MitoBD - Mitochondria in Brain Disorders

Current Advances in Mitochondrial Targeted Interventions in Alzheimer's Disease

Tiago Sousa; Paula I. Moreira; Susana Cardoso, 2023. Biomedicines. 2023. https://doi.org/10.3390/biomedicines11092331 . 10.3390/biomedicines11092331 . Biomedicines

Therapeutic potential of glutaminyl cyclases: Current status and emerging trends

Coimbra, Judite R.M.; Moreira, Paula I.; Santos, Armanda E.; Salvador, Jorge A.R., 2023. Drug Discovery Today. 2023. http://dx.doi.org/10.1016/j.drudis.2023.103644 . 10.1016/j.drudis.2023.103644 . Drug Discovery Today

Retinal imaging in animal models: Searching for biomarkers of neurodegeneration

Batista, Ana; Guimarães, Pedro; Serranho, Pedro; Nunes, Ana; Martins, João; Moreira, Paula I.; Ambrósio, António Francisco; et al, 2023. Frontiers in Ophthalmology. 3. 2023. http://dx.doi.org/10.3389/fopht.2023.1156605 . 10.3389/fopht.2023.1156605 . Frontiers in Ophthalmology

Redox signalling and proteostasis in neurodegeneration: In vivo effects of the mitochondria-targeted antioxidant MitoQ in Huntington's disease mice

Pinho, Brígida R.; Duarte, Ana I.; Canas, Paula M.; Moreira, Paula I.; Murphy, Michael P.; Oliveira, Jorge M.A., 2023. Free Radical Biology and Medicine. S5 - S6. 198. 2023. http://dx.doi.org/10.1016/j.freeradbiomed.2022.12.030 . 10.1016/j.freeradbiomed.2022.12.030 . Free Radical Biology and Medicine

Normative mice retinal thickness: 16-month longitudinal characterization of wild-type mice and changes in a model of Alzheimer's disease

Batista, Ana; Guimarães, Pedro; Martins, João; Moreira, Paula I.; Ambrósio, António Francisco; Castelo-Branco, Miguel; Serranho, Pedro; Bernardes, Rui, 2023. Frontiers in Aging Neuroscience. 15. 2023. http://dx.doi.org/10.3389/fnagi.2023.1161847 . 10.3389/fnagi.2023.1161847 . Frontiers in Aging Neuroscience

Metabolic defects shared by Alzheimer's disease and diabetes: A focus on mitochondria

Cristina Carvalho; Paula I. Moreira, 2023. Current Opinion in Neurobiology. 2023. https://doi.org/10.1016/j.conb.2023.102694 . 10.1016/j.conb.2023.102694 . Current Opinion in Neurobiology

WWOX inhibition by Zfra1-31 restores mitochondrial homeostasis and viability of neuronal cells exposed to high glucose

Cristina Carvalho; Sónia C. Correia; Raquel Seiça; Paula I. Moreira, 2022. Cellular and Molecular Life Sciences. 2022. https://doi.org/10.1007/s00018-022-04508-7 . 10.1007/s00018-022-04508-7 . Cellular and Molecular Life Sciences

ER-mitochondria communication is involved in NLRP3 inflammasome activation under stress conditions in the innate immune system

Pereira, Ana Catarina; De Pascale, Jessica; Resende, Rosa; Cardoso, Susana; Ferreira, Isabel; Neves, Bruno Miguel; Carrascal, Mylène A.; et al, 2022. Cellular and Molecular Life Sciences. 4. 79. 2022. http://dx.doi.org/10.1007/s00018-022-04211-7 . 10.1007/s00018-022-04211-7 . Cellular and Molecular Life Sciences

Hypoxic preconditioning averts sporadic Alzheimer’s disease-like phenotype in rats: a focus on mitochondria

Correia, Sónia C.; Alves, Marco G.; Oliveira, Pedro F.; Casadesus, Gemma; LaManna, Joseph; Perry, George; Moreira, Paula I., 2022. Antioxidants & Redox Signaling. 2022. http://dx.doi.org/10.1089/ars.2019.8007 . 10.1089/ars.2019.8007 . Antioxidants & Redox Signaling

Retinal Aging in 3× Tg-AD Mice Model of Alzheimer's Disease

Guimarães, Pedro; Serranho, Pedro; Martins, João; Moreira, Paula I.; Ambrósio, António Francisco; Castelo-Branco, Miguel; Bernardes, Rui, 2022. Frontiers in Aging Neuroscience. 14. 2022. http://dx.doi.org/10.3389/fnagi.2022.832195 . 10.3389/fnagi.2022.832195 . Frontiers in Aging Neuroscience

Longitudinal OCT texture analysis to assess the retinal changes in the triple-transgenic mouse model of Alzheimer's disease

Bernardes, Rui; Ghalati, Maryam; Ferreira, Hugo; Martins, João; Guimarães, Pedro; Moreira, Paula; Ambrósio, António; Castelo-Branco, Miguel; Serranho, Pedro, 2022. Acta Ophthalmologica. S275. 100. 2022. http://dx.doi.org/10.1111/j.1755-3768.2022.0173 . 10.1111/j.1755-3768.2022.0173 . Acta Ophthalmologica

Stage-independent biomarkers for Alzheimer’s disease from the living retina: an animal study

Ferreira, Hugo; Serranho, Pedro; Guimarães, Pedro; Trindade, Rita; Martins, João; Moreira, Paula I.; Ambrósio, António Francisco; Castelo-Branco, Miguel; Bernardes, Rui, 2022. Scientific Reports. 1. 12. 2022. http://dx.doi.org/10.1038/s41598-022-18113-y . 10.1038/s41598-022-18113-y . Scientific Reports

Type 2 Diabetes Induces a Pro-Oxidative Environment in Rat Epididymis by Disrupting SIRT1/PGC-1a/SIRT3 Pathway

Antónia Diniz; Marco G. Alves; Emanuel Candeias; Ana I. Duarte; Paula I. Moreira; Branca M. Silva; Pedro F. Oliveira; Luís Rato, 2022. International Journal of Molecular Sciences. 2022. https://doi.org/10.3390/ijms23168912 . 10.3390/ijms23168912 . International Journal of Molecular Sciences

WWOX: A New Therapeutic Target In Type 2 Diabetes-Associated Neurodegeneration

Carvalho, Cristina; Moreira, Paula I., 2021. Metabolism. 116. 2021. http://dx.doi.org/10.1016/j.metabol.2020.154616 . 10.1016/j.metabol.2020.154616 . Metabolism

IGF1R Deficiency Modulates Brain Signaling Pathways and Disturbs Mitochondria and Redox Homeostasis

Susana Cardoso; Icíar López; Sergio Piñeiro-Hermida; José Pichel; Paula Moreira, 2021. Biomedicines. 158 - 158. 2. 9. 2021. https://doi.org/10.3390/biomedicines9020158 . 10.3390/biomedicines9020158 . Biomedicines

Oxygen Sensing and Signaling in Alzheimer's Disease: A Breathtaking Story!

Sónia C. Correia; Paula I. Moreira, 2021. Cellular and Molecular Neurobiology. 2021. https://doi.org/10.1007/s10571-021-01148-6 . 10.1007/s10571-021-01148-6 . Cellular and Molecular Neurobiology

Intermittent Hypoxic Conditioning Rescues Cognition and Mitochondrial Bioenergetic Profile in the Triple Transgenic Mouse Model of Alzheimer's Disease

Sónia C. Correia; Nuno J. Machado; Marco G. Alves; Pedro F. Oliveira; Paula I. Moreira, 2021. International Journal of Molecular Sciences. 461 - 461. 1. 22. 2021. https://doi.org/10.3390/ijms22010461 . 10.3390/ijms22010461 . International Journal of Molecular Sciences

Structural and Functional Alterations in Mitochondria-Associated Membranes (MAMs) and in Mitochondria Activate Stress Response Mechanisms in an In Vitro Model of Alzheimer's Disease

Tânia Fernandes; Rosa Resende; Diana F. Silva; Ana P. Marques; Armanda E. Santos; Sandra M. Cardoso; M. Rosário Domingues; Paula I. Moreira; Cláudia F. Pereira, 2021. Biomedicines. 881 - 881. 8. 9. 2021. https://doi.org/10.3390/biomedicines9080881 . 10.3390/biomedicines9080881 . Biomedicines

Longitudinal normative OCT retinal thickness data for wild-type mice, and characterization of changes in the 3×Tg-AD mice model of Alzheimer's disease

Ferreira, Hugo; Martins, João; Moreira, Paula I.; Ambrósio, António Francisco; Castelo-Branco, Miguel; Serranho, Pedro; Bernardes, Rui, 2021. Aging. 2021. http://dx.doi.org/10.18632/aging.202916 . 10.18632/aging.202916 . Aging

Insulin-Induced Recurrent Hypoglycemia Up-Regulates Glucose Metabolism in the Brain Cortex of Chemically Induced Diabetic Rats

Susana Cardoso; Paula I. Moreira, 2021. International Journal of Molecular Sciences. 2021. https://doi.org/10.3390/ijms222413470 . 10.3390/ijms222413470 . International Journal of Molecular Sciences

Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)1

Klionsky, Daniel J.; Abdel-Aziz, Amal Kamal; Abdelfatah, Sara; Abdellatif, Mahmoud; Abdoli, Asghar; Abel, Steffen; Abeliovich, Hagai; et al, 2021. Autophagy. 1 - 382. 1. 17. 2021. http://dx.doi.org/10.1080/15548627.2020.1797280 . 10.1080/15548627.2020.1797280 . Autophagy

The interplay between redox signalling and proteostasis in neurodegeneration: In vivo effects of a mitochondria-targeted antioxidant in Huntington's disease mice

Pinho, Brígida R.; Duarte, Ana I.; Canas, Paula M.; Moreira, Paula I.; Murphy, Michael P.; Oliveira, Jorge M.A., 2020. Free Radical Biology and Medicine. 372 - 382. 146. 2020. http://dx.doi.org/10.1016/j.freeradbiomed.2019.11.021 . 10.1016/j.freeradbiomed.2019.11.021 . Free Radical Biology and Medicine

Liraglutide Protects Against Brain Amyloid-ß1-42 Accumulation in Female Mice with Early Alzheimer's Disease-Like Pathology by Partially Rescuing Oxidative/Nitrosative Stress and Inflammation

Ana I. Duarte; Emanuel Candeias; Inês N. Alves; Débora Mena; Daniela F. Silva; Nuno J. Machado; Elisa J. Campos; et al, 2020. International Journal of Molecular Sciences. 2020. https://doi.org/10.3390/ijms21051746 . 10.3390/ijms21051746 . International Journal of Molecular Sciences

Associations between Trace Elements and Cognitive Decline: An Exploratory 5-Year Follow-Up Study of an Elderly Cohort

Bianca Gerardo; Marina Cabral Pinto; Joana Nogueira; Paula Pinto; Agostinho Almeida; Edgar Pinto; Paula Marinho-Reis; et al, 2020. International Journal of Environmental Research and Public Health. 2020. https://doi.org/10.3390/ijerph17176051 . 10.3390/ijerph17176051 . International Journal of Environmental Research and Public Health

Combining Virtual Screening Protocol and In Vitro Evaluation towards the Discovery of BACE1 Inhibitors

Coimbra, Judite R. M.; Baptista, Salete J.; Dinis, Teresa C. P.; Silva, Maria M. C.; Moreira, Paula I.; Santos, Armanda E.; Salvador, Jorge A. R., 2020. Biomolecules. 4. 10. 2020. http://dx.doi.org/10.3390/biom10040535 . 10.3390/biom10040535 . Biomolecules

Characterization of the retinal changes of the 3×Tg-AD mouse model of Alzheimer's disease

Ferreira, Hugo; Martins, João; Nunes, Ana; Moreira, Paula I.; Castelo-Branco, Miguel; Ambrósio, António Francisco; Serranho, Pedro; Bernardes, Rui, 2020. Health and Technology. 1816 - 1821. 2020. http://dx.doi.org/10.1007/s12553-020-00413-w . 10.1007/s12553-020-00413-w . Health and Technology

Brain energy rescue: an emerging therapeutic concept for neurodegenerative disorders of ageing

Cunnane, Stephen C.; Trushina, Eugenia; Morland, Cecilie; Prigione, Alessandro; Casadesus, Gemma; Andrews, Zane B.; Beal, M. Flint; et al, 2020. Nature Reviews Drug Discovery. 2020. http://dx.doi.org/10.1038/s41573-020-0072-x . 10.1038/s41573-020-0072-x . Nature Reviews Drug Discovery

Characterization of the retina of the triple-transgenic mice model of Alzheimer's disease: onset and progression of the disease

Bernardes, Rui; Ferreira, Hugo; Martins, Joao; Moreira, Paula; Francisco Ambrosio, Antonio; Castelo-Branco, Miguel; Serranho, Pedro, 2020. Neurology. 2020. https://publons.com/wos-op/publon/40788837/ . Neurology

PINK1/PARKIN signalling in neurodegeneration and neuroinflammation

Quinn, Peter M. J.; Moreira, Paula I.; Ambrósio, António Francisco; Alves, C. Henrique, 2020. Acta Neuropathologica Communications. 1. 8. 2020. http://dx.doi.org/10.1186/s40478-020-01062-w . 10.1186/s40478-020-01062-w . published Acta Neuropathologica Communications

Mitochondria, endoplasmic reticulum and innate immune dysfunction in mood disorders: Do Mitochondria-Associated Membranes (MAMs) play a role?

Resende, R.; Fernandes, T.; Pereira, A.C.; De Pascale, J.; Marques, A.P.; Oliveira, P.; Morais, S.; et al, 2020. Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease. 6. 1866. 2020. http://dx.doi.org/10.1016/j.bbadis.2020.165752 . 10.1016/j.bbadis.2020.165752 . Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease

Tortuous Paths of Insulin Signaling and Mitochondria in Alzheimer's Disease.

