MMeta4Obesity - Mycobiota homeostasis under the regulation of adenosine receptors as pivotal players in obesity 

Overview

Project Summary

Metabolic diseases, including obesity are multifactorial, resulting both from genetics, and from individual environmental habits, such as diet or physical exercise. In the last decades it has become clear the importance of microbiota, particularly the gut microbiota/microbiome. However, most of the studies are focused on the bacterial components of the microbiota, and the role of the fungal elements of these microbial populations, the mycobiota, has been neglected. Nevertheless, recent data point to the importance of these commensal fungi in metabolic diseases, such as obesity, diabetes, or chronic inflammatory diseases. Importantly, another factor playing a role in metabolic diseases is the purinergic system, in particular adenosine and adenosine receptors. In fact, these receptors control cellular mechanisms that ultimately counteract obesity. On the other hand, we showed that the adenosine A2A receptor (A2AR) is able to modulate Candida albicans virulence, one of the main gut mycobiota elements, decreasing gut damage. With these premises in mind, we hypothesize that in people with obesity, mycobiota homeostasis is under the regulation of adenosine receptors; and that a balance between adenosine receptor expression and mycobiota will relate with metabolic health.

Main Goals

1) Characterize the gut mycobiota ;

 2) map the A2AR and A2BR expression in gut and adipose tissues from subjects with obesity at different stages of insulin sensitivity, with indication to bariartric surgery

 3) Overall inflammatory markers.

Project Details