CNC

Overview

Hugo Fernandes obtained his Applied Biology degree from the University of Minho (Portugal) after performing the final year internship at the Faculty of Medicine, University Complutense Madrid (Spain) under the supervision of Prof. José Ramon Regueiro. After graduating, H. Fernandes joined the group of Prof. Clemens van Blitterswijk and Prof. Jan de Boer at the University of Twente (The Netherlands) where he completed his Ph.D. in 2009. During this period, H. Fernandes made important contributions to the field of Bone Tissue Engineering by unraveling the biomaterial-driven molecular mechanisms governing the differentiation of human stem cells into osteoblasts. During his post-doctoral studies, H. Fernandes established the use of high-throughput screening technologies to identify and study the role of small molecules on endothelial differentiation and function. His main findings during this period were published in some of the top journals in the field, namely Proceedings of the National Academy of Sciences USA, Biomaterials and Tissue Engineering. In 2011, H. Fernandes was invited to implement and head a new research group at the University of Twente. Together with Prof. Daniel Saris (orthopedic surgeon at the University Medical Center Utrecht), H. Fernandes devised a research line focusing on the development of translational technologies to advance the field of skeletal Tissue Engineering. An important goal of the group was the development of technologies that could reach the Clinic within a short period of time and, as a result, a novel platform capable of capturing endogenous growth factors, in a spatially-controlled manner, was developed. During this period, H. Fernandes supervised in full-time 2 PhD students and 1 visiting PhD student from Rutgers University (USA) as well as 6 Master and 6 Bachelor students. The results obtained led to the publication of 7 peer-review articles and the submission of one international patent (P113734NL00). In 2014, H. Fernandes was awarded a grant from the Portuguese Foundation for Science and Technology and joined the Centre for Neuroscience and Cell Biology (CNC, Coimbra, Portugal). From 2014-17 H. Fernandes focused on the implementation of high-throughput screening platforms to identify small molecules and microRNAs capable of modulating stem cell fate and enhancing cell survival. During this period H. Fernandes supervised in full-time 1 postdoctoral fellow, 2 Master and 1 Bachelor Student and the results of his work were published in the Proceedings of the National Academy of Sciences and an international patent was filled (PCT/IB2013/061110). In 2017, H. Fernandes joined the team of Prof. Lino Ferreira (ERA Chair holder on Ageing) at the Faculty of Medicine, University of Coimbra where he focused on unraveling the molecular mechanism governing ageing and on the discovery of novel drugs capable of inhibiting or delaying cellular senescence. In 2020, H. Fernandes received the prestigious Stimuli to Scientific Employment Award from the Portuguese Foundation for Science and Technology to develop his research in the field of Molecular Bioengineering with special emphasis on the use of cell-based therapies for Regenerative Medicine. Currently, H. Fernandes supervises 5 PhD students working on the role of non-coding RNAs in Cardiovascular Regeneration and on Molecular Bioengineering of extracellular vesicles for Regenerative Medicine. H. Fernandes has published 41 papers in international peer-reviewed journals with over 1600 citations and h-index of 16, including papers in high impact factor journals in the field (PNAS, Biomaterials, Acta Biomaterialia, Tissue Engineering, Journal of Tissue Engineering …). H. Fernandes has secured more than 1 million Euros during the last 7 years both from Industry (€600k from Smith&Nephew - 2012-16), Academia (€60k from Co-tutella agreement between the University of Coimbra and the University of Maastricht - 2016-20) as well as from National and Internationally funding agencies (€130k from the Portuguese Foundation for Science and Technology - 2013-15; 323k Netherlands Organization for Health Research and Development - 2017-21 and 201k from the Portuguese Foundation Science and Technology - 2018-21). H. Fernandes acts as referee for several peer-review journals in the field (Biomaterials, Tissue Engineering, Acta Biomaterials, European Cells and Materials…) as well as Evaluator for several funding agencies (Marie Curie Program from EU, French National Research Agency and Polish Science Foundation. Furthermore, H. Fernandes frequently contributes to several outreaching activities with the general public as well as high-school students to explain the importance of science for the Society at large and how his research impacts people's life. Since 2019, H Fernandes is Board Member (Secretary) of the Portuguese Society for Stem Cells and Cell Therapy.

