MitoLab: Mitochondrial Signaling and Metabolic Dysfunction

SNHG1: Redefining the Landscape of Hepatocellular Carcinoma through Long Noncoding RNAs

Tiago S. Fonseca; Rui Miguel Martins; Anabela P. Rolo; Carlos M. Palmeira, 2024. Biomedicines. 2024. https://doi.org/10.3390/biomedicines12081696 . 10.3390/biomedicines12081696 . Biomedicines

Hydrolytic Activity of Mitochondrial F1FO-ATP Synthase as a Target for Myocardial Ischemia–Reperfusion Injury: Discovery and In Vitro and In Vivo Evaluation of Novel Inhibitors

Panagiota-Efstathia Nikolaou; George Lambrinidis; Maria Georgiou; Dimitrios Karagiannis; Panagiotis Efentakis; Pavlos Bessis-Lazarou; Konstantina Founta; et al, 2023. Journal of Medicinal Chemistry. 2023. https://doi.org/10.1021/acs.jmedchem.3c01048 . 10.1021/acs.jmedchem.3c01048 . Journal of Medicinal Chemistry

Loss of epigenetic information as a cause of mammalian aging

Yang, Jae-Hyun; Hayano, Motoshi; Griffin, Patrick T.; Amorim, João A.; Bonkowski, Michael S.; Apostolides, John K.; Salfati, Elias L.; et al, 2023. Cell. 305 - 326.e27. 2. 186. 2023. http://dx.doi.org/10.1016/j.cell.2022.12.027 . 10.1016/j.cell.2022.12.027 . Cell

Downregulation of Sirtuin 1 Does Not Account for the Impaired Long-Term Potentiation in the Prefrontal Cortex of Female APPswe/PS1dE9 Mice Modelling Alzheimer’s Disease

Cátia R. Lopes; Joana S. Silva; Joana Santos; Matilde S. Rodrigues; Daniela Madeira; Andreia Oliveira; Ana Moreira-de-Sá; et al, 2023. International Journal of Molecular Sciences. 2023. https://www.mdpi.com/1422-0067/24/8/6968 . 10.3390/ijms24086968 . International Journal of Molecular Sciences

Preservation of Mitochondrial Health in Liver Ischemia/Reperfusion Injury

Ivo F. Machado; Carlos M. Palmeira; Anabela P. Rolo, 2023. Biomedicines. 2023. https://doi.org/10.3390/biomedicines11030948 . 10.3390/biomedicines11030948 . Biomedicines

Targeting Oxidative Stress with Polyphenols to Fight Liver Diseases

Ivo F. Machado; Raul G. Miranda; Daniel J. Dorta; Anabela P. Rolo; Carlos M. Palmeira, 2023. Antioxidants. 2023. https://doi.org/10.3390/antiox12061212 . 10.3390/antiox12061212 . Antioxidants

IGL-2 as a Unique Solution for Cold Static Preservation and Machine Perfusion in Liver and Mitochondrial Protection

Rui Teixeira Da Silva; Raquel G. Bardallo; Emma Folch-Puy; Teresa Carbonell; Carlos M. Palmeira; Constantino Fondevila; René Adam; Joan Roselló-Catafau; Arnau Panisello-Roselló, 2022. Transplantation Proceedings. 73 - 76. 1. 54. 2022. https://doi.org/10.1016/j.transproceed.2021.10.008 . 10.1016/j.transproceed.2021.10.008 . Transplantation Proceedings

PEG35 as a Preconditioning Agent against Hypoxia/Reoxygenation Injury

Rui Teixeira da Silva; Ivo F. Machado; João S. Teodoro; Arnau Panisello-Roselló; Joan Roselló-Catafau; Anabela P. Rolo; Carlos M. Palmeira, 2022. International Journal of Molecular Sciences. 1156 - 1156. 3. 23. 2022. https://doi.org/10.3390/ijms23031156 . 10.3390/ijms23031156 . International Journal of Molecular Sciences

Mitochondrial and metabolic dysfunction in ageing and age-related diseases

Amorim, João A.; Coppotelli, Giuseppe; Rolo, Anabela P.; Palmeira, Carlos M.; Ross, Jaime M.; Sinclair, David A., 2022. Nature Reviews Endocrinology. 2022. http://dx.doi.org/10.1038/s41574-021-00626-7 . 10.1038/s41574-021-00626-7 . Nature Reviews Endocrinology

Liver Graft Hypothermic Static and Oxygenated Perfusion (HOPE) Strategies: A Mitochondrial Crossroads

Raquel G. Bardallo; Rui T. Da Silva; Teresa Carbonell; Carlos Palmeira; Emma Folch-Puy; Joan Roselló-Catafau; René Adam; Arnau Panisello-Rosello, 2022. International Journal of Molecular Sciences. 5742 - 5742. 10. 23. 2022. https://doi.org/10.3390/ijms23105742 . 10.3390/ijms23105742 . International Journal of Molecular Sciences

Shaping of Hepatic Ischemia/Reperfusion Events: The Crucial Role of Mitochondria

João S. Teodoro; Rui T. Da Silva; Ivo F. Machado; Arnau Panisello-Roselló; Joan Roselló-Catafau; Anabela P. Rolo; Carlos M. Palmeira, 2022. Cells. 688 - 688. 4. 11. 2022. https://doi.org/10.3390/cells11040688 . 10.3390/cells11040688 . Cells

miR-378a-3p Participates in Metformin’s Mechanism of Action on C2C12 Cells under Hyperglycemia

Machado, Ivo F.; Teodoro, João S.; Castela, Ana C.; Palmeira, Carlos M.; Rolo, Anabela P., 2021. International Journal of Molecular Sciences. 2. 22. 2021. http://dx.doi.org/10.3390/ijms22020541 . 10.3390/ijms22020541 . International Journal of Molecular Sciences

The potential role of sestrin 2 in liver regeneration

Oliveira, Raúl P.; Machado, Ivo F.; Palmeira, Carlos M.; Rolo, Anabela P., 2021. Free Radical Biology and Medicine. 255 - 267. 163. 2021. http://dx.doi.org/10.1016/j.freeradbiomed.2020.12.027 . 10.1016/j.freeradbiomed.2020.12.027 . Free Radical Biology and Medicine

Sestrin2 and mitochondrial quality control: Potential impact in myogenic differentiation

Piochi, Luiz F.; Machado, Ivo F.; Palmeira, Carlos M.; Rolo, Anabela P., 2021. Ageing Research Reviews. 67. 2021. http://dx.doi.org/10.1016/j.arr.2021.101309 . 10.1016/j.arr.2021.101309 . Ageing Research Reviews

Chenodeoxycholic Acid Has Non-Thermogenic, Mitodynamic Anti-Obesity Effects in an In Vitro CRISPR/Cas9 Model of Bile Acid Receptor TGR5 Knockdown

Teodoro, João S.; Machado, Ivo F.; Castela, Ana C.; Amorim, João A.; Jarak, Ivana; Carvalho, Rui A.; Palmeira, Carlos M.; Rolo, Anabela P., 2021. International Journal of Molecular Sciences. 21. 22. 2021. http://dx.doi.org/10.3390/ijms222111738 . 10.3390/ijms222111738 . International Journal of Molecular Sciences

Blueberry Counteracts Prediabetes in a Hypercaloric Diet-Induced Rat Model and Rescues Hepatic Mitochondrial Bioenergetics

Sara Nunes; Sofia D. Viana; Inês Preguiça; André Alves; R. Fernandes; Teodoro, J.S.; Patrícia Matos; et al, 2021. Nutrients. 2021. https://www.mdpi.com/2072-6643/13/12/4192 . 10.3390/nu13124192 . Nutrients

The yin and yang faces of the mitochondrial deacetylase sirtuin 3 in age-related disorders

Gomes, P.; Viana, S.D.; Nunes, S.; Rolo, A.P.; Palmeira, C.M.; Reis, F., 2020. Ageing Research Reviews. 57. 2020. http://www.scopus.com/inward/record.url?eid=2-s2.0-85076952156&partnerID=MN8TOARS . 10.1016/j.arr.2019.100983 . Ageing Research Reviews

Stimulation of cell invasion by the Golgi Ion Channel GAAP/TMBIM4 via an H<inf>2</inf>O<inf>2</inf>-Dependent Mechanism

Almeida, N.; Carrara, G.; Palmeira, C.M.; Fernandes, A.S.; Parsons, M.; Smith, G.L.; Saraiva, N., 2020. Redox Biology. 28. 2020. http://www.scopus.com/inward/record.url?eid=2-s2.0-85074222003&partnerID=MN8TOARS . 10.1016/j.redox.2019.101361 . Redox Biology