Moreira, PI, 2019. Advances in experimental medicine and biology. 2019. https://doi.org/10.1007/978-981-13-3540-2_9 . 10.1007/978-981-13-3540-2_9 . Advances in experimental medicine and biology

Diabesity and brain disturbances: A metabolic perspective

Susana Cardoso; Paula I. Moreira, 2019. Molecular Aspects of Medicine. 71 - 79. 66. 2019. https://doi.org/10.1016/j.mam.2018.10.002 . 10.1016/j.mam.2018.10.002 . Molecular Aspects of Medicine

The Retina as a Window or Mirror of the Brain Changes Detected in Alzheimer's Disease: Critical Aspects to Unravel

Chiquita, Samuel; Rodrigues-Neves, Ana C.; Baptista, Filipa I.; Carecho, Rafael; Moreira, Paula I.; Castelo-Branco, Miguel; Ambrósio, António F., 2019. Molecular Neurobiology. 5416 - 5435. 8. 56. 2019. http://dx.doi.org/10.1007/s12035-018-1461-6 . 10.1007/s12035-018-1461-6 . Molecular Neurobiology

Retinal thinning of inner sub-layers is associated with cortical atrophy in a mouse model of Alzheimer's disease: a longitudinal multimodal in vivo study

Chiquita, Samuel; Campos, Elisa J.; Castelhano, João; Ribeiro, Mário; Sereno, José; Moreira, Paula I.; Castelo-Branco, Miguel; Ambrósio, António Francisco, 2019. Alzheimer's Research & Therapy. 1. 11. 2019. http://dx.doi.org/10.1186/s13195-019-0542-8 . 10.1186/s13195-019-0542-8 . Alzheimer's Research & Therapy

A longitudinal multimodal in vivo molecular imaging study of the 3xTg-AD mouse model shows progressive early hippocampal and taurine loss

Chiquita, Samuel; Ribeiro, Mário; Castelhano, João; Oliveira, Francisco; Sereno, José; Batista, Marta; Abrunhosa, Antero; et al, 2019. Human Molecular Genetics. 2174 - 2188. 13. 28. 2019. http://dx.doi.org/10.1093/hmg/ddz045 . 10.1093/hmg/ddz045 . Human Molecular Genetics

Diminished O-GlcNAcylation in Alzheimer's disease is strongly correlated with mitochondrial anomalies

Pinho, Tiffany S.; Correia, Sónia C.; Perry, George; Ambrósio, António Francisco; Moreira, Paula I., 2019. Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease. 2048 - 2059. 8. 1865. 2019. http://dx.doi.org/10.1016/j.bbadis.2018.10.037 . 10.1016/j.bbadis.2018.10.037 . Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease

Retinal thickness of the triple-transgenic mice model of Alzheimer's disease at the age of one month

Bernardes, Rui; Ferreira, Hugo; Martins, João; Moreira, Paula I.; Castelo-Branco, Miguel; Ambrósio, António F.; Serranho, Pedro, 2019. Acta Ophthalmologica. S263. 97. 2019. http://dx.doi.org/10.1111/j.1755-3768.2019.5467 . 10.1111/j.1755-3768.2019.5467 . Acta Ophthalmologica

Can the retina show similar molecular and cellular changes as the brain in an animal model of Alzheimer's disease?

Rodrigues-Neves, Ana Catarina; Carecho, Rafael; Baptista, Filipa; Moreira, Paula; Ambrósio, António, 2019. Frontiers in Cellular Neuroscience. 13. 2019. http://dx.doi.org/10.3389/conf.fncel.2019.01.00020 . 10.3389/conf.fncel.2019.01.00020 . Frontiers in Cellular Neuroscience

Is Alzheimer's disease an inflammasomopathy?

Pereira, Claudia F.; Santos, Armanda E.; Moreira, Paula I.; Pereira, Ana Catarina; Sousa, Fabio J.; Cardoso, Sandra M.; Cruz, M. Teresa, 2019. Ageing Research Reviews. 56. 2019. http://dx.doi.org/10.1016/j.arr.2019.100966 . 10.1016/j.arr.2019.100966 . Ageing Research Reviews

Links between Cognitive Status and Trace Element Levels in Hair for an Environmentally Exposed Population: A Case Study in the Surroundings of the Estarreja Industrial Area

Cabral Pinto, Marina M. S.; Marinho-Reis, Paula; Almeida, Agostinho; Pinto, Edgar; Neves, Orquídia; Inácio, Manuela; Gerardo, Bianca; et al, 2019. International Journal of Environmental Research and Public Health. 22. 16. 2019. http://dx.doi.org/10.3390/ijerph16224560 . 10.3390/ijerph16224560 . International Journal of Environmental Research and Public Health

An overview of glutaminyl cyclase inhibitors for Alzheimer’s disease

Coimbra, Judite RM; Sobral, Pedro JM; Santos, Armanda E; Moreira, Paula I; Salvador, Jorge AR, 2019. Future Medicinal Chemistry. 3179 - 3194. 24. 11. 2019. http://dx.doi.org/10.4155/fmc-2019-0163 . 10.4155/fmc-2019-0163 . Future Medicinal Chemistry

Post-translational modifications in brain health and disease

Correia, Sónia C.; Carvalho, Cristina; Cardoso, Susana; Moreira, Paula I., 2019. Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease. 1947 - 1948. 8. 1865. 2019. http://dx.doi.org/10.1016/j.bbadis.2019.05.006 . 10.1016/j.bbadis.2019.05.006 . Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease

Sweet Mitochondria: A Shortcut to Alzheimer's Disease

Moreira, P.I., 2018. Journal of Alzheimer's Disease. 1391 - 1401. 3. 62. 2018. http://www.scopus.com/inward/record.url?eid=2-s2.0-85044360897&partnerID=MN8TOARS . 10.3233/JAD-170931 . Journal of Alzheimer's Disease

The beneficial role of exercise in mitigating doxorubicin-induced Mitochondrionopathy

Marques-Aleixo, I.; Santos-Alves, E.; Oliveira, P.J.; Moreira, P.I.; Magalhães, J.; Ascensão, A., 2018. Biochimica et Biophysica Acta - Reviews on Cancer. 189 - 199. 2. 1869. 2018. http://www.scopus.com/inward/record.url?eid=2-s2.0-85041805508&partnerID=MN8TOARS . 10.1016/j.bbcan.2018.01.002 . Biochimica et Biophysica Acta - Reviews on Cancer

Brain insulin signalling, glucose metabolism and females' reproductive aging: A dangerous triad in Alzheimer's disease

Duarte, A.I.; Santos, M.S.; Oliveira, C.R.; Moreira, P.I., 2018. Neuropharmacology. 2018. http://www.scopus.com/inward/record.url?eid=2-s2.0-85044268663&partnerID=MN8TOARS . 10.1016/j.neuropharm.2018.01.044 . Neuropharmacology

Dual Therapy with Liraglutide and Ghrelin Promotes Brain and Peripheral Energy Metabolism in the R6/2 Mouse Model of Huntington's Disease

Ana I. Duarte; Marie Sjögren; Maria S. Santos; Catarina R. Oliveira; Paula I. Moreira; Maria Björkqvist, 2018. Scientific Reports. 1. 8. 2018. https://doi.org/10.1038/s41598-018-27121-w . 10.1038/s41598-018-27121-w . Scientific Reports

Fingernail Trace Element Content in Environmentally Exposed Individuals and Its Influence on Their Cognitive Status in Ageing

Cabral Pinto, Marina M. S.; Marinho-Reis, A. Paula; Almeida, Agostinho; Freitas, Sandra; Simões, Mário R.; Diniz, M. Luísa; Pinto, Edgar; et al, 2018. Exposure and Health. 181 - 194. 3. 11. 2018. http://dx.doi.org/10.1007/s12403-018-0274-1 . 10.1007/s12403-018-0274-1 . Exposure and Health

O-GlcNAcylation and neuronal energy status: Implications for Alzheimer's disease

Tiffany S. Pinho; Diogo M. Verde; Sónia C. Correia; Susana M. Cardoso; Paula I. Moreira, 2018. Ageing Research Reviews. 32 - 41. 46. 2018. https://doi.org/10.1016/j.arr.2018.05.003 . 10.1016/j.arr.2018.05.003 . Ageing Research Reviews

Beneficial effects of white wine polyphenols-enriched diet on Alzheimer's disease-like pathology

Mendes, D.; Oliveira, M.M.; Moreira, P.I.; Coutinho, J.; Nunes, F.M.; Pereira, D.M.; Valentão, P.; Andrade, P.B.; Videira, R.A., 2018. Journal of Nutritional Biochemistry. 165 - 177. 55. 2018. http://www.scopus.com/inward/record.url?eid=2-s2.0-85043298266&partnerID=MN8TOARS . 10.1016/j.jnutbio.2018.02.001 . Journal of Nutritional Biochemistry

Selenoprotein S Reduces Endoplasmic Reticulum Stress-Induced Phosphorylation of Tau: Potential Role in Selenate Mitigation of Tau Pathology

Rueli, R.H.L.H.; Torres, D.J.; Dewing, A.S.T.; Kiyohara, A.C.; Barayuga, S.M.; Bellinger, M.T.; Uyehara-Lock, J.H.; et al, 2017. Journal of Alzheimer's Disease. 749 - 762. 2. 55. 2017. http://www.scopus.com/inward/record.url?eid=2-s2.0-84999116043&partnerID=MN8TOARS . 10.3233/JAD-151208 . Journal of Alzheimer's Disease

Mitochondria as a target for neuroprotection: implications for Alzheimer´s disease

Cardoso, S.; Seiça, R.M.; Moreira, P.I., 2017. Expert Review of Neurotherapeutics. 77 - 91. 1. 17. 2017. http://www.scopus.com/inward/record.url?eid=2-s2.0-85003782022&partnerID=MN8TOARS . 10.1080/14737175.2016.1205488 . Expert Review of Neurotherapeutics

Uncoupling Protein 2 Inhibition Exacerbates Glucose Fluctuation-Mediated Neuronal Effects

Cardoso, S.; Seiça, R.M.; Moreira, P.I., 2017. Neurotoxicity Research. 1 - 14. 2017. http://www.scopus.com/inward/record.url?eid=2-s2.0-85028984223&partnerID=MN8TOARS . 10.1007/s12640-017-9805-y . Neurotoxicity Research

Phosphatase 2A Inhibition Affects Endoplasmic Reticulum and Mitochondria Homeostasis Via Cytoskeletal Alterations in Brain Endothelial Cells

Ana I. Plácido; Cláudia M. F. Pereira; Sónia C. Correira; Cristina Carvalho; Catarina R. Oliveira; Paula I. Moreira, 2017. Molecular Neurobiology. 2017. http://dx.doi.org/10.1007/s12035-015-9640-1 . 10.1007/s12035-015-9640-1 . Molecular Neurobiology

Brain GLP-1/IGF-1 Signaling and Autophagy Mediate Exendin-4 Protection Against Apoptosis in Type 2 Diabetic Rats

Candeias, Emanuel; Sebastião, Inês; Cardoso, Susana; Carvalho, Cristina; Santos, Maria Sancha; Oliveira, Catarina Resende; Moreira, Paula I.; Duarte, Ana I., 2017. Molecular Neurobiology. 2017. http://dx.doi.org/10.1007/s12035-017-0622-3 . 10.1007/s12035-017-0622-3 . Molecular Neurobiology

Human predisposition to cognitive impairment and its relation with environmental exposure to potentially toxic elements

Cabral Pinto, M.M.S.; Marinho-Reis, A.P.; Almeida, A.; Ordens, C.M.; Silva, M.M.V.G.; Freitas, S.; Simões, M.R.; et al, 2017. Environmental Geochemistry and Health. 1 - 18. 2017. http://www.scopus.com/inward/record.url?eid=2-s2.0-85014615707&partnerID=MN8TOARS . 10.1007/s10653-017-9928-3 . Environmental Geochemistry and Health

Insights into the human brain proteome: Disclosing the biological meaning of protein networks in cerebrospinal fluid

Bastos, P.; Ferreira, R.; Manadas, B.; Moreira, P.I.; Vitorino, R., 2017. Critical Reviews in Clinical Laboratory Sciences. 185 - 204. 3. 54. 2017. http://www.scopus.com/inward/record.url?eid=2-s2.0-85019117156&partnerID=MN8TOARS . 10.1080/10408363.2017.1299682 . Critical Reviews in Clinical Laboratory Sciences

Mitochondrial traffic jams in Alzheimer's disease - pinpointing the roadblocks

Correia, S.C.; Perry, G.; Moreira, P.I., 2016. Biochimica et Biophysica Acta - Molecular Basis of Disease. 1909 - 1917. 10. 1862. 2016. http://www.scopus.com/inward/record.url?eid=2-s2.0-84979699672&partnerID=MN8TOARS . 10.1016/j.bbadis.2016.07.010 . Biochimica et Biophysica Acta - Molecular Basis of Disease

Middle-Aged Diabetic Females and Males Present Distinct Susceptibility to Alzheimer Disease-like Pathology

Candeias, E.; Duarte, A.I.; Sebastião, I.; Fernandes, M.A.; Plácido, A.I.; Carvalho, C.; Correia, S.; et al, 2016. Molecular Neurobiology. 1 - 19. 2016. http://www.scopus.com/inward/record.url?eid=2-s2.0-84991075553&partnerID=MN8TOARS . 10.1007/s12035-016-0155-1 . Molecular Neurobiology

Physical exercise mitigates doxorubicin-induced brain cortex and cerebellum mitochondrial alterations and cellular quality control signaling

Marques-Aleixo, I.; Santos-Alves, E.; Balça, M.M.; Moreira, P.I.; Oliveira, P.J.; Magalhães, J.; Ascensão, A., 2016. Mitochondrion. 43 - 57. 26. 2016. http://www.scopus.com/inward/record.url?eid=2-s2.0-84949871382&partnerID=MN8TOARS . 10.1016/j.mito.2015.12.002 . Mitochondrion

Erratum to: Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition) (Autophagy, 12, 1, 1-222, 10.1080/15548627.2015.1100356

Klionsky, D.J.; Abeliovich, H.; Agostinis, P.; Agrawal, D.K.; Aliev, G.; Askew, D.S.; Baba, M.; et al, 2016. Autophagy. 2. 12. 2016. http://www.scopus.com/inward/record.url?eid=2-s2.0-84975859238&partnerID=MN8TOARS . 10.1080/15548627.2016.1147886 . Autophagy

Alzheimer's Disease: From Mitochondrial Perturbations to Mitochondrial Medicine

Cardoso, S.; Carvalho, C.; Correia, S.C.; Seiça, R.M.; Moreira, P.I., 2016. Brain Pathology. 632 - 647. 5. 26. 2016. http://www.scopus.com/inward/record.url?eid=2-s2.0-84988642816&partnerID=MN8TOARS . 10.1111/bpa.12402 . Brain Pathology

Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)

Klionsky, D.J.; Abdelmohsen, K.; Abe, A.; Abedin, M.J.; Abeliovich, H.; Arozena, A.A.; Adachi, H.; et al, 2016. Autophagy. 1 - 222. 1. 12. 2016. http://www.scopus.com/inward/record.url?eid=2-s2.0-85013763791&partnerID=MN8TOARS . 10.1080/15548627.2015.1100356 . Autophagy

Alzheimer's disease-related misfolded proteins and dysfunctional organelles on autophagy menu

Correia, S.C.; Resende, R.; Moreira, P.I.; Pereira, C.M., 2015. DNA and Cell Biology. 261 - 273. 4. 34. 2015. http://www.scopus.com/inward/record.url?eid=2-s2.0-84926636149&partnerID=MN8TOARS . 10.1089/dna.2014.2757 . DNA and Cell Biology

Cerebrovascular and mitochondrial abnormalities in Alzheimer’s disease: a brief overview

Carvalho, C.; Correia, S.C.; Perry, G.; Castellani, R.J.; Moreira, P.I., 2015. Journal of Neural Transmission. 2015. http://www.scopus.com/inward/record.url?eid=2-s2.0-84922386380&partnerID=MN8TOARS . 10.1007/s00702-015-1367-7 . Journal of Neural Transmission

Age-dependent biochemical dysfunction in skeletal muscle of triple-transgenic mouse model of Alzheimer's disease

Monteiro-Cardoso, V.F.; Castro, M.; Oliveira, M.M.; Moreira, P.I.; Peixoto, F.; Videira, R.A., 2015. Current Alzheimer Research. 100 - 115. 2. 12. 2015. http://www.scopus.com/inward/record.url?eid=2-s2.0-84924862255&partnerID=MN8TOARS . Current Alzheimer Research

Type 2 diabetes aggravates alzheimer's disease-associated vascular alterations of the aorta in mice

Sena, C.M.; Pereira, A.M.; Carvalho, C.; Fernandes, R.; Seiça, R.M.; Oliveira, C.R.; Moreira, P.I., 2015. Journal of Alzheimer's Disease. 127 - 138. 1. 45. 2015. http://www.scopus.com/inward/record.url?eid=2-s2.0-84924181831&partnerID=MN8TOARS . 10.3233/JAD-141008 . Journal of Alzheimer's Disease

Daily consumption of white tea (Camellia sinensis (L.)) improves the cerebral cortex metabolic and oxidative profile in prediabetic Wistar rats

Nunes, A.R.; Alves, M.G.; Tomás, G.D.; Conde, V.R.; Cristóvão, A.C.; Moreira, P.I.; Oliveira, P.F.; Silva, B.M., 2015. British Journal of Nutrition. 832 - 842. 5. 113. 2015. http://www.scopus.com/inward/record.url?eid=2-s2.0-84926409736&partnerID=MN8TOARS . 10.1017/S0007114514004395 . British Journal of Nutrition

Kaurane diterpenes as mitochondrial alterations preventive agents under experimental oxidative stress conditions

González-Burgos, E.; Duarte, A.I.; Carretero, M.E.; Moreira, P.I.; Gómez-Serranillos, M.P., 2015. Pharmaceutical Biology. 2015. http://www.scopus.com/inward/record.url?eid=2-s2.0-84945231706&partnerID=MN8TOARS . 10.3109/13880209.2015.1072829 . Pharmaceutical Biology

Physical exercise improves brain cortex and cerebellum mitochondrial bioenergetics and alters apoptotic, dynamic and auto(mito)phagy markers

Marques-Aleixo, I.; Santos-Alves, E.; Balça, M.M.; Rizo-Roca, D.; Moreira, P.I.; Oliveira, P.J.; Magalhães, J.; Ascensão, A., 2015. Neuroscience. 480 - 495. 301. 2015. http://www.scopus.com/inward/record.url?eid=2-s2.0-84947795323&partnerID=MN8TOARS . 10.1016/j.neuroscience.2015.06.027 . Neuroscience

The role of mitochondrial disturbances in Alzheimer, Parkinson and Huntington diseases

Carvalho, C.; Correia, S.C.; Cardoso, S.; Plácido, A.I.; Candeias, E.; Duarte, A.I.; Moreira, P.I., 2015. Expert Review of Neurotherapeutics. 867 - 884. 8. 15. 2015. http://www.scopus.com/inward/record.url?eid=2-s2.0-84937838385&partnerID=MN8TOARS . 10.1586/14737175.2015.1058160 . Expert Review of Neurotherapeutics

Testosterone deficiency induced by progressive stages of diabetes mellitus impairs glucose metabolism and favors glycogenesis in mature rat Sertoli cells

Rato, L.; Alves, M.G.; Duarte, A.I.; Santos, M.S.; Moreira, P.I.; Cavaco, J.E.; Oliveira, P.F., 2015. International Journal of Biochemistry and Cell Biology. 1 - 10. 66. 2015. http://www.scopus.com/inward/record.url?eid=2-s2.0-84936877372&partnerID=MN8TOARS . 10.1016/j.biocel.2015.07.001 . International Journal of Biochemistry and Cell Biology

Alzheimer's disease and type 2 diabetes-related alterations in brain mitochondria, autophagy and synaptic markers

Carvalho, C.; Santos, M.S.; Oliveira, C.R.; Moreira, P.I., 2015. Biochimica et Biophysica Acta - Molecular Basis of Disease. 1665 - 1675. 8. 1852. 2015. http://www.scopus.com/inward/record.url?eid=2-s2.0-84929430489&partnerID=MN8TOARS . 10.1016/j.bbadis.2015.05.001 . Biochimica et Biophysica Acta - Molecular Basis of Disease

Metabolic fingerprints in testicular biopsies from type 1 diabetic patients

Alves, M.G.; Martins, A.D.; Moreira, P.I.; Carvalho, R.A.; Sousa, M.; Barros, A.; Silva, J.; et al, 2015. Cell and Tissue Research. 2015. http://www.scopus.com/inward/record.url?eid=2-s2.0-84930607586&partnerID=MN8TOARS . 10.1007/s00441-015-2217-5 . Cell and Tissue Research

Modulation of endoplasmic reticulum stress: An opportunity to prevent neurodegeneration?

Plácido, A.I.; Pereira, C.M.F.; Duarte, A.I.; Candeias, E.; Correia, S.C.; Carvalho, C.; Cardoso, S.; Oliveira, C.R.; Moreira, P.I., 2015. CNS and Neurological Disorders - Drug Targets. 518 - 533. 4. 14. 2015. http://www.scopus.com/inward/record.url?eid=2-s2.0-84929628537&partnerID=MN8TOARS . CNS and Neurological Disorders - Drug Targets

Metformin in the diabetic brain: friend or foe?

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Can tea consumption be a safe and effective therapy against diabetes mellitus-induced neurodegeneration?

Nunes, A.R.; Alves, M.G.; Moreira, P.I.; Oliveira, P.F.; Silva, B.M., 2014. Current Neuropharmacology. 475 - 489. 6. 12. 2014. http://www.scopus.com/inward/record.url?eid=2-s2.0-84924963252&partnerID=MN8TOARS . Current Neuropharmacology

The role of endoplasmic reticulum in amyloid precursor protein processing and trafficking: Implications for Alzheimer's disease

Plácido, A.I.; Pereira, C.M.F.; Duarte, A.I.; Candeias, E.; Correia, S.C.; Santos, R.X.; Carvalho, C.; et al, 2014. Biochimica et Biophysica Acta - Molecular Basis of Disease. 1444 - 1453. 9. 1842. 2014. http://www.scopus.com/inward/record.url?eid=2-s2.0-84903458925&partnerID=MN8TOARS . 10.1016/j.bbadis.2014.05.003 . Biochimica et Biophysica Acta - Molecular Basis of Disease

Insulin therapy modulates mitochondrial dynamics and biogenesis, autophagy and tau protein phosphorylation in the brain of type 1 diabetic rats

Santos, R.X.; Correia, S.C.; Alves, M.G.; Oliveira, P.F.; Cardoso, S.; Carvalho, C.; Duarte, A.I.; Santos, M.S.; Moreira, P.I., 2014. Biochimica et Biophysica Acta - Molecular Basis of Disease. 1154 - 1166. 7. 1842. 2014. http://www.scopus.com/inward/record.url?eid=2-s2.0-84899789863&partnerID=MN8TOARS . 10.1016/j.bbadis.2014.04.011 . Biochimica et Biophysica Acta - Molecular Basis of Disease

Enhanced Amyloidogenic Processing of Amyloid Precursor Protein and Cell Death Under Prolonged Endoplasmic Reticulum Stress in Brain Endothelial Cells

Plácido, A.I.; Oliveira, C.R.; Moreira, P.I.; Pereira, C.M.F., 2014. Molecular Neurobiology. 2014. http://www.scopus.com/inward/record.url?eid=2-s2.0-84905883677&partnerID=MN8TOARS . 10.1007/s12035-014-8819-1 . Molecular Neurobiology

Effects of methylglyoxal and pyridoxamine in rat brain mitochondria bioenergetics and oxidative status

Cardoso, S.; Carvalho, C.; Marinho, R.; Simões, A.; Sena, C.M.; Matafome, P.; Santos, M.S.; Seiça, R.M.; Moreira, P.I., 2014. Journal of Bioenergetics and Biomembranes. 2014. http://www.scopus.com/inward/record.url?eid=2-s2.0-84901509164&partnerID=MN8TOARS . 10.1007/s10863-014-9551-2 . Journal of Bioenergetics and Biomembranes

Cardiolipin profile changes are associated to the early synaptic mitochondrial dysfunction in Alzheimer's disease

Monteiro-Cardoso, V.F.; Oliveira, M.M.; Melo, T.; Domingues, M.R.M.; Moreira, P.I.; Ferreiro, E.; Peixoto, F.; Videira, R.A., 2014. Journal of Alzheimer's Disease. 1375 - 1392. 4. 43. 2014. http://www.scopus.com/inward/record.url?eid=2-s2.0-84919926803&partnerID=MN8TOARS . 10.3233/JAD-141002 . Journal of Alzheimer's Disease

Vascular, oxidative, and synaptosomal abnormalities during aging and the progression of type 2 diabetes

Carvalho, C.; Correia, S.C.; Santos, M.S.; Baldeiras, I.; Oliveira, C.R.; Seiça, R.; Moreira, P.I., 2014. Current Neurovascular Research. 330 - 339. 4. 11. 2014. http://www.scopus.com/inward/record.url?eid=2-s2.0-84925786114&partnerID=MN8TOARS . Current Neurovascular Research

Insulin as a bridge between type 2 diabetes and alzheimer disease - how anti-diabetics could be a solution for dementia

Sebastião, I.; Candeias, E.; Santos, M.S.; de Oliveira, C.R.; Moreira, P.I.; Duarte, A.I., 2014. Frontiers in Endocrinology. JUL. 5. 2014. http://www.scopus.com/inward/record.url?eid=2-s2.0-84905437740&partnerID=MN8TOARS . 10.3389/fendo.2014.00110 . Frontiers in Endocrinology

Pre-diabetes alters testicular PGC1-a/SIRT3 axis modulating mitochondrial bioenergetics and oxidative stress

Rato, L.; Duarte, A.I.; Tomás, G.D.; Santos, M.S.; Moreira, P.I.; Socorro, S.; Cavaco, J.E.; Alves, M.G.; Oliveira, P.F., 2014. Biochimica et Biophysica Acta - Bioenergetics. 335 - 344. 3. 1837. 2014. http://www.scopus.com/inward/record.url?eid=2-s2.0-84892411578&partnerID=MN8TOARS . 10.1016/j.bbabio.2013.12.008 . Biochimica et Biophysica Acta - Bioenergetics

Increased susceptibility to amyloid-ß toxicity in rat brain microvascular endothelial cells under hyperglycemic conditions

Carvalho, C.; Katz, P.S.; Dutta, S.; Katakam, P.V.G.; Moreira, P.I.; Busija, D.W., 2014. Journal of Alzheimer's Disease. 75 - 83. 1. 38. 2014. http://www.scopus.com/inward/record.url?eid=2-s2.0-84887249119&partnerID=MN8TOARS . 10.3233/JAD-130464 . Journal of Alzheimer's Disease

Mitochondrial quality control systems sustain brain mitochondrial bioenergetics in early stages of type 2 diabetes

Santos, R.X.; Correia, S.C.; Alves, M.G.; Oliveira, P.F.; Cardoso, S.; Carvalho, C.; Seiça, R.; Santos, M.S.; Moreira, P.I., 2014. Molecular and Cellular Biochemistry. 2014. http://www.scopus.com/inward/record.url?eid=2-s2.0-84901561690&partnerID=MN8TOARS . 10.1007/s11010-014-2076-5 . Molecular and Cellular Biochemistry

Amyloid-Beta Disrupts Calcium and Redox Homeostasis in Brain Endothelial Cells

Fonseca, A.C.R.G.; Moreira, P.I.; Oliveira, C.R.; Cardoso, S.M.; Pinton, P.; Pereira, C.F., 2014. Molecular Neurobiology. 2014. http://www.scopus.com/inward/record.url?eid=2-s2.0-84901537197&partnerID=MN8TOARS . 10.1007/s12035-014-8740-7 . Molecular Neurobiology

Metformin and male reproduction: Effects on Sertoli cell metabolism

Alves, M.G.; Martins, A.D.; Vaz, C.V.; Correia, S.; Moreira, P.I.; Oliveira, P.F.; Socorro, S., 2014. British Journal of Pharmacology. 1033 - 1042. 4. 171. 2014. http://www.scopus.com/inward/record.url?eid=2-s2.0-84893042451&partnerID=MN8TOARS . 10.1111/bph.12522 . British Journal of Pharmacology

Perspectives on mitochondrial uncoupling proteins-mediated neuroprotection

Cardoso, S.; Correia, S.; Carvalho, C.; Candeias, E.; Plácido, A.I.; Duarte, A.I.; Seiça, R.M.; Moreira, P.I., 2014. Journal of Bioenergetics and Biomembranes. 119 - 131. 1-2. 47. 2014. http://www.scopus.com/inward/record.url?eid=2-s2.0-84922536968&partnerID=MN8TOARS . 10.1007/s10863-014-9580-x . Journal of Bioenergetics and Biomembranes

Defective HIF signaling pathway and brain response to hypoxia in neurodegenera-tive diseases: Not an Iffy question!

