Publications
Information about journal articles, updated at 17-11-2024, from platform CIÊNCIAVITAE.
MiR-186-5p inhibition restores synaptic transmission and neuronal network activity in a model of chronic stress
Beatriz Rodrigues; Ricardo A. Leitão; Mónica Santos; Alexander Trofimov; Mariline Silva; Ângela S. Inácio; Mónica Abreu; et al, Molecular Psychiatry. 2024. https://doi.org/10.1038/s41380-024-02715-1 . 10.1038/s41380-024-02715-1 . Molecular Psychiatry
The amygdala NT3-TrkC pathway underlies inter-individual differences in fear extinction and related synaptic plasticity
Masella, Gianluca; Silva, Francisca; Corti, Elisa; Azkona, Garikoitz; Madeira, Maria Francisca; Tomé, Ângelo R.; Ferreira, Samira G.; et al, Molecular Psychiatry. 2024. http://dx.doi.org/10.1038/s41380-024-02412-z . 10.1038/s41380-024-02412-z . in press Molecular Psychiatry
TrkC Intracellular Signalling in the Brain Fear Network During the Formation of a Contextual Fear Memory
Francisca Silva; Gianluca Masella; Maria Francisca Madeira; Carlos B. Duarte; Mónica Santos, Molecular Neurobiology. 2023. https://doi.org/10.1007/s12035-023-03292-0 . 10.1007/s12035-023-03292-0 . Molecular Neurobiology
MeCP2 haplodeficiency and early-life stress interaction on anxiety-like behavior in adolescent female mice
María Abellán-Álvaro; Oliver Stork; Carmen Agustín-Pavón; Mónica Santos, Journal of Neurodevelopmental Disorders. 2021. https://doi.org/10.1186/s11689-021-09409-7 . 10.1186/s11689-021-09409-7 . Journal of Neurodevelopmental Disorders
Male-specific features are reduced in Mecp2-null mice: analyses of vasopressinergic innervation, pheromone production and social behaviour
Elena Martínez-Rodríguez; Ana Martín-Sánchez; Emre Kul; Aparajita Bose; Francisco José Martínez-Martínez; Oliver Stork; Fernando Martínez-García; et al, Brain Structure and Function. 2219 - 2238. 7. 225. 2020. https://doi.org/10.1007/s00429-020-02122-6 . 10.1007/s00429-020-02122-6 . Brain Structure and Function
Lack of MeCP2 leads to region-specific increase of doublecortin in the olfactory system
Martínez-Rodríguez, Elena; Martín-Sánchez, Ana; Coviello, Simona; Foiani, Cristina; Kul, Emre; Stork, Oliver; Martínez-García, Fernando; et al, Brain Structure and Function. 1647 - 1658. 4. 224. 2019. http://dx.doi.org/10.1007/s00429-019-01860-6 . 10.1007/s00429-019-01860-6 . published Brain Structure and Function
Erratum: Correction: Aberrant neuronal activity-induced signaling and gene expression in a mouse model of RASopathy (PLoS genetics (2017) 13 3 (e1006684))
Altmüller, F.; Pothula, S.; Annamneedi, A.; Nakhaei-Rad, S.; Montenegro-Venegas, C.; Pina-Fernández, E.; Marini, C.; et al, PLoS genetics. e1006843 - e1006843. 6. 13. 2017. http://www.scopus.com/inward/record.url?eid=2-s2.0-85054771599&partnerID=MN8TOARS . 10.1371/journal.pgen.1006843 . PLoS genetics
Aberrant neuronal activity-induced signaling and gene expression in a mouse model of RASopathy.
