Mitochondria and Neurodegenerative Disorders

Uncovering the Early Events Associated with Oligomeric Aß-Induced Src Activation

Sandra I. Mota; Lígia Fão; Patrícia Coelho; A. Cristina Rego, 2023. Antioxidants. 2023. https://doi.org/10.3390/antiox12091770 . 10.3390/antiox12091770 . Antioxidants

Apoe4 and Alzheimer’s Disease Pathogenesis—Mitochondrial Deregulation and Targeted Therapeutic Strategies

Mariana Pires; Ana Cristina Rego, 2023. International Journal of Molecular Sciences. 2023. https://doi.org/10.3390/ijms24010778 . 10.3390/ijms24010778 . International Journal of Molecular Sciences

Simultaneous Alteration of the Circadian Variation of Memory, Hippocampal Synaptic Plasticity, and Metabolism in a Triple Transgenic Mouse Model of Alzheimer’s Disease

Carvalho da Silva, A.M.; Lemos, C.; Silva, H.B.; Ferreira, I.L.; Tomé, A.R.; Rego, A.C.; Cunha, R.A., 2022. Frontiers in Aging Neuroscience. 14. 2022. http://www.scopus.com/inward/record.url?eid=2-s2.0-85128461886&partnerID=MN8TOARS . 10.3389/fnagi.2022.835885 . Frontiers in Aging Neuroscience

Mitochondrial function and dynamics in neural stem cells and neurogenesis: Implications for neurodegenerative diseases

Coelho, P.; Fão, L.; Mota, S.; Rego, A.C., 2022. Ageing Research Reviews. 80. 2022. http://www.scopus.com/inward/record.url?eid=2-s2.0-85133769957&partnerID=MN8TOARS . 10.1016/j.arr.2022.101667 . Ageing Research Reviews

Defective mitochondria-lysosomal axis enhances the release of extracellular vesicles containing mitochondrial DNA and proteins in Huntington's disease

Beatriz, Margarida; Vilaça, Rita; Anjo, Sandra I.; Manadas, Bruno; Januário, Cristina; Rego, A. Cristina; Lopes, Carla, 2022. Journal of Extracellular Biology. 10. 1. 2022. http://dx.doi.org/10.1002/jex2.65 . 10.1002/jex2.65 . published Journal of Extracellular Biology

Restored Fyn Levels in Huntington’s Disease Contributes to Enhanced Synaptic GluN2B-Composed NMDA Receptors and CREB Activity

Lígia Fão; Patrícia Coelho; Ricardo J. Rodrigues; A. Cristina Rego, 2022. Cells. 2022. https://doi.org/10.3390/cells11193063 . 10.3390/cells11193063 . Cells

Revisiting cell and gene therapies in Huntington’s disease

Beatriz, M.; Lopes, C.; Ribeiro, A.C.S.; Rego, A.C.C., 2021. Journal of Neuroscience Research. 1744 - 1762. 7. 99. 2021. http://www.scopus.com/inward/record.url?eid=2-s2.0-85104595808&partnerID=MN8TOARS . 10.1002/jnr.24845 . Journal of Neuroscience Research

Mitochondrial SIRT3 confers neuroprotection in Huntington's disease by regulation of oxidative challenges and mitochondrial dynamics

Luana Naia; Catarina Carmo; Susanna Campesan; Lígia Fão; Victoria E. Cotton; Jorge Valero; Carla Lopes; et al, 2021. Free Radical Biology and Medicine. 163 - 179. 163. 2021. https://doi.org/10.1016/j.freeradbiomed.2020.11.031 . 10.1016/j.freeradbiomed.2020.11.031 . Free Radical Biology and Medicine

Boldine Attenuates Synaptic Failure and Mitochondrial Deregulation in Cellular Models of Alzheimer's Disease

Toledo, Juan P.; Fernández-Pérez, Eduardo J.; Ferreira, Ildete L.; Marinho, Daniela; Riffo-Lepe, Nicolas O.; Pineda-Cuevas, Benjamin N.; Pinochet-Pino, Luis F.; et al, 2021. Frontiers in Neuroscience. 15. 2021. http://dx.doi.org/10.3389/fnins.2021.617821 . 10.3389/fnins.2021.617821 . published Frontiers in Neuroscience

Calcium signaling in aging and neurodegenerative diseases 2019

Cortes, L.; Malva, J.; Rego, A.C.; Pereira, C.F., 2020. International Journal of Molecular Sciences. 3. 21. 2020. http://www.scopus.com/inward/record.url?eid=2-s2.0-85078188992&partnerID=MN8TOARS . 10.3390/ijms21031125 . International Journal of Molecular Sciences

Microbial BMAA elicits mitochondrial dysfunction, innate immunity activation, and Alzheimer’s disease features in cortical neurons

Silva, D.F.; Candeias, E.; Esteves, A.R.; Magalhães, J.D.; Ferreira, I.L.; Nunes-Costa, D.; Rego, A.C.; Empadinhas, N.; Cardoso, S.M., 2020. Journal of Neuroinflammation. 1. 17. 2020. http://www.scopus.com/inward/record.url?eid=2-s2.0-85095130862&partnerID=MN8TOARS . 10.1186/s12974-020-02004-y . Journal of Neuroinflammation

Chronic hyperglycemia impairs hippocampal neurogenesis and memory in an Alzheimer's disease mouse model

Ferreiro, E.; Lanzillo, M.; Canhoto, D.; Carvalho da Silva, A.M.; Mota, S.I.; Dias, I.S.; Ferreira, I.L.; et al, 2020. Neurobiology of Aging. 98 - 113. 92. 2020. http://www.scopus.com/inward/record.url?eid=2-s2.0-85084468542&partnerID=MN8TOARS . 10.1016/j.neurobiolaging.2020.04.003 . Neurobiology of Aging

Mitochondrial and Redox Modifications in Huntington Disease Induced Pluripotent Stem Cells Rescued by CRISPR/Cas9 CAGs Targeting

Lopes, C.; Tang, Y.; Anjo, S.I.; Manadas, B.; Onofre, I.; de Almeida, L.P.; Daley, G.Q.; Schlaeger, T.M.; Rego, A.C.C., 2020. Frontiers in Cell and Developmental Biology. 8. 2020. http://www.scopus.com/inward/record.url?eid=2-s2.0-85092059116&partnerID=MN8TOARS . 10.3389/fcell.2020.576592 . Frontiers in Cell and Developmental Biology

Modified Glutamatergic Postsynapse in Neurodegenerative Disorders

Moraes, B.J.; Coelho, P.; Fão, L.; Ferreira, I.L.; Rego, A.C., 2020. Neuroscience. 116 - 139. 454. 2020. http://www.scopus.com/inward/record.url?eid=2-s2.0-85078098057&partnerID=MN8TOARS . 10.1016/j.neuroscience.2019.12.002 . published Neuroscience

Nuclear localization and phosphorylation modulate pathological effects of alpha-synuclein

Pinho, R.; Paiva, I.; Jercic, K.G.; Fonseca-Ornelas, L.; Gerhardt, E.; Fahlbusch, C.; Garcia-Esparcia, P.; et al, 2019. Human molecular genetics. 31 - 50. 1. 28. 2019. http://www.scopus.com/inward/record.url?eid=2-s2.0-85058740345&partnerID=MN8TOARS . 10.1093/hmg/ddy326 . Human molecular genetics

Chronic stress triggers divergent dendritic alterations in immature neurons of the adult hippocampus, depending on their ultimate terminal fields