Publications

Information about journal articles, updated at 11-01-2026, from platform CIÊNCIAVITAE.

Advanced Biomaterial Strategies for Overcoming Age-associated Wound Healing Impairments

Dores, Rodrigo; Rodrigues, Telma A.; Carvalho, Daniel; Batista, Eva; Kozak, Myroslava; Blanco, Cristina; Fernandes, Hugo; Bimbo, Luís M, APL Bioengineering. 2025. under revision APL Bioengineering

miRNA-642a-3p protects ß cells from glucolipotoxicity

Pinhanços, Sandra Sofia; Teixeira de Oliveira, João; Alves, C. Henrique; Deus, Cláudia M.; de Winter, Twan J.J.; Viana, Sofia; Reis, Flávio; et al, Molecular Therapy Nucleic Acids. 2025. https://doi.org/10.1016/j.omtn.2025.102498 . 10.1016/j.omtn.2025.102498 . Molecular Therapy Nucleic Acids

Extracellular vesicle transfer of lncRNA H19 splice variants to cardiac cells

Vilaça, Andreia; Jesus, Carlos; Lino, Miguel; Hayman, Danika; Emanueli, Costanza; Terracciano, Cesare M.; Fernandes, Hugo; de Windt, Leon J.; Ferreira, Lino, Molecular Therapy - Nucleic Acids. 2024. http://dx.doi.org/10.1016/j.omtn.2024.102233 . 10.1016/j.omtn.2024.102233 . accepted Molecular Therapy - Nucleic Acids

POSEIDON: Peptidic Objects SEquence-based Interaction with cellular DOmaiNs: a new database and predictor

Preto, António J.; Caniceiro, Ana B.; Duarte, Francisco; Fernandes, Hugo; Ferreira, Lino; Mourão, Joana; Moreira, Irina S., Journal of Cheminformatics. 1. 16. 2024. http://dx.doi.org/10.1186/s13321-024-00810-7 . 10.1186/s13321-024-00810-7 . Journal of Cheminformatics

TRAP1 Is Expressed in Human Retinal Pigment Epithelial Cells and Is Required to Maintain their Energetic Status

Ramos Rego, Inês; Silvério, Daniela; Eufrásio, Maria Isabel; Pinhanços, Sandra Sofia; Lopes da Costa, Bruna; Teixeira, José; Fernandes, Hugo; et al, Antioxidants. 2. 12. 2023. http://dx.doi.org/10.3390/antiox12020381 . 10.3390/antiox12020381 . Antioxidants

Strategies and challenges for non-viral delivery of non-coding RNAs to the heart

Vilaça, Andreia; de Windt, Leon J.; Fernandes, Hugo; Ferreira, Lino, Trends in Molecular Medicine. 2022. http://dx.doi.org/10.1016/j.molmed.2022.10.002 . 10.1016/j.molmed.2022.10.002 . in press Trends in Molecular Medicine

MicroRNA-124-3p-enriched small extracellular vesicles as a therapeutic approach for Parkinson’s disease

Esteves, Marta; Abreu, Ricardo; Fernandes, Hugo; Serra-Almeida, Catarina; Martins, Patrícia A.T.; Barão, Marta; Cristóvão, Ana Clara; et al, Molecular Therapy. 2022. http://dx.doi.org/10.1016/j.ymthe.2022.06.003 . 10.1016/j.ymthe.2022.06.003 . Molecular Therapy

Extracellular vesicles enriched with an endothelial cell pro-survival microRNA affects skin tissue regeneration

Fernandes, Hugo; Zonnari, Alessandra; Abreu, Ricardo; Aday, Sezin; Barão, Marta; Albino, Inês; Lino, Miguel; et al, Molecular Therapy - Nucleic Acids. 307 - 327. 28. 2022. http://dx.doi.org/10.1016/j.omtn.2022.03.018 . 10.1016/j.omtn.2022.03.018 . Molecular Therapy - Nucleic Acids

Intercellular transfer of miR-200c-3p impairs the angiogenic capacity of cardiac endothelial cells

