Metabolism, Aging and Disease

Amyloid pathology in Alzheimer’s disease

Alzheimer´s disease

BACE 1

Glutaminyl Cyclase

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Leader

Armanda Emanuela Santos

Researcher

aesantos@cnc.uc.pt

Research lines

Molecular mechanisms associated to the pathogenesis of diseases that have aging as a major risk factor, namely Alzheimer’s disease (AD), in order to reveal new therapeutic targets

New drugs targeting BACE1 and glutaminyl cyclase, which have the potential to act as disease-modifying drugs, preventing brain changes associated to AD

New blood biomarkers allowing for early detection of Alzheimer’s disease.

Home Research Research Groups

Team

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Armanda Emanuela Santos

Leader

Researcher
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Rosa Maria Branco de Matos Resende

Researcher

Former members

Publications

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Information about journal articles, updated at 01-12-2024, from platform CIÊNCIAVITAE.

New Low-Dose Curcumin Derivative with Therapeutic Potential in Alzheimer’s Disease

Beatriz Rodrigues; Eduarda Ventura; Patrícia Moreira; Rosa Resende; Joana Bicker; Santos, Armanda E; Cláudia Fragão Pereira; et al, 2024. Free Radical Biology and Medicine. 2024. submitted Free Radical Biology and Medicine

BACE1 Inhibitors for Alzheimer’s Disease: Current Challenges and Future Perspectives

Coimbra, Judite R.M.; Resende, Rosa; Custódio, José B.A.; Salvador, Jorge A.R.; Santos, Armanda E., 2024. Journal of Alzheimer's Disease. S53 - S78. s1. 101. 2024. http://dx.doi.org/10.3233/jad-240146 . 10.3233/jad-240146 . Journal of Alzheimer's Disease

Targeting Alzheimer's disease hallmarks with the Nrf2 activator Isoeugenol.

Ana Silva; Sónia Silva; Jéssica Macedo; Patrícia Moreira; Diana Baptista; Joana Bicker; Ana Fortuna; et al, 2024. 2024. https://doi.org/10.32388/LUXM7W . submitted

Therapeutic potential of glutaminyl cyclases: Current status and emerging trends

Coimbra, Judite R.M.; Moreira, Paula I.; Santos, Armanda E.; Salvador, Jorge A.R., 2023. Drug Discovery Today. 10. 28. 2023. http://dx.doi.org/10.1016/j.drudis.2023.103644 . 10.1016/j.drudis.2023.103644 . Drug Discovery Today

Structural and Functional Alterations in Mitochondria-Associated Membranes (MAMs) and in Mitochondria Activate Stress Response Mechanisms in an In Vitro Model of Alzheimer’s Disease

Fernandes, Tânia; Resende, Rosa; Silva, Diana F.; Marques, Ana P.; Santos, Armanda E.; Cardoso, Sandra M.; Domingues, M. Rosário; Moreira, Paula I.; Pereira, Cláudia F., 2021. Biomedicines. 8. 9. 2021. http://dx.doi.org/10.3390/biomedicines9080881 . 10.3390/biomedicines9080881 . Biomedicines

Calcium Modulation, Anti-Oxidant and Anti-Inflammatory Effect of Skin Allergens Targeting the Nrf2 Signaling Pathway in Alzheimer’s Disease Cellular Models

Santos, Armanda, 2020. International Journal of Molecular Sciences. 2020. https://www.mdpi.com/1422-0067/21/20/7791 . 10.3390/ijms21207791 . International Journal of Molecular Sciences

New BACE1 chimeric peptide inhibitors selectively prevent AßPP-ß cleavage decreasing Aß production and accumulation in AD models

Santos, Armanda E, 2020. Journal of Alzheimers Disease. 2020. https://content.iospress.com/articles/journal-of-alzheimers-disease/jad200381 . 10.3233/JAD-200381 . Journal of Alzheimers Disease

Combining Virtual Screening Protocol and In Vitro Evaluation towards the Discovery of BACE1 Inhibitors

Judite R. M. Coimbra; Salete J. Baptista; Teresa C. P. Dinis; Maria M. C. Silva; Paula I. Moreira; Armanda E. Santos; Jorge A. R. Salvador, 2020. Biomolecules. 535 - 535. 4. 10. 2020. https://doi.org/10.3390/biom10040535 . 10.3390/biom10040535 . Biomolecules

Is Alzheimer's disease an inflammasomopathy?