Correia, S.C.; Carvalho, C.; Cardoso, S.; Santos, R.X.; Plácido, A.I.; Candeias, E.; Duarte, A.I.; Moreira, P.I., 2013. Current Pharmaceutical Design. 6809 - 6822. 38. 19. 2013. http://www.scopus.com/inward/record.url?eid=2-s2.0-84884829985&partnerID=MN8TOARS . Current Pharmaceutical Design

Insulin-induced recurrent hypoglycemia exacerbates diabetic brain mitochondrial dysfunction and oxidative imbalance

Cardoso, S.; Santos, R.X.; Correia, S.C.; Carvalho, C.; Santos, M.S.; Baldeiras, I.; Oliveira, C.R.; Moreira, P.I., 2013. Neurobiology of Disease. 1 - 12. 1. 49. 2013. http://www.scopus.com/inward/record.url?eid=2-s2.0-84866491588&partnerID=MN8TOARS . 10.1016/j.nbd.2012.08.008 . Neurobiology of Disease

Mitochondrial-targeted protective properties of isolated diterpenoids from sideritis spp. in response to the deleterious changes induced by H 2O2

González-Burgos, E.; Duarte, A.I.; Carretero, M.E.; Moreira, P.I.; Gómez-Serranillos, M.P., 2013. Journal of Natural Products. 933 - 938. 5. 76. 2013. http://www.scopus.com/inward/record.url?eid=2-s2.0-84878260967&partnerID=MN8TOARS . 10.1021/np400118d . Journal of Natural Products

Molecular mechanisms beyond glucose transport in diabetes-related male infertility

Alves, M.G.; Martins, A.D.; Rato, L.; Moreira, P.I.; Socorro, S.; Oliveira, P.F., 2013. Biochimica et Biophysica Acta - Molecular Basis of Disease. 626 - 635. 5. 1832. 2013. http://www.scopus.com/inward/record.url?eid=2-s2.0-84874414576&partnerID=MN8TOARS . 10.1016/j.bbadis.2013.01.011 . Biochimica et Biophysica Acta - Molecular Basis of Disease

Crosstalk between diabetes and brain: Glucagon-like peptide-1 mimetics as a promising therapy against neurodegeneration

Duarte, A.I.; Candeias, E.; Correia, S.C.; Santos, R.X.; Carvalho, C.; Cardoso, S.; Plácido, A.; et al, 2013. Biochimica et Biophysica Acta - Molecular Basis of Disease. 527 - 541. 4. 1832. 2013. http://www.scopus.com/inward/record.url?eid=2-s2.0-84873306844&partnerID=MN8TOARS . 10.1016/j.bbadis.2013.01.008 . Biochimica et Biophysica Acta - Molecular Basis of Disease

Hyperglycemia, hypoglycemia and dementia: Role of mitochondria and uncoupling proteins

Cardoso, S.; Correia, S.C.; Santos, R.X.; Carvalho, C.; Candeias, E.; Duarte, A.I.; Plácido, A.I.; Santos, M.S.; Moreira, P.I., 2013. Current Molecular Medicine. 586 - 601. 4. 13. 2013. http://www.scopus.com/inward/record.url?eid=2-s2.0-84876735551&partnerID=MN8TOARS . 10.2174/1566524011313040010 . Current Molecular Medicine

Type 2 diabetic and alzheimer's disease mice present similar behavioral, cognitive, and vascular anomalies

Carvalho, C.; Machado, N.; Mota, P.C.; Correia, S.C.; Cardoso, S.; Santos, R.X.; Santos, M.S.; Oliveira, C.R.; Moreira, P.I., 2013. Journal of Alzheimer's Disease. 623 - 635. 3. 35. 2013. http://www.scopus.com/inward/record.url?eid=2-s2.0-84880196052&partnerID=MN8TOARS . 10.3233/JAD-130005 . Journal of Alzheimer's Disease

Exposure to 2,4-dichlorophenoxyacetic acid alters glucose metabolism in immature rat Sertoli cells

Alves, M.G.; Neuhaus-Oliveira, A.; Moreira, P.I.; Socorro, S.; Oliveira, P.F., 2013. Reproductive Toxicology. 81 - 88. 38. 2013. http://www.scopus.com/inward/record.url?eid=2-s2.0-84876339594&partnerID=MN8TOARS . 10.1016/j.reprotox.2013.03.005 . Reproductive Toxicology

Control of Sertoli cell metabolism by sex steroid hormones is mediated through modulation in glycolysis-related transporters and enzymes

Martins, A.D.; Alves, M.G.; Simões, V.L.; Dias, T.R.; Rato, L.; Moreira, P.I.; Socorro, S.; Cavaco, J.E.; Oliveira, P.F., 2013. Cell and Tissue Research. 861 - 868. 3. 354. 2013. http://www.scopus.com/inward/record.url?eid=2-s2.0-84890482473&partnerID=MN8TOARS . 10.1007/s00441-013-1722-7 . Cell and Tissue Research

Phosphorylation of tau protein as the link between oxidative stress, mitochondrial dysfunction, and connectivity failure: Implications for Alzheimer's disease

Mondragón-Rodríguez, S.; Perry, G.; Zhu, X.; Moreira, P.I.; Acevedo-Aquino, M.C.; Williams, S., 2013. Oxidative Medicine and Cellular Longevity. 2013. http://www.scopus.com/inward/record.url?eid=2-s2.0-84880863640&partnerID=MN8TOARS . 10.1155/2013/940603 . Oxidative Medicine and Cellular Longevity

Neurofilaments are the major neuronal target of hydroxynonenal-mediated protein cross-links

Perry, E.A.; Castellani, R.J.; Moreira, P.I.; Nunomura, A.; Lui, Q.; Harris, P.L.R.; Sayre, L.M.; et al, 2013. Free Radical Research. 507 - 510. 6-7. 47. 2013. http://www.scopus.com/inward/record.url?eid=2-s2.0-84878875361&partnerID=MN8TOARS . 10.3109/10715762.2013.794265 . Free Radical Research

High-sugar diets, type 2 diabetes and Alzheimer's disease

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Hormonal control of Sertoli cell metabolism regulates spermatogenesis

Alves, M.G.; Rato, L.; Carvalho, R.A.; Moreira, P.I.; Socorro, S.; Oliveira, P.F., 2013. Cellular and Molecular Life Sciences. 777 - 793. 5. 70. 2013. http://www.scopus.com/inward/record.url?eid=2-s2.0-84873719667&partnerID=MN8TOARS . 10.1007/s00018-012-1079-1 . Cellular and Molecular Life Sciences

UCP2 and ANT differently modulate proton-leak in brain mitochondria of long-term hyperglycemic and recurrent hypoglycemic rats

Cardoso, S.; Santos, M.S.; Moreno, A.; Moreira, P.I., 2013. Journal of Bioenergetics and Biomembranes. 397 - 407. 4. 45. 2013. http://www.scopus.com/inward/record.url?eid=2-s2.0-84881311117&partnerID=MN8TOARS . 10.1007/s10863-013-9503-2 . Journal of Bioenergetics and Biomembranes

Mechanism of inhibition of mitochondrial ATP synthase by 17ß-Estradiol

Moreno, A.J.M.; Moreira, P.I.; Custódio, J.B.A.; Santos, M.S., 2013. Journal of Bioenergetics and Biomembranes. 261 - 270. 3. 45. 2013. http://www.scopus.com/inward/record.url?eid=2-s2.0-84878642515&partnerID=MN8TOARS . 10.1007/s10863-012-9497-1 . Journal of Bioenergetics and Biomembranes

Mitochondrial abnormalities in a streptozotocin-induced rat model of sporadic Alzheimer's disease

Correia, S.C.; Santos, R.X.; Santos, M.S.; Casadesus, G.; LaManna, J.C.; Perry, G.; Smith, M.A.; Moreira, P.I., 2013. Current Alzheimer Research. 406 - 419. 4. 10. 2013. http://www.scopus.com/inward/record.url?eid=2-s2.0-84878623135&partnerID=MN8TOARS . 10.2174/1567205011310040006 . Current Alzheimer Research

Mitochondrial DNA oxidative damage and repair in aging and Alzheimer's disease

Santos, R.X.; Correia, S.C.; Zhu, X.; Smith, M.A.; Moreira, P.I.; Castellani, R.J.; Nunomura, A.; Perry, G., 2013. Antioxidants and Redox Signaling. 2444 - 2457. 18. 18. 2013. http://www.scopus.com/inward/record.url?eid=2-s2.0-84878619863&partnerID=MN8TOARS . 10.1089/ars.2012.5039 . Antioxidants and Redox Signaling

Is exercise-in-a-bottle likely to proffer new insights into Alzheimer's disease?

Correia, S.C.; Perry, G.; Castellani, R.; Moreira, P.I., 2013. Journal of Neurochemistry. 4 - 6. 1. 127. 2013. http://www.scopus.com/inward/record.url?eid=2-s2.0-84884846458&partnerID=MN8TOARS . 10.1111/jnc.12406 . Journal of Neurochemistry

Androgen-responsive and nonresponsive prostate cancer cells present a distinct glycolytic metabolism profile

Vaz, C.V.; Alves, M.G.; Marques, R.; Moreira, P.I.; Oliveira, P.F.; Maia, C.J.; Socorro, S., 2012. International Journal of Biochemistry and Cell Biology. 2077 - 2084. 11. 44. 2012. http://www.scopus.com/inward/record.url?eid=2-s2.0-84865554409&partnerID=MN8TOARS . 10.1016/j.biocel.2012.08.013 . International Journal of Biochemistry and Cell Biology

Hydroxynonenal-generated crosslinking fluorophore accumulation in Alzheimer disease reveals a dichotomy of protein turnover

Zhu, X.; Castellani, R.J.; Moreira, P.I.; Aliev, G.; Shenk, J.C.; Siedlak, S.L.; Harris, P.L.R.; et al, 2012. Free Radical Biology and Medicine. 699 - 704. 3. 52. 2012. http://www.scopus.com/inward/record.url?eid=2-s2.0-84856283539&partnerID=MN8TOARS . 10.1016/j.freeradbiomed.2011.11.004 . Free Radical Biology and Medicine

The role of iron as a mediator of oxidative stress in Alzheimer disease

Castellani, R.J.; Moreira, P.I.; Perry, G.; Zhu, X., 2012. BioFactors. 133 - 138. 2. 38. 2012. http://www.scopus.com/inward/record.url?eid=2-s2.0-84862817976&partnerID=MN8TOARS . 10.1002/biof.1010 . BioFactors

Cyanide preconditioning protects brain endothelial and NT2 neuron-like cells against glucotoxicity: Role of mitochondrial reactive oxygen species and HIF-1a

Correia, S.C.; Santos, R.X.; Cardoso, S.M.; Santos, M.S.; Oliveira, C.R.; Moreira, P.I., 2012. Neurobiology of Disease. 206 - 218. 1. 45. 2012. http://www.scopus.com/inward/record.url?eid=2-s2.0-81955160758&partnerID=MN8TOARS . 10.1016/j.nbd.2011.08.005 . Neurobiology of Disease

Impact of diabetes in blood-testis and blood-brain barriers: Resemblances and differences

Alves, M.G.; Oliveira, P.F.; Socorro, S.; Moreira, P.I., 2012. Current Diabetes Reviews. 401 - 412. 6. 8. 2012. http://www.scopus.com/inward/record.url?eid=2-s2.0-84870183874&partnerID=MN8TOARS . 10.2174/157339912803529896 . Current Diabetes Reviews

Physical exercise as a possible strategy for brain protection: Evidence from mitochondrial-mediated mechanisms

Marques-Aleixo, I.; Oliveira, P.J.; Moreira, P.I.; Magalhães, J.; Ascensão, A., 2012. Progress in Neurobiology. 149 - 162. 2. 99. 2012. http://www.scopus.com/inward/record.url?eid=2-s2.0-84867896217&partnerID=MN8TOARS . 10.1016/j.pneurobio.2012.08.002 . Progress in Neurobiology

Nuclear and mitochondrial DNA oxidation in Alzheimer's disease

Santos, R.X.; Correia, S.C.; Zhu, X.; Lee, H.-G.; Petersen, R.B.; Nunomura, A.; Smith, M.A.; Perry, G.; Moreira, P.I., 2012. Free Radical Research. 565 - 576. 4. 46. 2012. http://www.scopus.com/inward/record.url?eid=2-s2.0-84863229887&partnerID=MN8TOARS . 10.3109/10715762.2011.648188 . Free Radical Research

Guidelines for the use and interpretation of assays for monitoring autophagy

Klionsky, D.J.; Abdalla, F.C.; Abeliovich, H.; Abraham, R.T.; Acevedo-Arozena, A.; Adeli, K.; Agholme, L.; et al, 2012. Autophagy. 445 - 544. 4. 8. 2012. http://www.scopus.com/inward/record.url?eid=2-s2.0-84862295360&partnerID=MN8TOARS . 10.4161/auto.19496 . Autophagy

The impairment of insulin signaling in Alzheimer's disease

Candeias, E.; Duarte, A.I.; Carvalho, C.; Correia, S.C.; Cardoso, S.; Santos, R.X.; Plácido, A.I.; Perry, G.; Moreira, P.I., 2012. IUBMB Life. 951 - 957. 12. 64. 2012. http://www.scopus.com/inward/record.url?eid=2-s2.0-84870197271&partnerID=MN8TOARS . 10.1002/iub.1098 . IUBMB Life

Insulin signaling, glucose metabolism and mitochondria: Major players in Alzheimer's disease and diabetes interrelation

Correia, S.C.; Santos, R.X.; Carvalho, C.; Cardoso, S.; Candeias, E.; Santos, M.S.; Oliveira, C.R.; Moreira, P.I., 2012. Brain Research. 64 - 78. 1441. 2012. http://www.scopus.com/inward/record.url?eid=2-s2.0-84857788978&partnerID=MN8TOARS . 10.1016/j.brainres.2011.12.063 . Brain Research

Alzheimer's disease and diabetes: An integrative view of the role of mitochondria, oxidative stress, and insulin

Moreira, P.I., 2012. Journal of Alzheimer's Disease. SUPPL.2. 30. 2012. http://www.scopus.com/inward/record.url?eid=2-s2.0-84863002103&partnerID=MN8TOARS . 10.3233/JAD-2011-111127 . Journal of Alzheimer's Disease

Metabolic alterations induced by sucrose intake and Alzheimer's disease promote similar brain mitochondrial abnormalities

Carvalho, C.; Cardoso, S.; Correia, S.C.; Santos, R.X.; Santos, M.S.; Baldeiras, I.; Oliveira, C.R.; Moreira, P.I., 2012. Diabetes. 1234 - 1242. 5. 61. 2012. http://www.scopus.com/inward/record.url?eid=2-s2.0-84860599622&partnerID=MN8TOARS . 10.2337/db11-1186 . Diabetes

Glycogen synthase kinase 3: A point of integration in alzheimer's disease and a therapeutic target?