Chrysoula Dioli; Patrícia Patrício; Nuno Sousa; Nikolaos Kokras; Christina Dalla; Sara Guerreiro; Miguel A. Santos-Silva; et al, 2019. Translational Psychiatry. 1. 9. 2019. https://doi.org/10.1038/s41398-019-0477-7 . 10.1038/s41398-019-0477-7 . published Translational Psychiatry

c-Src regulates Nrf2 activity through PKCd after oxidant stimulus

Fão, L.; Mota, S.I.; Rego, A.C., 2019. Biochimica et Biophysica Acta - Molecular Cell Research. 686 - 698. 4. 1866. 2019. http://www.scopus.com/inward/record.url?eid=2-s2.0-85060844195&partnerID=MN8TOARS . 10.1016/j.bbamcr.2019.01.011 . Biochimica et Biophysica Acta - Molecular Cell Research

Amyloid ß Peptide Compromises Neural Stem Cell Fate by Irreversibly Disturbing Mitochondrial Oxidative State and Blocking Mitochondrial Biogenesis and Dynamics

Ribeiro, M.F.; Genebra, T.; Rego, A.C.; Rodrigues, C.M.P.; Solá, S., 2019. Molecular Neurobiology. 3922 - 3936. 6. 56. 2019. http://www.scopus.com/inward/record.url?eid=2-s2.0-85053603434&partnerID=MN8TOARS . 10.1007/s12035-018-1342-z . Molecular Neurobiology

Shaping the Nrf2-ARE-related pathways in Alzheimer's and Parkinson's diseases

Fão, L.; Mota, S.I.; Rego, A.C., 2019. Ageing Research Reviews. 54. 2019. http://www.scopus.com/inward/record.url?eid=2-s2.0-85070827540&partnerID=MN8TOARS . 10.1016/j.arr.2019.100942 . Ageing Research Reviews

A whole brain longitudinal study in the YAC128 mouse model of Huntington's disease shows distinct trajectories of neurochemical, structural connectivity and volumetric changes.

Rego, Ana, 2018. Human molecular genetics. 2018. https://doi.org/10.1093/hmg/ddy119 . 10.1093/hmg/ddy119 . Human molecular genetics

Coriolus versicolor biomass increases dendritic arborization of newly-generated neurons in mouse hippocampal dentate gyrus

Ferreiro, E.; Pita, I.R.; Mota, S.I.; Valero, J.; Ferreira, N.R.; Fernandes, T.; Calabrese, V.; et al, 2018. Oncotarget. 32929 - 32942. 68. 9. 2018. http://www.scopus.com/inward/record.url?eid=2-s2.0-85052580513&partnerID=MN8TOARS . 10.18632/oncotarget.25978 . Oncotarget

Characterization of subventricular zone-derived progenitor cells from mild and late symptomatic YAC128 mouse model of Huntington's disease

Silva, A.C.; Ferreira, I.L.; Hayden, M.R.; Ferreiro, E.; Rego, A.C., 2018. Biochimica et Biophysica Acta - Molecular Basis of Disease. 34 - 44. 1. 1864. 2018. http://www.scopus.com/inward/record.url?eid=2-s2.0-85031746642&partnerID=MN8TOARS . 10.1016/j.bbadis.2017.09.009 . Biochimica et Biophysica Acta - Molecular Basis of Disease

Mitochondrial Ca²⁺ handling in Huntington's and Alzheimer's diseases – Role of ER-mitochondria crosstalk

Naia, L.; Ferreira, I.L.; Ferreiro, E.; Rego, A.C., 2017. Biochemical and Biophysical Research Communications. 1069 - 1077. 4. 483. 2017. http://www.scopus.com/inward/record.url?eid=2-s2.0-84998772500&partnerID=MN8TOARS . 10.1016/j.bbrc.2016.07.122 . Biochemical and Biophysical Research Communications

Alpha-synuclein-induced oxidative stress correlates with altered superoxide dismutase and glutathione synthesis in human neuroblastoma SH-SY5Y cells

Perfeito, R.; Ribeiro, M.; Rego, A.C., 2017. Archives of Toxicology. 1245 - 1259. 3. 91. 2017. http://www.scopus.com/inward/record.url?eid=2-s2.0-84978795483&partnerID=MN8TOARS . 10.1007/s00204-016-1788-6 . Archives of Toxicology

The NAD+-dependent deacetylase SIRT2 attenuates oxidative stress and mitochondrial dysfunction and improves insulin sensitivity in hepatocytes.

Rego, Ana, 2017. Human molecular genetics. 2017. https://doi.org/10.1093/hmg/ddx298 . 10.1093/hmg/ddx298 . Human molecular genetics

Histone deacetylase inhibitors protect against pyruvate dehydrogenase dysfunction in huntington’s disease

Naia, L.; Cunha-Oliveira, T.; Rodrigues, J.; Rosenstock, T.R.; Oliveira, A.; Ribeiro, M.; Carmo, C.; et al, 2017. Journal of Neuroscience. 2776 - 2794. 10. 37. 2017. http://www.scopus.com/inward/record.url?eid=2-s2.0-85014750770&partnerID=MN8TOARS . 10.1523/JNEUROSCI.2006-14.2016 . Journal of Neuroscience

Expanded and Wild-type Ataxin-3 Modify the Redox Status of SH-SY5Y Cells Overexpressing a-Synuclein

Noronha, C.; Perfeito, R.; Laço, M.; Wüllner, U.; Rego, A.C., 2017. Neurochemical Research. 1430 - 1437. 5. 42. 2017. http://www.scopus.com/inward/record.url?eid=2-s2.0-85013849882&partnerID=MN8TOARS . 10.1007/s11064-017-2199-7 . Neurochemical Research

Comparative Mitochondrial-Based Protective Effects of Resveratrol and Nicotinamide in Huntington’s Disease Models

Naia, L.; Rosenstock, T.R.; Oliveira, A.M.; Oliveira-Sousa, S.I.; Caldeira, G.L.; Carmo, C.; Laço, M.N.; et al, 2017. Molecular Neurobiology. 5385 - 5399. 7. 54. 2017. http://www.scopus.com/inward/record.url?eid=2-s2.0-84984887332&partnerID=MN8TOARS . 10.1007/s12035-016-0048-3 . Molecular Neurobiology

Sodium butyrate rescues dopaminergic cells from alpha-synuclein-induced transcriptional deregulation and DNA damage

Paiva, I.; Pinho, R.; Pavlou, M.A.; Hennion, M.; Wales, P.; Schütz, A.-L.; Rajput, A.; et al, 2017. Human molecular genetics. 2231 - 2246. 12. 26. 2017. http://www.scopus.com/inward/record.url?eid=2-s2.0-85030984416&partnerID=MN8TOARS . 10.1093/hmg/ddx114 . Human molecular genetics

Revisiting Mitochondrial Function and Metabolism in Pluripotent Stem Cells: Where Do We Stand in Neurological Diseases?