Ottaviani, L.; Juni, R.P.; de Abreu, R.C.; Sansonetti, M.; Sampaio-Pinto, V.; Halkein, J.; Hegenbarth, J.C.; et al, Molecular Therapy. 2022. http://dx.doi.org/10.1016/j.ymthe.2022.03.002 . 10.1016/j.ymthe.2022.03.002 . Molecular Therapy

Exogenous loading of miRNAs into small extracellular vesicles

Abreu, Ricardo C.; Ramos, Cristiana V.; Becher, Clarissa; Lino, Miguel; Jesus, Carlos; Costa Martins, Paula A.; Martins, Patrícia A. T.; et al, Journal of Extracellular Vesicles. 10. 10. 2021. http://dx.doi.org/10.1002/jev2.12111 . 10.1002/jev2.12111 . Journal of Extracellular Vesicles

High-throughput screening of nanoparticles in drug delivery

Inês Tomé; Vitor Francisco; Hugo Fernandes; Lino Ferreira, APL Bioengineering. 2021. https://doi.org/10.1063/5.0057204 . 10.1063/5.0057204 . APL Bioengineering

Native and bioengineered extracellular vesicles for cardiovascular therapeutics

de Abreu, Ricardo Cerqueira; Fernandes, Hugo; da Costa Martins, Paula A.; Sahoo, Susmita; Emanueli, Costanza; Ferreira, Lino, Nature Reviews Cardiology. 685 - 697. 11. 17. 2020. http://dx.doi.org/10.1038/s41569-020-0389-5 . 10.1038/s41569-020-0389-5 . Nature Reviews Cardiology

A SOX2 Reporter System Identifies Gastric Cancer Stem-Like Cells Sensitive to Monensin

Pádua, Diana; Barros, Rita; Amaral, Ana Luísa; Mesquita, Patrícia; Freire, Ana Filipa; Sousa, Mafalda; Maia, André Filipe; et al, Cancers. 2. 12. 2020. http://dx.doi.org/10.3390/cancers12020495 . 10.3390/cancers12020495 . Cancers

A high-throughput screening platform to identify nanocarriers for efficient delivery of RNA-based therapies

Francisco, Vitor; Rebelo, Catarina; Rodrigues, Artur Filipe; Blersch, Josephine; Fernandes, Hugo; Ferreira, Lino, Methods. 2020. http://dx.doi.org/10.1016/j.ymeth.2020.12.002 . 10.1016/j.ymeth.2020.12.002 . Methods

The role of ENPP1/PC-1 in osteoinduction by calcium phosphate ceramics

Othman, Ziryan; Fernandes, Hugo; Groot, Arjan J.; Luider, Theo M.; Alcinesio, Alessandro; Pereira, Daniel de Melo; Guttenplan, Alexander P.M.; Yuan, Huipin; Habibovic, Pamela, Biomaterials. 12 - 24. 210. 2019. http://dx.doi.org/10.1016/j.biomaterials.2019.04.021 . 10.1016/j.biomaterials.2019.04.021 . Biomaterials

A High-Throughput Screening Method to Identify Compounds Displaying Human Vascular Embryonic Toxicity

Rosa, Susana; Pitrez, Patrícia; Fernandes, Hugo; Ferreira, Lino, Current Protocols in Stem Cell Biology. 1. 50. 2019. http://dx.doi.org/10.1002/cpsc.93 . 10.1002/cpsc.93 . Current Protocols in Stem Cell Biology

From fiber curls to mesh waves: a platform for the fabrication of hierarchically structured nanofibers mimicking natural tissue formation

Honglin Chen; Danielle F. Baptista; Giuseppe Criscenti; João Crispim; Hugo Fernandes; Clemens van Blitterswijk; Roman Truckenmüller; Lorenzo Moroni, Nanoscale. 14312 - 14321. 30. 11. 2019. https://doi.org/10.1039/C8NR10108F . 10.1039/C8NR10108F . Nanoscale

Bioactive Tape With BMP-2 Binding Peptides Captures Endogenous Growth Factors and Accelerates Healing After Anterior Cruciate Ligament Reconstruction.

Crispim JF; Fu SC; Lee YW; Fernandes HAM; Jonkheijm P; Yung PSH; Saris DBF, The American journal of sports medicine. 2018. http://europepmc.org/abstract/med/30074814 . 10.1177/0363546518787507 . The American journal of sports medicine

Soft-molecular imprinted electrospun scaffolds to mimic specific biological tissues.