Altered mitochondrial metabolism in the insulin-resistant heart

Makrecka-Kuka, M.; Liepinsh, E.; Murray, A.J.; Lemieux, H.; Dambrova, M.; Tepp, K.; Puurand, M.; et al, 2020. Acta Physiologica. 3. 228. 2020. http://www.scopus.com/inward/record.url?eid=2-s2.0-85077842678&partnerID=MN8TOARS . 10.1111/apha.13430 . Acta Physiologica

Blueberry Consumption Challenges Hepatic Mitochondrial Bioenergetics and Elicits Transcriptomics Reprogramming in Healthy Wistar Rats

Nunes, Sara; Viana, Sofia D.; Preguiça, Inês; Alves, André; Fernandes, Rosa; Teodoro, João S.; Figueirinha, Artur; et al, 2020. Pharmaceutics. 11. 12. 2020. http://dx.doi.org/10.3390/pharmaceutics12111094 . 10.3390/pharmaceutics12111094 . Pharmaceutics

The Soluble Adenylyl Cyclase Inhibitor LRE1 Prevents Hepatic Ischemia/Reperfusion Damage Through Improvement of Mitochondrial Function

Teodoro, João S.; Amorim, João A.; Machado, Ivo F.; Castela, Ana C.; Steegborn, Clemens; Sinclair, David A.; Rolo, Anabela P.; Palmeira, Carlos M., 2020. International Journal of Molecular Sciences. 14. 21. 2020. http://dx.doi.org/10.3390/ijms21144896 . 10.3390/ijms21144896 . International Journal of Molecular Sciences

Exploration of the cellular effects of the high-dose, long-term exposure to coffee roasting product furan and its by-product cis-2-butene-1,4-dial on human and rat hepatocytes

João S. Teodoro; Rui Silva; António Aguiar; Abílio J. F. N. Sobral; Anabela P. Rolo; Carlos M. Palmeira, 2020. Toxicology Mechanisms and Methods. 536 - 545. 7. 30. 2020. https://doi.org/10.1080/15376516.2020.1780361 . 10.1080/15376516.2020.1780361 . Toxicology Mechanisms and Methods

Mild hypothermia during the reperfusion phase protects mitochondrial bioenergetics against ischemia-reperfusion injury in an animal model of ex-vivo liver transplantation—An experimental study

Martins, R.M.; Teodoro, J.S.; Furtado, E.; Oliveira, R.C.; Tralhão, J.G.; Rolo, A.P.; Palmeira, C.M., 2019. International Journal of Medical Sciences. 1304 - 1312. 9. 16. 2019. http://www.scopus.com/inward/record.url?eid=2-s2.0-85072941379&partnerID=MN8TOARS . 10.7150/ijms.34617 . International Journal of Medical Sciences

Therapeutic options targeting oxidative stress, mitochondrial dysfunction and inflammation to hinder the progression of vascular complications of diabetes

Teodoro, J.S.; Nunes, S.; Rolo, A.P.; Reis, F.; Palmeira, C.M., 2019. Frontiers in Physiology. JAN. 10. 2019. http://www.scopus.com/inward/record.url?eid=2-s2.0-85065463466&partnerID=MN8TOARS . 10.3389/fphys.2018.01857 . Frontiers in Physiology

Evaluation of bioenergetic and mitochondrial function in liver transplantation

Martins, Rui Miguel; Teodoro, João Soeiro; Furtado, Emanuel; Rolo, Anabela Pinto; Palmeira, Carlos Marques; Tralhão, José Guilherme; Martins, R.M.; et al, 2019. Clinical and Molecular Hepatology. 190 - 198. 2. 25. 2019. http://dx.doi.org/10.3350/cmh.2018.0087 . 10.3350/cmh.2018.0087 . Clinical and Molecular Hepatology

Correspondence

Alexandrino, H.; Palmeira, C., 2019. British Journal of Surgery. 152 - 152. 1. 106. 2019. http://www.scopus.com/inward/record.url?eid=2-s2.0-85058912518&partnerID=MN8TOARS . 10.1002/bjs.11055 . British Journal of Surgery

Mitohormesis and metabolic health: The interplay between ROS, cAMP and sirtuins

Palmeira, C.M.; Teodoro, J.S.; Amorim, J.A.; Steegborn, C.; Sinclair, D.A.; Rolo, A.P., 2019. Free Radical Biology and Medicine. 483 - 491. 141. 2019. http://www.scopus.com/inward/record.url?eid=2-s2.0-85069629808&partnerID=MN8TOARS . 10.1016/j.freeradbiomed.2019.07.017 . Free Radical Biology and Medicine

Enhanced ATP release and CD73-mediated adenosine formation sustain adenosine A<inf>2A</inf> receptor over-activation in a rat model of Parkinson's disease

Carmo, M.; Gonçalves, F.Q.; Canas, P.M.; Oses, J.-P.; Fernandes, F.D.; Duarte, F.V.; Palmeira, C.M.; et al, 2019. British Journal of Pharmacology. 3666 - 3680. 18. 176. 2019. http://www.scopus.com/inward/record.url?eid=2-s2.0-85070072977&partnerID=MN8TOARS . 10.1111/bph.14771 . British Journal of Pharmacology

miR-378a: a new emerging microRNA in metabolism

Machado, I.F.; Teodoro, J.S.; Palmeira, C.M.; Rolo, A.P., 2019. Cellular and Molecular Life Sciences. 2019. http://www.scopus.com/inward/record.url?eid=2-s2.0-85075434955&partnerID=MN8TOARS . 10.1007/s00018-019-03375-z . Cellular and Molecular Life Sciences

Cytoprotective mechanisms in fatty liver preservation against cold ischemia injury: A comparison between IGL-1 and HTK

Panisello-Roselló, A.; Verde, E.; Lopez, A.; Flores, M.; Folch-Puy, E.; Rolo, A.; Palmeira, C.; et al, 2018. International Journal of Molecular Sciences. 2. 19. 2018. http://www.scopus.com/inward/record.url?eid=2-s2.0-85041019515&partnerID=MN8TOARS . 10.3390/ijms19020348 . International Journal of Molecular Sciences

Indirubin and NAD⁺ prevent mitochondrial ischaemia/reperfusion damage in fatty livers

Teodoro, J.S.; Varela, A.T.; Duarte, F.V.; Gomes, A.P.; Palmeira, C.M.; Rolo, A.P., 2018. European Journal of Clinical Investigation. 6. 48. 2018. http://www.scopus.com/inward/record.url?eid=2-s2.0-85045238716&partnerID=MN8TOARS . 10.1111/eci.12932 . European Journal of Clinical Investigation

A NEW MOUSE MODEL TO UNRAVEL THE MECHANISM OF SIRT1 ACTIVATION

Amorim, João; Thakur, Sachin; Bonkowski, Michael S; Rolo, Anabela P.; Palmeira, Carlos M.; Sinclair, David A., 2018. Innovation in Aging. 878 - 878. (Suppl 1). 2. 2018. https://academic.oup.com/innovateage/article/2/suppl_1/878/5183703 . Innovation in Aging

Role of aldehyde dehydrogenase 2 in ischemia reperfusion injury: An update

Panisello-Roselló, A.; Lopez, A.; Folch-Puy, E.; Carbonell, T.; Rolo, A.; Palmeira, C.; Adam, R.; Net, M.; Roselló-Catafau, J., 2018. World Journal of Gastroenterology. 2984 - 2994. 27. 24. 2018. http://www.scopus.com/inward/record.url?eid=2-s2.0-85050972436&partnerID=MN8TOARS . 10.3748/wjg.v24.i27.2984 . World Journal of Gastroenterology

Aldehyde dehydrogenase 2 (ALDH2) in rat fatty liver cold ischemia injury

Panisello-Roselló, A.; Alva, N.; Flores, M.; Lopez, A.; Benítez, C.C.; Folch-Puy, E.; Rolo, A.; et al, 2018. International Journal of Molecular Sciences. 9. 19. 2018. http://www.scopus.com/inward/record.url?eid=2-s2.0-85052507134&partnerID=MN8TOARS . 10.3390/ijms19092479 . International Journal of Molecular Sciences

Corrigendum to “European contribution to the study of ROS: A summary of the findings and prospects for the future from the COST action BM1203 (EU-ROS)” (Redox Biol. (2017) 13 (94–162)(S2213231717303373)(10.1016/j.redox.2017.05.007))

Egea, J.; Fabregat, I.; Frapart, Y.M.; Ghezzi, P.; Görlach, A.; Kietzmann, T.; Kubaichuk, K.; et al, 2018. Redox Biology. 694 - 696. 14. 2018. http://www.scopus.com/inward/record.url?eid=2-s2.0-85032289195&partnerID=MN8TOARS . 10.1016/j.redox.2017.10.001 . Redox Biology

Mitochondrial damage and apoptosis: Key features in BDE-153-induced hepatotoxicity

