Publications
Information about journal articles, updated at 17-11-2024, from platform CIÊNCIAVITAE.
Editorial: Drug discovery for emerging and neglected tropical diseases: advances, challenges and perspectives
Alcântara, Laura; Franco, Caio; Moretti, Nilmar; Pilger, Denise, Frontiers in Drug Discovery. 3. 2023. http://dx.doi.org/10.3389/fddsv.2023.1346042 . 10.3389/fddsv.2023.1346042 . accepted Frontiers in Drug Discovery
Microscopy-based phenotypic profiling of infection by Staphylococcus aureus clinical isolates reveals intracellular lifestyle as a prevalent feature
Rodrigues Lopes, Inês; Laura Maria Alcantara; Ricardo Silva; Jérôme JOSSE; Elena Pedrero Vega; Ana Marina Cabrerizo; Melanie Bonhomme; et al, Nature Communications. 1. 13. 2022. http://dx.doi.org/10.1038/s41467-022-34790-9 . 10.1038/s41467-022-34790-9 . Nature Communications
Drug Repurposing in Chagas Disease: Chloroquine Potentiates Benznidazole Activity against Trypanosoma cruzi <i>In Vitro</i> and <i>In Vivo</i>
Pandey, Ramendra P.; Nascimento, Marilda Savoia; Franco, Caio Haddad; Bortoluci, Karina; Silva, Marcelo Nunes; Zingales, Bianca; Gibaldi, Daniel; et al, Antimicrobial Agents and Chemotherapy. 2022. http://dx.doi.org/10.1128/aac.00284-22 . 10.1128/aac.00284-22 . published Antimicrobial Agents and Chemotherapy
Cyclophilin 19 secreted in the host cell cytosol by Trypanosoma cruzi promotes ROS production required for parasite growth
Santos, Gregory Pedroso; Abukawa, Fernanda Midori; Souza-Melo, Normanda; Alcântara, Laura Maria; Bittencourt-Cunha, Paula; Moraes, Carolina Borsoi; Jha, Bijay Kumar; et al, Cellular Microbiology. e13295. 2020. http://dx.doi.org/10.1111/cmi.13295 . 10.1111/cmi.13295 . published Cellular Microbiology
A Multi-Species Phenotypic Screening Assay for Leishmaniasis Drug Discovery Shows That Active Compounds Display a High Degree of Species-Specificity
Alcântara, Laura M.; Ferreira, Thalita C. S.; Fontana, Vanessa; Chatelain, Eric; Moraes, Carolina B.; Freitas-Junior, Lucio H., Molecules. 11. 25. 2020. http://dx.doi.org/10.3390/molecules25112551 . 10.3390/molecules25112551 . published Molecules
Identification of Inhibitors to Trypanosoma cruzi Sirtuins Based on Compounds Developed to Human Enzymes
Matutino Bastos, Tanira; Botelho Pereira Soares, Milena; Haddad Franco, Caio; Alcântara, Laura; Antonini, Lorenzo; Sabatino, Manuela; Mautone, Nicola; et al, International Journal of Molecular Sciences. 10. 21. 2020. http://dx.doi.org/10.3390/ijms21103659 . 10.3390/ijms21103659 . published International Journal of Molecular Sciences
Drug Discovery for Chagas Disease: Impact of Different Host Cell Lines on Assay Performance and Hit Compound Selection
Caio Haddad Franco; Laura Maria Alcântara; eric; Lucio Freitas-Junior; Carolina Borsoi Moraes, Tropical Medicine and Infectious Disease. 2019. 10.3390/tropicalmed4020082 . Tropical Medicine and Infectious Disease
Aryl thiosemicarbazones for the treatment of trypanosomatidic infections
Linciano, P.; Moraes, C.B.; Alcantara, L.M.; Franco, C.H.; Pascoalino, B.; Freitas-Junior, L.H.; Macedo, S.; et al, European Journal of Medicinal Chemistry. 423 - 434. 146. 2018. 10.1016/j.ejmech.2018.01.043 . European Journal of Medicinal Chemistry
Challenges in drug discovery targeting TriTryp diseases with an emphasis on leishmaniasis
Alcântara, L.M.; Ferreira, T.C.S.; Gadelha, F.R.; Miguel, D.C., International Journal for Parasitology: Drugs and Drug Resistance. 430 - 439. 3. 8. 2018. 10.1016/j.ijpddr.2018.09.006 . International Journal for Parasitology: Drugs and Drug Resistance
Exploiting the 2-Amino-1,3,4-thiadiazole scaffold to inhibit trypanosoma brucei pteridine reductase in support of early-stage drug discovery
Linciano, P.; Dawson, A.; Pöhner, I.; Costa, D.M.; Sa, M.S.; Cordeiro-Da-Silva, A.; Luciani, R.; et al, ACS Omega. 5666 - 5683. 9. 2. 2017. 10.1021/acsomega.7b00473 . ACS Omega