Mondragón-Rodríguez, S.; Perry, G.; Zhu, X.; Moreira, P.I.; Williams, S., 2012. International Journal of Alzheimer's Disease. 2012. http://www.scopus.com/inward/record.url?eid=2-s2.0-84863697825&partnerID=MN8TOARS . 10.1155/2012/276803 . International Journal of Alzheimer's Disease

Alzheimer disease as a vascular disorder: Where do mitochondria fit?

Correia, S.C.; Santos, R.X.; Cardoso, S.; Carvalho, C.; Candeias, E.; Duarte, A.I.; Plácido, A.I.; Santos, M.S.; Moreira, P.I., 2012. Experimental Gerontology. 878 - 886. 11. 47. 2012. http://www.scopus.com/inward/record.url?eid=2-s2.0-84867725518&partnerID=MN8TOARS . 10.1016/j.exger.2012.07.006 . Experimental Gerontology

Insulin in central nervous system: More than just a peripheral hormone

Duarte, A.I.; Moreira, P.I.; Oliveira, C.R., 2012. Journal of Aging Research. 2012. 2012. http://www.scopus.com/inward/record.url?eid=2-s2.0-84868282388&partnerID=MN8TOARS . 10.1155/2012/384017 . Journal of Aging Research

Mitochondrial importance in Alzheimer's, Huntington's and Parkinson's diseases

Correia, S.C.; Santos, R.X.; Perry, G.; Zhu, X.; Moreira, P.I.; Smith, M.A., 2012. Advances in Experimental Medicine and Biology. 205 - 221. 724. 2012. http://www.scopus.com/inward/record.url?eid=2-s2.0-84859514171&partnerID=MN8TOARS . 10.1007/978-1-4614-0653-2_16 . Advances in Experimental Medicine and Biology

Oxidative damage to RNA in aging and neurodegenerative disorders

Nunomura, A.; Moreira, P.I.; Castellani, R.J.; Lee, H.-G.; Zhu, X.; Smith, M.A.; Perry, G., 2012. Neurotoxicity Research. 231 - 248. 3. 22. 2012. http://www.scopus.com/inward/record.url?eid=2-s2.0-84865407887&partnerID=MN8TOARS . 10.1007/s12640-012-9331-x . Neurotoxicity Research

Impact of STZ-induced hyperglycemia and insulin-induced hypoglycemia in plasma amino acids and cortical synaptosomal neurotransmitters

Cardoso, S.; Carvalho, C.; Santos, R.; Correia, S.; Santos, M.S.; Seiça, R.; Oliveira, C.R.; Moreira, P.I., 2011. Synapse. 457 - 466. 6. 65. 2011. http://www.scopus.com/inward/record.url?eid=2-s2.0-79953276927&partnerID=MN8TOARS . 10.1002/syn.20863 . Synapse

SIRT3 Opposes Reprogramming of Cancer Cell Metabolism through HIF1a Destabilization

Finley, L.; Carracedo, A.; Lee, J.; Souza, A.; Egia, A.; Zhang, J.; Teruya-Feldstein, J.; et al, 2011. Cancer Cell. 416 - 428. 3. 19. 2011. http://www.scopus.com/inward/record.url?eid=2-s2.0-79952501323&partnerID=MN8TOARS . 10.1016/j.ccr.2011.02.014 . Cancer Cell

New insights into the mechanisms of mitochondrial preconditioning-triggered neuroprotection

Correia, S.C.; Cardoso, S.; Santos, R.X.; Carvalho, C.; Santos, M.S.; Perry, G.; Smith, M.A.; Moreira, P.I., 2011. Current Pharmaceutical Design. 3381 - 3389. 31. 17. 2011. http://www.scopus.com/inward/record.url?eid=2-s2.0-80055089996&partnerID=MN8TOARS . 10.2174/138161211798072490 . Current Pharmaceutical Design

Mitophagy in neurodegeneration: An opportunity for therapy?

Santos, R.X.; Correia, S.C.; Carvalho, C.; Cardoso, S.; Santos, M.S.; Moreira, P.I., 2011. Current Drug Targets. 790 - 799. 6. 12. 2011. http://www.scopus.com/inward/record.url?eid=2-s2.0-79955585040&partnerID=MN8TOARS . 10.2174/138945011795528813 . Current Drug Targets

Oxidative Stress and Balance in Neurodegenerative Diseases

Collins, G.H.; Mondragón-Rodríguez, S.; Nunomura, A.; Zhu, X.; Moreira, P.I.; Smith, M.A., 2011. Neurodegeneration: The Molecular Pathology of Dementia and Movement Disorders: Second Edition. 10 - 12. 2011. http://www.scopus.com/inward/record.url?eid=2-s2.0-84886036204&partnerID=MN8TOARS . 10.1002/9781444341256.ch3 . Neurodegeneration: The Molecular Pathology of Dementia and Movement Disorders: Second Edition

Mitochondria as potential targets in antidiabetic therapy

Moreira, P.I.; Oliveira, C.R., 2011. Handbook of Experimental Pharmacology. 331 - 356. 203. 2011. http://www.scopus.com/inward/record.url?eid=2-s2.0-79955615960&partnerID=MN8TOARS . 10.1007/978-3-642-17214-4-14 . Handbook of Experimental Pharmacology

Association of mitochondrial signaling in Alzheimer's disease and hypoxia

Carvalho, C.; Correia, S.C.; Santos, R.X.; Cardoso, S.; Moreira, P.I.; Zhu, X.; Smith, M.A.; Perry, G., 2011. Molecular Aspects of Neurodegeneration and Neuroprotection. 50 - 61. 2011. http://www.scopus.com/inward/record.url?eid=2-s2.0-84884443449&partnerID=MN8TOARS . 10.2174/978160805092511101010050 . Molecular Aspects of Neurodegeneration and Neuroprotection

Neurofilamentopathy in neurodegenerative diseases

Liu, Q.; Xie, F.; Alvarado-Diaz, A.; Smith, M.A.; Moreira, P.I.; Zhu, X.; Perry, G., 2011. Open Neurology Journal. 58 - 62. 1. 5. 2011. http://www.scopus.com/inward/record.url?eid=2-s2.0-80053515856&partnerID=MN8TOARS . 10.2174/1874205X01105010058 . Open Neurology Journal

Using biology to untie the Gordian knot of Alzheimer's disease

Perry, G.; Smith, M.A.; Casadesus, G.; Lee, H.-G.; Moreira, P.I.; Castellani, R.J.; Zhu, X., 2011. Journal of Alzheimer's Disease. SUPPL. 1. 23. 2011. http://www.scopus.com/inward/record.url?eid=2-s2.0-79952176838&partnerID=MN8TOARS . 10.3233/JAD-2011-001433 . Journal of Alzheimer's Disease

Mitochondria from distinct tissues are differently affected by 17ß-estradiol and tamoxifen

Moreira, P.I.; Custódio, J.B.A.; Nunes, E.; Oliveira, P.J.; Moreno, A.; Seia, R.; Oliveira, C.R.; Santos, M.S., 2011. Journal of Steroid Biochemistry and Molecular Biology. 8 - 16. 1-2. 123. 2011. http://www.scopus.com/inward/record.url?eid=2-s2.0-78650578395&partnerID=MN8TOARS . 10.1016/j.jsbmb.2010.09.004 . Journal of Steroid Biochemistry and Molecular Biology

Effects of rapamycin and TOR on aging and memory: Implications for Alzheimer's disease

Santos, R.X.; Correia, S.C.; Cardoso, S.; Carvalho, C.; Santos, M.S.; Moreira, P.I., 2011. Journal of Neurochemistry. 927 - 936. 6. 117. 2011. http://www.scopus.com/inward/record.url?eid=2-s2.0-79957971392&partnerID=MN8TOARS . 10.1111/j.1471-4159.2011.07262.x . Journal of Neurochemistry

Mitochondrial preconditioning: A potential neuroprotective strategy

Correia, S.C.; Carvalho, C.; Cardoso, S.; Santos, R.X.; Santos, M.S.; Oliveira, C.R.; Perry, G.; et al, 2010. Frontiers in Aging Neuroscience. AUG. 2. 2010. http://www.scopus.com/inward/record.url?eid=2-s2.0-79955962818&partnerID=MN8TOARS . 10.3389/fnagi.2010.00138 . Frontiers in Aging Neuroscience

Mitochondrial dysfunction is a trigger of Alzheimer's disease pathophysiology

Moreira, P.I.; Carvalho, C.; Zhu, X.; Smith, M.A.; Perry, G., 2010. Biochimica et Biophysica Acta - Molecular Basis of Disease. 2 - 10. 1. 1802. 2010. http://www.scopus.com/inward/record.url?eid=2-s2.0-71749121998&partnerID=MN8TOARS . 10.1016/j.bbadis.2009.10.006 . Biochimica et Biophysica Acta - Molecular Basis of Disease

Alzheimer's Disease: An Overview

Moreira, P.I.; Zhu, X.; Smith, M.A.; Perry, G.; Castellani, R.J., 2010. Encyclopedia of Neuroscience. 259 - 263. 2010. http://www.scopus.com/inward/record.url?eid=2-s2.0-84882903387&partnerID=MN8TOARS . 10.1016/B978-008045046-9.00544-1 . Encyclopedia of Neuroscience

Mitochondrial control of autophagic lysosomal pathway in Alzheimer's disease

Cardoso, S.M.; Pereira, C.F.; Moreira, P.I.; Arduino, D.M.; Esteves, A.R.; Oliveira, C.R., 2010. Experimental Neurology. 294 - 298. 2. 223. 2010. http://www.scopus.com/inward/record.url?eid=2-s2.0-77952549554&partnerID=MN8TOARS . 10.1016/j.expneurol.2009.06.008 . Experimental Neurology

Targeting autophagy in the brain: A promising approach?

Santos, R.X.; Cardoso, S.; Correia, S.; Carvalho, C.; Santos, M.S.; Moreira, P.I., 2010. Central Nervous System Agents in Medicinal Chemistry. 158 - 168. 2. 10. 2010. http://www.scopus.com/inward/record.url?eid=2-s2.0-77953681716&partnerID=MN8TOARS . Central Nervous System Agents in Medicinal Chemistry

Detection and localization of markers of oxidative stress by in situ methods: application in the study of Alzheimer disease.

Moreira, P.I.; Sayre, L.M.; Zhu, X.; Nunomura, A.; Smith, M.A.; Perry, G., 2010. Methods in molecular biology (Clifton, N.J.). 419 - 434. 610. 2010. http://www.scopus.com/inward/record.url?eid=2-s2.0-77449159407&partnerID=MN8TOARS . Methods in molecular biology (Clifton, N.J.)

Mitochondria: A therapeutic target in neurodegeneration

Moreira, P.I.; Zhu, X.; Wang, X.; Lee, H.-g.; Nunomura, A.; Petersen, R.B.; Perry, G.; Smith, M.A., 2010. Biochimica et Biophysica Acta - Molecular Basis of Disease. 212 - 220. 1. 1802. 2010. http://www.scopus.com/inward/record.url?eid=2-s2.0-71849088759&partnerID=MN8TOARS . 10.1016/j.bbadis.2009.10.007 . Biochimica et Biophysica Acta - Molecular Basis of Disease

Cortical and hippocampal mitochondria bioenergetics and oxidative status during hyperglycemia and/or insulin-induced hypoglycemia

Cardoso, S.; Santos, M.S.; Seiça, R.; Moreira, P.I., 2010. Biochimica et Biophysica Acta - Molecular Basis of Disease. 942 - 951. 11. 1802. 2010. http://www.scopus.com/inward/record.url?eid=2-s2.0-77956710094&partnerID=MN8TOARS . 10.1016/j.bbadis.2010.07.001 . Biochimica et Biophysica Acta - Molecular Basis of Disease

Alzheimer's disease: Diverse aspects of mitochondrial malfunctioning

Santos, R.X.; Correia, S.C.; Wang, X.; Perry, G.; Smith, M.A.; Moreira, P.I.; Zhu, X., 2010. International Journal of Clinical and Experimental Pathology. 570 - 581. 6. 3. 2010. http://www.scopus.com/inward/record.url?eid=2-s2.0-77956026971&partnerID=MN8TOARS . International Journal of Clinical and Experimental Pathology

Autophagy in Alzheimers disease

Moreira, P.I.; Santos, R.X.; Zhu, X.; Lee, H.-G.; Smith, M.A.; Casadesus, G.; Perry, G., 2010. Expert Review of Neurotherapeutics. 1209 - 1218. 7. 10. 2010. http://www.scopus.com/inward/record.url?eid=2-s2.0-77954196784&partnerID=MN8TOARS . 10.1586/ern.10.84 . Expert Review of Neurotherapeutics

Effects of estrogen in the brain: Is it a neuroprotective agent in alzheimer's disease?

Correia, S.C.; Santos, R.X.; Cardoso, S.; Carvalho, C.; Santos, M.S.; Oliveira, C.R.; Moreira, P.I., 2010. Current Aging Science. 113 - 126. 2. 3. 2010. http://www.scopus.com/inward/record.url?eid=2-s2.0-77953736213&partnerID=MN8TOARS . 10.2174/1874609811003020113 . Current Aging Science

Hypoxia-inducible factor 1: A new hope to counteract neurodegeneration?