Pereira, L.C.; Cabral Miranda, L.F.; Franco-Bernardes, M.F.; Tasso, M.J.; Duarte, F.V.; Inácio Varela, A.T.; Rolo, A.P.; Marques Palmeira, C.M.; Dorta, D.J., 2018. Chemico-Biological Interactions. 192 - 201. 291. 2018. http://www.scopus.com/inward/record.url?eid=2-s2.0-85049064624&partnerID=MN8TOARS . 10.1016/j.cbi.2018.06.021 . Chemico-Biological Interactions

Research update for articles published in EJCI in 2016

Adlbrecht, C.; Blanco-Verea, A.; Bouzas-Mosquera, M.C.; Brion, M.; Burtscher, M.; Carbone, F.; Chang, T.-T.; et al, 2018. European Journal of Clinical Investigation. 10. 48. 2018. http://www.scopus.com/inward/record.url?eid=2-s2.0-85053529293&partnerID=MN8TOARS . 10.1111/eci.13016 . European Journal of Clinical Investigation

Addition of berberine to preservation solution in an animal model of ex vivo liver transplant preserves mitochondrial function and bioenergetics from the damage induced by ischemia/reperfusion

Martins, R.M.; Rolo, A.P.; Teodoro, J.S.; Furtado, E.; Oliveira, R.C.; Tralhão, J.G.; Palmeira, C.M., 2018. International Journal of Molecular Sciences. 1. 19. 2018. http://www.scopus.com/inward/record.url?eid=2-s2.0-85040938454&partnerID=MN8TOARS . 10.3390/ijms19010284 . International Journal of Molecular Sciences

Recent insights into mitochondrial targeting strategies in liver transplantation

Martins, R.M.; Teodoro, J.S.; Furtado, E.; Rolo, A.P.; Palmeira, C.M.; Tralhão, J.G., 2018. International Journal of Medical Sciences. 248 - 256. 3. 15. 2018. http://www.scopus.com/inward/record.url?eid=2-s2.0-85045188539&partnerID=MN8TOARS . 10.7150/ijms.22891 . International Journal of Medical Sciences

An autophagic process is activated in HepG2 cells to mediate BDE-100-induced toxicity.

Pereira LC; Duarte FV; Varela AT; Rolo AP; Palmeira CM; Dorta DJ, 2017. 2017. http://europepmc.org/abstract/med/27234317 . 10.1016/j.tox.2016.05.022 .

Unacylated ghrelin prevents mitochondrial dysfunction in a model of ischemia/reperfusion liver injury

Rossetti, A.; Togliatto, G.; Rolo, A.P.; Teodoro, J.S.; Granata, R.; Ghigo, E.; Columbano, A.; Palmeira, C.M.; Brizzi, M.F., 2017. Cell Death Discovery. 1. 3. 2017. http://www.scopus.com/inward/record.url?eid=2-s2.0-85051289736&partnerID=MN8TOARS . 10.1038/cddiscovery.2017.77 . Cell Death Discovery

GSK3ß and VDAC Involvement in ER Stress and Apoptosis Modulation during Orthotopic Liver Transplantation.

Zaouali MA; Panisello A; Lopez A; Castro C; Folch E; Carbonell T; Rolo A; et al, 2017. 2017. http://europepmc.org/abstract/med/28282906 . 10.3390/ijms18030591 .

European contribution to the study of ROS: A summary of the findings and prospects for the future from the COST action BM1203 (EU-ROS)

Egea, J.; Fabregat, I.; Frapart, Y.M.; Ghezzi, P.; Görlach, A.; Kietzmann, T.; Kubaichuk, K.; et al, 2017. Redox Biology. 94 - 162. 13. 2017. http://www.scopus.com/inward/record.url?eid=2-s2.0-85020032301&partnerID=MN8TOARS . 10.1016/j.redox.2017.05.007 . Redox Biology

Adenosine receptors: regulatory players in the preservation of mitochondrial function induced by ischemic preconditioning of rat liver

Duarte, F.V.; Amorim, J.A.; Varela, A.T.; Teodoro, J.S.; Gomes, A.P.; Cunha, R.A.; Palmeira, C.M.; et al, 2017. Purinergic Signalling. 179 - 190. 2. 13. 2017. http://www.scopus.com/inward/record.url?eid=2-s2.0-84995486129&partnerID=MN8TOARS . 10.1007/s11302-016-9548-x . Purinergic Signalling

Mitochondria in Excitatory and Inhibitory Synapses have Similar Susceptibility to Amyloid-ß Peptides Modeling Alzheimer's Disease

Amorim, J.A.; Canas, P.M.; Tomé, A.R.; Rolo, A.P.; Agostinho, P.; Palmeira, C.M.; Cunha, R.A., 2017. Journal of Alzheimer's Disease. 525 - 536. 2. 60. 2017. http://www.scopus.com/inward/record.url?eid=2-s2.0-85029613373&partnerID=MN8TOARS . 10.3233/JAD-170356 . Journal of Alzheimer's Disease

Lack of additive effects of resveratrol and energy restriction in the treatment of hepatic steatosis in rats

Milton-Laskibar, I.; Aguirre, L.; Fernández-Quintela, A.; Rolo, A.P.; Teodoro, J.S.; Palmeira, C.M.; Portillo, M.P., 2017. Nutrients. 7. 9. 2017. http://www.scopus.com/inward/record.url?eid=2-s2.0-85023760594&partnerID=MN8TOARS . 10.3390/nu9070737 . Nutrients

Bioenergetic adaptations of the human liver in the ALPPS procedure – how liver regeneration correlates with mitochondrial energy status

Alexandrino, H.; Rolo, A.; Teodoro, J.S.; Donato, H.; Martins, R.; Serôdio, M.; Martins, M.; et al, 2017. HPB. 1091 - 1103. 12. 19. 2017. http://www.scopus.com/inward/record.url?eid=2-s2.0-85029605721&partnerID=MN8TOARS . 10.1016/j.hpb.2017.08.005 . HPB

Exposure to BDE-153 induces autophagy in HepG2 cells.

Pereira LC; Duarte FV; Varela ATIF; Rolo AP; Palmeira CMM; Dorta DJ, 2017. 2017. http://europepmc.org/abstract/med/28396260 . 10.1016/j.tiv.2017.04.005 .

Exposure to decabromodiphenyl ether (BDE-209) produces mitochondrial dysfunction in rat liver and cell death

Pereira, L.C.; Souza, A.O.; Tasso, M.J.; Oliveira, A.M.C.; Duarte, F.V.; Palmeira, C.M.; Dorta, D.J., 2017. Journal of Toxicology and Environmental Health - Part A: Current Issues. 1129 - 1144. 19-21. 80. 2017. http://www.scopus.com/inward/record.url?eid=2-s2.0-85033371791&partnerID=MN8TOARS . 10.1080/15287394.2017.1357370 . Journal of Toxicology and Environmental Health - Part A: Current Issues

Low-dose, subchronic exposure to silver nanoparticles causes mitochondrial alterations in Sprague-Dawley rats.

Teodoro JS; Silva R; Varela AT; Duarte FV; Rolo AP; Hussain S; Palmeira CM, 2016. 2016. http://europepmc.org/abstract/med/27171910 . 10.2217/nnm-2016-0049 .

Mitochondrial bioenergetics and posthepatectomy liver dysfunction.

Alexandrino H; Varela AT; Teodoro JS; Martins MA; Rolo AP; Tralhão JG; Palmeira CM; Castro E Sousa F, 2016. 2016. http://europepmc.org/abstract/med/27138992 . 10.1111/eci.12639 .

Evaluation of Polybrominated Diphenyl Ether Toxicity on HepG2 Cells - Hexabrominated Congener (BDE-154) Is Less Toxic than Tetrabrominated Congener (BDE-47).

Souza AO; Tasso MJ; Oliveira AM; Pereira LC; Duarte FV; Oliveira DP; Palmeira CM; Dorta DJ, 2016. 2016. http://europepmc.org/abstract/med/27060917 . 10.1111/bcpt.12598 .

The bile acid chenodeoxycholic acid directly modulates metabolic pathways in white adipose tissue in vitro: insight into how bile acids decrease obesity.

Teodoro JS; Rolo AP; Jarak I; Palmeira CM; Carvalho RA, 2016. 2016. http://europepmc.org/abstract/med/27488269 . 10.1002/nbm.3583 .

Hepatic and skeletal muscle mitochondrial toxicity of chitosan oligosaccharides of normal and diabetic rats.

Teodoro JS; Gomes AP; Varela AT; Duarte FV; Rolo AP; Palmeira CM, 2016. 2016. http://europepmc.org/abstract/med/27790925 . 10.1080/15376516.2016.1222643 .

Regulation of Mitochondrial Function and its Impact in Metabolic Stress.