Rego, A. Cristina, 2016. Molecular neurobiology. 2016. https://doi.org/10.1007/s12035-016-9714-8 . 10.1007/s12035-016-9714-8 . Molecular neurobiology

Insulin and IGF-1 regularize energy metabolites in neural cells expressing full-length mutant huntingtin

Naia, L.; Ribeiro, M.; Rodrigues, J.; Duarte, A.I.; Lopes, C.; Rosenstock, T.R.; Hayden, M.R.; Rego, A.C., 2016. Neuropeptides. 73 - 81. 58. 2016. http://www.scopus.com/inward/record.url?eid=2-s2.0-84957398906&partnerID=MN8TOARS . 10.1016/j.npep.2016.01.009 . Neuropeptides

Dominant-negative effects of adult-onset huntingtin mutations alter the division of human embryonic stem cells-derived neural cells

Lopes, C.; Aubert, S.; Bourgois-Rocha, F.; Barnat, M.; Rego, A.C.; Déglon, N.; Perrier, A.L.; Humbert, S., 2016. PLoS ONE. 2. 11. 2016. http://www.scopus.com/inward/record.url?eid=2-s2.0-84959377608&partnerID=MN8TOARS . 10.1371/journal.pone.0148680 . PLoS ONE

Sirtuins: Double players in Huntington's disease

Naia, L.; Rego, A.C., 2015. Biochimica et Biophysica Acta - Molecular Basis of Disease. 2183 - 2194. 10. 1852. 2015. http://www.scopus.com/inward/record.url?eid=2-s2.0-84938718400&partnerID=MN8TOARS . 10.1016/j.bbadis.2015.07.003 . Biochimica et Biophysica Acta - Molecular Basis of Disease

Limited effect of chronic valproic acid treatment in a mouse model of Machado-Joseph disease

Esteves, S.; Duarte-Silva, S.; Naia, L.; Neves-Carvalho, A.; Teixeira-Castro, A.; Rego, A.C.; Silva-Fernandes, A.; Maciel, P., 2015. PLoS ONE. 10. 10. 2015. http://www.scopus.com/inward/record.url?eid=2-s2.0-84949591193&partnerID=MN8TOARS . 10.1371/journal.pone.0141610 . PLoS ONE

Erratum: Overexpression of BDNF and Full-Length TrkB Receptor Ameliorate Striatal Neural Survival in Huntingtons Disease (Neurodegenerative Diseases (2015) 15 (207-218) DOI:10.1159/000375447)

Silva, A.; Naia, L.; Dominguez, A.; Ribeiro, M.; Rodrigues, J.; Vieira, O.V.; Lessmann, V.; Rego, A.C., 2015. Neurodegenerative Diseases. 4. 15. 2015. http://www.scopus.com/inward/record.url?eid=2-s2.0-84939538133&partnerID=MN8TOARS . 10.1159/000433587 . Neurodegenerative Diseases

Oxidative stress involving changes in Nrf2 and ER stress in early stages of Alzheimer's disease

Mota, S.I.; Costa, R.O.; Ferreira, I.L.; Santana, I.; Caldeira, G.L.; Padovano, C.; Fonseca, A.C.; et al, 2015. Biochimica et Biophysica Acta - Molecular Basis of Disease. 1428 - 1441. 7. 1852. 2015. http://www.scopus.com/inward/record.url?eid=2-s2.0-84928128412&partnerID=MN8TOARS . 10.1016/j.bbadis.2015.03.015 . Biochimica et Biophysica Acta - Molecular Basis of Disease

Protective effects of 3-alkyl luteolin derivatives are mediated by Nrf2 transcriptional activity and decreased oxidative stress in Huntington's disease mouse striatal cells

Oliveira, A.M.; Cardoso, S.M.; Ribeiro, M.; Seixas, R.S.G.R.; Silva, A.M.S.; Rego, A.C., 2015. Neurochemistry International. 1 - 12. 91. 2015. http://www.scopus.com/inward/record.url?eid=2-s2.0-84950980628&partnerID=MN8TOARS . 10.1016/j.neuint.2015.10.004 . Neurochemistry International

Aß and NMDAR activation cause mitochondrial dysfunction involving ER calcium release

Ferreira, Ildete Luísa; Ferreiro, Elisabete; Schmidt, Jeannette; Cardoso, João M; Pereira, Cláudia M F; Carvalho, Ana Luísa; Oliveira, Catarina R; Rego, A Cristina; Rego, A. Cristina, 2015. Neurobiology of aging. 2015. http://hdl.handle.net/10316/80131 . 10.1016/j.neurobiolaging.2014.09.006 . Neurobiology of aging

Overexpression of BDNF and Full-Length TrkB Receptor Ameliorate Striatal Neural Survival in Huntington's Disease

Silva, A.; Naia, L.; Dominguez, A.; Ribeiro, M.; Rodrigues, J.; Vieira, O.V.; Lessmann, V.; Rego, A.C., 2015. Neurodegenerative Diseases. 207 - 218. 4. 15. 2015. http://www.scopus.com/inward/record.url?eid=2-s2.0-84939565482&partnerID=MN8TOARS . 10.1159/000375447 . Neurodegenerative Diseases

OXPHOS dysfunction regulates integrin-ß1 modifications and enhances cell motility and migration.

Rego, A. Cristina, 2014. Human molecular genetics. 2014. https://doi.org/10.1093/hmg/ddu612 . 10.1093/hmg/ddu612 . Human molecular genetics

Dysfunctional synapse in Alzheimer's disease - A focus on NMDA receptors

Mota, S.I.; Ferreira, I.L.; Rego, A.C., 2014. Neuropharmacology. 16 - 26. PART A. 76. 2014. http://www.scopus.com/inward/record.url?eid=2-s2.0-84886641553&partnerID=MN8TOARS . 10.1016/j.neuropharm.2013.08.013 . Neuropharmacology

Impaired Src signaling and post-synaptic actin polymerization in Alzheimer's disease mice hippocampus - Linking NMDA receptors and the reelin pathway

Mota, S.I.; Ferreira, I.L.; Valero, J.; Ferreiro, E.; Carvalho, A.L.; Oliveira, C.R.; Rego, A.C., 2014. Experimental Neurology. 698 - 709. 261. 2014. http://www.scopus.com/inward/record.url?eid=2-s2.0-84908339906&partnerID=MN8TOARS . 10.1016/j.expneurol.2014.07.023 . Experimental Neurology

Activation of IGF-1 and Insulin Signaling Pathways Ameliorate Mitochondrial Function and Energy Metabolism in Huntington’s Disease Human Lymphoblasts

Naia, L.; Ferreira, I.L.; Cunha-Oliveira, T.; Duarte, A.I.; Ribeiro, M.; Rosenstock, T.R.; Laço, M.N.; et al, 2014. Molecular Neurobiology. 331 - 348. 1. 51. 2014. http://www.scopus.com/inward/record.url?eid=2-s2.0-84938698507&partnerID=MN8TOARS . 10.1007/s12035-014-8735-4 . Molecular Neurobiology

Linking alpha-synuclein phosphorylation to reactive oxygen species formation and mitochondrial dysfunction in SH-SY5Y cells

Perfeito, R.; Lázaro, D.F.; Outeiro, T.F.; Rego, A.C., 2014. Molecular and Cellular Neuroscience. 51 - 59. 62. 2014. http://www.scopus.com/inward/record.url?eid=2-s2.0-84906751686&partnerID=MN8TOARS . 10.1016/j.mcn.2014.08.002 . Molecular and Cellular Neuroscience

Current therapeutic advances in patients and experimental models of Huntington's disease

Brett, A.C.; Rosenstock, T.R.; Rego, A.C., 2014. Current Drug Targets. 313 - 334. 3. 15. 2014. http://www.scopus.com/inward/record.url?eid=2-s2.0-84896718561&partnerID=MN8TOARS . 10.2174/1389450114666131124140704 . Current Drug Targets

Insulin and IGF-1 improve mitochondrial function in a PI-3K/Akt-dependent manner and reduce mitochondrial generation of reactive oxygen species in Huntington’s disease knock-in striatal cells

Ribeiro, Márcio; Rosenstock, Tatiana R.; Oliveira, Ana M.; Oliveira, Catarina R.; Rego, A. Cristina; Ribeiro, M.; Rosenstock, T.R.; et al, 2014. Free Radical Biology and Medicine. 129 - 144. 74. 2014. http://hdl.handle.net/10316/27852 . 10.1016/j.freeradbiomed.2014.06.023 . Free Radical Biology and Medicine

IGF-1 intranasal administration rescues Huntington's disease phenotypes in YAC128 mice