Criscenti G; De Maria C; Longoni A; van Blitterswijk CA; Fernandes HAM; Vozzi G; Moroni L, Biofabrication. 2018. http://europepmc.org/abstract/med/30024388 . 10.1088/1758-5090/aad48a . Biofabrication

Muscle-Secreted Factors Improve Anterior Cruciate Ligament Graft Healing: An In Vitro and In Vivo Analysis

Ghebes, Corina Adriana; Groen, Nathalie; Cheuk, Yau Chuk; Fu, Sai Chuen; Fernandes, Hugo Machado; Saris, Daniel B.F., Tissue Engineering Part A. 322 - 334. 3-4. 24. 2018. http://dx.doi.org/10.1089/ten.tea.2016.0546 . 10.1089/ten.tea.2016.0546 . Tissue Engineering Part A

High throughput screening of photocatalytic conversion of pharmaceutical contaminants in water

Romão, Joana; Barata, David; Ribeiro, Nelson; Habibovic, Pamela; Fernandes, Hugo; Mul, Guido, Environmental Pollution. 1199 - 1207. 220. 2017. http://dx.doi.org/10.1016/j.envpol.2016.11.015 . 10.1016/j.envpol.2016.11.015 . Environmental Pollution

Prolotherapy Induces an Inflammatory Response in Human Tenocytes In Vitro

Ekwueme, Emmanuel C.; Mohiuddin, Mahir; Yarborough, Jazmin A.; Brolinson, P. Gunnar; Docheva, Denitsa; Fernandes, Hugo A. M.; Freeman, Joseph W., Clinical Orthopaedics and Related Research®. 2117 - 2127. 8. 475. 2017. http://dx.doi.org/10.1007/s11999-017-5370-1 . 10.1007/s11999-017-5370-1 . Clinical Orthopaedics and Related Research®

High-throughput identification of small molecules that affect human embryonic vascular development.

Vazão H; Rosa S; Barata T; Costa R; Pitrez PR; Honório I; de Vries MR; et al, 2017. http://europepmc.org/abstract/med/28348206 . 10.1073/pnas.1617451114 .

TGF-ß1 activation in human hamstring cells through growth factor binding peptides on polycaprolactone surfaces

Crispim, J.; Fernandes, H.A.M.; Fu, S.C.; Lee, Y.W.; Jonkheijm, P.; Saris, D.B.F., Acta Biomaterialia. 165 - 178. 53. 2017. http://dx.doi.org/10.1016/j.actbio.2017.01.066 . 10.1016/j.actbio.2017.01.066 . Acta Biomaterialia

Means of enhancing bone fracture healing: optimal cell source, isolation methods and acoustic stimulation.

Ghebes CA; Braham MV; Zeegers AV; Renard AJ; Fernandes H; Saris DB, 2016. http://europepmc.org/abstract/med/27955656 .

High-Throughput Screening Assay Identifies Small Molecules Capable of Modulating the BMP-2 and TGF-ß1 Signaling Pathway

Ghebes, Corina-Adriana; van Lente, Jéré; Post, Janine Nicole; Saris, Daniel B. F.; Fernandes, Hugo, SLAS DISCOVERY: Advancing Life Sciences R&D. 40 - 50. 1. 22. 2016. http://dx.doi.org/10.1177/1087057116669346 . 10.1177/1087057116669346 . SLAS DISCOVERY: Advancing Life Sciences R&D

Anterior cruciate ligament- and hamstring tendon-derived cells: in vitro differential properties of cells involved in ACL reconstruction

Ghebes, Corina Adriana; Kelder, Cindy; Schot, Thomas; Renard, Auke J.; Pakvis, Dean F. M.; Fernandes, Hugo; Saris, Daniel B., Journal of Tissue Engineering and Regenerative Medicine. 1077 - 1088. 4. 11. 2015. http://dx.doi.org/10.1002/term.2009 . 10.1002/term.2009 . Journal of Tissue Engineering and Regenerative Medicine

Cross-Talk Between Human Tenocytes and Bone Marrow Stromal Cells Potentiates Extracellular Matrix Remodeling In Vitro