Duarte FV; Amorim JA; Palmeira CM; Rolo AP, 2015. 2015. http://europepmc.org/abstract/med/25973983 . 10.2174/0929867322666150514095910 .

Editorial: Metabolic Diseases: Drugs and Mitochondrial Targets.

Palmeira CM; Rolo AP; Palmeira, C.M.; Rolo, A.P., 2015. Current Medicinal Chemistry. 20. 22. 2015. http://europepmc.org/abstract/med/26549543 . 10.2174/092986732220150722123617 . Current Medicinal Chemistry

Impairment of mitochondrial energy metabolism of two marine fish by in vitro mercuric chloride exposure.

Mieiro CL; Pardal M; Duarte A; Pereira E; Palmeira CM, 2015. 2015. http://europepmc.org/abstract/med/26026249 . 10.1016/j.marpolbul.2015.05.054 .

Biochemical and physiological responses of Carcinus maenas to temperature and the fungicide azoxystrobin.

Rodrigues ET; Moreno A; Mendes T; Palmeira C; Pardal MÂ, 2015. 2015. http://europepmc.org/abstract/med/25835271 . 10.1016/j.chemosphere.2015.03.011 .

Losartan activates sirtuin 1 in rat reduced-size orthotopic liver transplantation.

Pantazi E; Bejaoui M; Zaouali MA; Folch-Puy E; Pinto Rolo A; Panisello A; Palmeira CM; Roselló-Catafau J, 2015. 2015. http://europepmc.org/abstract/med/26185373 . 10.3748/wjg.v21.i26.8021 .

Sirtuin 1 in rat orthotopic liver transplantation: an IGL-1 preservation solution approach.

Pantazi E; Zaouali MA; Bejaoui M; Folch-Puy E; Ben Abdennebi H; Varela AT; Rolo AP; Palmeira CM; Roselló-Catafau J, 2015. 2015. http://europepmc.org/abstract/med/25684941 . 10.3748/wjg.v21.i6.1765 .

PPARa Agonist WY-14643 Induces SIRT1 Activity in Rat Fatty Liver Ischemia-Reperfusion Injury.

Pantazi E; Folch-Puy E; Bejaoui M; Panisello A; Varela AT; Rolo AP; Palmeira CM; Roselló-Catafau J, 2015. 2015. http://europepmc.org/abstract/med/26539534 . 10.1155/2015/894679 .

Reactive oxygen species, nutrition, hypoxia and diseases: Problems solved?

Görlach A; Dimova EY; Petry A; Martínez-Ruiz A; Hernansanz-Agustín P; Rolo AP; Palmeira CM; Kietzmann T, 2015. 2015. http://europepmc.org/abstract/med/26339717 . 10.1016/j.redox.2015.08.016 .

Enhancement of brown fat thermogenesis using chenodeoxycholic acid in mice.

Teodoro JS; Zouhar P; Flachs P; Bardova K; Janovska P; Gomes AP; Duarte FV; et al, 2014. 2014. http://europepmc.org/abstract/med/24310401 . 10.1038/ijo.2013.230 .

The Role of microRNAs in Mitochondria: Small Players Acting Wide.

Duarte FV; Palmeira CM; Rolo AP, 2014. 2014. http://europepmc.org/abstract/med/25264560 . 10.3390/genes5040865 .

The P2X7 receptor antagonist Brilliant Blue G attenuates contralateral rotations in a rat model of Parkinsonism through a combined control of synaptotoxicity, neurotoxicity and gliosis.

Carmo MR; Menezes AP; Nunes AC; Pliássova A; Rolo AP; Palmeira CM; Cunha RA; Canas PM; Andrade GM, 2014. 2014. http://europepmc.org/abstract/med/24508709 . 10.1016/j.neuropharm.2014.01.045 .

High-fat and obesogenic diets: current and future strategies to fight obesity and diabetes.

Teodoro JS; Varela AT; Rolo AP; Palmeira CM, 2014. 2014. http://europepmc.org/abstract/med/24842072 . 10.1007/s12263-014-0406-6 .

Berberine reverts hepatic mitochondrial dysfunction in high-fat fed rats: A possible role for SirT3 activation

Teodoro, J.S.; Duarte, F.V.; Gomes, A.P.; Varela, A.T.; Peixoto, F.M.; Rolo, A.P.; Palmeira, C.M., 2013. Mitochondrion. 637 - 646. 6. 13. 2013. http://www.scopus.com/inward/record.url?eid=2-s2.0-84884937949&partnerID=MN8TOARS . 10.1016/j.mito.2013.09.002 . Mitochondrion

Therapeutic concentrations of mitoxantrone elicit energetic imbalance in H9c2 cells as an earlier event

Rossato, L.G.; Costa, V.M.; Vilas-Boas, V.; De Lourdes Bastos, M.; Rolo, A.; Palmeira, C.; Remião, F., 2013. Cardiovascular Toxicology. 413 - 425. 4. 13. 2013. http://www.scopus.com/inward/record.url?eid=2-s2.0-84890559945&partnerID=MN8TOARS . 10.1007/s12012-013-9224-0 . Cardiovascular Toxicology

Dibenzofuran-induced mitochondrial dysfunction: Interaction with ANT carrier

Duarte, F.V.; Gomes, A.P.; Teodoro, J.S.; Varela, A.T.; Moreno, A.J.M.; Rolo, A.P.; Palmeira, C.M., 2013. Toxicology in Vitro. 2160 - 2168. 8. 27. 2013. http://www.scopus.com/inward/record.url?eid=2-s2.0-84885795993&partnerID=MN8TOARS . 10.1016/j.tiv.2013.08.009 . Toxicology in Vitro

Mitochondrial Cumulative Damage Induced by Mitoxantrone: Late Onset Cardiac Energetic Impairment.

Rossato LG; Costa VM; Dallegrave E; Arbo M; Silva R; Ferreira R; Amado F; et al, 2013. 2013. http://europepmc.org/abstract/med/24096626 . 10.1007/s12012-013-9230-2 .

Cumulative Mitoxantrone-induced Haematological and Hepatic Adverse Effects in a Sub-Chronic In Vivo Study.

Rossato LG; Costa VM; Dallegrave E; Arbo M; Dinis-Oliveira RJ; Santos-Silva A; Duarte JA; et al, 2013. 2013. http://europepmc.org/abstract/med/24119282 . 10.1111/bcpt.12143 .

The metabolic profile of mitoxantrone and its relation with mitoxantrone-induced cardiotoxicity.

Rossato LG; Costa VM; de Pinho PG; Arbo MD; de Freitas V; Vilain L; de Lourdes Bastos M; Palmeira C; Remião F, 2013. 2013. http://europepmc.org/abstract/med/23545721 . 10.1007/s00204-013-1040-6 .

Declining NAD(+) induces a pseudohypoxic state disrupting nuclear-mitochondrial communication during aging.

Gomes AP; Price NL; Ling AJ; Moslehi JJ; Montgomery MK; Rajman L; White JP; et al, 2013. 2013. http://europepmc.org/abstract/med/24360282 . 10.1016/j.cell.2013.11.037 .

The NAD ratio redox paradox: why does too much reductive power cause oxidative stress?

Teodoro JS; Rolo AP; Palmeira CM, 2013. 2013. http://europepmc.org/abstract/med/23256455 . 10.3109/15376516.2012.759305 .

Uncovering the beginning of diabetes: the cellular redox status and oxidative stress as starting players in hyperglycemic damage.

Teodoro JS; Gomes AP; Varela AT; Duarte FV; Rolo AP; Palmeira CM, 2013. 2013. http://europepmc.org/abstract/med/23292031 . 10.1007/s11010-012-1555-9 .

Preface

Palmeira, C.M.; Moreno, A.J., 2012. Methods in Molecular Biology. 810. 2012. http://www.scopus.com/inward/record.url?eid=2-s2.0-82355193804&partnerID=MN8TOARS . Methods in Molecular Biology

Role of oxidative stress in the pathogenesis of nonalcoholic steatohepatitis.

Rolo AP; Teodoro JS; Palmeira CM, 2012. 2012. http://europepmc.org/abstract/med/22064361 . 10.1016/j.freeradbiomed.2011.10.003 .

SIRT1 is required for AMPK activation and the beneficial effects of resveratrol on mitochondrial function.

Price NL; Gomes AP; Ling AJ; Duarte FV; Martin-Montalvo A; North BJ; Agarwal B; et al, 2012. 2012. http://europepmc.org/abstract/med/22560220 . 10.1016/j.cmet.2012.04.003 .

Exposure to dibenzofuran triggers autophagy in lung cells.

Duarte FV; Teodoro JS; Rolo AP; Palmeira CM, 2012. 2012. http://europepmc.org/abstract/med/22173198 . 10.1016/j.toxlet.2011.11.029 .