Lopes, C.; Ribeiro, M.; Duarte, A.I.; Humbert, S.; Saudou, F.; Pereira De Almeida, L.; Hayden, M.; Rego, A.C., 2014. Molecular Neurobiology. 1126 - 1142. 3. 49. 2014. http://www.scopus.com/inward/record.url?eid=2-s2.0-84902546185&partnerID=MN8TOARS . 10.1007/s12035-013-8585-5 . Molecular Neurobiology

Mitochondrial respiratory chain complex activity and bioenergetic alterations in human platelets derived from pre-symptomatic and symptomatic huntington's disease carriers

Silva, A.C.; Almeida, S.; Laço, M.; Duarte, A.I.; Domingues, J.; Oliveira, C.R.; Januário, C.; Rego, A.C., 2013. Mitochondrion. 801 - 809. 6. 13. 2013. http://www.scopus.com/inward/record.url?eid=2-s2.0-84887018742&partnerID=MN8TOARS . 10.1016/j.mito.2013.05.006 . Mitochondrion

Oxidizing effects of exogenous stressors in Huntington's disease knock-in striatal cells-protective effect oflcystamine and creatine

Ribeiro, M.; Silva, A.C.; Rodrigues, J.; Naia, L.; Rego, A.C., 2013. Toxicological Sciences. 487 - 499. 2. 136. 2013. http://www.scopus.com/inward/record.url?eid=2-s2.0-84890357270&partnerID=MN8TOARS . 10.1093/toxsci/kft199 . Toxicological Sciences

Impaired transcription in Alzheimer's disease: Key role in mitochondrial dysfunction and oxidative stress

Caldeira, G.L.; Ferreira, I.L.; Rego, A.C., 2013. Journal of Alzheimer's Disease. 115 - 131. 1. 34. 2013. http://www.scopus.com/inward/record.url?eid=2-s2.0-84874303866&partnerID=MN8TOARS . 10.3233/JAD-121444 . Journal of Alzheimer's Disease

Oxidative stress and drugs of abuse: An update

Cunha-Oliveira, T.; Rego, A.C.; Oliveira, C.R., 2013. Mini-Reviews in Organic Chemistry. 321 - 334. 4. 10. 2013. http://www.scopus.com/inward/record.url?eid=2-s2.0-84892954534&partnerID=MN8TOARS . 10.2174/1570193X113106660026 . Mini-Reviews in Organic Chemistry

Reprint of: Revisiting oxidative stress and mitochondrial dysfunction in the pathogenesis of Parkinson disease—resemblance to the effect of amphetamine drugs of abuse

Perfeito, Rita; Cunha-Oliveira, Teresa; Rego, Ana Cristina; Perfeito, R.; Cunha-Oliveira, T.; Rego, A.C., 2013. Free Radical Biology and Medicine. 1791 - 1806. 9. 53. 2013. http://hdl.handle.net/10316/44869 . 10.1016/j.freeradbiomed.2013.05.042 . Free Radical Biology and Medicine

Valosin-Containing Protein (VCP/p97) Is an Activator of Wild-Type Ataxin-3

Laço, M.N.; Cortes, L.; Travis, S.M.; Paulson, H.L.; Rego, A.C., 2012. PLoS ONE. 9. 7. 2012. http://www.scopus.com/inward/record.url?eid=2-s2.0-84866103154&partnerID=MN8TOARS . 10.1371/journal.pone.0043563 . PLoS ONE

Role of alpha-synuclein and Parkinson's disease-associated mitochondrial dysfunction,Papel da alfa-sinucleína e da disfunção mitocondrial associada à doença de Parkinson

Perfeito, R.; Rego Prof., A.C., 2012. Revista Neurociencias. 273 - 284. 2. 20. 2012. http://www.scopus.com/inward/record.url?eid=2-s2.0-84863884807&partnerID=MN8TOARS . Revista Neurociencias

Endoplasmic reticulum stress occurs downstream of GluN2B subunit of N-methyl-d-aspartate receptor in mature hippocampal cultures treated with amyloid-ß oligomers

Costa, R.O.; Lacor, P.N.; Ferreira, I.L.; Resende, R.; Auberson, Y.P.; Klein, W.L.; Oliveira, C.R.; Rego, A.C.; Pereira, C.M.F., 2012. Aging Cell. 823 - 833. 5. 11. 2012. http://www.scopus.com/inward/record.url?eid=2-s2.0-84866452758&partnerID=MN8TOARS . 10.1111/j.1474-9726.2012.00848.x . Aging Cell

Compromised mitochondrial complex II in models of Machado-Joseph disease

Laço, M.N.; Oliveira, C.R.; Paulson, H.L.; Rego, A.C., 2012. Biochimica et Biophysica Acta - Molecular Basis of Disease. 139 - 149. 2. 1822. 2012. http://www.scopus.com/inward/record.url?eid=2-s2.0-83155185511&partnerID=MN8TOARS . 10.1016/j.bbadis.2011.10.010 . Biochimica et Biophysica Acta - Molecular Basis of Disease

Amyloid beta peptide 1-42 disturbs intracellular calcium homeostasis through activation of GluN2B-containing N-methyl-d-aspartate receptors in cortical cultures

Ferreira, I.L.; Bajouco, L.M.; Mota, S.I.; Auberson, Y.P.; Oliveira, C.R.; Rego, A.C., 2012. Cell Calcium. 95 - 106. 2. 51. 2012. http://www.scopus.com/inward/record.url?eid=2-s2.0-84856958510&partnerID=MN8TOARS . 10.1016/j.ceca.2011.11.008 . Cell Calcium

Mitochondrial and metabolic-based protective strategies in Huntington's disease: The case of creatine and coenzyme Q

Naia, L.; Ribeiro, M.J.; Rego, A.C., 2012. Reviews in the Neurosciences. 13 - 28. 1. 23. 2012. http://www.scopus.com/inward/record.url?eid=2-s2.0-84860539153&partnerID=MN8TOARS . 10.1515/rns.2011.060 . Reviews in the Neurosciences

Mitochondrial- and endoplasmic reticulum-associated oxidative stress in alzheimers disease: From pathogenesis to biomarkers

Ferreiro, E.; Baldeiras, I.; Ferreira, I.L.; Costa, R.O.; Rego, A.C.; Pereira, C.F.; Oliveira, C.R., 2012. International Journal of Cell Biology. 2012. http://www.scopus.com/inward/record.url?eid=2-s2.0-84863688106&partnerID=MN8TOARS . 10.1155/2012/735206 . International Journal of Cell Biology

Amyloid-beta peptide 1-42 causes microtubule deregulation through N-methyl-D-aspartate receptors in mature hippocampal cultures

Mota, S.I.; Ferreira, I.L.; Pereira, C.; Oliveira, C.R.; Rego, A.C., 2012. Current Alzheimer Research. 844 - 856. 7. 9. 2012. http://www.scopus.com/inward/record.url?eid=2-s2.0-84866468436&partnerID=MN8TOARS . 10.2174/156720512802455322 . Current Alzheimer Research

Disruption of striatal glutamatergic/GABAergic homeostasis following acute methamphetamine in mice

Pereira, Frederico; Cunha-Oliveira, Teresa; Viana, Sofia; Travassos, Ana Sofia; Nunes, Sara; Silva, Carlos; Prediger, Rui; et al, 2012. Neurotoxicology and teratology. 2012. http://hdl.handle.net/10316/20663 . 10.1016/j.ntt.2012.07.005 . Neurotoxicology and teratology

Glutathione redox cycle dysregulation in Huntington’s disease knock-in striatal cells