Correia, S.C.; Moreira, P.I., 2010. Journal of Neurochemistry. 1 - 12. 1. 112. 2010. http://www.scopus.com/inward/record.url?eid=2-s2.0-71649085107&partnerID=MN8TOARS . 10.1111/j.1471-4159.2009.06443.x . Journal of Neurochemistry

Mitochondrial dysfunction and oxidative stress in Alzheimer's disease

Moreira, P.I., 2010. European Neurological Review. 17 - 21. 1. 5. 2010. http://www.scopus.com/inward/record.url?eid=2-s2.0-84858166678&partnerID=MN8TOARS . European Neurological Review

Chronic hypoxia potentiates age-related oxidative imbalance in brain vessels and synaptosomes

Carvalho, C.; Santos, M.S.; Baldeiras, I.; Oliveira, C.R.; Seiça, R.; Moreira, P.I., 2010. Current Neurovascular Research. 288 - 300. 4. 7. 2010. http://www.scopus.com/inward/record.url?eid=2-s2.0-78650657043&partnerID=MN8TOARS . Current Neurovascular Research

A synergistic dysfunction of mitochondrial fission/fusion dynamics and mitophagy in Alzheimer's disease

Santos, R.X.; Correia, S.C.; Wang, X.; Perry, G.; Smith, M.A.; Moreira, P.I.; Zhu, X., 2010. Journal of Alzheimer's Disease. SUPPL.2. 20. 2010. http://www.scopus.com/inward/record.url?eid=2-s2.0-77956199031&partnerID=MN8TOARS . 10.3233/JAD-2010-100666 . Journal of Alzheimer's Disease

Mitochondria: The missing link between preconditioning and neuroprotection

Correia, S.C.; Santos, R.X.; Perry, G.; Zhu, X.; Moreira, P.I.; Smith, M.A., 2010. Journal of Alzheimer's Disease. SUPPL.2. 20. 2010. http://www.scopus.com/inward/record.url?eid=2-s2.0-77956220265&partnerID=MN8TOARS . 10.3233/JAD-2010-100669 . Journal of Alzheimer's Disease

Role of mitochondrial-mediated signaling pathways in Alzheimer disease and hypoxia

Carvalho, C.; Correia, S.C.; Santos, R.X.; Cardoso, S.; Moreira, P.I.; Clark, T.A.; Zhu, X.; Smith, M.A.; Perry, G., 2009. Journal of Bioenergetics and Biomembranes. 433 - 440. 5. 41. 2009. http://www.scopus.com/inward/record.url?eid=2-s2.0-70449397210&partnerID=MN8TOARS . 10.1007/s10863-009-9247-1 . Journal of Bioenergetics and Biomembranes

Mitochondria as a therapeutic target in Alzheimer's disease and diabetes

Moreira, P.I.; Cardoso, S.M.; Pereira, C.M.; Santos, M.S.; Oliveira, C.R., 2009. CNS and Neurological Disorders - Drug Targets. 492 - 511. 6. 8. 2009. http://www.scopus.com/inward/record.url?eid=2-s2.0-75849136180&partnerID=MN8TOARS . 10.2174/187152709789824651 . CNS and Neurological Disorders - Drug Targets

Altered redox balance in disease: Can we change the new equilibria?

Perry, G.; Xiongvei, Z.; Moreira, P.I.; Smith, M.A., 2009. Annals of Neurology. 121 - 122. 2. 65. 2009. http://www.scopus.com/inward/record.url?eid=2-s2.0-62549117802&partnerID=MN8TOARS . 10.1002/ana.21608 . Annals of Neurology

Natural oxidant balance in Parkinson disease

Perry, G.; Moreira, P.I.; Siedlak, S.L.; Nunomura, A.; Zhu, X.; Smith, M.A., 2009. Archives of Neurology. 12. 66. 2009. http://www.scopus.com/inward/record.url?eid=2-s2.0-73549092919&partnerID=MN8TOARS . 10.1001/archneurol.2009.261 . Archives of Neurology

Food deprivation promotes oxidative imbalance in rat brain

Santos, R.X.; Cardoso, S.; Silva, S.; Correia, S.; Carvalho, C.; Crisóstomo, J.; Rodrigues, L.; et al, 2009. Journal of Food Science. 1. 74. 2009. http://www.scopus.com/inward/record.url?eid=2-s2.0-58649112769&partnerID=MN8TOARS . 10.1111/j.1750-3841.2008.00982.x . Journal of Food Science

An integrative view of the role of oxidative stress, mitochondria and insulin in Alzheimer's disease

Moreira, P.I.; Duarte, A.I.; Santos, M.S.; Rego, A.C.; Oliveira, C.R., 2009. Journal of Alzheimer's Disease. 741 - 761. 4. 16. 2009. http://www.scopus.com/inward/record.url?eid=2-s2.0-67649687039&partnerID=MN8TOARS . 10.3233/JAD-2009-0972 . Journal of Alzheimer's Disease

Insulin is a two-edged knife on the brain

Cardoso, S.; Correia, S.; Santos, R.X.; Carvalho, C.; Santos, M.S.; Oliveira, C.R.; Perry, G.; et al, 2009. Journal of Alzheimer's Disease. 483 - 507. 3. 18. 2009. http://www.scopus.com/inward/record.url?eid=2-s2.0-75249106915&partnerID=MN8TOARS . Journal of Alzheimer's Disease

Doxorubicin: The good, the bad and the ugly effect

Carvalho, C.; Santos, R.X.; Cardoso, S.; Correia, S.; Oliveira, P.J.; Santos, M.S.; Moreira, P.I., 2009. Current Medicinal Chemistry. 3267 - 3285. 25. 16. 2009. http://www.scopus.com/inward/record.url?eid=2-s2.0-70450215499&partnerID=MN8TOARS . 10.2174/092986709788803312 . Current Medicinal Chemistry

RNA oxidation in Alzheimer disease and related neurodegenerative disorders

Nunomura, A.; Hofer, T.; Moreira, P.I.; Castellani, R.J.; Smith, M.A.; Perry, G., 2009. Acta Neuropathologica. 151 - 166. 1. 118. 2009. http://www.scopus.com/inward/record.url?eid=2-s2.0-67349251839&partnerID=MN8TOARS . 10.1007/s00401-009-0508-1 . Acta Neuropathologica

Therapeutic opportunities in Alzheimer disease: Current concepts

Marlatt, M.W.; Moreira, P.I.; Lee, H.-g.; Casadesus, G.; Castellani, R.J.; Takeda, A.; Nunomura, A.; et al, 2009. Frontiers in Medicinal Chemistry. 767 - 788. 1. 4. 2009. http://www.scopus.com/inward/record.url?eid=2-s2.0-84880176698&partnerID=MN8TOARS . Frontiers in Medicinal Chemistry

Oxidative stress signaling in Alzheimer's disease

Su, B.; Wang, X.; Nunomura, A.; Moreira, P.I.; Lee, H.-G.; Perry, G.; Smith, M.A.; Zhu, X., 2008. Current Alzheimer Research. 525 - 532. 6. 5. 2008. http://www.scopus.com/inward/record.url?eid=2-s2.0-58049202374&partnerID=MN8TOARS . 10.2174/156720508786898451 . Current Alzheimer Research

Guidelines for the use and interpretation of assays for monitoring autophagy in higher eukaryotes

Klionsky, D.J.; Abeliovich, H.; Agostinis, P.; Agrawal, D.K.; Aliev, G.; Askew, D.S.; Baba, M.; et al, 2008. Autophagy. 151 - 175. 2. 4. 2008. http://www.scopus.com/inward/record.url?eid=2-s2.0-38949108670&partnerID=MN8TOARS . Autophagy

Metformin protects the brain against the oxidative imbalance promoted by type 2 diabetes

Correia, S.; Carvalho, C.; Santos, M.S.; Proença, T.; Nunes, E.; Duarte, A.I.; Monteiro, P.; et al, 2008. Medicinal Chemistry. 358 - 364. 4. 4. 2008. http://www.scopus.com/inward/record.url?eid=2-s2.0-50049125341&partnerID=MN8TOARS . 10.2174/157340608784872299 . Medicinal Chemistry

Brain oxidative stress in a triple-transgenic mouse model of Alzheimer disease

Resende, R.; Moreira, P.I.; Proença, T.; Deshpande, A.; Busciglio, J.; Pereira, C.; Oliveira, C.R., 2008. Free Radical Biology and Medicine. 2051 - 2057. 12. 44. 2008. http://www.scopus.com/inward/record.url?eid=2-s2.0-43849096294&partnerID=MN8TOARS . 10.1016/j.freeradbiomed.2008.03.012 . Free Radical Biology and Medicine

Sublethal RNA oxidation as a mechanism for neurodegenerative disease

Castellani, R.J.; Nunomura, A.; Rolston, R.K.; Moreira, P.I.; Takeda, A.; Perry, G.; Smith, M.A., 2008. International Journal of Molecular Sciences. 789 - 806. 5. 9. 2008. http://www.scopus.com/inward/record.url?eid=2-s2.0-44649138016&partnerID=MN8TOARS . 10.3390/ijms9050789 . International Journal of Molecular Sciences

Mechanisms of action of metformin in type 2 diabetes and associated complications: an overview.

Correia, S.; Carvalho, C.; Santos, M.S.; Seiça, R.; Oliveira, C.R.; Moreira, P.I., 2008. Mini reviews in medicinal chemistry. 1343 - 1354. 13. 8. 2008. http://www.scopus.com/inward/record.url?eid=2-s2.0-58149377770&partnerID=MN8TOARS . 10.2174/138955708786369546 . Mini reviews in medicinal chemistry

Nucleic acid oxidation in Alzheimer disease

Moreira, P.I.; Nunomura, A.; Nakamura, M.; Takeda, A.; Shenk, J.C.; Aliev, G.; Smith, M.A.; Perry, G., 2008. Free Radical Biology and Medicine. 1493 - 1505. 8. 44. 2008. http://www.scopus.com/inward/record.url?eid=2-s2.0-41149166082&partnerID=MN8TOARS . 10.1016/j.freeradbiomed.2008.01.002 . Free Radical Biology and Medicine

Alzheimer disease and the role of free radicals in the pathogenesis of the disease

Moreira, P.I.; Santos, M.S.; Oliveira, C.R.; Shenk, J.C.; Nunomura, A.; Smith, M.A.; Zhu, X.; Perry, G., 2008. CNS and Neurological Disorders - Drug Targets. 3 - 10. 1. 7. 2008. http://www.scopus.com/inward/record.url?eid=2-s2.0-42049116923&partnerID=MN8TOARS . 10.2174/187152708783885156 . CNS and Neurological Disorders - Drug Targets

Doxorubicin increases the susceptibility of brain mitochondria to Ca2+-induced permeability transition and oxidative damage

Cardoso, S.; Santos, R.X.; Carvalho, C.; Correia, S.; Pereira, G.C.; Pereira, S.S.; Oliveira, P.J.; et al, 2008. Free Radical Biology and Medicine. 1395 - 1402. 10. 45. 2008. http://www.scopus.com/inward/record.url?eid=2-s2.0-54349099428&partnerID=MN8TOARS . 10.1016/j.freeradbiomed.2008.08.008 . Free Radical Biology and Medicine

Antioxidant therapy in Alzheimer's disease: theory and practice.

Aliev, G.; Obrenovich, M.E.; Reddy, V.P.; Shenk, J.C.; Moreira, P.I.; Nunomura, A.; Zhu, X.; Smith, M.A.; Perry, G., 2008. Mini reviews in medicinal chemistry. 1395 - 1406. 13. 8. 2008. http://www.scopus.com/inward/record.url?eid=2-s2.0-58149374037&partnerID=MN8TOARS . 10.2174/138955708786369582 . Mini reviews in medicinal chemistry

Metformin promotes isolated rat liver mitochondria impairment

Carvalho, C.; Correia, S.; Santos, M.S.; Seiça, R.; Oliveira, C.R.; Moreira, P.I., 2008. Molecular and Cellular Biochemistry. 75 - 83. 1-2. 308. 2008. http://www.scopus.com/inward/record.url?eid=2-s2.0-38649115973&partnerID=MN8TOARS . 10.1007/s11010-007-9614-3 . Molecular and Cellular Biochemistry

Amyloid-ß overproduction causes abnormal mitochondrial dynamics via differential modulation of mitochondrial fission/fusion proteins

Wang, X.; Su, B.; Siedlak, S.L.; Moreira, P.I.; Fujioka, H.; Wang, Y.; Casadesus, G.; Zhu, X., 2008. Proceedings of the National Academy of Sciences of the United States of America. 19318 - 19323. 49. 105. 2008. http://www.scopus.com/inward/record.url?eid=2-s2.0-58049218922&partnerID=MN8TOARS . 10.1073/pnas.0804871105 . Proceedings of the National Academy of Sciences of the United States of America

Neuropathology and treatment of Alzheimer disease: Did we lose the forest for the trees?