Ekwueme, Emmanuel C.; Shah, Jay V.; Mohiuddin, Mahir; Ghebes, Corina A.; Crispim, João F.; Saris, Daniël B.F.; Fernandes, Hugo A.M.; Freeman, Joseph W., Journal of Cellular Biochemistry. 684 - 693. 3. 117. 2015. http://dx.doi.org/10.1002/jcb.25353 . 10.1002/jcb.25353 . Journal of Cellular Biochemistry

Spatiotemporal proliferation of human stromal cells adjusts to nutrient availability and leads to stanniocalcin-1 expression in vitro and in vivo

Higuera, Gustavo A.; Fernandes, Hugo; Spitters, Tim W.G.M.; van de Peppel, Jeroen; Aufferman, Nils; Truckenmueller, Roman; Escalante, Maryana; et al, Biomaterials. 190 - 202. 61. 2015. http://dx.doi.org/10.1016/j.biomaterials.2015.05.017 . 10.1016/j.biomaterials.2015.05.017 . Biomaterials

High throughput screening assay for the identification of compounds enhancing collagenous extracellular matrix production by ATDC5 cells.

Le B; Fernandes H; Bouten C; Karperien M; van Blitterswijk C; de Boer J, 2015. http://europepmc.org/abstract/med/25604243 . 10.1089/ten.TEC.2014.0088 .

A small molecule approach to engineering vascularized tissue

Doorn, Joyce; Fernandes, Hugo A. M.; Le, Bach Q.; van de Peppel, Jeroen; van Leeuwen, Johannes P. T. M.; De Vries, Margreet R.; Aref, Zeen; et al, Biomaterials. 3053 - 3063. 12. 34. 2013. 10.1016/j.biomaterials.2012.12.037 . Biomaterials

Mesenchymal stromal cell-derived extracellular matrix influences gene expression of chondrocytes

Thakkar, Shraddha; Ghebes, Corina A.; Ahmed, Maqsood; Kelder, Cindy; van Blitterswijk, Clemens A.; Saris, Daniel; Fernandes, Hugo A. M.; Moroni, Lorenzo, Biofabrication. 2. 5. 2013. 10.1088/1758-5082/5/2/025003 . Biofabrication

Molecular mechanisms of biomaterial-driven osteogenic differentiation in human mesenchymal stromal cells

Barradas, Ana M. C.; Monticone, Veronica; Hulsman, Marc; Danoux, Charlene; Fernandes, Hugo; Birgani, Zeinab Tahmasebi; Barrere-de Groot, Florence; et al, Integrative Biology. 920 - 931. 7. 5. 2013. 10.1039/c3ib40027a . Integrative Biology

A calcium-induced signaling cascade leading to osteogenic differentiation of human bone marrow-derived mesenchymal stromal cells

Barradas, Ana M.C.; Fernandes, Hugo A.M.; Groen, Nathalie; Chai, Yoke Chin; Schrooten, Jan; van de Peppel, Jeroen; van Leeuwen, Johannes P.T.M.; van Blitterswijk, Clemens A.; de Boer, Jan, Biomaterials. 3205 - 3215. 11. 33. 2012. http://dx.doi.org/10.1016/j.biomaterials.2012.01.020 . 10.1016/j.biomaterials.2012.01.020 . Biomaterials

The influence of genetic factors on the osteoinductive potential of calcium phosphate ceramics in mice

Barradas, Ana M.C.; Yuan, Huipin; van der Stok, Johan; Le Quang, Bach; Fernandes, Hugo; Chaterjea, Anindita; Hogenes, Marieke C.H.; et al, Biomaterials. 5696 - 5705. 23. 33. 2012. http://dx.doi.org/10.1016/j.biomaterials.2012.04.021 . 10.1016/j.biomaterials.2012.04.021 . Biomaterials

Spatial distribution and survival of human and goat mesenchymal stromal cells on hydroxyapatite and ß-tricalcium phosphate.

Prins HJ; Fernandes H; Rozemuller H; van Blitterswijk C; de Boer J; Martens AC, 2012. http://europepmc.org/abstract/med/23255230 . 10.1002/term.1681 .