Berberine protects against high fat diet-induced dysfunction in muscle mitochondria by inducing SIRT1-dependent mitochondrial biogenesis.

Gomes AP; Duarte FV; Nunes P; Hubbard BP; Teodoro JS; Varela AT; Jones JG; et al, 2012. 2012. http://europepmc.org/abstract/med/22027215 . 10.1016/j.bbadis.2011.10.008 .

Antioxidant capacity and toxicological evaluation of Pterospartum tridentatum flower extracts

Ferreira, F.M.; Dinis, L.T.; Azedo, P.; Galhano, C.I.C.; Simões, A.; Cardoso, S.M.; Domingues, M.R.M.; et al, 2012. CYTA - Journal of Food. 92 - 102. 2. 10. 2012. http://www.scopus.com/inward/record.url?eid=2-s2.0-84860268444&partnerID=MN8TOARS . 10.1080/19476337.2011.590233 . CYTA - Journal of Food

Nerolidol effects on mitochondrial and cellular energetics.

Ferreira FM; Palmeira CM; Oliveira MM; Santos D; Simões AM; Rocha SM; Coimbra MA; Peixoto F, 2012. 2012. http://europepmc.org/abstract/med/22138475 . 10.1016/j.tiv.2011.11.009 .

Fatty liver and ischemia/reperfusion: are there drugs able to mitigate injury?

Varela AT; Rolo AP; Palmeira CM, 2011. 2011. http://europepmc.org/abstract/med/22050747 . 10.2174/092986711797535164 .

Regulation of mitochondrial biogenesis in metabolic syndrome.

Rolo AP; Gomes AP; Palmeira CM, 2011. 2011. http://europepmc.org/abstract/med/21269264 . 10.2174/138945011795529056 .

Ursodeoxycholic acid treatment of hepatic steatosis: a (13)C NMR metabolic study.

Nunes PM; Jones JG; Rolo AP; Palmeira CM; Carvalho RA, 2011. 2011. http://europepmc.org/abstract/med/21538633 . 10.1002/nbm.1672 .

Hepatic FXR: key regulator of whole-body energy metabolism.

Teodoro JS; Rolo AP; Palmeira CM, 2011. 2011. http://europepmc.org/abstract/med/21862343 . 10.1016/j.tem.2011.07.002 .

Exposure to dibenzofuran affects lung mitochondrial function in vitro.

Duarte FV; Simões AM; Teodoro JS; Rolo AP; Palmeira CM, 2011. 2011. http://europepmc.org/abstract/med/21554085 . 10.3109/15376516.2011.576714 .

Assessment of the toxicity of silver nanoparticles in vitro: a mitochondrial perspective.

Teodoro JS; Simões AM; Duarte FV; Rolo AP; Murdoch RC; Hussain SM; Palmeira CM, 2011. 2011. http://europepmc.org/abstract/med/21232593 . 10.1016/j.tiv.2011.01.004 .

Differential sex, morphotype and tissue accumulation of mercury in the crab Carcinus maenas

Costa, S.; Viegas, I.; Pereira, E.; Duarte, A.C.; Palmeira, C.M.; Pardal, M.A., 2011. Water, Air, and Soil Pollution. 65 - 75. 1-4. 222. 2011. http://www.scopus.com/inward/record.url?eid=2-s2.0-80755188894&partnerID=MN8TOARS . 10.1007/s11270-011-0809-6 . Water, Air, and Soil Pollution

Regulation of the mPTP by SIRT3-mediated deacetylation of CypD at lysine 166 suppresses age-related cardiac hypertrophy

Hafner, A.V.; Dai, J.; Gomes, A.P.; Xiao, C.-Y.; Palmeira, K.C.M.; Rosenzweig, A.; Sinclair, D.A.; et al, 2010. Aging. 914 - 923. 12. 2. 2010. http://www.scopus.com/inward/record.url?eid=2-s2.0-79952266729&partnerID=MN8TOARS . Aging

Indirubin-3'-oxime prevents hepatic I/R damage by inhibiting GSK-3beta and mitochondrial permeability transition.

Varela AT; Simões AM; Teodoro JS; Duarte FV; Gomes AP; Palmeira CM; Rolo AP, 2010. 2010. http://europepmc.org/abstract/med/20433952 . 10.1016/j.mito.2010.04.006 .

Metabolic remodeling associated with subchronic doxorubicin cardiomyopathy.

Carvalho RA; Sousa RP; Cadete VJ; Lopaschuk GD; Palmeira CM; Bjork JA; Wallace KB, 2010. 2010. http://europepmc.org/abstract/med/20132857 . 10.1016/j.tox.2010.01.019 .

Exposure to 2, 3, 7, 8-tetrachlorodibenzo-p-dioxin and tetraethyl lead affects lung mitochondria bioenergetics.

Simões AM; Duarte FV; Teodoro JS; Rolo AP; Palmeira CM, 2010. 2010. http://europepmc.org/abstract/med/20158383 . 10.3109/15376510903527916 .

Prevention of I/R injury in fatty livers by ischemic preconditioning is associated with increased mitochondrial tolerance: the key role of ATPsynthase and mitochondrial permeability transition.

Rolo AP; Teodoro JS; Peralta C; Rosello-Catafau J; Palmeira CM, 2009. 2009. http://europepmc.org/abstract/med/19619169 . 10.1111/j.1432-2277.2009.00916.x .

Biosensor plates detect mitochondrial physiological regulators and mutations in vivo.

Rolo AP; Palmeira CM; Cortopassi GA, 2009. 2009. http://europepmc.org/abstract/med/18950600 . 10.1016/j.ab.2008.10.002 .

Mitochondria a key role in microcystin-LR kidney intoxication.

La-Salete R; Oliveira MM; Palmeira CA; Almeida J; Peixoto FP, 2008. 2008. http://europepmc.org/abstract/med/17461434 . 10.1002/jat.1251 .

Differential alterations in mitochondrial function induced by a choline-deficient diet: understanding fatty liver disease progression.

Teodoro JS; Rolo AP; Duarte FV; Simões AM; Palmeira CM, 2008. 2008. http://europepmc.org/abstract/med/18765303 . 10.1016/j.mito.2008.07.008 .

Indirubin-3'-oxime impairs mitochondrial oxidative phosphorylation and prevents mitochondrial permeability transition induction.

Varela AT; Gomes AP; Simões AM; Teodoro JS; Duarte FV; Rolo AP; Palmeira CM, 2008. 2008. http://europepmc.org/abstract/med/18786556 . 10.1016/j.taap.2008.08.005 .

Estimating gluconeogenesis by NMR isotopomer distribution analysis of [13C]bicarbonate and [1-13C]lactate.

Alves TC; Nunes PM; Palmeira CM; Jones JG; Carvalho RA, 2008. 2008. http://europepmc.org/abstract/med/17683055 . 10.1002/nbm.1195 .

Evaluation of olive oil mill wastewater toxicity on the mitochondrial bioenergetics after treatment with Candida oleophila

Peixoto, F.; Martins, F.; Amaral, C.; Gomes-Laranjo, J.; Almeida, J.; Palmeira, C.M., 2008. Ecotoxicology and Environmental Safety. 266 - 275. 2. 70. 2008. http://www.scopus.com/inward/record.url?eid=2-s2.0-42049108014&partnerID=MN8TOARS . 10.1016/j.ecoenv.2007.11.003 . Ecotoxicology and Environmental Safety

Hyperglycemia decreases mitochondrial function: the regulatory role of mitochondrial biogenesis.

Palmeira CM; Rolo AP; Berthiaume J; Bjork JA; Wallace KB, 2007. 2007. http://europepmc.org/abstract/med/17761203 . 10.1016/j.taap.2007.07.015 .

Decreased ANT content in Zucker fatty rats: relevance for altered hepatic mitochondrial bioenergetics in steatosis.

Teodoro J; Rolo AP; Oliveira PJ; Palmeira CM, 2006. 2006. http://europepmc.org/abstract/med/16554051 . 10.1016/j.febslet.2006.02.078 .

Mitochondrial Bioenergetics, Diabetes, and Aging: Top-Down Analysis Using the Diabetic Goto-Kakizaki (GK) Rat as a Model.

Ferreira FM; Moreno AJ; Seiça R; Santos MS; Palmeira CM, 2006. 2006. http://europepmc.org/abstract/med/20021031 . 10.1080/15376520600616925 .

Diabetes and mitochondrial function: role of hyperglycemia and oxidative stress.

Rolo AP; Palmeira CM, 2006. 2006. http://europepmc.org/abstract/med/16490224 . 10.1016/j.taap.2006.01.003 .

Mitochondrial function is not affected by renal morphological changes in diabetic goto-kakizaki rat.

Seiça R; Santos DL; Palmeira CM; Moreno AJ; Sena C; Cunha MF; Santos MS, 2005. 2005. http://europepmc.org/abstract/med/20021090 . 10.1080/15376520590968806 .