Chroman-4-one derivatives targeting pteridine reductase 1 and showing anti-parasitic activity
Di Pisa, F.; Landi, G.; Dello Iacono, L.; Pozzi, C.; Borsari, C.; Ferrari, S.; Santucci, M.; et al, Molecules. 3. 22. 2017. 10.3390/molecules22030426 . Molecules
Computer-aided discovery of two novel chalcone-like compounds active and selective against Leishmania infantum
Gomes, M.N.; Alcântara, L.M.; Neves, B.J.; Melo-Filho, C.C.; Freitas-Junior, L.H.; Moraes, C.B.; Ma, R.; et al, Bioorganic and Medicinal Chemistry Letters. 2459 - 2464. 11. 27. 2017. 10.1016/j.bmcl.2017.04.010 . Bioorganic and Medicinal Chemistry Letters
Methoxylated 2'-hydroxychalcones as antiparasitic hit compounds
Borsari, C.; Santarem, N.; Torrado, J.; Olías, A.I.; Corral, M.J.; Baptista, C.; Gul, S.; et al, European Journal of Medicinal Chemistry. 1129 - 1135. 126. 2017. 10.1016/j.ejmech.2016.12.017 . European Journal of Medicinal Chemistry
N-[4-[Benzyloxy] benzyl]-benzenemethaneamines with High Biological Activity against Intracellular Trypanosoma cruzi and Leishmania infantum Amastigotes.
Gabrielle Frizzo Souza; Simon Bernhard Cämmerer; Caio Haddad Franco; Alcântara, Laura; Carolina Borsoi Moraes; Lucio Freitas-Junior, International Journal of Chemistry and Pharmaceutical Sciences.. 570 - 578. 11. 4. 2016. published International Journal of Chemistry and Pharmaceutical Sciences.
Chemosensitization potential of P-glycoprotein inhibitors in malaria parasites
Alcantara, L.M.; Kim, J.; Moraes, C.B.; Franco, C.H.; Franzoi, K.D.; Lee, S.; Freitas-Junior, L.H.; Ayong, L.S., Experimental Parasitology. 235 - 243. 2. 134. 2013. 10.1016/j.exppara.2013.03.022 . Experimental Parasitology
5 15 out of 15 Publications
All projects
Information of exclusive responsibility of the researcher 17-11-2024 , from platform CIÊNCIAVITAE.
2022/01 -
Identification of host microRNAs regulating the infection of macrophages by invasive and non-invasive Salmonella strains.
EXPL/BIA-MIC/1251/2021
Other
Centro de Inovação em Biomedicina e Biotecnologia (CIBB)
Funders: Fundação para a Ciência e a Tecnologia
2020/10 -
Large-scale identification and functional characterization of host microRNAs regulating infection by clinically relevant Staphylococcus aureus strains
POCI-01-0145-FEDER-029999
Other
Centro de Inovação em Biomedicina e Biotecnologia (CIBB)
Funders: Fundação para a Ciência e a Tecnologia
2020/10 - 2022/10
Functional high-throughput analysis of the role of microRNAs in regulating Staphylococcus aureus infection (miRs4Staph).
Marie Sklodowska-Curie fellowship 893942
Post-doc Fellow
Centro de Inovação em Biomedicina e Biotecnologia (CIBB)
Funders: EU Framework Programme for Research and Innovation Marie Sklodowska-Curie Actions
2019/04 - 2020/09
New therapies for Chagas Disease: repurposing of drugs with synergistic effect with Benznidazole to counteract Trypanosoma cruzi infection
CAPES/FCT - 28/2017
Post-doc Fellow
Instituto do Coração do Hospital das Clínicas da FMUSP - Incor
Funders: Coordenação de Aperfeiçoamento de Pessoal de Nível Superior; Fundação para a Ciência e a Tecnologia
2017 - 2018
Identification of starting points for drug discovery and target identification against major neglected diseases
MMV2016
Post-doc Fellow
Universidade de São Paulo
Funders: Medicines for Malaria Venture
2017/11 - 2019/03
Development of secondary in vitro assays for Chagas disease and leishmaniasis early drug discovery.
VPPIS-003-PPE-15-2-6
Post-doc Fellow
Universidade de São Paulo
Funders: Drugs for Neglected Diseases initiative
2014 - 2017
NMTrypl - New Drugs for Trypanosomatidic Infections
603240
PhD Student Fellow
Centro Nacional de Pesquisa em Energia e Materiais
Funders: European Commission Seventh Framework Programme for Research and Technological Development
5 7 out of 7 projects
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