Caio Haddad Franco

Novel structural CYP51 mutation in Trypanosoma cruzi associated with multidrug resistance to CYP51 inhibitors and reduced infectivity

Franco, Caio H.; Warhurst, David C.; Bhattacharyya, Tapan; Au, Ho Y.A.; Le, Hai; Giardini, Miriam A.; Pascoalino, Bruno S.; et al, International Journal for Parasitology: Drugs and Drug Resistance. 107 - 120. 13. 2020. http://dx.doi.org/10.1016/j.ijpddr.2020.06.001 . 10.1016/j.ijpddr.2020.06.001 . published International Journal for Parasitology: Drugs and Drug Resistance

Prospecting and Identifying Phyllanthus amarus Lignans with Antileishmanial and Antitrypanosomal Activity

Conrado, Gabrielly Galdino; Grazzia, Nathalia; de Oliveira, Adriana da Silva S.; Franco, Caio Haddad; Moraes, Carolina Borsoi; Gadelha, Fernanda Ramos; Miguel, Danilo Ciccone; Garcia, Vera Lucia, Planta Medica. 782 - 789. 11. 86. 2020. http://dx.doi.org/10.1055/a-1179-1003 . 10.1055/a-1179-1003 . published Planta Medica

Discovery of new potent hits against intracellular Trypanosoma cruzi by QSAR-based virtual screening

Melo-Filho, Cleber C.; Braga, Rodolpho C.; Muratov, Eugene N.; Franco, Caio Haddad; Moraes, Carolina B.; Freitas-Junior, Lucio H.; Andrade, Carolina Horta, European Journal of Medicinal Chemistry. 649 - 659. 163. 2019. http://dx.doi.org/10.1016/j.ejmech.2018.11.062 . 10.1016/j.ejmech.2018.11.062 . published European Journal of Medicinal Chemistry

Discovery of a benzothiophene-flavonol halting miltefosine and antimonial drug resistance in Leishmania parasites through the application of medicinal chemistry, screening and genomics

Borsari, Chiara; Jiménez-Antón, María Dolores; Eick, Julia; Bifeld, Eugenia; Torrado, Juan José; Olías-Molero, Ana Isabel; Corral, María Jesús; et al, European Journal of Medicinal Chemistry. 183. 2019. http://dx.doi.org/10.1016/j.ejmech.2019.111676 . 10.1016/j.ejmech.2019.111676 . published European Journal of Medicinal Chemistry

Drug Discovery for Chagas Disease: Impact of Different Host Cell Lines on Assay Performance and Hit Compound Selection

Franco, Caio Haddad; Alcântara, Laura Maria; Chatelain, Eric; Freitas-Junior, Lucio; Moraes, Carolina Borsoi, Tropical Medicine and Infectious Disease. 2. 4. 2019. http://dx.doi.org/10.3390/tropicalmed4020082 . 10.3390/tropicalmed4020082 . published Tropical Medicine and Infectious Disease

Synthesis and structure-activity relationship of nitrile-based cruzain inhibitors incorporating a trifluoroethylamine-based P2 amide replacement

Gomes, Juliana C.; Cianni, Lorenzo; Ribeiro, Jean; dos Reis Rocho, Fernanda; da Costa Martins Silva, Samelyn; Batista, Pedro Henrique Jatai; Moraes, Carolina Borsoi; et al, Bioorganic & Medicinal Chemistry. 22. 27. 2019. http://dx.doi.org/10.1016/j.bmc.2019.115083 . 10.1016/j.bmc.2019.115083 . published Bioorganic & Medicinal Chemistry

Enhancement of Benzothiazoles as Pteridine Reductase-1 Inhibitors for the Treatment of Trypanosomatidic Infections

Linciano, Pasquale; Pozzi, Cecilia; Iacono, Lucia dello; di Pisa, Flavio; Landi, Giacomo; Bonucci, Alessio; Gul, Sheraz; et al, Journal of Medicinal Chemistry. 3989 - 4012. 8. 62. 2019. http://dx.doi.org/10.1021/acs.jmedchem.8b02021 . 10.1021/acs.jmedchem.8b02021 . published Journal of Medicinal Chemistry