Pereira, C.F.; Santos, A.E.; Moreira, P.I.; Pereira, A.C.; Sousa, F.J.; Cardoso, S.M.; Cruz, M.T., 2019. Ageing Research Reviews. 56. 2019. http://www.scopus.com/inward/record.url?eid=2-s2.0-85072809334&partnerID=MN8TOARS . 10.1016/j.arr.2019.100966 . Ageing Research Reviews

An overview of glutaminyl cyclase inhibitors for Alzheimer's disease

Coimbra, J.R.M.; Sobral, P.J.M.; Santos, A.E.; Moreira, P.I.; Salvador, J.A.R., 2019. Future Medicinal Chemistry. 3179 - 3194. 24. 11. 2019. http://www.scopus.com/inward/record.url?eid=2-s2.0-85076529321&partnerID=MN8TOARS . 10.4155/fmc-2019-0163 . Future Medicinal Chemistry

Highlights in BACE1 inhibitors for Alzheimer's disease treatment

Coimbra, J.R.M.; Marques, D.F.F.; Baptista, S.J.; Pereira, C.M.F.; Moreira, P.I.; Dinis, T.C.P.; Santos, A.E.; Salvador, J.A.R., 2018. Frontiers in Chemistry. MAY. 6. 2018. http://www.scopus.com/inward/record.url?eid=2-s2.0-85048225310&partnerID=MN8TOARS . 10.3389/fchem.2018.00178 . Frontiers in Chemistry

Polyphenolic characterization and bioactivity of an Oxalis pes-caprae L. leaf extract.

Santos, Armanda, 2018. Natural Product Research. 2018. https://www.ncbi.nlm.nih.gov/pubmed/28627294 . 10.1080/14786419.2017.1335728 . Natural Product Research

The activation of the G protein-coupled estrogen receptor (GPER) inhibits the proliferation of mouse melanoma K1735-M2 cells

Mariana P.C. Ribeiro; Armanda E. Santos; José B.A. Custódio, 2017. Chemico-Biological Interactions. 176 - 184. 277. 2017. https://doi.org/10.1016/j.cbi.2017.09.017 . 10.1016/j.cbi.2017.09.017 . Chemico-Biological Interactions

Ionotropic glutamate receptor antagonists and cancer therapy: time to think out of the box?

Ribeiro, M.P.C.; Custódio, J.B.A.; Santos, A.E., 2017. Cancer Chemotherapy and Pharmacology. 219 - 225. 2. 79. 2017. http://www.scopus.com/inward/record.url?eid=2-s2.0-84984821839&partnerID=MN8TOARS . 10.1007/s00280-016-3129-0 . Cancer Chemotherapy and Pharmacology

Multiple domains in the C-terminus of NMDA receptor GluN2B subunit contribute to neuronal death following in vitro ischemia

Vieira, M.M.; Schmidt, J.; Ferreira, J.S.; She, K.; Oku, S.; Mele, M.; Santos, A.E.; et al, 2016. Neurobiology of Disease. 223 - 234. 89. 2016. http://www.scopus.com/inward/record.url?eid=2-s2.0-84959360132&partnerID=MN8TOARS . 10.1016/j.nbd.2015.11.007 . Neurobiology of Disease

Rethinking tamoxifen in the management of melanoma: New answers for an old question

Ribeiro, M.P.C.; Santos, A.E.; Custódio, J.B.A., 2015. European Journal of Pharmacology. 372 - 378. 764. 2015. http://www.scopus.com/inward/record.url?eid=2-s2.0-84937509486&partnerID=MN8TOARS . 10.1016/j.ejphar.2015.07.023 . European Journal of Pharmacology

Ischemic insults induce necroptotic cell death in hippocampal neurons through the up-regulation of endogenous RIP3

Vieira, M.; Fernandes, J.; Carreto, L.; Anuncibay-Soto, B.; Santos, M.; Han, J.; Fernández-López, A.; et al, 2014. Neurobiology of Disease. 26 - 36. 68. 2014. http://www.scopus.com/inward/record.url?eid=2-s2.0-84899850247&partnerID=MN8TOARS . 10.1016/j.nbd.2014.04.002 . Neurobiology of Disease

The combination of glutamate receptor antagonist MK-801 with tamoxifen and its active metabolites potentiates their antiproliferative activity in mouse melanoma K1735-M2 cells

Ribeiro, M.P.C.; Nunes-Correia, I.; Santos, A.E.; Custódio, J.B.A., 2014. Experimental Cell Research. 288 - 296. 2. 321. 2014. http://www.scopus.com/inward/record.url?eid=2-s2.0-84895063788&partnerID=MN8TOARS . 10.1016/j.yexcr.2013.11.002 . Experimental Cell Research

Interplay between estrogen and retinoid signaling in breast cancer - Current and future perspectives

Ribeiro, M.P.C.; Santos, A.E.; Custódio, J.B.A., 2014. Cancer Letters. 17 - 24. 1. 353. 2014. http://www.scopus.com/inward/record.url?eid=2-s2.0-84908364519&partnerID=MN8TOARS . 10.1016/j.canlet.2014.07.009 . Cancer Letters

Mitochondria: The gateway for tamoxifen-induced liver injury

Ribeiro, M.P.C.; Santos, A.E.; Custódio, J.B.A., 2014. Toxicology. 10 - 18. 323. 2014. http://www.scopus.com/inward/record.url?eid=2-s2.0-84902357447&partnerID=MN8TOARS . 10.1016/j.tox.2014.05.009 . Toxicology

In vitro ischemia triggers a transcriptional response to down-regulate synaptic proteins in hippocampal neurons

