Alcino Jorge Lopes Leitão

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Publications

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Information about journal articles, updated at 11-10-2026, from platform CIÊNCIAVITAE.

32nd Annual GP2A Medicinal Chemistry Conference

Jean-Jacques Hélesbeux; Florence O. McCarthy; Maria Manuel Silva; Alcino J. Leitão; Anthony Burke; Jorge A. R. Salvador; Rui Moreira; et al, Drugs and Drug Candidates. 2025. https://doi.org/10.3390/ddc4010002 . 10.3390/ddc4010002 . Drugs and Drug Candidates

Synthesis of Carvone Derivatives and In Silico and In Vitro Screening of Anti-Inflammatory Activity in Murine Macrophages

Moço, Gabriela; Sousa, Cátia; Capitão, Ana; MacKinnon, Stephen Scott; Leitão, Alcino Jorge; Mendes, Alexandrina F., 2023. https://hdl.handle.net/10316/113974 . https://doi.org/10.3390/ijms24032263 .

Molecular Mechanisms Underlying the Anti-Inflammatory Properties of (R)-(-)-Carvone: Potential Roles of JNK1, Nrf2 and NF-¿B

Sousa, Cátia; Neves, Bruno Miguel; Leitão, Alcino Jorge; Mendes, Alexandrina F., 2023. https://hdl.handle.net/10316/114833 . https://doi.org/10.3390/pharmaceutics15010249 .

Elucidation of the Mechanism Underlying the Anti-Inflammatory Properties of (S)-(+)-Carvone Identifies a Novel Class of Sirtuin-1 Activators in a Murine Macrophage Cell Line

Leitão, Alcino, Biomedicines. 777 - 777. 7. 9. 2021. http://dx.doi.org/10.3390/biomedicines9070777 . 10.3390/biomedicines9070777 . Biomedicines

Standardised comparison of limonene-derived monoterpenes identifies structural determinants of anti-inflammatory activity

Sousa, Cátia; Leitão, Alcino Jorge; Neves, Bruno Miguel; Judas, Fernando; Cavaleiro, Carlos; Mendes, Alexandrina Ferreira, Scientific Reports. 1 - 14. 7199. 10. 2020. http://dx.doi.org/10.1038/s41598-020-64032-1 . 10.1038/s41598-020-64032-1 . Scientific Reports

In vitro anti-Leishmania activity of T6 synthetic compound encapsulated in yeast-derived ß-(1,3)-D-glucan particles

Volpato, H.; Scariot, D.B.; Soares, E.F.P.; Jacomini, A.P.; Rosa, F.A.; Sarragiotto, M.H.; Ueda-Nakamura, T.; et al, International Journal of Biological Macromolecules. 1264 - 1275. 119. 2018. http://www.scopus.com/inward/record.url?eid=2-s2.0-85051375846&partnerID=MN8TOARS . 10.1016/j.ijbiomac.2018.08.019 . International Journal of Biological Macromolecules

Testing the excitation/inhibition imbalance hypothesis in a mouse model of the autism spectrum disorder: in vivo neurospectroscopy and molecular evidence for regional phenotypes

Gonçalves, Joana; Violante, Inês R.; Sereno, José; Leitão, Ricardo A.; Cai, Ying; Abrunhosa, Antero; Silva, Ana Paula; Silva, Alcino J.; Castelo-Branco, Miguel, 2017. https://hdl.handle.net/10316/108275 . https://doi.org/10.1186/s13229-017-0166-4 .

Assessment of cell line competence for studies of pharmacological GPR30 modulation

Sousa, C.; Ribeiro, M.; Rufino, A.T.; Leitão, A.J.; Mendes, A.F., Journal of Receptors and Signal Transduction. 181 - 188. 2. 37. 2017. http://www.scopus.com/inward/record.url?eid=2-s2.0-84978069234&partnerID=MN8TOARS . 10.1080/10799893.2016.1203943 . Journal of Receptors and Signal Transduction

Neurosteroids: Can a 2alpha,3alpha-epoxy ring make up for the 3alpha-hydroxyl group?

