Axons, Alzheimer's disease, Autophagy, Rare diseases, Neurodevelopment.
To characterize the role of heterogeneous nuclear ribonucleoproteins (hnRNPs) in neurodevelopmental disorders
To study the role of intra-axonal autophagy in the pathogenesis of Alzheimer’s disease
The laboratory research focuses on intra-axonal and dendritic signalling pathways, in hippocampal and cortical neurons, under physiological and pathological conditions. In particular, the research group aims to study the involvement of intra-axonal autophagy dysfunction in Alzheimer’s disease onset and understand the role of RNA-binding proteins in rare neurodevelopmental disorders and epilepsy.
The techniques applied in this laboratory include primary cell cultures, in vivo transfection of nucleic acids (in utero electroporation), in vitro and in vivo pharmacology, biochemical assays, immunocytochemistry, and confocal (live-)imaging.
These strategies allow a solid study of neuronal development and the mechanisms underlying brain neurodegenerative disorders, aiming at the development of new therapeutical approaches.
Information about journal articles, updated at 01-12-2024, from platform CIÊNCIAVITAE.
Brain-derived neurotrophic factor -induced regulation of RNA metabolism in neuronal development and synaptic plasticity
Rui O. Costa; Luís F. Martins; Emanuel Tahiri; Carlos B. Duarte, 2022. WIREs RNA. 2022. https://doi.org/10.1002/wrna.1713 . 10.1002/wrna.1713 . WIREs RNA
Isolation and Culture of Chick Ciliary Ganglion Neurons
Costa, Filipa J.; Dias, Marta S.; Costa, Rui O.; Pedro, Joana R.; Almeida, Ramiro D., 2020. Journal of Visualized Experiments. 162. 2020. http://dx.doi.org/10.3791/61431 . 10.3791/61431 . Journal of Visualized Experiments
Synaptogenesis Stimulates a Proteasome-Mediated Ribosome Reduction in Axons
Costa, Rui O.; Martins, Helena; Martins, Luís F.; Cwetsch, Andrzej W.; Mele, Miranda; Pedro, Joana R.; Tomé, Diogo; et al, 2019. Cell Reports. 864 - 876.e6. 4. 28. 2019. http://dx.doi.org/10.1016/j.celrep.2019.06.080 . 10.1016/j.celrep.2019.06.080 . Cell Reports
Alterations in GABAA-Receptor Trafficking and Synaptic Dysfunction in Brain Disorders
Mele, Miranda; Costa, Rui O.; Duarte, Carlos B., 2019. Frontiers in Cellular Neuroscience. 13. 2019. http://dx.doi.org/10.3389/fncel.2019.00077 . 10.3389/fncel.2019.00077 . Frontiers in Cellular Neuroscience
Mesenchymal stem cells secretome-induced axonal outgrowth is mediated by BDNF
Martins, L.F.; Costa, R.O.; Pedro, J.R.; Aguiar, P.; Serra, S.C.; Teixeira, F.G.; Sousa, N.; Salgado, A.J.; Almeida, R.D., 2017. Scientific Reports. 1. 7. 2017. http://www.scopus.com/inward/record.url?eid=2-s2.0-85021292472&partnerID=MN8TOARS . 10.1038/s41598-017-03592-1 . Scientific Reports
The RNA-Binding Protein hnRNP K Mediates the Effect of BDNF on Dendritic mRNA Metabolism and Regulates Synaptic NMDA Receptors in Hippocampal Neurons
Graciano Leal; Diogo Comprido; Pasqualino de Luca; Eduardo Morais; Luís Rodrigues; Miranda Mele; Ana R. Santos; et al, 2017. eneuro. ENEURO.0268 - 17.2017. 6. 4. 2017. https://doi.org/10.1523/ENEURO.0268-17.2017 . 10.1523/ENEURO.0268-17.2017 . eneuro
Preparation of Primary Cultures of Embryonic Rat Hippocampal and Cerebrocortical Neurons
Salazar, Ivan; Mele, Miranda; Caldeira, Margarida; Costa, Rui; Correia, Bárbara; Frisari, Simone; Duarte, Carlos; Costa RO, 2017. BIO-PROTOCOL. 18. 7. 2017. http://dx.doi.org/10.21769/bioprotoc.2551 . 10.21769/bioprotoc.2551 . BIO-PROTOCOL
PROneurotrophins and CONSequences
Costa, R.O.; Perestrelo, T.; Almeida, R.D., 2017. Molecular Neurobiology. 1 - 18. 2017. http://www.scopus.com/inward/record.url?eid=2-s2.0-85018273843&partnerID=MN8TOARS . 10.1007/s12035-017-0505-7 . Molecular Neurobiology
Visualizing K48 ubiquitination during presynaptic formation by ubiquitination-induced fluorescence complementation (UiFC)
Pinto, M.J.; Pedro, J.R.; Costa, R.O.; Almeida, R.D., 2016. Frontiers in Molecular Neuroscience. JUNE. 9. 2016. http://www.scopus.com/inward/record.url?eid=2-s2.0-84978476683&partnerID=MN8TOARS . 10.3389/fnmol.2016.00043 . Frontiers in Molecular Neuroscience