Fernandes, J.; Vieira, M.; Carreto, L.; Santos, M.A.S.; Duarte, C.B.; Carvalho, A.L.; Santos, A.E., 2014. PLoS ONE. 6. 9. 2014. http://www.scopus.com/inward/record.url?eid=2-s2.0-84903512303&partnerID=MN8TOARS . 10.1371/journal.pone.0099958 . PLoS ONE

Effects of all-trans-retinoic acid on the permeability transition and bioenergetic functions of rat liver mitochondria in combination with endoxifen

Ribeiro, M.P.C.; Santos, A.E.; Santos, M.S.; Custódio, J.B.A., 2013. Life Sciences. 96 - 107. 2-3. 93. 2013. http://www.scopus.com/inward/record.url?eid=2-s2.0-84880250995&partnerID=MN8TOARS . 10.1016/j.lfs.2013.05.027 . Life Sciences

The antiestrogen endoxifen protects rat liver mitochondria from permeability transition pore opening and oxidative stress at concentrations that do not affect the phosphorylation efficiency

Ribeiro, M.P.C.; Silva, F.S.G.; Santos, A.E.; Santos, M.S.; Custódio, J.B.A., 2013. Toxicology and Applied Pharmacology. 104 - 112. 1. 267. 2013. http://www.scopus.com/inward/record.url?eid=2-s2.0-84872252817&partnerID=MN8TOARS . 10.1016/j.taap.2012.12.012 . Toxicology and Applied Pharmacology

The combination of the antiestrogen endoxifen with all-trans-retinoic acid has anti-proliferative and anti-migration effects on melanoma cells without inducing significant toxicity in non-neoplasic cells

Ribeiro, M.P.C.; Silva, F.S.G.; Paixão, J.; Santos, A.E.; Custódio, J.B.A., 2013. European Journal of Pharmacology. 354 - 362. 1-3. 715. 2013. http://www.scopus.com/inward/record.url?eid=2-s2.0-84885471345&partnerID=MN8TOARS . 10.1016/j.ejphar.2013.04.038 . European Journal of Pharmacology

Cleavage of the vesicular glutamate transporters under excitotoxic conditions

Lobo, A.C.; Gomes, J.R.; Catarino, T.; Mele, M.; Fernandez, P.; Inácio, A.R.; Bahr, B.A.; et al, 2011. Neurobiology of Disease. 292 - 303. 3. 44. 2011. http://www.scopus.com/inward/record.url?eid=2-s2.0-80053269066&partnerID=MN8TOARS . 10.1016/j.nbd.2011.07.010 . Neurobiology of Disease

Excitotoxicity through Ca2+-permeable AMPA receptors requires Ca2+dependent JNK activation

Vieira, M.; Fernandes, J.; Burgeiro, A.; Thomas, G.M.; Huganir, R.L.; Duarte, C.B.; Carvalho, A.L.; Santos, A.E., 2010. Neurobiology of Disease. 645 - 655. 3. 40. 2010. http://www.scopus.com/inward/record.url?eid=2-s2.0-77957795389&partnerID=MN8TOARS . 10.1016/j.nbd.2010.08.008 . Neurobiology of Disease

Excitotoxicity mediated by Ca2+-permeable GluR4-containing AMPA receptors involves the AP-1 transcription factor

Santos, A.E.; Duarte, C.B.; Iizuka, M.; Barsoumian, E.L.; Ham, J.; Lopes, M.C.; Carvalho, A.P.; Carvalho, A.L., 2006. Cell Death and Differentiation. 652 - 660. 4. 13. 2006. http://www.scopus.com/inward/record.url?eid=2-s2.0-33644935364&partnerID=MN8TOARS . 10.1038/sj.cdd.4401785 . Cell Death and Differentiation

Differential postreceptor signaling events triggered by excitotoxic stimulation of different ionotropic glutamate receptors in retinal Neurons

Santos, A.E.; Carvalho, A.L.; Lopes, M.C.; Carvalho, A.P., 2001. Journal of Neuroscience Research. 643 - 655. 4. 66. 2001. http://www.scopus.com/inward/record.url?eid=2-s2.0-0035889524&partnerID=MN8TOARS . 10.1002/jnr.10036 . Journal of Neuroscience Research

Sulfonated Chloroaluminum Phthalocyanine Incorporates into Human Plasma Lipoproteins: Photooxidation of Low-Density Lipoproteins

Santos, A.E.; Laranjinha, J.A.N.; Almeida, L.M., 1998. Photochemistry and Photobiology. 378 - 385. 4. 67. 1998. http://www.scopus.com/inward/record.url?eid=2-s2.0-0032040364&partnerID=MN8TOARS . Photochemistry and Photobiology

Regulation of intracellular [Ca2+] and GABA release by presynaptic GABAB receptors in rat cerebrocortical synaptosomes

Santos, A.E.; Carvalho, C.M.; Macedo, T.A.; Carvalho, A.P., 1995. Neurochemistry International. 397 - 406. 4-5. 27. 1995. http://www.scopus.com/inward/record.url?eid=2-s2.0-0028981911&partnerID=MN8TOARS . 10.1016/0197-0186(95)00021-Y . Neurochemistry International

5 30 out of 30 Publications

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