Bile acids are toxic for isolated cardiac mitochondria: A possible cause for hepatic-derived cardiomyopathies?

Ferreira, M.; Coxito, P.M.; Sardão, V.A.; Palmeira, C.M.; Oliveira, P.J.; Ferreira M; Coxito PM; et al, 2005. Cardiovascular Toxicology. 63 - 73. 1. 5. 2005. http://www.scopus.com/inward/record.url?eid=2-s2.0-18544374442&partnerID=MN8TOARS . 10.1385/CT:5:1:063 . Cardiovascular Toxicology

Mitochondrially-mediated toxicity of bile acids.

Palmeira CM; Rolo AP, 2004. 2004. http://europepmc.org/abstract/med/15363577 . 10.1016/j.tox.2004.06.001 .

Carvedilol inhibits the mitochondrial permeability transition by an antioxidant mechanism.

Oliveira PJ; Esteves T; Rolo AP; Palmeira CM; Moreno AJ, 2004. 2004. http://europepmc.org/abstract/med/15034201 . 10.1385/CT:4:1:11 .

Advantages in the use of carvedilol versus propranolol for the protection of cardiac mitochondrial function.

Oliveira PJ; Rolo AP; Sardão VA; Monteiro P; Gonçalves L; Providência LA; Palmeira CM; et al, 2004. Revista Portuguesa de Cardiologia. 1291 - 1298. 10. 23. 2004. http://europepmc.org/abstract/med/15641294 . Revista Portuguesa de Cardiologia

Vitamin E or coenzyme Q10 administration is not fully advantageous for heart mitochondrial function in diabetic goto kakizaki rats.

Oliveira PJ; Seica R; Santos DL; Rolo AP; Sardao VA; Ferreira FM; Palmeira CM; Santos MS; Moreno AJ, 2004. 2004. http://europepmc.org/abstract/med/16120365 . 10.1016/j.mito.2004.02.005 .

Role of mitochondrial dysfunction in combined bile acid-induced cytotoxicity: the switch between apoptosis and necrosis.

Rolo AP; Palmeira CM; Holy JM; Wallace KB, 2004. 2004. http://europepmc.org/abstract/med/14976352 . 10.1093/toxsci/kfh078 .

Carvedilol: Relation between antioxidant activity and inhibition of the mitochondrial permeability transition | Carvedilol: Relação entre a actividade antioxidante e inibição da transição de permeabilidade mitocondrial

Oliveira, P.J.; Esteves, T.; Rolo, A.P.; Monteiro, P.; Gonçalves, L.; Palmeira, C.M.; Moreno, A.J., 2003. Revista Portuguesa de Cardiologia. 55 - 62. 1. 22. 2003. http://www.scopus.com/inward/record.url?eid=2-s2.0-0346034614&partnerID=MN8TOARS . Revista Portuguesa de Cardiologia

Chronic cholestasis and cardiac mitochondrial function in Wistar rats: a model for cardiovascular alterations in chronic liver disease?

Oliveira PJ; Rolo AP; Seiça R; Santos MS; Palmeira CM; Moreno AJ, 2003. 2003. http://europepmc.org/abstract/med/12712811 .

Reduction in cardiac mitochondrial calcium loading capacity is observable during alpha-naphthylisothiocyanate-induced acute cholestasis: a clue for hepatic-derived cardiomyopathies?

Oliveira PJ; Rolo AP; Seiça R; Santos MS; Palmeira CM; Moreno AJ, 2003. 2003. http://europepmc.org/abstract/med/12527405 . 10.1016/S0925-4439(02)00212-0 .

Carvedilol: relation between antioxidant activity and inhibition of the mitochondrial permeability transition.

Oliveira PJ; Esteves T; Rolo AP; Monteiro P; Gonçalves L; Palmeira CM; Moreno AJ, 2003. 2003. http://europepmc.org/abstract/med/12712810 .

Protection against post-ischemic mitochondrial injury in rat liver by silymarin or TUDC.

Rolo AP; Oliveira PJ; Moreno AJ; Palmeira CM, 2003. 2003. http://europepmc.org/abstract/med/12850694 . 10.1016/S1386-6346(03)00108-6 .

Enhanced permeability transition explains the reduced calcium uptake in cardiac mitochondria from streptozotocin-induced diabetic rats.

Oliveira PJ; Seiça R; Coxito PM; Rolo AP; Palmeira CM; Santos MS; Moreno AJ, 2003. 2003. http://europepmc.org/abstract/med/14623121 . 10.1016/S0014-5793(03)01233-X .

Histological changes and impairment of liver mitochondrial bioenergetics after long-term treatment with alpha-naphthyl-isothiocyanate (ANIT).

Palmeira CM; Ferreira FM; Rolo AP; Oliveira PJ; Santos MS; Moreno AJ; Cipriano MA; Martins MI; Seiça R, 2003. 2003. http://europepmc.org/abstract/med/12927374 . 10.1016/S0300-483X(03)00163-X .

Diabetes and mitochondrial oxidative stress: a study using heart mitochondria from the diabetic Goto-Kakizaki rat.

Santos DL; Palmeira CM; Seiça R; Dias J; Mesquita J; Moreno AJ; Santos MS, 2003. 2003. http://europepmc.org/abstract/med/12841358 . 10.1023/A:1023475022025 .

Diabetes and mitochondrial bioenergetics: alterations with age.

Ferreira FM; Palmeira CM; Seiça R; Moreno AJ; Santos MS, 2003. 2003. http://europepmc.org/abstract/med/12898645 . 10.1002/jbt.10081 .

Cholestasis induced by chronic treatment with alpha-naphthyl-isothiocyanate (ANIT) affects rat renal mitochondrial bioenergetics.

Ferreira FM; Oliveira PJ; Rolo AP; Santos MS; Moreno AJ; da Cunha MF; Seiça R; et al, 2003. Archives of Toxicology. 194 - 200. 4. 77. 2003. http://europepmc.org/abstract/med/12698234 . 10.1007/s00204-003-0441-3 . Archives of Toxicology

Mitochondrially mediated synergistic cell killing by bile acids.

Rolo AP; Palmeira CM; Wallace KB, 2003. 2003. http://europepmc.org/abstract/med/12527417 . 10.1016/S0925-4439(02)00224-7 .

Chronic cholestasis and cardiac mitochondrial function in wistar rats: A model for cardiovascular alterations in chronic liver disease? | Colestase crónica e funçá~o mitocondrial cardíaca em ratos wistar: Um modelo para alterações cardiovasculares no contexto de doenças hepáticas crónicas?

Oliveira, P.J.; Rolo, A.P.; Seiça, R.; Santos, M.S.; Palmeira, C.M.; Moreno, A.J., 2003. Revista Portuguesa de Cardiologia. 67 - 75. 1. 22. 2003. http://www.scopus.com/inward/record.url?eid=2-s2.0-0344951202&partnerID=MN8TOARS . Revista Portuguesa de Cardiologia

Chenodeoxycholate induction of mitochondrial permeability transition pore is associated with increased membrane fluidity and cytochrome c release: protective role of carvedilol.

Rolo AP; Oliveira PJ; Moreno AJ; Palmeira CM, 2003. 2003. http://europepmc.org/abstract/med/16120330 . 10.1016/S1567-7249(03)00007-2 .

Diabetes induces metabolic adaptations in rat liver mitochondria: role of coenzyme Q and cardiolipin contents.

Ferreira FM; Seiça R; Oliveira PJ; Coxito PM; Moreno AJ; Palmeira CM; Santos MS, 2003. 2003. http://europepmc.org/abstract/med/14559118 . 10.1016/j.bbadis.2003.08.001 .

Cardiac mitochondrial calcium loading capacity is severely affected after chronic cholestasis in Wistar rats.

Oliveira PJ; Rolo AP; Seiça R; Santos MS; Palmeira CM; Moreno AJ; Oliveira, P.J.; et al, 2003. Journal of Investigative Medicine. 86 - 94. 2. 51. 2003. http://europepmc.org/abstract/med/12643513 . Journal of Investigative Medicine

Impact of carvedilol on the mitochondrial damage induced by hypoxanthine and xantine oxidase - What role in myocardial ischemia and reperfusion? | Impacto do carvedilol sobre o dano mitocondrial induzido por hipoxantina/xantina oxidase - Que papel na isquemia e reperfusão do miocárdio?