Ribeiro, Márcio; Rosenstock, Tatiana; Cunha-Oliveira, Teresa; Ferreira, Ildete; Oliveira, Catarina R.; Rego, Ana Cristina; Ribeiro, M.; et al, 2012. Free Radical Biology and Medicine. 1857 - 1867. 10. 53. 2012. http://hdl.handle.net/10316/20850 . 10.1016/j.freeradbiomed.2012.09.004 . Free Radical Biology and Medicine

Bioenergetic dysfunction in Huntington's disease human cybrids

Ferreira, I.L.; Cunha-Oliveira, T.; Nascimento, M.V.; Ribeiro, M.; Proença, M.T.; Januário, C.; Oliveira, C.R.; Rego, A.C., 2011. Experimental Neurology. 127 - 134. 1. 231. 2011. http://www.scopus.com/inward/record.url?eid=2-s2.0-79961028116&partnerID=MN8TOARS . 10.1016/j.expneurol.2011.05.024 . Experimental Neurology

IGF-1 protects against diabetic features in an in vivo model of Huntington's disease

Duarte, A.I.; Petit, G.H.; Ranganathan, S.; Li, J.-Y.; Oliveira, C.R.; Brundin, P.; Björkqvist, M.; Rego, A.C., 2011. Experimental Neurology. 314 - 319. 2. 231. 2011. http://www.scopus.com/inward/record.url?eid=2-s2.0-80052520685&partnerID=MN8TOARS . 10.1016/j.expneurol.2011.06.016 . Experimental Neurology

FK506 ameliorates cell death features in Huntington's disease striatal cell models

Rosenstock, T.R.; De Brito, O.M.; Lombardi, V.; Louros, S.; Ribeiro, M.; Almeida, S.; Ferreira, I.L.; Oliveira, C.R.; Rego, A.C., 2011. Neurochemistry International. 600 - 609. 5. 59. 2011. http://www.scopus.com/inward/record.url?eid=2-s2.0-80052936684&partnerID=MN8TOARS . 10.1016/j.neuint.2011.04.009 . Neurochemistry International

Mitochondrial-associated metabolic changes and neurodegeneration in Huntington's disease - from clinical features to the bench

Rosenstock, T.R.; Duarte, A.I.; Rego, A.C., 2010. Current Drug Targets. 1218 - 1236. 10. 11. 2010. http://www.scopus.com/inward/record.url?eid=2-s2.0-77957993152&partnerID=MN8TOARS . Current Drug Targets

Multiple defects in energy metabolism in Alzheimer's disease

Ferreira, I.L.; Resende, R.; Ferreiro, E.; Rego, A.C.; Pereira, C.F., 2010. Current Drug Targets. 1193 - 1206. 10. 11. 2010. http://www.scopus.com/inward/record.url?eid=2-s2.0-77957994659&partnerID=MN8TOARS . Current Drug Targets

Central and peripheral metabolic changes in neurodegenerative diseases

Rego, A.C., 2010. Current Drug Targets. 10. 11. 2010. http://www.scopus.com/inward/record.url?eid=2-s2.0-77958018980&partnerID=MN8TOARS . published Current Drug Targets

Mitochondrial-dependent apoptosis in Huntington's disease human cybrids

Ferreira, I.L.; Nascimento, M.V.; Ribeiro, M.; Almeida, S.; Cardoso, S.M.; Grazina, M.; Pratas, J.; et al, 2010. Experimental Neurology. 243 - 255. 2. 222. 2010. http://www.scopus.com/inward/record.url?eid=2-s2.0-77549084450&partnerID=MN8TOARS . 10.1016/j.expneurol.2010.01.002 . Experimental Neurology

Dysregulation of CREB activation and histone acetylation in 3-nitropropionic acid-treated cortical neurons: prevention by BDNF and NGF.

Almeida, S.; Cunha-Oliveira, T.; Laço, M.; Oliveira, C.R.; Rego, A.C., 2010. Neurotoxicity research. 399 - 405. 4. 17. 2010. http://www.scopus.com/inward/record.url?eid=2-s2.0-77953951286&partnerID=MN8TOARS . 10.1007/s12640-009-9116-z . Neurotoxicity research

BDNF regulates BIM expression levels in 3-nitropropionic acid-treated cortical neurons

Almeida, S.; Laço, M.; Cunha-Oliveira, T.; Oliveira, C.R.; Rego, A.C., 2009. Neurobiology of Disease. 448 - 456. 3. 35. 2009. http://www.scopus.com/inward/record.url?eid=2-s2.0-68149169019&partnerID=MN8TOARS . 10.1016/j.nbd.2009.06.006 . Neurobiology of Disease

BDNF and extracellular matrix regulate differentiation of mice neurosphere-derived cells into a GABAergic neuronal phenotype

Silva, A.; Pereira, J.; Oliveira, C.R.; Relvas, J.B.; Rego, A.C., 2009. Journal of Neuroscience Research. 1986 - 1996. 9. 87. 2009. http://www.scopus.com/inward/record.url?eid=2-s2.0-66049114646&partnerID=MN8TOARS . 10.1002/jnr.22041 . Journal of Neuroscience Research

An integrative view of the role of oxidative stress, mitochondria and insulin in Alzheimer's disease

Moreira, P.I.; Duarte, A.I.; Santos, M.S.; Rego, A.C.; Oliveira, C.R., 2009. Journal of Alzheimer's Disease. 741 - 761. 4. 16. 2009. http://www.scopus.com/inward/record.url?eid=2-s2.0-67649687039&partnerID=MN8TOARS . 10.3233/JAD-2009-0972 . Journal of Alzheimer's Disease

The R6 lines of transgenic mice: A model for screening new therapies for Huntington's disease

Gil, J.M.; Rego, A.C., 2009. Brain Research Reviews. 410 - 431. 2. 59. 2009. http://www.scopus.com/inward/record.url?eid=2-s2.0-60549103857&partnerID=MN8TOARS . 10.1016/j.brainresrev.2008.12.001 . Brain Research Reviews

Mechanisms of neurodegeneration in Huntington's disease

Gil, Joana M.; Rego, Ana Cristina; Gil, J.M.; Rego, A.C., 2008. European Journal of Neuroscience. 2803 - 2820. 11. 27. 2008. http://hdl.handle.net/10316/8401 . 10.1111/j.1460-9568.2008.06310.x . European Journal of Neuroscience

Cellular and molecular mechanisms involved in the neurotoxicity of opioid and psychostimulant drugs

Cunha-Oliveira, T.; Rego, A.C.; Oliveira, C.R.; Cunha-Oliveira, Teresa; Rego, Ana Cristina; Oliveira, Catarina R., 2008. Brain Research Reviews. 192 - 208. 1. 58. 2008. http://www.scopus.com/inward/record.url?eid=2-s2.0-45549108542&partnerID=MN8TOARS . 10.1016/j.brainresrev.2008.03.002 . Brain Research Reviews

Mechanisms of neurodegeneration in Huntington's disease (European Journal of Neuroscience (2008) 27, (2803-2820))

Gil, J.M.; Rego, A.C., 2008. European Journal of Neuroscience. 10. 28. 2008. http://www.scopus.com/inward/record.url?eid=2-s2.0-55949114690&partnerID=MN8TOARS . 10.1111/j.1460-9568.2008.06522.x . European Journal of Neuroscience

Evidence of apoptosis and mitochondrial abnormalities in peripheral blood cells of Huntington's disease patients

Almeida, S.; Sarmento-Ribeiro, A.B.; Januário, C.; Rego, A.C.; Oliveira, C.R., 2008. Biochemical and Biophysical Research Communications. 599 - 603. 4. 374. 2008. http://www.scopus.com/inward/record.url?eid=2-s2.0-49449107322&partnerID=MN8TOARS . 10.1016/j.bbrc.2008.07.009 . Biochemical and Biophysical Research Communications