Altmüller F; Pothula S; Annamneedi A; Nakhaei-Rad S; Montenegro-Venegas C; Pina-Fernández E; Marini C; et al, PLoS genetics. 2017. http://europepmc.org/abstract/med/28346493 . 10.1371/journal.pgen.1006684 . PLoS genetics
Selective rescue of heightened anxiety but not gait ataxia in a premutation 90CGG mouse model of Fragile X-associated tremor/ataxia syndrome
Castro, Hoanna; Kul, Emre; Buijsen, Ronald A.M.; Severijnen, Lies-Anne W.F.M.; Willemsen, Rob; Hukema, Renate K.; Stork, Oliver; Santos, Mónica, Human Molecular Genetics. 2133 - 2145. 11. 26. 2017. http://dx.doi.org/10.1093/hmg/ddx108 . 10.1093/hmg/ddx108 . published Human Molecular Genetics
Infralimbic Neurotrophin-3 Infusion Rescues Fear Extinction Impairment in a Mouse Model of Pathological Fear
D'Amico, Davide; Gener, Thomas; de Lagrán, Maria Martínez; Sanchez-Vives, Maria V; Santos, Mónica; Dierssen, Mara, Neuropsychopharmacology. 462 - 472. 2. 42. 2016. http://dx.doi.org/10.1038/npp.2016.154 . 10.1038/npp.2016.154 . published Neuropsychopharmacology
Fragile X-Associated Tremor/Ataxia Syndrome (FXTAS) Motor Dysfunction Modeled in Mice
Foote, Molly; Arque, Gloria; Berman, Robert F.; Santos, Mónica, The Cerebellum. 611 - 622. 5. 15. 2016. http://dx.doi.org/10.1007/s12311-016-0797-6 . 10.1007/s12311-016-0797-6 . published The Cerebellum
Genome-wide miR-155 and miR-802 target gene identification in the hippocampus of Ts65Dn Down syndrome mouse model by miRNA sponges
Bofill-De Ros, Xavier; Santos, Mónica; Vila-Casadesús, Maria; Villanueva, Eneko; Andreu, Nuria; Dierssen, Mara; Fillat, Cristina, BMC Genomics. 1. 16. 2015. http://dx.doi.org/10.1186/s12864-015-2160-6 . 10.1186/s12864-015-2160-6 . published BMC Genomics
From neural to genetic substrates of panic disorder: Insights from human and mouse studies
Santos, Mónica; D’Amico, Davide; Dierssen, Mara, European Journal of Pharmacology. 127 - 141. 759. 2015. http://dx.doi.org/10.1016/j.ejphar.2015.03.039 . 10.1016/j.ejphar.2015.03.039 . published European Journal of Pharmacology
Identification of key genes involved in Down syndrome pathogenesis by gene therapy,Identificación de genes clave implicados en el síndrome de Down mediante terapia génica
Fillat, C.; Bofill-De Ros, X.; Santos, M.; Martín, E.D.; Andreu, N.; Villanueva, E.; D'Amico, D.; Dierssen, M.; Altafaj, X., SD Revista Medica Internacional sobre el Sindrome de Down. 21 - 28. 2. 18. 2014. http://www.scopus.com/inward/record.url?eid=2-s2.0-84940262370&partnerID=MN8TOARS . 10.1016/S1138-2074(14)70049-1 . published SD Revista Medica Internacional sobre el Sindrome de Down
Hippocampal Hyperexcitability Underlies Enhanced Fear Memories in TgNTRK3, a Panic Disorder Mouse Model
Santos, M.; D'Amico, D.; Spadoni, O.; Amador-Arjona, A.; Stork, O.; Dierssen, M., Journal of Neuroscience. 15259 - 15271. 38. 33. 2013. http://dx.doi.org/10.1523/jneurosci.2161-13.2013 . 10.1523/jneurosci.2161-13.2013 . published Journal of Neuroscience
Rett syndrome with and without detected MECP2 mutations: An attempt to redefine phenotypes
Temudo, Teresa; Santos, Mónica; Ramos, Elisabete; Dias, Karin; Vieira, José Pedro; Moreira, Ana; Calado, Eulália; et al, Brain and Development. 69 - 76. 1. 33. 2011. http://dx.doi.org/10.1016/j.braindev.2010.01.004 . 10.1016/j.braindev.2010.01.004 . published Brain and Development
Monoamine deficits in the brain of methyl-CpG binding protein 2 null mice suggest the involvement of the cerebral cortex in early stages of Rett syndrome
Santos, M.; Summavielle, T.; Teixeira-Castro, A.; Silva-Fernandes, A.; Duarte-Silva, S.; Marques, F.; Martins, L.; et al, Neuroscience. 453 - 467. 2. 170. 2010. http://dx.doi.org/10.1016/j.neuroscience.2010.07.010 . 10.1016/j.neuroscience.2010.07.010 . published Neuroscience