Oliveira, P.J.; Rolo, A.P.; Monteiro, P.; Conçalves, L.; Palmeira, C.M.; Moreno, A.J., 2002. Revista Portuguesa de Cardiologia. 1447 - 1455. 12. 21. 2002. http://www.scopus.com/inward/record.url?eid=2-s2.0-0036998602&partnerID=MN8TOARS . Revista Portuguesa de Cardiologia

Disruption of mitochondrial calcium homeostasis after chronic a-naphthylisothiocyanate administration: Relevance for cholestasis

Rolo, A.P.; Oliveira, P.J.; Seiça, R.; Santos, M.S.; Moreno, A.J.; Palmeira, C.M.; Rolo AP; et al, 2002. Journal of Investigative Medicine. 193 - 200. 3. 50. 2002. http://www.scopus.com/inward/record.url?eid=2-s2.0-0036092085&partnerID=MN8TOARS . Journal of Investigative Medicine

Impact of carvedilol on the mitochondrial damage induced by hypoxanthine and xantine oxidase--what role in myocardial ischemia and reperfusion?

Oliveira PJ; Rolo AP; Monteiro P; Gonçalves L; Palmeira CM; Moreno AJ, 2002. 2002. http://europepmc.org/abstract/med/12621918 .

Improved efficiency of hepatic mitochondrial function in rats with cholestasis induced by an acute dose of alpha-naphthylisothiocyanate.

Rolo AP; Oliveira PJ; Seiça R; Santos MS; Moreno AJ; Palmeira CM, 2002. 2002. http://europepmc.org/abstract/med/12127259 . 10.1006/taap.2002.9434 .

Impact of diabetes on induction of the mitochondrial permeability transition.

Oliveira PJ; Rolo AP; Seiça R; Sardão V; Monteiro P; Gonçalves L; Providência L; et al, 2002. Revista portuguesa de cardiologia : orgao oficial da Sociedade Portuguesa de Cardiologia = Portuguese journal of cardiology : an official journal of the Portuguese Society of Cardiology. 759 - 766. 6. 21. 2002. http://europepmc.org/abstract/med/12194377 . Revista portuguesa de cardiologia : orgao oficial da Sociedade Portuguesa de Cardiologia = Portuguese journal of cardiology : an official journal of the Portuguese Society of Cardiology

Interactions of combined bile acids on hepatocyte viability: cytoprotection or synergism.

Rolo AP; Palmeira CM; Wallace KB, 2002. 2002. http://europepmc.org/abstract/med/11814708 . 10.1016/S0378-4274(01)00464-7 .

Carvedilol in heart mitochondria - Protonophore or opener of the mitochondrial K<inf>ATP</inf> channels?

Oliveira, P.J.; Rolo, A.P.; Sardão, V.A.; Coxito, P.M.; Palmeira, C.M.; Moreno, A.J.M., 2001. Life Sciences. 123 - 132. 2. 69. 2001. http://www.scopus.com/inward/record.url?eid=2-s2.0-0035371154&partnerID=MN8TOARS . 10.1016/S0024-3205(01)01109-2 . Life Sciences

Enhanced mitochondrial testicular antioxidant capacity in Goto-Kakizaki diabetic rats: Role of coenzyme Q

Palmeira, C.M.; Santos, D.L.; Seiça, R.; Moreno, A.J.; Santos, M.S.; Palmeira CM; Santos DL; et al, 2001. American Journal of Physiology - Cell Physiology. 3 50-3. 281. 2001. http://www.scopus.com/inward/record.url?eid=2-s2.0-0034838234&partnerID=MN8TOARS . American Journal of Physiology - Cell Physiology

Brain and liver mitochondria isolated from diabetic Goto-Kakizaki rats show different susceptibility to induced oxidative stress

Santos, M.S.; Santos, D.L.; Palmeira, C.M.; Seiça, R.; Moreno, A.J.; Oliveira, C.R., 2001. Diabetes/Metabolism Research and Reviews. 223 - 230. 3. 17. 2001. http://www.scopus.com/inward/record.url?eid=2-s2.0-0034944055&partnerID=MN8TOARS . 10.1002/dmrr.200 . Diabetes/Metabolism Research and Reviews

Decreased susceptibility of heart mitochondria from diabetic GK rats to mitochondrial permeability transition induced by calcium phosphate.

Oliveira PJ; Rolo AP; Seiça R; Palmeira CM; Santos MS; Moreno AJ; Oliveira, P.J.; et al, 2001. Bioscience Reports. 45 - 53. 1. 21. 2001. http://europepmc.org/abstract/med/11508693 . 10.1023/a:1010482017540 . Bioscience Reports

Doxorubicin-induced persistent oxidative stress to cardiac myocytes

Zhou, S.; Palmeira, C.M.; Wallace, K.B., 2001. Toxicology Letters. 151 - 157. 3. 121. 2001. http://www.scopus.com/inward/record.url?eid=2-s2.0-0035912594&partnerID=MN8TOARS . 10.1016/S0378-4274(01)00329-0 . Toxicology Letters

Inhibitory effect of carvedilol in the high-conductance state of the mitochondrial permeability transition pore

Oliveira, P.J.; Coxito, P.M.; Rolo, A.P.; Santos, D.L.; Palmeira, C.M.; Moreno, A.J.M., 2001. European Journal of Pharmacology. 231 - 237. 3. 412. 2001. http://www.scopus.com/inward/record.url?eid=2-s2.0-0035793307&partnerID=MN8TOARS . 10.1016/S0014-2999(01)00745-2 . European Journal of Pharmacology

Chenodeoxycholate is a potent inducer of the permeability transition pore in rat liver mitochondria

Rolo, A.P.; Oliveira, P.J.; Moreno, A.J.M.; Palmeira, C.M., 2001. Bioscience Reports. 73 - 80. 1. 21. 2001. http://www.scopus.com/inward/record.url?eid=2-s2.0-0034899577&partnerID=MN8TOARS . 10.1023/A:1010438202519 . Bioscience Reports

Protective effect of carvedilol on chenodeoxycholate induction of the permeability transition pore

Rolo, A.P.; Oliveira, P.J.; Moreno, A.J.M.; Palmeira, C.M., 2001. Biochemical Pharmacology. 1449 - 1454. 11. 61. 2001. http://www.scopus.com/inward/record.url?eid=2-s2.0-0035370544&partnerID=MN8TOARS . 10.1016/S0006-2952(01)00620-7 . Biochemical Pharmacology

Carvedilol reduces mitochondrial damage induced by hypoxanthine/xanthine oxidase: Relevance to hypoxia/reoxygenation injury

Oliveira, P.J.; Rolo, A.P.; Palmeira, C.M.; Moreno, A.J.M., 2001. Cardiovascular Toxicology. 205 - 213. 3. 1. 2001. http://www.scopus.com/inward/record.url?eid=2-s2.0-0035750084&partnerID=MN8TOARS . 10.1385/CT:1:3:205 . Cardiovascular Toxicology

Cholestasis and mitochondrial dysfunction: A review

Rolo, A.P.; Palmeira, C.M., 2000. Toxic Substance Mechanisms. 83 - 98. 2. 19. 2000. http://www.scopus.com/inward/record.url?eid=2-s2.0-0034458883&partnerID=MN8TOARS . 10.1080/10769180052008878 . Toxic Substance Mechanisms

Bile acids affect liver mitochondrial bioenergetics: possible relevance for cholestasis therapy.

Rolo AP; Oliveira PJ; Moreno AJ; Palmeira CM; Rolo, A.P.; Oliveira, P.J.; Moreno, A.J.M.; Palmeira, C.M., 2000. Toxicological Sciences. 177 - 185. 1. 57. 2000. http://europepmc.org/abstract/med/10966524 . 10.1093/toxsci/57.1.177 . Toxicological Sciences

Induction of the mitochondrial permeability transition in vitro by short-chain carboxylic acids

Palmeira, C.M.; Rana, M.I.; Frederick, C.B.; Wallace, K.B., 2000. Biochemical and Biophysical Research Communications. 431 - 435. 2. 272. 2000. http://www.scopus.com/inward/record.url?eid=2-s2.0-0034616658&partnerID=MN8TOARS . 10.1006/bbrc.2000.2797 . Biochemical and Biophysical Research Communications

Higher efficiency of the liver phosphorylative system in diabetic Goto-Kakizaki (GK) rats

Palmeira, C.M.; Ferreira, F.M.L.; Santos, D.L.; Ceiça, R.; Suzuki, K.-I.; Santos, M.S., 1999. FEBS Letters. 103 - 106. 2. 458. 1999. http://www.scopus.com/inward/record.url?eid=2-s2.0-0032842698&partnerID=MN8TOARS . 10.1016/S0014-5793(99)01144-8 . FEBS Letters

Age-related alterations in liver mitochondrial bioenergetics of diabetic Goto-Kakizaki rats.