Insulin neuroprotection against oxidative stress is mediated by Akt and GSK-3ß signaling pathways and changes in protein expression

Duarte, A.I.; Santos, P.; Oliveira, C.R.; Santos, M.S.; Rego, A.C., 2008. Biochimica et Biophysica Acta - Molecular Cell Research. 994 - 1002. 6. 1783. 2008. http://www.scopus.com/inward/record.url?eid=2-s2.0-43549087343&partnerID=MN8TOARS . 10.1016/j.bbamcr.2008.02.016 . Biochimica et Biophysica Acta - Molecular Cell Research

Toxicity of ß-amyloid in HEK293 cells expressing NR1/NR2A or NR1/NR2B N-methyl-d-aspartate receptor subunits

Domingues, A.; Almeida, S.; da Cruz e Silva, E.F.; Oliveira, C.R.; Rego, A.C., 2007. Neurochemistry International. 872 - 880. 6. 50. 2007. http://www.scopus.com/inward/record.url?eid=2-s2.0-34248172476&partnerID=MN8TOARS . 10.1016/j.neuint.2007.03.001 . Neurochemistry International

Trolox protection of myelin membrane in hydrogen peroxide-treated mature oligodendrocytes

Perfeito, R.; Pereira, J.; Oliveira, C.; Bettencourt-Relvas, J.; Rego, A.C., 2007. Free Radical Research. 444 - 451. 4. 41. 2007. http://www.scopus.com/inward/record.url?eid=2-s2.0-33947493269&partnerID=MN8TOARS . 10.1080/10715760601134442 . Free Radical Research

Mitochondrial dysfunction in Huntington's disease: The bioenergetics of isolated and in situ mitochondria from transgenic mice

Oliveira, J.M.A.; Jekabsons, M.B.; Chen, S.; Lin, A.; Rego, A.C.; Gonçalves, J.; Ellerby, L.M.; Nicholls, D.G., 2007. Journal of Neurochemistry. 241 - 249. 1. 101. 2007. http://www.scopus.com/inward/record.url?eid=2-s2.0-33947200596&partnerID=MN8TOARS . 10.1111/j.1471-4159.2006.04361.x . Journal of Neurochemistry

Bcl-2 overexpression protects against amyloid-beta and prion toxicity in GT1-7 neural cells

Ferreiro, E.; Eufrásio, A.; Pereira, C.; Oliveira, C.R.; Rego, A.C., 2007. Journal of Alzheimer's Disease. 223 - 228. 3. 12. 2007. http://www.scopus.com/inward/record.url?eid=2-s2.0-36549064191&partnerID=MN8TOARS . Journal of Alzheimer's Disease

Street heroin induces mitochondrial dysfunction and apoptosis in rat cortical neurons

Cunha-Oliveira, T.; Rego, A.C.; Garrido, J.; Borges, F.; Macedo, T.; Oliveira, C.R., 2007. Journal of Neurochemistry. 543 - 554. 2. 101. 2007. http://www.scopus.com/inward/record.url?eid=2-s2.0-34047138450&partnerID=MN8TOARS . 10.1111/j.1471-4159.2006.04406.x . Journal of Neurochemistry

Expression of NR1/NR2B N-methyl-D-aspartate receptors enhances heroin toxicity in HEK293 cells

Rego, A. Cristina, 2006. Ann N Y Acad Sci. 2006. http://www.ncbi.nlm.nih.gov/pubmed/17105944 . 10.1196/annals.1369.046 . Ann N Y Acad Sci

Synthesis and cytotoxic profile of 3,4-methylenedioxymethamphetamine ("ecstasy") and its metabolites on undifferentiated PC12 cells: A putative structure-toxicity relationship.

Rego, A. Cristina, 2006. Chemical research in toxicology. 2006. https://doi.org/10.1021/tx060123i . 10.1021/tx060123i . Chemical research in toxicology

Mitochondrial dysfunction and caspase activation in rat cortical neurons treated with cocaine or amphetamine

Cunha-Oliveira, T.; Rego, A.C.; Cardoso, S.M.; Borges, F.; Swerdlow, R.H.; Macedo, T.; de Oliveira, C.R., 2006. Brain Research. 44 - 54. 1. 1089. 2006. http://www.scopus.com/inward/record.url?eid=2-s2.0-33646756208&partnerID=MN8TOARS . 10.1016/j.brainres.2006.03.061 . Brain Research

Insulin restores metabolic function in cultured cortical neurons subjected to oxidative stress

Duarte, A.I.; Proença, T.; Oliveira, C.R.; Santos, M.S.; Rego, A.C.; Duarte, Ana I.; Proença, Teresa; et al, 2006. Diabetes. 2863 - 2870. 10. 55. 2006. http://www.scopus.com/inward/record.url?eid=2-s2.0-33750882488&partnerID=MN8TOARS . 10.2337/db06-0030 . Diabetes

Mitochondrial-dependent Ca²⁺ handling in Huntington's disease striatal cells: Effect of histone deacetylase inhibitors

Oliveira, J.M.A.; Chen, S.; Almeida, S.; Riley, R.; Gonçalves, J.; Oliveira, C.R.; Hayden, M.R.; et al, 2006. Journal of Neuroscience. 11174 - 11186. 43. 26. 2006. http://www.scopus.com/inward/record.url?eid=2-s2.0-33751106144&partnerID=MN8TOARS . 10.1523/JNEUROSCI.3004-06.2006 . Journal of Neuroscience

Caspase-dependent and -independent cell death induced by 3-nitropropionic acid in rat cortical neurons

Almeida, S.; Brett, A.C.; Góis, I.N.; Oliveira, C.R.; Rego, A.C.; Almeida, Sandra; Brett, Ana C.; et al, 2006. Journal of Cellular Biochemistry. 93 - 101. 1. 98. 2006. http://www.scopus.com/inward/record.url?eid=2-s2.0-33645957926&partnerID=MN8TOARS . 10.1002/jcb.20748 . Journal of Cellular Biochemistry

Differential cytotoxic responses of PC12 cells chronically exposed to psychostimulants or to hydrogen peroxide

Cunha-Oliveira, T.; Rego, A.C.; Morgadinho, M.T.; Macedo, T.; Oliveira, C.R., 2006. Toxicology. 54 - 62. 1. 217. 2006. http://www.ncbi.nlm.nih.gov/pubmed/16242230 . 10.1016/j.tox.2005.08.022 . Toxicology

Effect of chronic exposure to aluminium on isoform expression and activity of rat (Na⁺/K⁺)ATPase

Silva, V.S.; Duarte, A.I.; Rego, A.C.; Oliveira, C.R.; Gonçalves, P.P., 2005. Toxicological Sciences. 485 - 494. 2. 88. 2005. http://www.scopus.com/inward/record.url?eid=2-s2.0-27944510677&partnerID=MN8TOARS . 10.1093/toxsci/kfi324 . Toxicological Sciences

Protective effect of zinc on amyloid-ß 25-35 and 1-40 mediated toxicity

Cardoso, S.M.; Rego, A.C.; Pereira, C.; Oliveira, C.R., 2005. Neurotoxicity Research. 273 - 281. 4. 7. 2005. http://www.scopus.com/inward/record.url?eid=2-s2.0-27744456147&partnerID=MN8TOARS . 10.1007/BF03033885 . Neurotoxicity Research

Insulin neuroprotection against oxidative stress in cortical neurons - Involvement of uric acid and glutathione antioxidant defenses

Duarte, A.I.; Santos, M.S.; Oliveira, C.R.; Rego, A.C., 2005. Free Radical Biology and Medicine. 876 - 889. 7. 39. 2005. http://www.scopus.com/inward/record.url?eid=2-s2.0-33644623231&partnerID=MN8TOARS . 10.1016/j.freeradbiomed.2005.05.002 . Free Radical Biology and Medicine