Antimicrobial, antiparasitic and antiproliferative effects of the extract of Bacillus safensis SG-32 isolated from a Brazilian oil reservoir

Tiago, Rodrigues e Silva; Eugenio, Vaz dos Santos Neto; Ana, Lucia Tasca Goiz Ruiz; Mary, Ann Foglio; Caio, Haddad Franco; Carolina, Borsoi Moraes; Valéria, Maia de Oliveira, African Journal of Microbiology Research. 897 - 907. 37. 12. 2018. http://dx.doi.org/10.5897/ajmr2018.8940 . 10.5897/ajmr2018.8940 . published African Journal of Microbiology Research

Tetracycline@Silver Ions-Functionalized Mesoporous Silica for High Bactericidal Activity at Ultra-Low Concentration

Bouchmella, Karim; Campanaro, Felipe Davi; Mondo, Gabriela Borba; Santos, Murilo Izidoro; Franco, Caio Haddad; Moraes, Carolina Borsoi; Biolley, Christine; Mehdi, Ahmad; Cardoso, Mateus Borba, Nanomedicine. 1731 - 1751. 14. 13. 2018. http://dx.doi.org/10.2217/nnm-2018-0027 . 10.2217/nnm-2018-0027 . published Nanomedicine

Identification of di-substituted ureas that prevent growth of trypanosomes through inhibition of translation initiation

Machado, Fabricio Castro; Franco, Caio Haddad; dos Santos Neto, Jose Vitorino; Dias-Teixeira, Karina Luiza; Moraes, Carolina Borsoi; Lopes, Ulisses Gazos; Aktas, Bertal Huseyin; Schenkman, Sergio, Scientific Reports. 1. 8. 2018. http://dx.doi.org/10.1038/s41598-018-23259-9 . 10.1038/s41598-018-23259-9 . published Scientific Reports

Bacteria from Antarctic environments: diversity and detection of antimicrobial, antiproliferative, and antiparasitic activities

Silva, Tiago R.; Duarte, Alysson W. F.; Passarini, Michel R. Z.; Ruiz, Ana Lucia T. G.; Franco, Caio Haddad; Moraes, Carolina Borsoi; de Melo, Itamar Soares; et al, Polar Biology. 1505 - 1519. 7. 41. 2018. http://dx.doi.org/10.1007/s00300-018-2300-y . 10.1007/s00300-018-2300-y . published Polar Biology

Aryl thiosemicarbazones for the treatment of trypanosomatidic infections

Linciano, Pasquale; Moraes, Carolina B.; Alcantara, Laura M.; Franco, Caio H.; Pascoalino, Bruno; Freitas-Junior, Lucio H.; Macedo, Sara; et al, European Journal of Medicinal Chemistry. 423 - 434. 146. 2018. http://dx.doi.org/10.1016/j.ejmech.2018.01.043 . 10.1016/j.ejmech.2018.01.043 . published European Journal of Medicinal Chemistry

Investigating the structure-activity relationships of N’ -[(5-nitrofuran-2-yl) methylene] substituted hydrazides against Trypanosoma cruzi to design novel active compounds

Palace-Berl, Fanny; Pasqualoto, Kerly Fernanda Mesquita; Zingales, Bianca; Moraes, Carolina Borsoi; Bury, Mariana; Franco, Caio Haddad; da Silva Neto, Adelson Lopes; et al, European Journal of Medicinal Chemistry. 29 - 40. 144. 2018. http://dx.doi.org/10.1016/j.ejmech.2017.12.011 . 10.1016/j.ejmech.2017.12.011 . published European Journal of Medicinal Chemistry

A comparative study of warheads for design of cysteine protease inhibitors

Silva, Daniel G.; Ribeiro, Jean F.R.; De Vita, Daniela; Cianni, Lorenzo; Franco, Caio Haddad; Freitas-Junior, Lucio H.; Moraes, Carolina Borsoi; et al, Bioorganic & Medicinal Chemistry Letters. 5031 - 5035. 22. 27. 2017. http://dx.doi.org/10.1016/j.bmcl.2017.10.002 . 10.1016/j.bmcl.2017.10.002 . published Bioorganic & Medicinal Chemistry Letters