Endothelial Differentiation of Mesenchymal Stromal Cells

Portalska, Karolina Janeczek; Leferink, Anne; Groen, Nathalie; Fernandes, Hugo; Moroni, Lorenzo; van Blitterswijk, Clemens; de Boer, Jan, Plos One. 10. 7. 2012. 10.1371/journal.pone.0046842 . Plos One

'Smart' biomaterials and osteoinductivity

Yuan, Huipin; Fernandes, Hugo; Habibovic, Pamela; de Boer, Jan; Barradas, Ana M. C.; de Ruiter, Ad; Walsh, William R.; van Blitterswijk, Clemens A.; de Bruijn, Joost D., Nature Reviews Rheumatology. 1 - 1. 4. 7. 2011. 10.1038/nrrheum.2010.210-c1 . Nature Reviews Rheumatology

Osteoinductive ceramics as a synthetic alternative to autologous bone grafting

Yuan, Huipin; Fernandes, Hugo; Habibovic, Pamela; de Boer, Jan; Barradas, Ana M. C.; de Ruiter, Ad; Walsh, William R.; van Blitterswijk, Clemens A.; de Bruijn, Joost D., Proceedings of the National Academy of Sciences of the United States of America. 13614 - 13619. 31. 107. 2010. 10.1073/pnas.1003600107 . Proceedings of the National Academy of Sciences of the United States of America

Effect of Chordin-Like 1 on MC3T3-E1 and Human Mesenchymal Stem Cells

Fernandes, Hugo; Dechering, Koen; van Someren, Eugene; Steeghs, Ilse; Apotheker, Marion; Mentink, Anouk; van Blitterswijk, Clemens; de Boer, Jan, Cells Tissues Organs. 443 - 452. 6. 191. 2010. 10.1159/000281825 . Cells Tissues Organs

Fabrication of Bioactive Composite Scaffolds by Electrospinning for Bone Regeneration

Nandakumar, Anandkumar; Fernandes, Hugo; de Boer, Jan; Moroni, Lorenzo; Habibovic, Pamela; van Blitterswijk, Clemens A., Macromolecular Bioscience. 1365 - 1373. 11. 10. 2010. http://dx.doi.org/10.1002/mabi.201000145 . 10.1002/mabi.201000145 . Macromolecular Bioscience

In Vitro and In Vivo Bioluminescent Imaging of Hypoxia in Tissue-Engineered Grafts

Liu, Jun; Barradas, Ana; Fernandes, Hugo; Janssen, Frank; Papenburg, Bernke; Stamatialis, Dimitrios; Martens, Anton; van Blitterswijk, Clemens; de Boer, Jan, Tissue Engineering Part C-Methods. 479 - 485. 3. 16. 2010. 10.1089/ten.tec.2009.0278 . Tissue Engineering Part C-Methods

In vivo evaluation of highly macroporous ceramic scaffolds for bone tissue engineering

Teixeira, S.; Fernandes, H.; Leusink, A.; van Blitterswijk, C.; Ferraz, M. P.; Monteiro, F. J.; de Boer, J., Journal of Biomedical Materials Research Part a. 567 - 575. 2. 93A. 2010. 10.1002/jbm.a.32532 . Journal of Biomedical Materials Research Part a

Endogenous Collagen Influences Differentiation of Human Multipotent Mesenchymal Stromal Cells

Fernandes, Hugo; Mentink, Anouk; Bank, Ruud; Stoop, Reinout; van Blitterswijk, Clemens; de Boer, Jan, Tissue Engineering Part a. 1693 - 1702. 5. 16. 2010. 10.1089/ten.tea.2009.0341 . Tissue Engineering Part a

cAMP/PKA Signaling Inhibits Osteogenic Differentiation and Bone Formation in Rodent Models

Siddappa, Ramakrishnaiah; Mulder, Winfried; Steeghs, Ilse; van de Klundert, Christine; Fernandes, Hugo; Liu, Jun; Arends, Roel; van Blitterswijk, Clemens; de Boer, Jan, Tissue Engineering Part A. 2135 - 2143. 8. 15. 2009. http://dx.doi.org/10.1089/ten.tea.2008.0512 . 10.1089/ten.tea.2008.0512 . Tissue Engineering Part A