Castellani, R.J.; Zhu, X.; Lee, H.-G.; Moreira, P.I.; Perry, G.; Smith, M.A., 2007. Expert Review of Neurotherapeutics. 473 - 485. 5. 7. 2007. http://www.scopus.com/inward/record.url?eid=2-s2.0-34248326079&partnerID=MN8TOARS . 10.1586/14737175.7.5.473 . Expert Review of Neurotherapeutics

Indices of metabolic dysfunction and oxidative stress

Casadesus, G.; Moreira, P.I.; Nunomura, A.; Siedlak, S.L.; Bligh-Glover, W.; Balraj, E.; Petot, G.; Smith, M.A.; Perry, G., 2007. Neurochemical Research. 717 - 722. 4-5. 32. 2007. http://www.scopus.com/inward/record.url?eid=2-s2.0-33947593456&partnerID=MN8TOARS . 10.1007/s11064-007-9296-y . Neurochemical Research

Prevention and treatment of Alzheimer disease and aging: Antioxidants

Liu, Q.; Xie, F.; Rolston, R.; Moreira, P.I.; Nunomura, A.; Zhu, X.; Smith, M.A.; Perry, G., 2007. Mini-Reviews in Medicinal Chemistry. 171 - 180. 2. 7. 2007. http://www.scopus.com/inward/record.url?eid=2-s2.0-33847776693&partnerID=MN8TOARS . 10.2174/138955707779802552 . Mini-Reviews in Medicinal Chemistry

Vascular oxidative stress in Alzheimer disease

Zhu, X.; Smith, M.A.; Honda, K.; Aliev, G.; Moreira, P.I.; Nunomura, A.; Casadesus, G.; et al, 2007. Journal of the Neurological Sciences. 240 - 246. 1-2. 257. 2007. http://www.scopus.com/inward/record.url?eid=2-s2.0-34249776958&partnerID=MN8TOARS . 10.1016/j.jns.2007.01.039 . Journal of the Neurological Sciences

Estradiol affects liver mitochondrial function in ovariectomized and tamoxifen-treated ovariectomized female rats

Moreira, P.I.; Custódio, J.B.A.; Nunes, E.; Moreno, A.; Seiça, R.; Oliveira, C.R.; Santos, M.S., 2007. Toxicology and Applied Pharmacology. 102 - 110. 1. 221. 2007. http://www.scopus.com/inward/record.url?eid=2-s2.0-34247869542&partnerID=MN8TOARS . 10.1016/j.taap.2007.02.006 . Toxicology and Applied Pharmacology

Iron: The redox-active center of oxidative stress in Alzheimer disease

Castellani, R.J.; Moreira, P.I.; Liu, G.; Dobson, J.; Perry, G.; Smith, M.A.; Zhu, X., 2007. Neurochemical Research. 1640 - 1645. 10. 32. 2007. http://www.scopus.com/inward/record.url?eid=2-s2.0-34548744723&partnerID=MN8TOARS . 10.1007/s11064-007-9360-7 . Neurochemical Research

Soybean oil treatment impairs glucose-stimulated insulin secretion and changes fatty acid composition of normal and diabetic islets

Nunes, E.; Peixoto, F.; Louro, T.; Sena, C.M.; Santos, M.S.; Matafome, P.; Moreira, P.I.; Seiça, R., 2007. Acta Diabetologica. 121 - 130. 3. 44. 2007. http://www.scopus.com/inward/record.url?eid=2-s2.0-34548177719&partnerID=MN8TOARS . 10.1007/s00592-007-0252-8 . Acta Diabetologica

Erratum: Autophagocytosis of mitochondria is prominent in Alzheimer disease (Journal of Neuropathology and Experimental Neurology (2007) 66, (525-532))

Moreira, P.I.; Siedlak, S.L.; Wang, X.; Santos, M.S.; Oliveira, C.R.; Tabaton, M.; Nunomura, A.; et al, 2007. Journal of Neuropathology and Experimental Neurology. 7. 66. 2007. http://www.scopus.com/inward/record.url?eid=2-s2.0-34447321588&partnerID=MN8TOARS . 10.1097/01.jnen.0000263876.99435.cb . Journal of Neuropathology and Experimental Neurology

Neuronal death and survival under oxidative stress in Alzheimer and Parkinson diseases

Nunomura, A.; Moreira, P.I.; Lee, H.G.; Zhu, X.; Castellani, R.J.; Smith, M.A.; Perry, G., 2007. CNS and Neurological Disorders - Drug Targets. 411 - 423. 6. 6. 2007. http://www.scopus.com/inward/record.url?eid=2-s2.0-41749088686&partnerID=MN8TOARS . 10.2174/187152707783399201 . CNS and Neurological Disorders - Drug Targets

Erratum: Increased autophagic degradation of mitochondria in Alzheimer disease (Autophagy)

Moreira, P.I.; Siedlak, S.L.; Wang, X.; Santos, M.S.; Oliveira, C.R.; Tabaton, M.; Nunomura, A.; et al, 2007. Autophagy. 614 - 615. 6. 3. 2007. http://www.scopus.com/inward/record.url?eid=2-s2.0-35848931249&partnerID=MN8TOARS . Autophagy

Lipoic acid and N-acetyl cysteine decrease mitochondrial-related oxidative stress in Alzheimer disease patient fibroblasts

Moreira, P.I.; Harris, P.L.R.; Zhu, X.; Santos, M.S.; Oliveira, C.R.; Smith, M.A.; Perry, G., 2007. Journal of Alzheimer's Disease. 195 - 206. 2. 12. 2007. http://www.scopus.com/inward/record.url?eid=2-s2.0-34848890388&partnerID=MN8TOARS . Journal of Alzheimer's Disease

The key role of oxidative stress in alzheimer's disease

Moreira, P.I.; Nunomura, A.; Honda, K.; Aliev, G.; Casadesus, G.; Zhu, X.; Smith, M.A.; Perry, G., 2007. Oxidative Stress and Neurodegenerative Disorders. 267 - 281. 2007. http://www.scopus.com/inward/record.url?eid=2-s2.0-84882487316&partnerID=MN8TOARS . 10.1016/B978-044452809-4/50153-8 . Oxidative Stress and Neurodegenerative Disorders

Autophagocytosis of mitochondria is prominent in Alzheimer disease

Moreira, P.I.; Siedlak, S.L.; Wang, X.; Santos, M.S.; Oliveira, C.R.; Tabaton, M.; Nunomura, A.; et al, 2007. Journal of Neuropathology and Experimental Neurology. 525 - 532. 6. 66. 2007. http://www.scopus.com/inward/record.url?eid=2-s2.0-34249881080&partnerID=MN8TOARS . 10.1097/01.jnen.0000240476.73532.b0 . Journal of Neuropathology and Experimental Neurology

Brain mitochondrial dysfunction as a link between Alzheimer's disease and diabetes

Moreira, P.I.; Santos, M.S.; Seiça, R.; Oliveira, C.R., 2007. Journal of the Neurological Sciences. 206 - 214. 1-2. 257. 2007. http://www.scopus.com/inward/record.url?eid=2-s2.0-34249821079&partnerID=MN8TOARS . 10.1016/j.jns.2007.01.017 . Journal of the Neurological Sciences

Oxidative RNA damage and neurodegeneration

Nunomura, A.; Moreira, P.I.; Takeda, A.; Smith, M.A.; Perry, G., 2007. Current Medicinal Chemistry. 2968 - 2975. 28. 14. 2007. http://www.scopus.com/inward/record.url?eid=2-s2.0-36849076772&partnerID=MN8TOARS . 10.2174/092986707782794078 . Current Medicinal Chemistry

Neurodegeneration in Alzheimer's disease: Inter-organelle cross-talk and oxidative stress in cell life and death decisions

Ferreiro, Elisabete; Resende, Rosa; Costa, Rui Miguel Oliveira da; Moreira, Paula Isabel; Morais Cardoso, Sandra; Pereira, Cláudia; Resende de Oliveira, Catarina; et al, 2007. Free Radical Research. S11 - S11. 41. 2007. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000252296300021&KeyUID=WOS:000252296300021 . Free Radical Research

Alzheimer's disease: A lesson from mitochondrial dysfunction

Moreira, P.I.; Santos, M.S.; Oliveira, C.R., 2007. Antioxidants and Redox Signaling. 1621 - 1630. 10. 9. 2007. http://www.scopus.com/inward/record.url?eid=2-s2.0-34648831384&partnerID=MN8TOARS . 10.1089/ars.2007.1703 . Antioxidants and Redox Signaling

Compensatory responses induced by oxidative stress in Alzheimer disease

Moreira, P.I.; Zhu, X.; Liu, Q.; Honda, K.; Siedlak, S.L.; Harris, P.L.; Smith, M.A.; Perry, G., 2006. Biological Research. 7 - 13. 1. 39. 2006. http://www.scopus.com/inward/record.url?eid=2-s2.0-33745840777&partnerID=MN8TOARS . Biological Research

Mitochondrial abnormalities and oxidative imbalance in Alzheimer disease

Zhu, X.; Perry, G.; Moreira, P.I.; Aliev, G.; Cash, A.D.; Hirai, K.; Smith, M.A., 2006. Journal of Alzheimer's Disease. 147 - 153. 2. 9. 2006. http://www.scopus.com/inward/record.url?eid=2-s2.0-33746089859&partnerID=MN8TOARS . Journal of Alzheimer's Disease

Presenilin mutation: A deadly first hit in Alzheimer disease - A commentary on "aging sensitizes towards ROS formation and lipid peroxidation in PS1M146L transgenic mice"

Zhu, X.; Lee, H.-G.; Moreira, P.I.; Smith, M.A.; Perry, G., 2006. Free Radical Biology and Medicine. 737 - 739. 5. 40. 2006. http://www.scopus.com/inward/record.url?eid=2-s2.0-33644659794&partnerID=MN8TOARS . 10.1016/j.freeradbiomed.2005.12.028 . Free Radical Biology and Medicine

The (un)balance between metabolic and oxidative abnormalities and cellular compensatory responses in Alzheimer disease

Moreira, P.I.; Zhu, X.; Lee, H.-G.; Honda, K.; Smith, M.A.; Perry, G., 2006. Mechanisms of Ageing and Development. 501 - 506. 6. 127. 2006. http://www.scopus.com/inward/record.url?eid=2-s2.0-33646160622&partnerID=MN8TOARS . 10.1016/j.mad.2006.01.024 . Mechanisms of Ageing and Development

Neuropathology in Alzheimer's disease: awaking from a hundred-year-old dream.

Nunomura, A.; Castellani, R.J.; Lee, H.G.; Moreira, P.I.; Zhu, X.; Perry, G.; Smith, M.A., 2006. Science of aging knowledge environment : SAGE KE. 8. 2006. 2006. http://www.scopus.com/inward/record.url?eid=2-s2.0-33744531637&partnerID=MN8TOARS . 10.1126/sageke.2006.8.pe10 . Science of aging knowledge environment : SAGE KE

Involvement of oxidative stress in Alzheimer disease

Nunomura, A.; Castellani, R.J.; Zhu, X.; Moreira, P.I.; Perry, G.; Smith, M.A., 2006. Journal of Neuropathology and Experimental Neurology. 631 - 641. 7. 65. 2006. http://www.scopus.com/inward/record.url?eid=2-s2.0-33747861696&partnerID=MN8TOARS . 10.1097/01.jnen.0000228136.58062.bf . Journal of Neuropathology and Experimental Neurology

Brain and brawn: Parallels in oxidative strength

Moreira, P.I.; Honda, K.; Zhu, X.; Nunomura, A.; Casadesus, G.; Smith, M.A.; Perry, G., 2006. Neurology. 2 SUPPL. 1. 66. 2006. http://www.scopus.com/inward/record.url?eid=2-s2.0-33644850568&partnerID=MN8TOARS . Neurology

Telomeres and telomerase in Alzheimer's disease: Epiphenomena or a new focus for therapeutic strategy?

Franco, S.; Blasco, M.A.; Siedlak, S.L.; Harris, P.L.R.; Moreira, P.I.; Perry, G.; Smith, M.A., 2006. Alzheimer's and Dementia. 164 - 168. 3. 2. 2006. http://www.scopus.com/inward/record.url?eid=2-s2.0-33744931650&partnerID=MN8TOARS . 10.1016/j.jalz.2006.03.001 . Alzheimer's and Dementia

Insulin attenuates diabetes-related mitochondrial alterations: A comparative study

Moreira, P.I.; Rolo, A.P.; Sena, C.; Seiça, R.; Oliveira, C.R.; Santos, M.S., 2006. Medicinal Chemistry. 299 - 308. 3. 2. 2006. http://www.scopus.com/inward/record.url?eid=2-s2.0-33746153746&partnerID=MN8TOARS . 10.2174/157340606776930754 . Medicinal Chemistry

The key role of mitochondria in Alzheimer's disease

Moreira, P.I.; Cardoso, S.M.; Santos, M.S.; Oliveira, C.R., 2006. Journal of Alzheimer's Disease. 101 - 110. 2. 9. 2006. http://www.scopus.com/inward/record.url?eid=2-s2.0-33746066329&partnerID=MN8TOARS . Journal of Alzheimer's Disease

Therapeutic options in Alzheimer's disease

Moreira, P.I.; Zhu, X.; Nunomura, A.; Smith, M.A.; Perry, G., 2006. Expert Review of Neurotherapeutics. 897 - 910. 6. 6. 2006. http://www.scopus.com/inward/record.url?eid=2-s2.0-33745486884&partnerID=MN8TOARS . 10.1586/14737175.6.6.897 . Expert Review of Neurotherapeutics

Foreword: Mitochondria in Alzheimer disease

Moreira, P.I.; Oliveira, C., 2006. Journal of Alzheimer's Disease. 2. 9. 2006. http://www.scopus.com/inward/record.url?eid=2-s2.0-33746065622&partnerID=MN8TOARS . Journal of Alzheimer's Disease

Tamoxifen and estradiol interact with the flavin mononucleotide site of complex I leading to mitochondrial failure

Moreira, P.I.; Custódio, J.; Moreno, A.; Oliveira, C.R.; Santos, M.S., 2006. Journal of Biological Chemistry. 10143 - 10152. 15. 281. 2006. http://www.scopus.com/inward/record.url?eid=2-s2.0-33744518169&partnerID=MN8TOARS . 10.1074/jbc.M510249200 . Journal of Biological Chemistry

Oxidative stress mechanisms and potential therapeutics in Alzheimer disease

Moreira, P.I.; Siedlak, S.L.; Aliev, G.; Zhu, X.; Cash, A.D.; Smith, M.A.; Perry, G., 2005. Journal of Neural Transmission. 921 - 932. 7. 112. 2005. http://www.scopus.com/inward/record.url?eid=2-s2.0-20944449836&partnerID=MN8TOARS . 10.1007/s00702-004-0242-8 . Journal of Neural Transmission

Mitogen- and stress-activated protein kinase 1: Convergence of the ERK and p38 pathways in Alzheimer's disease

Webber, K.M.; Smith, M.A.; Lee, H.-G.; Harris, P.L.; Moreira, P.; Perry, G.; Zhu, X., 2005. Journal of Neuroscience Research. 554 - 560. 4. 79. 2005. http://www.scopus.com/inward/record.url?eid=2-s2.0-14144250344&partnerID=MN8TOARS . 10.1002/jnr.20380 . Journal of Neuroscience Research

Chronological primacy of oxidative stress in Alzheimer disease

Smith, M.A.; Nunomura, A.; Lee, H.-G.; Zhu, X.; Moreira, P.I.; Avila, J.; Perry, G., 2005. Neurobiology of Aging. 579 - 580. 5. 26. 2005. http://www.scopus.com/inward/record.url?eid=2-s2.0-13644249113&partnerID=MN8TOARS . 10.1016/j.neurobiolaging.2004.09.021 . Neurobiology of Aging

Alzheimer's disease and oxidative stress: The old problem remains unsolved

Moreira, P.I.; Honda, K.; Liu, Q.; Aliev, G.; Oliveira, C.R.; Santos, M.S.; Zhu, X.; Smith, M.A.; Perry, G., 2005. Current Medicinal Chemistry - Central Nervous System Agents. 51 - 62. 1. 5. 2005. http://www.scopus.com/inward/record.url?eid=2-s2.0-15344351142&partnerID=MN8TOARS . Current Medicinal Chemistry - Central Nervous System Agents

Alzheimer-specific epitopes of tau represent lipid peroxidation-induced conformations

Liu, Q.; Smith, M.A.; Avilá, J.; DeBernardis, J.; Kansal, M.; Takeda, A.; Zhu, X.; et al, 2005. Free Radical Biology and Medicine. 746 - 754. 6. 38. 2005. http://www.scopus.com/inward/record.url?eid=2-s2.0-13844267510&partnerID=MN8TOARS . 10.1016/j.freeradbiomed.2004.11.005 . Free Radical Biology and Medicine

Oxidative damage and Alzheimer's disease: Are antioxidant therapies useful?