Mutations in the MECP2 Gene Are Not a Major Cause of Rett Syndrome-Like or Related Neurodevelopmental Phenotype in Male Patients
Santos, Mónica; Temudo, Teresa; Kay, Teresa; Carrilho, Inês; Medeira, Ana; Cabral, Helena; Gomes, Roseli; et al, Journal of Child Neurology. 49 - 55. 1. 24. 2009. http://dx.doi.org/10.1177/0883073808321043 . 10.1177/0883073808321043 . published Journal of Child Neurology
Analysis of Highly Conserved Regions of the 3’UTR of MECP2 Gene in Patients with Clinical Diagnosis of Rett Syndrome and Other Disorders Associated with Mental Retardation
Santos, Mónica; Yan, Jin; Temudo, Teresa; Oliveira, Guiomar; Vieira, José Pedro; Fen, Jinong; Sommer, Steve; Maciel, Patrícia, Disease Markers. 319 - 324. 6. 24. 2008. http://dx.doi.org/10.1155/2008/738401 . 10.1155/2008/738401 . published Disease Markers
The C677T Polymorphism inMTHFRIs Not Associated with Migraine in Portugal
Ferro, Anabela; Castro, Maria-José; Lemos, Carolina; Santos, Mónica; Sousa, Alda; Pereira-Monteiro, José; Sequeiros, Jorge; Maciel, Patrícia, Disease Markers. 107 - 113. 2. 25. 2008. http://dx.doi.org/10.1155/2008/178679 . 10.1155/2008/178679 . published Disease Markers
T-1237C polymorphism of TLR9 gene is not associated with multiple sclerosis in the Portuguese population
Carvalho, A.; Santos, M.; Maciel, P.; Rodrigues, F., Multiple Sclerosis Journal. 550 - 552. 4. 14. 2008. http://dx.doi.org/10.1177/1352458507084594 . 10.1177/1352458507084594 . published Multiple Sclerosis Journal
Evidence for abnormal early development in a mouse model of Rett syndrome.
Santos M; Silva-Fernandes A; Oliveira P; Sousa N; Maciel P; Santos, M.; Silva-Fernandes, A.; et al, Genes, Brain and Behavior. 277 - 286. 3. 6. 2007. http://europepmc.org/abstract/med/16848781 . 10.1111/j.1601-183X.2006.00258.x . published Genes, Brain and Behavior
An explanation for another familial case of Rett syndrome: maternal germline mosaicism
Venâncio, Margarida; Santos, Mónica; Pereira, Susana Aires; Maciel, Patrícia; Saraiva, Jorge M, European Journal of Human Genetics. 902 - 904. 8. 15. 2007. http://dx.doi.org/10.1038/sj.ejhg.5201835 . 10.1038/sj.ejhg.5201835 . published European Journal of Human Genetics
Stereotypies in Rett syndrome: Analysis of 83 patients with and without detected MECP2 mutations
Temudo, T.; Oliveira, P.; Santos, M.; Dias, K.; Vieira, J.; Moreira, A.; Calado, E.; et al, Neurology. 1183 - 1187. 15. 68. 2007. http://dx.doi.org/10.1212/01.wnl.0000259086.34769.78 . 10.1212/01.wnl.0000259086.34769.78 . published Neurology
Corrigendum to "Linkage disequilibrium screening for multiple sclerosis implicates JAG1 and POU2AF1 as susceptibility genes in Europeans" [J. Neuroimmunol. 179 (2006) 108-116] (DOI:10.1016/j.jneuroim.2006.06.003)
Ban, M.; Booth, D.; Heard, R.; Stewart, G.; Goris, A.; Vandenbroeck, K.; Dubois, B.; et al, Journal of Neuroimmunology. 175 - 176. 1-2. 189. 2007. http://www.scopus.com/inward/record.url?eid=2-s2.0-34548554091&partnerID=MN8TOARS . 10.1016/j.jneuroim.2007.08.003 . Journal of Neuroimmunology
MECP2 coding sequence and 3'UTR variation in 172 unrelated autistic patients
Coutinho, Ana M.; Oliveira, Guiomar; Katz, Cécile; Feng, Jinong; Yan, Jin; Yang, Chunmei; Marques, Carla; et al, American Journal of Medical Genetics Part B: Neuropsychiatric Genetics. 475 - 483. 4. 144B. 2007. http://dx.doi.org/10.1002/ajmg.b.30490 . 10.1002/ajmg.b.30490 . published American Journal of Medical Genetics Part B: Neuropsychiatric Genetics
Linkage disequilibrium screening for multiple sclerosis implicates JAG1 and POU2AF1 as susceptibility genes in Europeans