Ferreira FM; Seiça R; Santos MS; Palmeira CM; Ferreira, F.M.L.; Seiça, R.; Santos, M.S.; Palmeira, C.M., 1999. Acta Diabetologica. 173 - 177. 4. 36. 1999. http://europepmc.org/abstract/med/10664324 . 10.1007/s005920050163 . Acta Diabetologica

Alterations of liver mitochondrial bioenergetics in diabetic Goto- Kakizaki rats

Ferreira, F.M.L.; Palmeira, C.M.; Seiça, R.; Santos, M.S., 1999. Metabolism: Clinical and Experimental. 1115 - 1119. 9. 48. 1999. http://www.scopus.com/inward/record.url?eid=2-s2.0-0032857256&partnerID=MN8TOARS . 10.1016/S0026-0495(99)90124-5 . Metabolism: Clinical and Experimental

Decreased susceptibility to lipid peroxidation of Goto-Kakizaki rats: Relationship to mitochondrial antioxidant capacity

Ferreira, F.M.L.; Palmeira, C.M.; Matos, M.J.; Seiç, R.; Santos, M.S., 1999. Life Sciences. 1013 - 1025. 10. 65. 1999. http://www.scopus.com/inward/record.url?eid=2-s2.0-0033618489&partnerID=MN8TOARS . 10.1016/S0024-3205(99)00332-X . Life Sciences

Herbicide-induced mitochondrial and cellular liver toxicity: A review of paraquat, dinoseb, and 2,4-D effects

Palmeira, C.M., 1999. Toxic Substance Mechanisms. 187 - 204. 4. 18. 1999. http://www.scopus.com/inward/record.url?eid=2-s2.0-0033457940&partnerID=MN8TOARS . 10.1080/107691899229070 . Toxic Substance Mechanisms

Cardioselective and cumulative oxidation of mitochondrial DNA following subchronic doxorubicin administration

Serrano, J.; Palmeira, C.M.; Kuehl, D.W.; Wallace, K.B., 1999. Biochimica et Biophysica Acta - Bioenergetics. 201 - 205. 1. 1411. 1999. http://www.scopus.com/inward/record.url?eid=2-s2.0-0032961434&partnerID=MN8TOARS . 10.1016/S0005-2728(99)00011-0 . Biochimica et Biophysica Acta - Bioenergetics

Acrylic acid induces the glutathione-independent mitochondrial permeability transition in vitro

Custodio, J.B.A.; Palmeira, C.M.; Moreno, A.J.; Wallace, K.B., 1998. Toxicological Sciences. 19 - 27. 1. 43. 1998. http://www.scopus.com/inward/record.url?eid=2-s2.0-0031831694&partnerID=MN8TOARS . 10.1006/toxs.1998.2448 . Toxicological Sciences

Ischemic heart disease: The role of mitochondria - Carvedilol prevents lipid peroxidation of mitochondrial membranes

Moreno, A.J.M.; Santos, D.J.S.L.; Palmeira, C.M.; Moreno AJ; Santos DJ; Palmeira CM, 1998. Revista Portuguesa de Cardiologia. 63 - 77. SUPPL. 2. 17. 1998. http://www.scopus.com/inward/record.url?eid=2-s2.0-0031759966&partnerID=MN8TOARS . Revista Portuguesa de Cardiologia

Benzoquinone inhibits the voltage-dependent induction of the mitochondrial permeability transition caused by redox-cycling naphthoquinones

Palmeira, C.M.; Wallace, K.B., 1997. Toxicology and Applied Pharmacology. 338 - 347. 2. 143. 1997. http://www.scopus.com/inward/record.url?eid=2-s2.0-0030932708&partnerID=MN8TOARS . 10.1006/taap.1996.8099 . Toxicology and Applied Pharmacology

Preferential oxidation of cardiac mitochondrial DNA following acute intoxication with doxorubicin

Palmeira, C.M.; Serrano, J.; Kuehl, D.W.; Wallace, K.B., 1997. Biochimica et Biophysica Acta - Bioenergetics. 101 - 106. 2. 1321. 1997. http://www.scopus.com/inward/record.url?eid=2-s2.0-0030880285&partnerID=MN8TOARS . 10.1016/S0005-2728(97)00055-8 . Biochimica et Biophysica Acta - Bioenergetics

Mercuric chloride toxicity in rat liver mitochondria and isolated hepatocytes

Palmeira, C.M.; Madeira, V.M.C., 1997. Environmental Toxicology and Pharmacology. 229 - 235. 3. 3. 1997. http://www.scopus.com/inward/record.url?eid=2-s2.0-0030758726&partnerID=MN8TOARS . 10.1016/S1382-6689(97)00018-5 . Environmental Toxicology and Pharmacology

Continuous monitoring of mitochondrial membrane potential in hepatocyte cell suspensions

Palmeira, C.M.; Moreno, A.J.M.; Madeira, V.M.C.; Wallace, K.B., 1996. Journal of Pharmacological and Toxicological Methods. 35 - 43. 1. 35. 1996. http://www.scopus.com/inward/record.url?eid=2-s2.0-0029925338&partnerID=MN8TOARS . 10.1016/1056-8719(95)00131-X . Journal of Pharmacological and Toxicological Methods

Determination of 8-hydroxydeoxyguanosine in biological tissue by liquid chromatography/electrospray ionization-mass spectrometry/mass spectrometry

Serrano, J.; Palmeira, C.M.; Wallace, K.B.; Kuehl, D.W., 1996. Rapid Communications in Mass Spectrometry. 1789 - 1791. 14. 10. 1996. http://www.scopus.com/inward/record.url?eid=2-s2.0-0030478989&partnerID=MN8TOARS . 10.1002/(SICI)1097-0231(199611)10:14<1789::AID-RCM752>3.0.CO;2-6 . Rapid Communications in Mass Spectrometry

Effects of paraquat, dinoseb and 2,4-D on intracellular calcium and on vasopressin-induced calcium mobilization in isolated hepatocytes

Palmeira, C.M.; Moreno, A.J.; Madeira, V.M.C., 1995. Archives of Toxicology. 460 - 466. 7. 69. 1995. http://www.scopus.com/inward/record.url?eid=2-s2.0-0029054234&partnerID=MN8TOARS . 10.1007/s002040050199 . Archives of Toxicology

Mitochondrial bioenergetics is affected by the herbicide paraquat

Palmeira, C.M.; Moreno, A.J.; Madeira, V.M.C., 1995. Biochimica et Biophysica Acta - Bioenergetics. 187 - 192. 2. 1229. 1995. http://www.scopus.com/inward/record.url?eid=2-s2.0-0028961733&partnerID=MN8TOARS . 10.1016/0005-2728(94)00202-G . Biochimica et Biophysica Acta - Bioenergetics

Thiols metabolism is altered by the herbicides paraquat, dinoseb and 2,4-D: A study in isolated hepatocytes

Palmeira, C.M.; Moreno, A.J.; Madeira, V.M.C., 1995. Toxicology Letters. 115 - 123. 2-3. 81. 1995. http://www.scopus.com/inward/record.url?eid=2-s2.0-0029590153&partnerID=MN8TOARS . 10.1016/0378-4274(95)03414-5 . Toxicology Letters

Metabolic alterations in hepatocytes promoted by the herbicides paraquat, dinoseb and 2,4-D

Palmeira, C.M.; Moreno, A.J.; Madeira, V.M.C., 1994. Archives of Toxicology. 24 - 31. 1. 68. 1994. http://www.scopus.com/inward/record.url?eid=2-s2.0-0028009773&partnerID=MN8TOARS . 10.1007/s002040050025 . Archives of Toxicology

Interactions of herbicides 2,4-D and dinoseb with liver mitochondrial bioenergetics

Palmeira, C.M.; Moreno, A.J.; Madeira, V.M.C., 1994. Toxicology and Applied Pharmacology. 50 - 57. 1. 127. 1994. http://www.scopus.com/inward/record.url?eid=2-s2.0-0028146853&partnerID=MN8TOARS . 10.1006/taap.1994.1138 . Toxicology and Applied Pharmacology

Membrane lipid peroxidation induces changes in ¿-[3H]aminobutyric acid transport and calcium uptake by synaptosomes

Palmeira, C.M.; Santos, M.S.; Carvalho, A.P.; Oliveira, C.R.; Palmeira CM; Santos MS; Carvalho AP; Oliveira CR, 1993. Brain Research. 117 - 123. 1-2. 609. 1993. http://www.scopus.com/inward/record.url?eid=2-s2.0-0027309463&partnerID=MN8TOARS . 10.1016/0006-8993(93)90863-I . Brain Research

Partitioning and membrane disordering effects of dopamine antagonists: Influence of lipid peroxidation, temperature, and drug concentration

Palmeira, C.M.; Oliveira, C.R., 1992. Archives of Biochemistry and Biophysics. 161 - 171. 1. 295. 1992. http://www.scopus.com/inward/record.url?eid=2-s2.0-0026729101&partnerID=MN8TOARS . 10.1016/0003-9861(92)90502-N . Archives of Biochemistry and Biophysics