Moreira, P.I.; Smith, M.A.; Zhu, X.; Honda, K.; Lee, H.-G.; Aliev, G.; Perry, G., 2005. Drug News and Perspectives. 13 - 19. 1. 18. 2005. http://www.scopus.com/inward/record.url?eid=2-s2.0-17444377148&partnerID=MN8TOARS . 10.1358/dnp.2005.18.1.877165 . Drug News and Perspectives

A second look into the oxidant mechanisms in Alzheimer's disease

Moreira, P.I.; Oliveira, C.R.; Santos, M.S.; Nunomura, A.; Honda, K.; Zhu, X.; Smith, M.A.; Perry, G., 2005. Current Neurovascular Research. 179 - 184. 2. 2. 2005. http://www.scopus.com/inward/record.url?eid=2-s2.0-18744402471&partnerID=MN8TOARS . 10.2174/1567202053586758 . Current Neurovascular Research

Tau phosphorylation in Alzheimer's disease: Pathogen or protector?

Lee, H.-G.; Perry, G.; Moreira, P.I.; Garrett, M.R.; Liu, Q.; Zhu, X.; Takeda, A.; Nunomura, A.; Smith, M.A., 2005. Trends in Molecular Medicine. 164 - 169. 4. 11. 2005. http://www.scopus.com/inward/record.url?eid=2-s2.0-17044435830&partnerID=MN8TOARS . 10.1016/j.molmed.2005.02.008 . Trends in Molecular Medicine

Ribosomal RNA in Alzheimer disease is oxidized by bound redox-active iron

Honda, K.; Smithi, M.A.; Zhu, X.; Baus, D.; Merrick, W.C.; Tartakoff, A.M.; Hattier, T.; et al, 2005. Journal of Biological Chemistry. 20978 - 20986. 22. 280. 2005. http://www.scopus.com/inward/record.url?eid=2-s2.0-20444383489&partnerID=MN8TOARS . 10.1074/jbc.M500526200 . Journal of Biological Chemistry

Therapeutic opportunities in Alzheimer Disease: One for all or all for one?

Marlatt, M.W.; Webber, K.M.; Moreira, P.I.; Lee, H.-G.; Casadesus, G.; Honda, K.; Zhu, X.; Perry, G.; Smith, M.A., 2005. Current Medicinal Chemistry. 1137 - 1147. 10. 12. 2005. http://www.scopus.com/inward/record.url?eid=2-s2.0-18544380930&partnerID=MN8TOARS . 10.2174/0929867053764644 . Current Medicinal Chemistry

Alzheimer's disease: An intracellular movement disorder?

Zhu, X.; Moreira, P.I.; Smith, M.A.; Perry, G., 2005. Trends in Molecular Medicine. 391 - 393. 9. 11. 2005. http://www.scopus.com/inward/record.url?eid=2-s2.0-24344483065&partnerID=MN8TOARS . 10.1016/j.molmed.2005.07.002 . Trends in Molecular Medicine

CoQ10 therapy attenuates amyloid ß-peptide toxicity in brain mitochondria isolated from aged diabetic rats

Moreira, P.I.; Santos, M.S.; Sena, C.; Nunes, E.; Seiça, R.; Oliveira, C.R., 2005. Experimental Neurology. 112 - 119. 1. 196. 2005. http://www.scopus.com/inward/record.url?eid=2-s2.0-26244447857&partnerID=MN8TOARS . 10.1016/j.expneurol.2005.07.012 . Experimental Neurology

Oxidative stress: The old enemy in Alzheimer's disease pathophysiology

Moreira, P.I.; Honda, K.; Liu, Q.; Santos, M.S.; Oliveira, C.R.; Aliev, G.; Nunomura, A.; et al, 2005. Current Alzheimer Research. 403 - 408. 4. 2. 2005. http://www.scopus.com/inward/record.url?eid=2-s2.0-24644443839&partnerID=MN8TOARS . 10.2174/156720505774330537 . Current Alzheimer Research

Redox active iron at the center of oxidative stress in Alzheimer disease

Honda, K.; Moreira, P.I.; Liu, Q.; Siedlak, S.L.; Zhu, X.; Smith, M.A.; Perry, G., 2005. Letters in Drug Design and Discovery. 479 - 482. 6. 2. 2005. http://www.scopus.com/inward/record.url?eid=2-s2.0-24744432930&partnerID=MN8TOARS . 10.2174/1570180054771545 . Letters in Drug Design and Discovery

Oxidative stress and neurodegeneration

Moreira, P.I.; Smith, M.A.; Zhu, X.; Nunomura, A.; Castellani, R.J.; Perry, G., 2005. Annals of the New York Academy of Sciences. 545 - 552. 1043. 2005. http://www.scopus.com/inward/record.url?eid=2-s2.0-23744439419&partnerID=MN8TOARS . 10.1196/annals.1333.062 . Annals of the New York Academy of Sciences

Metal ions and oxidative protein modification in neurological disease

Sayre, L.M.; Moreira, P.I.; Smith, M.A.; Perry, G., 2005. Annali dell'Istituto Superiore di Sanita. 143 - 164. 2. 41. 2005. http://www.scopus.com/inward/record.url?eid=2-s2.0-31644435822&partnerID=MN8TOARS . Annali dell'Istituto Superiore di Sanita

Alzheimer's disease-associated neurotoxic mechanisms and neuroprotective strategies

Pereira, C.; Agostinho, P.; Moreira, P.I.; Cardoso, S.M.; Oliveira, C.R., 2005. Current Drug Targets: CNS and Neurological Disorders. 383 - 403. 4. 4. 2005. http://www.scopus.com/inward/record.url?eid=2-s2.0-23144463734&partnerID=MN8TOARS . 10.2174/1568007054546117 . Current Drug Targets: CNS and Neurological Disorders

Brain mitochondrial injury induced by oxidative stress-related events is prevented by tamoxifen

Moreira, P.I.; Custódio, J.B.; Oliveira, C.R.; Santos, M.S., 2005. Neuropharmacology. 435 - 447. 3. 48. 2005. http://www.scopus.com/inward/record.url?eid=2-s2.0-13844275276&partnerID=MN8TOARS . 10.1016/j.neuropharm.2004.10.012 . Neuropharmacology

Neurodegenerative pathways in Parkinson's disease: Therapeutic strategies

Cardoso, S.M.; Moreira, P.I.; Agostinho, P.; Pereira, C.; Oliveira, C.R., 2005. Current Drug Targets: CNS and Neurological Disorders. 405 - 419. 4. 4. 2005. http://www.scopus.com/inward/record.url?eid=2-s2.0-23144431757&partnerID=MN8TOARS . 10.2174/1568007054546072 . Current Drug Targets: CNS and Neurological Disorders

Redox metals and oxidative abnormalities in human prion diseases

Petersen, R.B.; Siedlak, S.L.; Lee, H.-G.; Kim, Y.-S.; Nunomura, A.; Tagliavini, F.; Ghetti, B.; et al, 2005. Acta Neuropathologica. 232 - 238. 3. 110. 2005. http://www.scopus.com/inward/record.url?eid=2-s2.0-26444549058&partnerID=MN8TOARS . 10.1007/s00401-005-1034-4 . Acta Neuropathologica

Insulin protects against amyloid ß-peptide toxicity in brain mitochondria of diabetic rats

Moreira, P.I.; Santos, M.S.; Sena, C.; Seiça, R.; Oliveira, C.R., 2005. Neurobiology of Disease. 628 - 637. 3. 18. 2005. http://www.scopus.com/inward/record.url?eid=2-s2.0-14744294296&partnerID=MN8TOARS . 10.1016/j.nbd.2004.10.017 . Neurobiology of Disease

Neurofilament proteins in neurodegenerative diseases

Liu, Q.; Xie, F.; Siedlak, S.L.; Nunomura, A.; Honda, K.; Moreira, P.I.; Zhua, X.; Smith, M.A.; Perry, G., 2004. Cellular and Molecular Life Sciences. 3057 - 3075. 24. 61. 2004. http://www.scopus.com/inward/record.url?eid=2-s2.0-12144265815&partnerID=MN8TOARS . 10.1007/s00018-004-4268-8 . Cellular and Molecular Life Sciences

Staying connected: Synapses in alzheimer disease

Lee, H.-G.; Moreira, P.I.; Zhu, X.; Smith, M.A.; Perry, G., 2004. American Journal of Pathology. 1461 - 1464. 5. 165. 2004. http://www.scopus.com/inward/record.url?eid=2-s2.0-7244252913&partnerID=MN8TOARS . American Journal of Pathology

Therapeutic potential of oxidant mechanisms in Alzheimer's disease

Moreira, P.I.; Smith, M.A.; Zhu, X.; Santos, M.S.; Oliveira, C.R.; Perry, G., 2004. Expert Review of Neurotherapeutics. 995 - 1004. 6. 4. 2004. http://www.scopus.com/inward/record.url?eid=2-s2.0-8344235899&partnerID=MN8TOARS . 10.1586/14737175.4.6.995 . Expert Review of Neurotherapeutics

Effect of streptozotocin-induced diabetes on rat brain mitochondria

Moreira, P.I.; Santos, M.S.; Moreno, A.M.; Proença, T.; Seiça, R.; de Oliveira, C.R., 2004. Journal of Neuroendocrinology. 32 - 38. 1. 16. 2004. http://www.scopus.com/inward/record.url?eid=2-s2.0-0742324515&partnerID=MN8TOARS . 10.1111/j.1365-2826.2004.01107.x . Journal of Neuroendocrinology

Hydroxytamoxifen protects against oxidative stress in brain mitochondria

Moreira, P.I.; Custódio, J.B.; Oliveira, C.R.; Santos, M.S., 2004. Biochemical Pharmacology. 195 - 204. 1. 68. 2004. http://www.scopus.com/inward/record.url?eid=2-s2.0-2942568021&partnerID=MN8TOARS . 10.1016/j.bcp.2004.03.019 . Biochemical Pharmacology

Neuroprotection strategies: Effect of vinpocetinein in vitro oxidative stress models | Estratégias de neuroprotecção: Efeito da vimpocetina em modelos in vitro de stresse oxidativo

Pereira, C.; Agostinho, P.; Moreira, P.I.; Duarte, A.I.; Santos, M.S.; Oliveira, C.R., 2003. Acta Medica Portuguesa. 401 - 406. 6. 16. 2003. http://www.scopus.com/inward/record.url?eid=2-s2.0-9644310235&partnerID=MN8TOARS . Acta Medica Portuguesa

Increased vulnerability of brain mitochondria in diabetic (goto-kakizaki) rats with aging and amyloid-ß exposure

Moreira, P.I.; Santos, M.S.; Moreno, A.M.; Seiça, R.; Oliveira, C.R., 2003. Diabetes. 1449 - 1456. 6. 52. 2003. http://www.scopus.com/inward/record.url?eid=2-s2.0-0038321341&partnerID=MN8TOARS . 10.2337/diabetes.52.6.1449 . Diabetes

Effect of amyloid ß-peptide on permeability transition pore: A comparative study

Moreira, P.I.; Santos, M.S.; Moreno, A.; Rego, A.C.; Oliveira, C., 2002. Journal of Neuroscience Research. 257 - 267. 2. 69. 2002. http://www.scopus.com/inward/record.url?eid=2-s2.0-0037100213&partnerID=MN8TOARS . 10.1002/jnr.10282 . Journal of Neuroscience Research

Amyloid ß-peptide promotes permeability transition pore in brain mitochondria

Moreira, P.I.; Santos, M.S.; Moreno, A.; Oliveira, C., 2001. Bioscience Reports. 789 - 800. 6. 21. 2001. http://www.scopus.com/inward/record.url?eid=2-s2.0-0035780141&partnerID=MN8TOARS . 10.1023/A:1015536808304 . Bioscience Reports

Synaptosomal response to oxidative stress: Effect of vinpocetine

Santos, M.S.; Duarte, A.I.; Moreira, P.I.; Oliveira, C.R., 2000. Free Radical Research. 57 - 66. 1. 32. 2000. http://www.scopus.com/inward/record.url?eid=2-s2.0-0033988559&partnerID=MN8TOARS . Free Radical Research

Effect of zinc ions on the cytotoxicity induced by the amyloid ß- peptide

Moreira, P.; Pereira, C.; Santos, M.S.; Oliveira, C., 2000. Antioxidants and Redox Signaling. 317 - 325. 2. 2. 2000. http://www.scopus.com/inward/record.url?eid=2-s2.0-0033949740&partnerID=MN8TOARS . Antioxidants and Redox Signaling

Susceptibility to ß-amyloid-induced toxicity is decreased in Goto- Kakizaki diabetic rats: Involvement of oxidative stress

Pereira, C.; Moreira, P.; Seiça, R.; Santos, M.S.; Oliveira, C.R., 2000. Experimental Neurology. 383 - 391. 1. 161. 2000. http://www.scopus.com/inward/record.url?eid=2-s2.0-0034051172&partnerID=MN8TOARS . 10.1006/exnr.1999.7270 . Experimental Neurology

Effect of Zinc Ions on the Cytotoxicity Induced by the Amyloid beta-Peptide

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