The GAMES Collaborative Group, Journal of Neuroimmunology. 108 - 116. 1-2. 179. 2006. http://dx.doi.org/10.1016/j.jneuroim.2006.06.003 . 10.1016/j.jneuroim.2006.06.003 . published Journal of Neuroimmunology
APOE epsilon variation in multiple sclerosis susceptibility and disease severity: Some answers
Burwick, R. M.; Ramsay, P. P.; Haines, J. L.; Hauser, S. L.; Oksenberg, J. R.; Pericak-Vance, M. A.; Schmidt, S.; et al, Neurology. 1373 - 1383. 9. 66. 2006. http://dx.doi.org/10.1212/01.wnl.0000210531.19498.3f . 10.1212/01.wnl.0000210531.19498.3f . published Neurology
Chromatin remodeling and neuronal function: exciting links
Santos, M.; Coelho, P. A.; Maciel, P., Genes, Brain and Behavior. 80 - 91. 5. 2006. http://dx.doi.org/10.1111/j.1601-183x.2006.00227.x . 10.1111/j.1601-183x.2006.00227.x . published Genes, Brain and Behavior
Detection of heterozygous deletions and duplications in the MECP2 gene in Rett syndrome by Robust Dosage PCR (RD-PCR)
Shi, Jinxiu; Shibayama, Akane; Liu, Qiang; Nguyen, Vu Q.; Feng, Jinong; Santos, Monica; Temudo, Teresa; Maciel, Patricia; Sommer, Steve S., Human Mutation. 505 - 505. 5. 25. 2005. http://dx.doi.org/10.1002/humu.9338 . 10.1002/humu.9338 . published Human Mutation
Genotypes at the APOE and SCA2 loci do not predict the course of multiple sclerosis in patients of Portuguese origin
Santos, Mónica; do Carmo Costa, Maria; Rio, Maria Edite; Sá, Maria José; Monteiro, Marta; Valença, Angela; Sá, Alfredo; et al, Multiple Sclerosis Journal. 153 - 157. 2. 10. 2004. http://dx.doi.org/10.1191/1352458504ms998oa . 10.1191/1352458504ms998oa . published Multiple Sclerosis Journal
A whole genome screen for association with multiple sclerosis in Portuguese patients
Santos, M.; Pinto-Basto, J.; Rio, M.E.; Sá, M.J.; Valença, A.; Sá, A.; Dinis, J.; et al, Journal of Neuroimmunology. 112 - 115. 1-2. 143. 2003. http://dx.doi.org/10.1016/j.jneuroim.2003.08.023 . 10.1016/j.jneuroim.2003.08.023 . published Journal of Neuroimmunology
5 32 out of 32 Publications
All projects
Information of exclusive responsibility of the researcher 17-11-2024 , from platform CIÊNCIAVITAE.
2024/03/01 - 2025/02/28
Drug screening - ProRett
2024/1
Co-Principal Investigator (Co-PI)
Universidade de Coimbra Centro de Neurociências e Biologia Celular
Funders: Pro RETT Ricerca
2021/07/01 - 2023/06/30
An investigation on the MeCP2-early life stress interaction effects in anxiety sensitivity later in life in a mouse model of Rett syndrome
2046/2021
Principal investigator
Universidade de Coimbra Centro de Neurociências e Biologia Celular
Funders: Fondation Jérôme Lejeune
2021/03/01 - 2021/05/31
Regulation of mitochondria fission by brain-derived neurotrophic factor (BDNF): role in synaptic plasticity and in epileptogenesis
PTDC/MED-NEU/3736/2020
Other
Universidade de Coimbra Centro de Neurociências e Biologia Celular
Funders: Fundação para a Ciência e a Tecnologia
2020 - 2023
Structural plasticity in the olfactory system: impact of maternity, early stress and Mecp2 deficiency
PID2019-107322GB-C22
Other
Universitat de València
Funders: Gobierno de España Ministerio de Ciencia e Innovación
2019/10/07 - 2021/04/06
The endocannabinoid system and Rett syndrome: neuroanatomical, neurochemical and behavioural analyses
2/2019
Principal investigator
Universitat de Valencia Facultat de Ciències Biològiques; Centro de Inovação em Biomedicina e Biotecnologia (CIBB)
Funders: FinRett
2019/03/01 - 2022/02/28
Role of NT3/TrkC in the regulation of fear
85/18
Principal investigator
Centro de Inovação em Biomedicina e Biotecnologia (CIBB)
Funders: Fundação Bial
2019/10/08 - 2020/12/31
BrainHealth 2020 - Early detection, Neuromodulation and Advanced Therapies to Brain Disorders.