Kasal, A.; Budešínský, M.; Mareš, P.; Krištofíková, Z.; Leitão, A.J.; Sá e Melo, M.L.; Silva, M.M.C., Steroids. 12 - 18. 105. 2016. http://www.scopus.com/inward/record.url?eid=2-s2.0-84949519080&partnerID=MN8TOARS . 10.1016/j.steroids.2015.11.007 . Steroids

Anticancer steroids: Linking natural and semi-synthetic compounds

Salvador, J.A.R.; Carvalho, J.F.S.; Neves, M.A.C.; Silvestre, S.M.; Leitão, A.J.; Silva, M.M.C.; Sá E Melo, M.L., Natural Product Reports. 324 - 374. 2. 30. 2013. http://www.scopus.com/inward/record.url?eid=2-s2.0-84872556406&partnerID=MN8TOARS . 10.1039/c2np20082a . Natural Product Reports

Reactions in Epoxysteroides with Metal-free Hydrazine Reagents

Leitão, Alcino, Drugs of the Future. 93 - 93. Suppl A. 34. 2009. Drugs of the Future

Hydrazine sulphate: a cheap and efficient catalyst for the regioselective ring-opening of epoxides. A metal-free procedure for the preparation of ß-alkoxy alcohols

Leitão, A.J.L.; Salvador, J.A.R.; Pinto, R.M.A.; Sá e Melo, M.L., Tetrahedron Letters. 1694 - 1697. 10. 49. 2008. http://www.scopus.com/inward/record.url?eid=2-s2.0-38949187114&partnerID=MN8TOARS . 10.1016/j.tetlet.2007.12.121 . Tetrahedron Letters

Hydrazine hydrate induced reductive cleavage of a,ß-epoxy ketones: An efficient procedure for the preparation of ß-hydroxy ketones

Salvador, J.A.R.; Leitão, A.J.L.; Sá E Melo, M.L.; Hanson, J.R., Tetrahedron Letters. 1067 - 1070. 7. 46. 2005. http://www.scopus.com/inward/record.url?eid=2-s2.0-12344252059&partnerID=MN8TOARS . 10.1016/j.tetlet.2004.12.103 . Tetrahedron Letters

Synthesis and some reactions of 2-acyl-2-alkyl-1,3-dithiolane 1,1-dioxides

Barros, M.T.; Henriques, A.S.; Leitão, A.J.; Maycock, C.D., Helvetica Chimica Acta. 4079 - 4085. 11. 85. 2002. http://www.scopus.com/inward/record.url?eid=2-s2.0-0347297136&partnerID=MN8TOARS . 10.1002/1522-2675(200211)85:11<4079::AID-HLCA4079>3.0.CO;2-S . Helvetica Chimica Acta

Enhanced diastereo and enantioselectivity in the formation of acyldithiolane sulphoxides by the asymmetric oxidation of their enolsilyl ethers

Barros, M.T.; Leitão, A.J.; Maycock, C.D., Tetrahedron Letters. 5047 - 5050. 28. 38. 1997. http://www.scopus.com/inward/record.url?eid=2-s2.0-0030763953&partnerID=MN8TOARS . 10.1016/S0040-4039(97)01101-5 . Tetrahedron Letters

Chiral dithiolane sulphoxides: An efficient stereoselective synthesis of (R) and (S)-3-benzoyloxy-2-butanone

Barros, M.T.; Leitão, A.J.; Maycock, C.D., Tetrahedron Letters. 6537 - 6540. 36. 36. 1995. http://www.scopus.com/inward/record.url?eid=2-s2.0-0029094325&partnerID=MN8TOARS . 10.1016/0040-4039(95)01280-U . Tetrahedron Letters

All projects

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Information of exclusive responsibility of the researcher 11-10-2026 , from platform CIÊNCIAVITAE.

2013/01/01 - 2015/12/31

Do espaço químico à função biológica: uma viagem pela mão da UC-NMR

RECI/QEQ-QFI/0168/2012

Universidade de Coimbra

Funders: Fundação para a Ciência e a Tecnologia

2013/01/01 - 2015/12/31

Do espaço químico à função biológica: uma viagem pela mão da UC-NMR

RECI/QEQ-QFI/0168/2012

Universidade de Coimbra

Funders: Fundação para a Ciência e a Tecnologia

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