Extracellular matrix and tissue engineering applications

Fernandes, Hugo; Moroni, Lorenzo; van Blitterswijk, Clemens; de Boer, Jan, Journal of Materials Chemistry. 5474 - 5484. 31. 19. 2009. 10.1039/b822177d . Journal of Materials Chemistry

Growth, Metabolism, and Growth Inhibitors of Mesenchymal Stem Cells

Schop, Deborah; Janssen, Frank W.; van Rijn, Linda D.S.; Fernandes, Hugo; Bloem, Rolf M.; de Bruijn, Joost D.; van Dijkhuizen-Radersma, Riemke, Tissue Engineering Part A. 1877 - 1886. 8. 15. 2009. http://dx.doi.org/10.1089/ten.tea.2008.0345 . 10.1089/ten.tea.2008.0345 . Tissue Engineering Part A

The Role of Collagen Crosslinking in Differentiation of Human Mesenchymal Stem Cells and MC3T3-E1 Cells

Fernandes, Hugo; Dechering, Koen; Van Someren, Eugene; Steeghs, Ilse; Apotheker, Marion; Leusink, Anouk; Bank, Ruud; et al, Tissue Engineering Part A. 3857 - 3867. 12. 15. 2009. http://dx.doi.org/10.1089/ten.tea.2009.0011 . 10.1089/ten.tea.2009.0011 . Tissue Engineering Part A

The response of human mesenchymal stem cells to osteogenic signals and its impact on bone tissue engineering.

Siddappa, Ramakrishnaiah; Fernandes, Hugo; Liu, Jun; van Blitterswijk, Clemens; de Boer, Jan, Current stem cell research & therapy. 209 - 20. 3. 2. 2007. 10.2174/157488807781696267 . Current stem cell research & therapy

Mesenchymal stem cell proliferation and morphological analysis on interconnected macroporous structures

Teixeira, S.; Fernandes, H.M.; De Boer, J.; Ferraz, M.P.; Monteiro, F.J., Key Engineering Materials. 1129 - 1132. 330-332 II. 2007. http://www.scopus.com/inward/record.url?eid=2-s2.0-33846317063&partnerID=MN8TOARS . Key Engineering Materials

5 50 out of 50 Publications

All projects

Information of exclusive responsibility of the researcher 11-01-2026 , from platform CIÊNCIAVITAE.

2023/03 -

miRNA-engineered EVs for the treatment of diabetic wounds

Principal investigator

Funders: Sociedade Portuguesa de Diabetologia

2022/07/01 - 2023/06/30

BIO-MED: Biomolecular Engineering of extracellular vesicles for Regenerative Medicine

AAC nº01/SAICT/2021 - Project #181228

Co-Principal Investigator (Co-PI)

Funders: Programa Operacional Regional do Centro

2021/11 - 2023/04

EV-Heart: cardioprotection and regeneration mediated by systemic administration of targeted miRNA-modulated extracellular vesicles

CEECIND/01880/2018

Researcher

Universidade de Coimbra Faculdade de Medicina

Funders: Fundação para a Ciência e a Tecnologia, I.P.

2018/08 - 2021/08

Exo-Heart: cardiac protection and regeneration mediated by systemic administration of targeted exosomes

029919

Funders: Fundação para a Ciência e a Tecnologia

2017/06/01 - 2021/06/01

Towards personalized beta-cell mass imaging in type 2 Diabetes

95105008

Integration into Research Grant Fellow

ZonMw

Funders: ZonMw

2015/07/01 -

Role of microRNAs in chondrogenesis of human mesenchymal stromal cells

TAS Breakthrough #116005004

Integration into Research Grant Fellow

Nederlandse Organisatie voor Wetenschappelijk Onderzoek

2015/07/01 -

Role of microRNAs in chondrogenesis of human mesenchymal stromal cells

Integration into Research Grant Fellow

Nederlandse Organisatie voor Wetenschappelijk Onderzoek

2013/07 - 2015/06

Combinatorial approaches to promote cell survival - PROSURVIVAL

125994

Funders: Fundação para a Ciência e a Tecnologia, I.P.

2012/02/01 - 2016/02/01

Advanced Tendon and Ligament Healing

Principal investigator

Smith & Nephew

5 9 out of 9 projects

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Hugo A. Machado Fernandes

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