CENTRO-01-0145-FEDER-000008
Research Fellow
Universidade de Coimbra Centro de Neurociências e Biologia Celular; Centro de Inovação em Biomedicina e Biotecnologia (CIBB)
Funders: PT2020-CENTRO 2020 (FEDER)
2016 - 2018
Neurobiology of social behaviour. Experimental study of the aggressive and autistic brain in mice models
UJI-B2016-45
Other
Facultat De Ciencies De La Salut, Universitat Jaume I
Funders: Universitat Jaume I
2016/12/30 - 2020/07/29
Maternal Defence, Reward and Olfaction: Neurobiology of Social Behaviours Guided by Pheromones in Mice
BFU2016-77691-C2-1-P
Other
Facultat De Ciencies De La Salut, Universitat Jaume I
Funders: Ministry of Economy, Industry and Competitiveness
2015/03/01 - 2018/03/30
Preclinical approaches towards therapeutic intervention for fragile X premutation carriers
01GM1505
Other
Otto-von-Guericke-Universität Magdeburg Fakultät für Naturwissenschaften
Funders: Bundesministerium fur Bildung und Forschung Dienststelle Bonn
2015 - 2017
Neurobiology and Neurocognitive function in mousse models of Rasopathies.
FKZ 1GM1519A
Other
Otto-von-Guericke-Universität Magdeburg Fakultät für Naturwissenschaften
Funders: Bundesministerium fur Bildung und Forschung Dienststelle Bonn
2013/09/01 - 2016/04/30
Experimental approaches towards therapeutic intervention for Fragile X-associated Tremor Ataxia Syndrome
01GM1302
Principal investigator
Otto-von-Guericke-Universität Magdeburg Fakultät für Naturwissenschaften
Funders: Bundesministerium fur Bildung und Forschung Dienststelle Bonn
2012/07/01 - 2013/06/30
Knockdown of HAS 21-syntenic miRNAs in Ts65Dn mice by adeno-associated viral vectors. Consequences on hippocampus-dependent phenotypes
01_CF
Post-doc
Institut d'Investigacions Biomèdiques August Pi i Sunyer
Funders: Fondation Jérôme Lejeune
2012/07/01 - 2013/06/30
Phenotypic rescue of the Ts65Dn Down syndrome mouse model using a miRNA decoy approach.
U716
Post-doc Fellow
Centre de Regulació Genòmica; Institut d'Investigacions Biomèdiques August Pi i Sunyer
Funders: Centro de Investigación Biomédica en Red de Enfermedades Raras
2011/01/01 - 2012/06/30
Molecular bases of the functional role of the alternative splicing Ntrk3 WT and insert isoforms in learning and memory processes that rely on the cortico-hippocampal circuit.
07_M
Post-doc Fellow
Centro de Regulación Genómica
Funders: Fundación Ramon Areces
2008/01/01 - 2010/12/31
Understanding the impact of panic attacks on brain systems involved in the pathophysiology of panic disorder: cognitive, neural and molecular mechanisms.
SFRH/BPD/28555/2006
Post-doc Fellow
Centre de Regulació Genòmica
Funders: Fundação para a Ciência e a Tecnologia
2002/12/01 - 2006/11/30
Study of Rett syndrome pathogenesis and the role of MeCP2 protein in the neuronal function.
SFRH/BD/9111/2002
PhD Student Fellow
Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde
Funders: Fundação para a Ciência e a Tecnologia
2002 - 2005
Clinical, epidemiological and genetic study of Rett syndrome in Portugal.
POCTI 41416/2001
Researcher
Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde
Funders: Fundação para a Ciência e a Tecnologia
2001 - 2003
Genetic Analysis of Multiple sclerosis in EuropeanS (GAMES). Genomic screen of 6000 markers in the pooled Portuguese sample.
057097
Research Technician Fellow
Universidade do Porto Instituto de Biologia Molecular e Celular; Addenbrooke's Hospital Department of Neurology
Funders: Welkome Trust (UK)
5 19 out of 19 projects
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