. http://www.scopus.com/inward/record.url?eid=2-s2.0-4344716319&partnerID=MN8TOARS . 10.1016/j.jep.2004.06.012 . Journal of Ethnopharmacology

Biocompatibility of chemoenzymatically derived dextran-acrylate hydrogels

Ferreira, L.; Rafael, A.; Lamghari, M.; Barbosa, M.A.; Gil, M.H.; Cabrita, A.M.S.; Dordick, J.S., 2004. Journal of Biomedical Materials Research - Part A. 584 - 596. 3. 68. 2004. http://www.scopus.com/inward/record.url?eid=2-s2.0-1342280525&partnerID=MN8TOARS . Journal of Biomedical Materials Research - Part A

Protective activity of hesperidin and lipoic acid against sodium arsenite acute toxicity in mice

Pires Das Neves, R.N.; Carvalho, F.; Carvalho, M.; Fernandes, E.; Soares, E.; Bastos, M.D.L.; Pereira, M.D.L., 2004. Toxicologic Pathology. 527 - 535. 5. 32. 2004. http://www.scopus.com/inward/record.url?eid=2-s2.0-4544289287&partnerID=MN8TOARS . 10.1080/01926230490502566 . Toxicologic Pathology

Influence of different silica derivatives in the immobilization and stabilization of a Bacillus licheniformis protease (Subtilisin Carlsberg)

Ferreira, L.; Ramos, M.A.; Dordick, J.S.; Gil, M.H., 2003. Journal of Molecular Catalysis B: Enzymatic. 189 - 199. 4-6. 21. 2003. http://www.scopus.com/inward/record.url?eid=2-s2.0-0347297355&partnerID=MN8TOARS . 10.1016/S1381-1177(02)00223-0 . Journal of Molecular Catalysis B: Enzymatic

Biocatalytic polytransesterification of inulin with divinyladipate

Ferreira, L.; Gil, M.H.; Carvalho, R.; Geraldes, C.F.G.C.; Kim, D.-Y.; Dordick, J.S., 2002. Chemistry of Materials. 4009 - 4011. 10. 14. 2002. http://www.scopus.com/inward/record.url?eid=2-s2.0-0036799646&partnerID=MN8TOARS . 10.1021/cm020393w . Chemistry of Materials

Effect of 3,4-methylenedioxymethamphetamine ("ecstasy") on body temperature and liver antioxidant status in mice: Influence of ambient temperature

Carvalho, M.; Carvalho, F.; Remião, F.; De Lourdes Pereira, M.; Pires-Das-Neves, R.; De Lourdes Bastos, M., 2002. Archives of Toxicology. 166 - 172. 3. 76. 2002. http://www.scopus.com/inward/record.url?eid=2-s2.0-0036214775&partnerID=MN8TOARS . 10.1007/s00204-002-0324-z . Archives of Toxicology

Enzymatic synthesis of dextran-containing hydrogels

Ferreira, L.; Gil, M.H.; Dordick, J.S.; Carvalho, R., 2002. Biomaterials. 3957 - 3967. 19. 23. 2002. http://www.scopus.com/inward/record.url?eid=2-s2.0-0036020043&partnerID=MN8TOARS . 10.1016/S0142-9612(02)00132-1 . Biomaterials

Cr(V) involvement in the toxicity pathway of testicular damage

Pereira, M.L.; Santos, T.M.; Pires das Neves, R.; Costa, F.G.; Pedrosa de Jesus, J., 2002. Asian Journal of Andrology. 153 - 155. 2. 4. 2002. http://www.scopus.com/inward/record.url?eid=2-s2.0-0035987253&partnerID=MN8TOARS . Asian Journal of Andrology

Comparative histological studies on liver of mice exposed to Cr(VI) and Cr(V) compounds

Pires Das Neves, R.; Santos, T.M.; De Lourdes Pereira, M.; Pedrosa De Jesus, J., 2002. Human and Experimental Toxicology. 365 - 369. 7. 21. 2002. http://www.scopus.com/inward/record.url?eid=2-s2.0-0036656032&partnerID=MN8TOARS . 10.1191/0960327102ht243oa . Human and Experimental Toxicology

Exquisite regioselectivity and increased transesterification activity of an immobilized Bacillus subtilis protease

Ferreira, L.; Ramos, M.A.; Gil, M.H.; Dordick, J.S., 2002. Biotechnology Progress. 986 - 993. 5. 18. 2002. http://www.scopus.com/inward/record.url?eid=2-s2.0-0036753108&partnerID=MN8TOARS . 10.1021/bp0255457 . Biotechnology Progress

Design of a drug-delivery system based on polyacrylamide hydrogels. Evaluation of structural properties

Ferreira, Lino, 2001. Chemical educator. 2001. http://link.springer.com/article/10.1007%2Fs00897010461a . 10.1007/s00897010461a . Chemical educator

Chromium(VI) induced alterations in mouse spleen cells: A short-term assay

Das Neves, R.P.; Santos, T.M.; Pereira, M.D.L.; De Jesus, J.P., 2001. Cytobios. 27 - 34. 1 SUPPL.. 413. 2001. http://www.scopus.com/inward/record.url?eid=2-s2.0-0348238820&partnerID=MN8TOARS . Cytobios

Evaluation of poly(2-hydroxyethyl methacrylate) gels as drug delivery systems at different pH values

Ferreira, L.; Vidal, M.M.; Gil, M.H., 2000. International Journal of Pharmaceutics. 169 - 180. 2. 194. 2000. http://www.scopus.com/inward/record.url?eid=2-s2.0-0033968976&partnerID=MN8TOARS . 10.1016/S0378-5173(99)00375-0 . International Journal of Pharmaceutics

Preparation and characterization of gels based on sucrose modified with glycidyl methacrylate

Ferreira, L.; Vidal, M.M.; Geraldes, C.F.G.C.; Gil, M.H., 2000. Carbohydrate Polymers. 15 - 24. 1. 41. 2000. http://www.scopus.com/inward/record.url?eid=2-s2.0-0033908440&partnerID=MN8TOARS . 10.1016/S0144-8617(99)00064-8 . Carbohydrate Polymers