Synthesis and trypanocidal activity of a library of 4-substituted 2-(1H-pyrrolo[3,2-c]pyridin-2-yl)propan-2-ols

Balfour, Michael N.; Franco, Caio H.; Moraes, Carolina B.; Freitas-Junior, Lucio H.; Stefani, Hélio A., European Journal of Medicinal Chemistry. 202 - 212. 128. 2017. http://dx.doi.org/10.1016/j.ejmech.2017.01.040 . 10.1016/j.ejmech.2017.01.040 . published European Journal of Medicinal Chemistry

Methoxylated 2'-hydroxychalcones as antiparasitic hit compounds

Borsari, Chiara; Santarem, Nuno; Torrado, Juan; Olías, Ana Isabel; Corral, María Jesús; Baptista, Catarina; Gul, Sheraz; et al, European Journal of Medicinal Chemistry. 1129 - 1135. 126. 2017. http://dx.doi.org/10.1016/j.ejmech.2016.12.017 . 10.1016/j.ejmech.2016.12.017 . published European Journal of Medicinal Chemistry

Design, synthesis and antitrypanosomal activity of some nitrofurazone 1,2,4-triazolic bioisosteric analogues

Silva, Fredson T.; Franco, Caio H.; Favaro, Denize C.; Freitas-Junior, Lucio H.; Moraes, Carolina B.; Ferreira, Elizabeth I., European Journal of Medicinal Chemistry. 553 - 560. 121. 2016. http://dx.doi.org/10.1016/j.ejmech.2016.04.065 . 10.1016/j.ejmech.2016.04.065 . published European Journal of Medicinal Chemistry

Highly improved antiparasitic activity after introduction of an N-benzylimidazole moiety on protein farnesyltransferase inhibitors

Bosc, Damien; Mouray, Elisabeth; Cojean, Sandrine; Franco, Caio Haddad; Loiseau, Philippe M.; Freitas-Junior, Lucio H.; Moraes, Carolina Borsoi; Grellier, Philippe; Dubois, Joëlle, European Journal of Medicinal Chemistry. 173 - 186. 109. 2016. http://dx.doi.org/10.1016/j.ejmech.2015.12.045 . 10.1016/j.ejmech.2015.12.045 . published European Journal of Medicinal Chemistry

Novel drug discovery for Chagas disease

Moraes, Carolina B.; Franco, Caio H., Expert Opinion on Drug Discovery. 447 - 455. 5. 11. 2016. http://dx.doi.org/10.1517/17460441.2016.1160883 . 10.1517/17460441.2016.1160883 . published Expert Opinion on Drug Discovery

Mutagenic potential of lettuce grown from irradiated seeds

Franco, Caio Haddad; dos Santos, Valter H.M.; Silva, Luciana P.; Arthur, Valter; Silva, Regildo M.G., Scientia Horticulturae. 27 - 30. 182. 2015. http://dx.doi.org/10.1016/j.scienta.2014.11.011 . 10.1016/j.scienta.2014.11.011 . published Scientia Horticulturae

Nitroheterocyclic compounds are more efficacious than CYP51 inhibitors against Trypanosoma cruzi: implications for Chagas disease drug discovery and development

Moraes, Carolina B.; Giardini, Miriam A.; Kim, Hwayoung; Franco, Caio H.; Araujo-Junior, Adalberto M.; Schenkman, Sergio; Chatelain, Eric; Freitas-Junior, Lucio H., Scientific Reports. 1. 4. 2014. http://dx.doi.org/10.1038/srep04703 . 10.1038/srep04703 . published Scientific Reports

Chemosensitization potential of P-glycoprotein inhibitors in malaria parasites

Alcantara, Laura M.; Kim, Junwon; Moraes, Carolina B.; Franco, Caio H.; Franzoi, Kathrin D.; Lee, Sukjun; Freitas-Junior, Lucio H.; Ayong, Lawrence S., Experimental Parasitology. 235 - 243. 2. 134. 2013. http://dx.doi.org/10.1016/j.exppara.2013.03.022 . 10.1016/j.exppara.2013.03.022 . published Experimental Parasitology