Molecular targets and therapeutic strategies in Huntington's Disease

Rego, A.C.; de Almeida, L.P., 2005. Current Drug Targets: CNS and Neurological Disorders. 361 - 381. 4. 4. 2005. http://www.scopus.com/inward/record.url?eid=2-s2.0-23144446194&partnerID=MN8TOARS . 10.2174/1568007054546081 . Current Drug Targets: CNS and Neurological Disorders

Apoptotic cell death induced by hydrogen peroxide in NT2 parental and mitochondrial DNA depleted cells

Cardoso, S.M.; Rego, A.C.; Penacho, N.; Oliveira, C.R., 2004. Neurochemistry International. 693 - 698. 5. 45. 2004. http://www.scopus.com/inward/record.url?eid=2-s2.0-3042590296&partnerID=MN8TOARS . 10.1016/j.neuint.2004.03.003 . Neurochemistry International

Carvedilol protects ischemic cardiac mitochondria by preventing oxidative stress | O carvedilol protege mitocôndrias cardíacas isquémicas de lesões induzidas por stress oxidativo

Carreira, R.; Duarte, A.; Monteiro, P.; Sancha Santos, M.; Rego, A.C.; Oliveira, C.R.; Gonçalves, L.M.; Providência, L.A., 2004. Rev Port Cardiol.. 1447 - 1455. 11. 23. 2004. http://www.scopus.com/inward/record.url?eid=2-s2.0-11244328526&partnerID=MN8TOARS . Rev Port Cardiol.

FK506 prevents mitochondrial-dependent apoptotic cell death induced by 3-nitropropionic acid in rat primary cortical cultures

Almeida, S.; Domingues, A.; Rodrigues, L.; Oliveira, C.R.; Rego, A.C., 2004. Neurobiology of Disease. 435 - 444. 3. 17. 2004. http://www.scopus.com/inward/record.url?eid=2-s2.0-9644265271&partnerID=MN8TOARS . 10.1016/j.nbd.2004.07.002 . Neurobiology of Disease

Mitochondrial apoptotic cell death and moderate superoxide generation upon selective activation of non-desensitizing AMPA receptors in hippocampal cultures

Rego, A. Cristina; Monteiro, Nuno M.; Silva, Ana P.; Gil, Joana; Malva, João O.; Oliveira, Catarina R.; Rego, A.C.; et al, 2003. Journal of Neurochemistry. 792 - 804. 4. 86. 2003. http://hdl.handle.net/10316/8429 . 10.1046/j.1471-4159.2003.01898.x . Journal of Neurochemistry

Mitochondrial dysfunction and reactive oxygen species in excitotoxicity and apoptosis: Implications for the pathogenesis of neurodegenerative diseases

Rego, A.C.; Oliveira, C.R., 2003. Neurochemical Research. 1563 - 1574. 10. 28. 2003. http://www.scopus.com/inward/record.url?eid=2-s2.0-0141705360&partnerID=MN8TOARS . 10.1023/A:1025682611389 . Neurochemical Research

Bcl-2 Prevents Loss of Cell Viability and Caspase Activation Induced by 3-Nitropropionic Acid in GT1-7 Cells

Brito, O.; Almeida, S.; Oliveira, C.R.; Rego, A.C., 2003. Ann. NY Acad. Sci.. 148 - 152. 1010. 2003. http://www.scopus.com/inward/record.url?eid=2-s2.0-1342284294&partnerID=MN8TOARS . 10.1196/annals.1299.024 . published Ann. NY Acad. Sci.

Cytosolic and mitochondrial ROS in staurosporine-induced retinal cell apoptosis

Gil, J.; Almeida, S.; Oliveira, C.R.; Rego, A.C., 2003. Free Radical Biology and Medicine. 1500 - 1514. 11. 35. 2003. http://www.scopus.com/inward/record.url?eid=2-s2.0-0344012006&partnerID=MN8TOARS . 10.1016/j.freeradbiomed.2003.08.022 . Free Radical Biology and Medicine

Drugs of Abuse Induce Apoptotic Features in PC12 Cells

Oliveira, M.T.; Rego, A.C.; Macedo, T.R.A.; Oliveira, C.R., 2003. Ann. NY Acad. Sci.. 667 - 670. 1010. 2003. http://www.scopus.com/inward/record.url?eid=2-s2.0-1342284249&partnerID=MN8TOARS . 10.1196/annals.1299.121 . published Ann. NY Acad. Sci.

Toxic effects of opioid and stimulant drugs on undifferentiated PC12 cells

Oliveira, M.T.; Rego, A.C.; Morgadinho, M.T.; Macedo, T.R.A.; Oliveira, C.R., 2002. Ann. NY Acad. Sci.. 487 - 496. 965. 2002. http://www.scopus.com/inward/record.url?eid=2-s2.0-0036290212&partnerID=MN8TOARS . published Ann. NY Acad. Sci.

Effect of amyloid ß-peptide on permeability transition pore: A comparative study

Moreira, P.I.; Santos, M.S.; Moreno, A.; Rego, A.C.; Oliveira, C., 2002. Journal of Neuroscience Research. 257 - 267. 2. 69. 2002. http://www.scopus.com/inward/record.url?eid=2-s2.0-0037100213&partnerID=MN8TOARS . 10.1002/jnr.10282 . Journal of Neuroscience Research

Developmental profile of excitatory GABA<inf>A</inf> responses in cultured rat cerebellar granule cells

Rego, A.C.; Lambert, J.J.; Nicholls, D.G., 2001. NeuroReport. 477 - 482. 3. 12. 2001. http://www.scopus.com/inward/record.url?eid=2-s2.0-0035809757&partnerID=MN8TOARS . 10.1097/00001756-200103050-00011 . NeuroReport

Antioxidant effect of flavonoids after ascorbate/Fe²⁺-induced oxidative stress in cultured retinal cells

Areias, F.M.; Rego, A.Cristina; Oliveira, C.R.; Seabra, R.M., 2001. Biochemical Pharmacology. 111 - 118. 1. 62. 2001. http://www.scopus.com/inward/record.url?eid=2-s2.0-0035400513&partnerID=MN8TOARS . 10.1016/S0006-2952(01)00621-9 . Biochemical Pharmacology

Mitochondria control AMPA/kainate receptor-induced cytoplasmic calcium deregulation in rat cerebellar granule cells

Rego, A.C.; Ward, M.W.; Nicholls, D.G., 2001. Journal of Neuroscience. 1893 - 1901. 6. 21. 2001. http://www.scopus.com/inward/record.url?eid=2-s2.0-0035869336&partnerID=MN8TOARS . Journal of Neuroscience

Glutamate regulates the viability of retinal cells in culture

Rego, A.C.; Santos, M.S.; Areias, F.; Proença, T.; Oliveira, C.R., 2001. Vision Research. 841 - 851. 7. 41. 2001. http://www.scopus.com/inward/record.url?eid=2-s2.0-0035094616&partnerID=MN8TOARS . 10.1016/S0042-6989(00)00309-6 . Vision Research

The mechanism of mitochondrial membrane potential retention following release of cytochrome c in apoptotic GT1-7 neural cells

Rego, A.C.; Vesce, S.; Nicholls, D.G., 2001. Cell Death and Differentiation. 995 - 1003. 10. 8. 2001. http://www.scopus.com/inward/record.url?eid=2-s2.0-0034781572&partnerID=MN8TOARS . 10.1038/sj.cdd.4400916 . Cell Death and Differentiation

Adenosine A(2A) receptors regulate the extracellular accumulation of excitatory amino acids upon metabolic dysfunction in chick cultured retinal cells

Rego, A.C.; Agostinho, P.; Melo, J.; Cunha, R.A.; Oliveira, C.R., 2000. Experimental Eye Research. 577 - 587. 5. 70. 2000. http://www.scopus.com/inward/record.url?eid=2-s2.0-0033623815&partnerID=MN8TOARS . 10.1006/exer.1999.0815 . Experimental Eye Research

Adenosine A2AReceptors Regulate the Extracellular Accumulation of Excitatory Amino Acids upon Metabolic Dysfunction in Chick Cultured Retinal Cells

Rego, Ana Cristina; Agostinho, Paula; Melo, Joana; Cunha, Rodrigo A.; Oliveira, Catarina R., 2000. 2000. http://hdl.handle.net/10316/4839 .