Oxidative stress involving changes in Nrf2 and ER stress in early stages of Alzheimer's disease
Costa, R.O.; Mota, S.I.; Ferreira, I.L.; Santana, I.; Caldeira, G.L.; Padovano, C.; Fonseca, A.C.; et al, 2015. Biochimica et Biophysica Acta - Molecular Basis of Disease. 1428 - 1441. 7. 1852. 2015. http://www.scopus.com/inward/record.url?eid=2-s2.0-84928128412&partnerID=MN8TOARS . 10.1016/j.bbadis.2015.03.015 . Biochimica et Biophysica Acta - Molecular Basis of Disease
Inhibition of mitochondrial cytochrome c oxidase potentiates Aß-induced ER stress and cell death in cortical neurons
Costa, R.O.; Ferreiro, E.; Oliveira, C.R.; Pereira, C.M.F., 2013. Molecular and Cellular Neuroscience. 1 - 8. 52. 2013. http://www.scopus.com/inward/record.url?eid=2-s2.0-84870349573&partnerID=MN8TOARS . 10.1016/j.mcn.2012.09.005 . Molecular and Cellular Neuroscience
Leptin and ghrelin prevent hippocampal dysfunction induced by Aß oligomers
Martins, I.; Gomes, S.; Costa, R.O.; Otvos, L.; Oliveira, C.R.; Resende, R.; Pereira, C.M.F., 2013. Neuroscience. 41 - 51. 241. 2013. http://www.scopus.com/inward/record.url?eid=2-s2.0-84876430099&partnerID=MN8TOARS . 10.1016/j.neuroscience.2013.02.062 . Neuroscience
Endoplasmic reticulum stress occurs downstream of GluN2B subunit of N-methyl-d-aspartate receptor in mature hippocampal cultures treated with amyloid-ß oligomers
Costa, R.O.; Lacor, P.N.; Ferreira, I.L.; Resende, R.; Auberson, Y.P.; Klein, W.L.; Oliveira, C.R.; Rego, A.C.; Pereira, C.M.F., 2012. Aging Cell. 823 - 833. 5. 11. 2012. http://www.scopus.com/inward/record.url?eid=2-s2.0-84866452758&partnerID=MN8TOARS . 10.1111/j.1474-9726.2012.00848.x . Aging Cell
Amyloid ß-induced ER stress is enhanced under mitochondrial dysfunction conditions
Costa, R.O.; Ferreiro, E.; Martins, I.; Santana, I.; Cardoso, S.M.; Oliveira, C.R.; Pereira, C.M.F., 2012. Neurobiology of Aging. 4. 33. 2012. http://www.scopus.com/inward/record.url?eid=2-s2.0-84856951448&partnerID=MN8TOARS . 10.1016/j.neurobiolaging.2011.04.011 . Neurobiology of Aging
Mitochondrial- and endoplasmic reticulum-associated oxidative stress in alzheimers disease: From pathogenesis to biomarkers
Ferreiro, E.; Baldeiras, I.; Ferreira, I.L.; Costa, R.O.; Rego, A.C.; Pereira, C.F.; Oliveira, C.R., 2012. International Journal of Cell Biology. 2012. http://www.scopus.com/inward/record.url?eid=2-s2.0-84863688106&partnerID=MN8TOARS . 10.1155/2012/735206 . International Journal of Cell Biology
ER stress-mediated apoptotic pathway induced by aß peptide requires the presence of functional mitochondria
Costa, R.O.; Ferreiro, E.; Cardoso, S.M.; Oliveira, C.R.; Pereira, C.M.F., 2010. Journal of Alzheimer's Disease. 625 - 636. 2. 20. 2010. http://www.scopus.com/inward/record.url?eid=2-s2.0-77954516455&partnerID=MN8TOARS . 10.3233/JAD-2010-091369 . Journal of Alzheimer's Disease
Involvement of mitochondria in endoplasmic reticulum stress-induced apoptotic cell death pathway triggered by the prion peptide PrP 106-126
Ferreiro, E.; Costa, R.; Marques, S.; Cardoso, S.M.; Oliveira, C.R.; Pereira, C.M.F., 2008. Journal of Neurochemistry. 766 - 776. 3. 104. 2008. http://www.scopus.com/inward/record.url?eid=2-s2.0-38049162500&partnerID=MN8TOARS . 10.1111/j.1471-4159.2007.05048.x . Journal of Neurochemistry
An endoplasmic-reticulum-specific apoptotic pathway is involved in prion and amyloid-beta peptides neurotoxicity
Ferreiro, E.; Resende, R.; Costa, R.; Oliveira, C.R.; Pereira, C.M.F., 2006. Neurobiology of Disease. 669 - 678. 3. 23. 2006. http://www.scopus.com/inward/record.url?eid=2-s2.0-33747195017&partnerID=MN8TOARS . 10.1016/j.nbd.2006.05.011 . Neurobiology of Disease
5 18 out of 18 Publications
Scientific Incentive Grant
Portuguese Epilepsy foundation (LPCE)
Best oral comunication at the 36º "Encontro Nacional de Epileptologia"
Title: The RNA-binding protein hnRNP H2: a novel player in epileptogenesis
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