Adenosine modulation of D-[³H]aspartate release in cultured retina cells exposed to oxidative stress

Agostinho, P.; Caseiro, P.; Rego, A.C.; Duarte, E.P.; Cunha, R.A.; Oliveira, C.R., 2000. Neurochemistry International. 255 - 265. 3. 36. 2000. http://www.scopus.com/inward/record.url?eid=2-s2.0-0033979263&partnerID=MN8TOARS . 10.1016/S0197-0186(99)00113-8 . Neurochemistry International

Glutamate-mediated inhibition of oxidative phosphorylation in cultured retinal cells

Rego, A.C.; Sancha Santos, M.; Oliveira, C.R.; Rego, Ana Cristina; Sancha Santos, Maria; Oliveira, Catarina Resende, 2000. Neurochemistry International. 159 - 166. 2. 36. 2000. http://www.scopus.com/inward/record.url?eid=2-s2.0-0033990365&partnerID=MN8TOARS . 10.1016/S0197-0186(99)00107-2 . Neurochemistry International

Mitochondrial membrane potential and glutamate excitotoxicity in cultured cerebellar granule cells

Ward, M.W.; Rego, A.C.; Frenguelli, B.G.; Nicholls, D.G., 2000. Journal of Neuroscience. 7208 - 7219. 19. 20. 2000. http://www.scopus.com/inward/record.url?eid=2-s2.0-0034307759&partnerID=MN8TOARS . Journal of Neuroscience

Distinct Glycolysis Inhibitors Determine Retinal Cell Sensitivity to Glutamate-Mediated Injury

Rego, Ana Cristina; Areias, Filipe; Santos, Maria Sancha; Oliveira, Catarina, 1999. 1999. http://hdl.handle.net/10316/8510 .

Influence of ¿-aminobutyric acid on retinal cells excitotoxicity upon glucose deprivation

Rego, A.C.; Oliveira, C.R., 1999. Neuroscience Research. 31 - 36. 1. 34. 1999. http://www.scopus.com/inward/record.url?eid=2-s2.0-0033026964&partnerID=MN8TOARS . 10.1016/S0168-0102(99)00030-9 . Neuroscience Research

Influence of the antioxidants vitamin E and idebenone on retinal cell injury mediated by chemical ischemia, hypoglycemia, or oxidative stress

Rego, Ana Cristina; Santos, Maria Sancha; Oliveira, Catarina R.; Rego, A.C.; Santos, M.S.; Oliveira, C.R., 1999. Free Radical Biology and Medicine. 1405 - 1417. 11-12. 26. 1999. http://hdl.handle.net/10316/4848 . 10.1016/S0891-5849(98)00337-2 . Free Radical Biology and Medicine

Distinct glycolysis inhibitors determine retinal cell sensitivity to glutamate-mediated injury

Rego, A.C.; Areias, F.M.; Santos, M.S.; De Oliveira, C.I.R., 1999. Neurochemical Research. 351 - 358. 3. 24. 1999. http://www.scopus.com/inward/record.url?eid=2-s2.0-0032964352&partnerID=MN8TOARS . 10.1023/A:1020977331372 . Neurochemical Research

Effect of Glucose Deprivation and Acute Glutamate Exposure in Cultured Retinal Cells

Rego, Ana Cristina; Areias, Filipe Miguel; Santos, Maria Sancha; Oliveira, Catarina R., 1998. 1998. http://hdl.handle.net/10316/4857 .

Influence of vitamin E succinate on retinal cell survival

Rego, A.C.; Santos, M.S.; Proença, M.T.; Oliveira, C.R.; Rego, Ana Cristina; Santos, Maria Sancha; Proença, Maria Teresa; Oliveira, Catarina R., 1998. Toxicology. 113 - 124. 2. 128. 1998. http://www.scopus.com/inward/record.url?eid=2-s2.0-0032479530&partnerID=MN8TOARS . 10.1016/S0300-483X(98)00054-7 . Toxicology

Effect of glucose deprivation and acute glutamate exposure in cultured retinal cells

Rego, A.C.; Areias, F.M.; Santos, M.S.; Oliveira, C.R., 1998. Experimental Neurology. 128 - 134. 1. 153. 1998. http://www.scopus.com/inward/record.url?eid=2-s2.0-0031663392&partnerID=MN8TOARS . 10.1006/exnr.1998.6865 . Experimental Neurology

Alteration of nitric oxide synthase activity upon oxidative stress in cultured retinal cells

Rego, A.C.; Oliveira, C.R., 1998. Journal of Neuroscience Research. 627 - 635. 5. 51. 1998. http://www.scopus.com/inward/record.url?eid=2-s2.0-0032032525&partnerID=MN8TOARS . 10.1002/(SICI)1097-4547(19980301)51:5<627::AID-JNR10>3.0.CO;2-# . Journal of Neuroscience Research

Adenosine triphosphate degradation products after oxidative stress and metabolic dysfunction in cultured retinal cells

Rego, A.C.; Santos, M.S.; Oliveira, C.R., 1997. Journal of Neurochemistry. 1228 - 1235. 3. 69. 1997. http://www.scopus.com/inward/record.url?eid=2-s2.0-0030792543&partnerID=MN8TOARS . Journal of Neurochemistry

Oxidative stress, hypoxia, and ischemia-like conditions increase the release of endogenous amino acids by distinct mechanisms in cultured retinal cells

Rego, A.C.; Santos, M.S.; Oliveira, C.R., 1996. Journal of Neurochemistry. 2506 - 2516. 6. 66. 1996. http://www.scopus.com/inward/record.url?eid=2-s2.0-0029992779&partnerID=MN8TOARS . Journal of Neurochemistry

Oxidative stress in acidic conditions increases the production of inositol phosphates in chick retinal cells in culture

Rego, A.C.; Duarte, E.P.; Oliveira, C.R., 1996. Free Radical Biology and Medicine. 175 - 187. 2. 20. 1996. http://www.scopus.com/inward/record.url?eid=2-s2.0-0030034476&partnerID=MN8TOARS . 10.1016/0891-5849(95)02029-2 . Free Radical Biology and Medicine

Dual effect of lipid peroxidation on the membrane order of retinal cells in culture

Rego, A.C.; Oliveira, C.R., 1995. Archives of Biochemistry and Biophysics. 127 - 136. 1. 321. 1995. http://www.scopus.com/inward/record.url?eid=2-s2.0-0029081382&partnerID=MN8TOARS . 10.1006/abbi.1995.1377 . Archives of Biochemistry and Biophysics

Influence of lipid peroxidation on [3H]ketanserin binding to 5-HT2 prefrontal cortex receptors

Rego, A.C.; Oliveira, C.R., 1995. Neurochemistry International. 489 - 496. 6. 27. 1995. http://www.scopus.com/inward/record.url?eid=2-s2.0-0028889729&partnerID=MN8TOARS . 10.1016/0197-0186(95)80007-8 . Neurochemistry International